{"id":"https://openalex.org/W4379794323","doi":"https://doi.org/10.1371/journal.pcbi.1011218","title":"Mslar: Microbial synthetic lethal and rescue database","display_name":"Mslar: Microbial synthetic lethal and rescue database","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4379794323","doi":"https://doi.org/10.1371/journal.pcbi.1011218","pmid":"https://pubmed.ncbi.nlm.nih.gov/37289843"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011218&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059437393","display_name":"Sen-Bin Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sen-Bin Zhu","raw_affiliation_strings":["Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China","School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0009-0002-7094-0017","affiliations":[{"raw_affiliation_string":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110987751","display_name":"Qian-Hu Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian-Hu Jiang","raw_affiliation_strings":["School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742807","display_name":"Zhiguo Chen","orcid":"https://orcid.org/0000-0003-3269-9170"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Guo Chen","raw_affiliation_strings":["School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103092350","display_name":"Xiang Zhou","orcid":"https://orcid.org/0009-0003-3063-1743"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiang Zhou","raw_affiliation_strings":["School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0009-0003-3063-1743","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051946493","display_name":"Yan-Ting Jin","orcid":"https://orcid.org/0000-0001-6700-8494"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-ting Jin","raw_affiliation_strings":["School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781054","display_name":"Zixin Deng","orcid":"https://orcid.org/0000-0003-0724-3390"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zixin Deng","raw_affiliation_strings":["Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079147107","display_name":"Feng\u2010Biao Guo","orcid":"https://orcid.org/0000-0002-1129-5233"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng-Biao Guo","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-1129-5233","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234","https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5051946493","https://openalex.org/A5059437393","https://openalex.org/A5079147107","https://openalex.org/A5100742807","https://openalex.org/A5100781054","https://openalex.org/A5103092350","https://openalex.org/A5110987751"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I37461747","https://openalex.org/I4210120234"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2907,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62481833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"19","issue":"6","first_page":"e1011218","last_page":"e1011218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7090370059013367},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6723419427871704},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.582211971282959},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5547823309898376},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5180552005767822},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.5093165636062622},{"id":"https://openalex.org/keywords/lethal-allele","display_name":"Lethal allele","score":0.502159595489502},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48849594593048096},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.4554774761199951},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.43884390592575073},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.43352165818214417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.09832119941711426}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7090370059013367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6723419427871704},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.582211971282959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5547823309898376},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5180552005767822},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.5093165636062622},{"id":"https://openalex.org/C43934763","wikidata":"https://www.wikidata.org/wiki/Q927843","display_name":"Lethal allele","level":3,"score":0.502159595489502},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48849594593048096},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4554774761199951},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43884390592575073},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43352165818214417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09832119941711426}],"mesh":[{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37289843","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37289843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10284384","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10284384","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10284384/pdf/pcbi.1011218.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f4f4e10bbab743709cd317b61e8f1cde","is_oa":true,"landing_page_url":"https://doaj.org/article/f4f4e10bbab743709cd317b61e8f1cde","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 6, p e1011218 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3534538627","display_name":null,"funder_award_id":"2018YFA0903702","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5389991281","display_name":null,"funder_award_id":"31871335","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379794323.pdf","grobid_xml":"https://content.openalex.org/works/W4379794323.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W147290053","https://openalex.org/W1530814332","https://openalex.org/W1885504063","https://openalex.org/W1965372971","https://openalex.org/W1967638691","https://openalex.org/W1978244614","https://openalex.org/W2001673920","https://openalex.org/W2003438913","https://openalex.org/W2008402427","https://openalex.org/W2011242261","https://openalex.org/W2022589976","https://openalex.org/W2032664706","https://openalex.org/W2043510671","https://openalex.org/W2081933515","https://openalex.org/W2086833219","https://openalex.org/W2111967267","https://openalex.org/W2116586551","https://openalex.org/W2119673997","https://openalex.org/W2123027763","https://openalex.org/W2127073167","https://openalex.org/W2132620143","https://openalex.org/W2135561070","https://openalex.org/W2145996960","https://openalex.org/W2147681274","https://openalex.org/W2148726194","https://openalex.org/W2150749732","https://openalex.org/W2153932901","https://openalex.org/W2159906261","https://openalex.org/W2168244801","https://openalex.org/W2169076068","https://openalex.org/W2279299471","https://openalex.org/W2522417827","https://openalex.org/W2552981562","https://openalex.org/W2563859344","https://openalex.org/W2594902416","https://openalex.org/W3000025696","https://openalex.org/W3106353906"],"related_works":["https://openalex.org/W4223896405","https://openalex.org/W2059629050","https://openalex.org/W2258998699","https://openalex.org/W2074740504","https://openalex.org/W3013644380","https://openalex.org/W1996935079","https://openalex.org/W3210243923","https://openalex.org/W2145833061","https://openalex.org/W1998405066","https://openalex.org/W2171737904"],"abstract_inverted_index":{"Synthetic":[0,94,175],"lethality":[1],"(SL)":[2],"occurs":[3],"when":[4,166],"mutations":[5],"in":[6,20,102,117,140,192],"two":[7],"genes":[8,39,156,197],"together":[9],"lead":[10],"to":[11,35,49,72,183,204],"cell":[12],"or":[13,37],"organism":[14],"death,":[15],"while":[16],"a":[17,26,66,69,81,160,185],"single":[18],"mutation":[19],"either":[21],"gene":[22,54,76,97],"does":[23],"not":[24],"have":[25,46,159],"significant":[27],"impact.":[28],"This":[29],"concept":[30],"can":[31],"also":[32],"be":[33,184],"extended":[34],"three":[36],"more":[38],"for":[40,57,85,189],"SL.":[41,172],"Computational":[42],"and":[43,51,59,92,132,151,157,171,177,195,206],"experimental":[44],"methods":[45],"been":[47],"developed":[48],"predict":[50],"verify":[52],"SL":[53,75,91,110,137,194],"pairs,":[55],"especially":[56],"yeast":[58],"Escherichia":[60],"coli.":[61],"However,":[62],"there":[63],"is":[64,181,201],"currently":[65],"lack":[67],"of":[68,148,163,198],"specialized":[70],"platform":[71],"collect":[73],"microbial":[74,86],"pairs.":[77],"Therefore,":[78],"we":[79,144,167],"designed":[80],"synthetic":[82],"interaction":[83,138],"database":[84,122],"genetics":[87],"that":[88,99,153],"collects":[89],"13,313":[90],"2,994":[93],"Rescue":[95,178],"(SR)":[96],"pairs":[98,111],"are":[100],"reported":[101],"the":[103,136,141,146,154,193,209],"literature,":[104],"as":[105,107,128],"well":[106],"86,981":[108],"putative":[109],"got":[112],"through":[113],"homologous":[114],"transfer":[115],"method":[116],"281":[118],"bacterial":[119],"genomes.":[120],"Our":[121],"website":[123],"provides":[124],"multiple":[125],"functions":[126],"such":[127],"search,":[129],"browse,":[130],"visualization,":[131],"Blast.":[133],"Based":[134],"on":[135,208],"data":[139],"S.":[142],"cerevisiae,":[143],"review":[145],"issue":[147],"duplications'":[149],"essentiality":[150],"observed":[152],"duplicated":[155],"singletons":[158],"similar":[161],"ratio":[162],"being":[164],"essential":[165],"consider":[168],"both":[169],"individual":[170],"The":[173],"Microbial":[174],"Lethal":[176],"Database":[179],"(Mslar)":[180],"expected":[182],"useful":[186],"reference":[187],"resource":[188],"researchers":[190],"interested":[191],"SR":[196],"microorganisms.":[199],"Mslar":[200],"open":[202],"freely":[203],"everyone":[205],"available":[207],"web":[210],"at":[211],"http://guolab.whu.edu.cn/Mslar/.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}