{"id":"https://openalex.org/W4391885636","doi":"https://doi.org/10.1371/journal.pcbi.1011252","title":"Enhanced perfusion following exposure to radiotherapy: A theoretical investigation","display_name":"Enhanced perfusion following exposure to radiotherapy: A theoretical investigation","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391885636","doi":"https://doi.org/10.1371/journal.pcbi.1011252","pmid":"https://pubmed.ncbi.nlm.nih.gov/38363799"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011252","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011252&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011252&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006531182","display_name":"Jakub K\u00f6ry","orcid":"https://orcid.org/0000-0002-4476-2547"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jakub K\u00f6ry","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Oxford, United Kingdom","School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044300716","display_name":"V.S. Narain","orcid":"https://orcid.org/0000-0003-0754-0088"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vedang Narain","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006355933","display_name":"Bernadette J. Stolz","orcid":"https://orcid.org/0000-0001-8658-8666"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH","GB"],"is_corresponding":true,"raw_author_name":"Bernadette J. Stolz","raw_affiliation_strings":["Laboratory for Topology and Neuroscience, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Laboratory for Topology and Neuroscience, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047777713","display_name":"Jakob Kaeppler","orcid":"https://orcid.org/0000-0001-5973-0049"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jakob Kaeppler","raw_affiliation_strings":["Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210106471","https://openalex.org/I2801316944","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041997129","display_name":"Bo\u0161tjan Markelc","orcid":"https://orcid.org/0000-0002-8674-702X"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I3019592416","display_name":"Institute of Oncology Ljubljana","ror":"https://ror.org/00y5zsg21","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3019592416"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB","SI"],"is_corresponding":true,"raw_author_name":"Bostjan Markelc","raw_affiliation_strings":["Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom","Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210106471","https://openalex.org/I2801316944","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3019592416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064457809","display_name":"Ruth J. Muschel","orcid":"https://orcid.org/0000-0002-5656-5970"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ruth J. Muschel","raw_affiliation_strings":["Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210106471","https://openalex.org/I2801316944","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025791169","display_name":"Philip K. Maini","orcid":"https://orcid.org/0000-0002-0146-9164"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philip K. Maini","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081431968","display_name":"Joe Pitt\u2010Francis","orcid":"https://orcid.org/0000-0002-5094-5403"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joe M. Pitt-Francis","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087448925","display_name":"Helen M. Byrne","orcid":"https://orcid.org/0000-0003-1771-5910"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Helen M. Byrne","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5006355933","https://openalex.org/A5006531182","https://openalex.org/A5025791169","https://openalex.org/A5041997129","https://openalex.org/A5044300716","https://openalex.org/A5047777713","https://openalex.org/A5064457809","https://openalex.org/A5081431968","https://openalex.org/A5087448925"],"corresponding_institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I3019592416","https://openalex.org/I40120149","https://openalex.org/I4210106471","https://openalex.org/I5124864","https://openalex.org/I7882870"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.944,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.83107577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"20","issue":"2","first_page":"e1011252","last_page":"e1011252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9789000153541565,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.8962928056716919},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.6383697986602783},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.6186776161193848},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.5741595029830933},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5340055227279663},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.45689910650253296},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43529263138771057},{"id":"https://openalex.org/keywords/perfusion-scanning","display_name":"Perfusion scanning","score":0.4307098984718323},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3511502742767334},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3411356508731842},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.32164642214775085},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.27383241057395935},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.2691982090473175},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25346994400024414},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17172834277153015},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.10067158937454224},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.06615075469017029}],"concepts":[{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.8962928056716919},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6383697986602783},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6186776161193848},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5741595029830933},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5340055227279663},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.45689910650253296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43529263138771057},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.4307098984718323},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3511502742767334},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3411356508731842},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32164642214775085},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.27383241057395935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2691982090473175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25346994400024414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17172834277153015},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10067158937454224},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06615075469017029},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1011252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011252","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011252&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38363799","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38363799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:321557","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.gla.ac.uk/321557/1/321557.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:10903964","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10903964","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10903964/pdf/pcbi.1011252.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bc036081c6b94ada82eb532b05c135a7","is_oa":true,"landing_page_url":"https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)","raw_type":"article"},{"id":"pmh:oai:infoscience.epfl.ch:309799","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/206426","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011252","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011252&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1099494159","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1107224731","display_name":null,"funder_award_id":"C5255/A1593","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1132496359","display_name":"Application driven Topological Data Analysis","funder_award_id":"EP/R018472/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1271970818","display_name":null,"funder_award_id":"A18085","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1325498775","display_name":null,"funder_award_id":"C5255","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G148533892","display_name":"Radiation and Tumour Blood Vessels","funder_award_id":"625631","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1998776115","display_name":null,"funder_award_id":"J3-2529","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G2014253402","display_name":null,"funder_award_id":"C5255/A15935","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2203179303","display_name":null,"funder_award_id":"R014604/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2689612763","display_name":null,"funder_award_id":"Marie","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2801358579","display_name":null,"funder_award_id":"P3-0003, J3-2529","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G3514550006","display_name":null,"funder_award_id":"Centre","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3691759950","display_name":null,"funder_award_id":"EP/R014604/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3814908810","display_name":null,"funder_award_id":"C5255/A15935","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3981126665","display_name":null,"funder_award_id":"Seventh Framework Programme","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4096213317","display_name":null,"funder_award_id":"Programme","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4681381370","display_name":null,"funder_award_id":"Marie Curie","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5116299453","display_name":null,"funder_award_id":"A15935","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5159139918","display_name":null,"funder_award_id":"Marie Curie Actions","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5450091064","display_name":"Isaac Newton Institute for Mathematical Sciences","funder_award_id":"EP/R014604/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6000436894","display_name":null,"funder_award_id":"C5255/A18085 and C5255/A15935","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6066696820","display_name":null,"funder_award_id":"EP/R018472/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6617956305","display_name":null,"funder_award_id":"No. C5255/A18085 and No. C5255/A15935","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6763375396","display_name":null,"funder_award_id":"C5255/A15935","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6987710327","display_name":null,"funder_award_id":"C5255/A18085","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6997492455","display_name":null,"funder_award_id":"No 625631","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8112475816","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8152579551","display_name":null,"funder_award_id":"EP/R018472/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G8654818507","display_name":null,"funder_award_id":"Mathematics","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8841238962","display_name":null,"funder_award_id":"P3-0003","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8961036091","display_name":null,"funder_award_id":"C2195/A31281","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391885636.pdf","grobid_xml":"https://content.openalex.org/works/W4391885636.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W115452890","https://openalex.org/W1531444659","https://openalex.org/W1607213229","https://openalex.org/W1814118778","https://openalex.org/W1906190317","https://openalex.org/W1915374658","https://openalex.org/W1970744454","https://openalex.org/W1978550123","https://openalex.org/W1985345792","https://openalex.org/W1991566301","https://openalex.org/W1992112921","https://openalex.org/W1993202788","https://openalex.org/W1997122877","https://openalex.org/W2003933044","https://openalex.org/W2014073279","https://openalex.org/W2020422943","https://openalex.org/W2022540958","https://openalex.org/W2027097550","https://openalex.org/W2046322851","https://openalex.org/W2047027201","https://openalex.org/W2048195900","https://openalex.org/W2049681345","https://openalex.org/W2065977830","https://openalex.org/W2086918224","https://openalex.org/W2096736341","https://openalex.org/W2102240528","https://openalex.org/W2102916742","https://openalex.org/W2102917242","https://openalex.org/W2115538252","https://openalex.org/W2121421529","https://openalex.org/W2126410943","https://openalex.org/W2134648876","https://openalex.org/W2149185044","https://openalex.org/W2159328080","https://openalex.org/W2168957713","https://openalex.org/W2233496256","https://openalex.org/W2272065411","https://openalex.org/W2321944794","https://openalex.org/W2398223210","https://openalex.org/W2513508797","https://openalex.org/W2518488580","https://openalex.org/W2528381731","https://openalex.org/W2580361293","https://openalex.org/W2583167946","https://openalex.org/W2613261988","https://openalex.org/W2735813259","https://openalex.org/W2894918092","https://openalex.org/W2895680199","https://openalex.org/W2910867684","https://openalex.org/W2925050677","https://openalex.org/W2941564413","https://openalex.org/W2950753216","https://openalex.org/W2953157390","https://openalex.org/W2964237352","https://openalex.org/W2987284967","https://openalex.org/W2990146178","https://openalex.org/W3012553271","https://openalex.org/W3013843370","https://openalex.org/W3015234645","https://openalex.org/W3016857495","https://openalex.org/W3082181200","https://openalex.org/W3118794388","https://openalex.org/W3119647002","https://openalex.org/W3126096896","https://openalex.org/W3136970255","https://openalex.org/W3142622887","https://openalex.org/W3167698219","https://openalex.org/W3175446266","https://openalex.org/W3176756166","https://openalex.org/W4206942166","https://openalex.org/W4226011862","https://openalex.org/W4236463097","https://openalex.org/W4244224006","https://openalex.org/W4252712324","https://openalex.org/W4255383393","https://openalex.org/W4256353056","https://openalex.org/W4281870735","https://openalex.org/W4285800863","https://openalex.org/W4293759272","https://openalex.org/W6776143347"],"related_works":["https://openalex.org/W2026961173","https://openalex.org/W2139059299","https://openalex.org/W2467919609","https://openalex.org/W3032083687","https://openalex.org/W2383101986","https://openalex.org/W2471267301","https://openalex.org/W2467341106","https://openalex.org/W2385340480","https://openalex.org/W2133730772","https://openalex.org/W2015301357"],"abstract_inverted_index":{"Tumour":[0],"angiogenesis":[1],"leads":[2],"to":[3,30,79,96,142,173,177,188],"the":[4,81,98,122,143,156,164,169,190],"formation":[5],"of":[6,100,118,145,158,192],"blood":[7,16,88,104,150],"vessels":[8,101],"that":[9,57,102,108,180],"are":[10,181],"structurally":[11],"and":[12,23,87,115,131,187],"spatially":[13],"heterogeneous.":[14],"Poor":[15],"perfusion,":[17],"in":[18,45,65,90,125],"conjunction":[19],"with":[20,59,111],"increased":[21],"hypoxia":[22],"oxygen":[24],"heterogeneity,":[25],"impairs":[26],"a":[27,75],"tumour's":[28],"response":[29],"radiotherapy.":[31],"The":[32],"optimal":[33,165],"strategy":[34],"for":[35,128,184],"enhancing":[36],"tumour":[37],"perfusion":[38,61,89,93,126,139,185],"remains":[39],"unclear,":[40],"preventing":[41],"its":[42],"regular":[43],"deployment":[44],"combination":[46,193],"therapies.":[47,194],"In":[48,168],"this":[49],"work,":[50],"we":[51,73,106,171],"first":[52],"identify":[53,136,178],"vascular":[54,70,109],"architectural":[55,85],"features":[56,86],"correlate":[58],"enhanced":[60],"following":[62],"radiotherapy,":[63],"using":[64],"vivo":[66],"imaging":[67],"data":[68],"from":[69],"tumours.":[71,133],"Then,":[72],"present":[74],"novel":[76],"computational":[77],"model":[78],"determine":[80],"relationship":[82],"between":[83],"these":[84],"silico.":[91],"If":[92],"is":[94],"defined":[95],"be":[97],"proportion":[99],"support":[103],"flow,":[105],"find":[107],"networks":[110],"small":[112],"mean":[113],"diameters":[114],"large":[116],"numbers":[117],"angiogenic":[119],"sprouts":[120],"show":[121],"largest":[123],"increases":[124,140],"post-irradiation":[127],"both":[129],"biological":[130],"synthetic":[132],"We":[134],"also":[135],"cases":[137],"where":[138],"due":[141],"pruning":[144],"hypoperfused":[146],"vessels,":[147],"rather":[148],"than":[149],"being":[151],"rerouted.":[152],"These":[153],"results":[154],"indicate":[155],"importance":[157],"considering":[159],"network":[160],"composition":[161],"when":[162],"determining":[163],"irradiation":[166],"strategy.":[167],"future,":[170],"aim":[172],"use":[174],"our":[175],"findings":[176],"tumours":[179],"good":[182],"candidates":[183],"enhancement":[186],"improve":[189],"efficacy":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}