{"id":"https://openalex.org/W4376643074","doi":"https://doi.org/10.1371/journal.pcbi.1011100","title":"Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements","display_name":"Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements","publication_year":2023,"publication_date":"2023-05-15","ids":{"openalex":"https://openalex.org/W4376643074","doi":"https://doi.org/10.1371/journal.pcbi.1011100","pmid":"https://pubmed.ncbi.nlm.nih.gov/37186644"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011100&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000900837","display_name":"Ruolin He","orcid":"https://orcid.org/0000-0003-2163-5526"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruolin He","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434992","display_name":"Jinyu Zhang","orcid":"https://orcid.org/0000-0002-9200-5348"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinyu Zhang","raw_affiliation_strings":["Savaid Medical School, University of Chinese Academy of Sciences, Beijing, PR China","State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China"],"affiliations":[{"raw_affiliation_string":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I4210134982","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101045802","display_name":"Yuanzhe Shao","orcid":"https://orcid.org/0009-0003-6739-4198"},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanzhe Shao","raw_affiliation_strings":["Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075758666","display_name":"Shaohua Gu","orcid":"https://orcid.org/0000-0003-3071-5747"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaohua Gu","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727994","display_name":"Chen Song","orcid":"https://orcid.org/0000-0001-9730-3216"},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Song","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022358779","display_name":"Long Qian","orcid":"https://orcid.org/0000-0003-3728-7917"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Long Qian","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058910088","display_name":"Wen\u2010Bing Yin","orcid":"https://orcid.org/0000-0002-9184-3198"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen-Bing Yin","raw_affiliation_strings":["Savaid Medical School, University of Chinese Academy of Sciences, Beijing, PR China","State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China"],"affiliations":[{"raw_affiliation_string":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I4210134982","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100337921","display_name":"Zhiyuan Li","orcid":"https://orcid.org/0000-0001-6662-2636"},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiyuan Li","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000900837","https://openalex.org/A5022358779","https://openalex.org/A5058910088","https://openalex.org/A5075758666","https://openalex.org/A5100337921","https://openalex.org/A5100434992","https://openalex.org/A5100727994","https://openalex.org/A5101045802"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210134982","https://openalex.org/I4210160507","https://openalex.org/I4210165038"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.6343,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.9792808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"5","first_page":"e1011100","last_page":"e1011100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6598834991455078},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5302184224128723},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.46420201659202576},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4251059293746948},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.417830228805542},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36610737442970276},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34323662519454956},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2407625913619995},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.23833820223808289}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6598834991455078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5302184224128723},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.46420201659202576},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4251059293746948},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.417830228805542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36610737442970276},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34323662519454956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2407625913619995},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.23833820223808289}],"mesh":[{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37186644","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37186644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10212144","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10212144","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10212144/pdf/pcbi.1011100.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a7f20af8e059472f9765e2bcb4674df2","is_oa":true,"landing_page_url":"https://doaj.org/article/a7f20af8e059472f9765e2bcb4674df2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 5, p e1011100 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1122660348","display_name":null,"funder_award_id":"2021YFF1200500","funder_id":"https://openalex.org/F4320335774","funder_display_name":"Key Technologies Research and Development Program"},{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1767360706","display_name":null,"funder_award_id":"KFJ-BRP-009","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G2082826544","display_name":null,"funder_award_id":"Postdoctoral","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2376276132","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2527590156","display_name":null,"funder_award_id":"No. BX2021012","funder_id":"https://openalex.org/F4320335768","funder_display_name":"National Postdoctoral Program for Innovative Talents"},{"id":"https://openalex.org/G2802911279","display_name":null,"funder_award_id":"Young","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3280662447","display_name":null,"funder_award_id":"32071255","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3736819789","display_name":null,"funder_award_id":"ZDBS-LY-SM01","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5312938379","display_name":null,"funder_award_id":"42107140","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5640293734","display_name":null,"funder_award_id":"ZDBS-LY-SM016","funder_id":"https://openalex.org/F4320336758","funder_display_name":"Key Project of Frontier Science Research of Chinese Academy of Sciences"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6058138561","display_name":null,"funder_award_id":", No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6212677711","display_name":null,"funder_award_id":"2021012","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6258415954","display_name":null,"funder_award_id":"Chinese","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7166655543","display_name":null,"funder_award_id":"2021012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7655889372","display_name":null,"funder_award_id":"BX2021012","funder_id":"https://openalex.org/F4320335768","funder_display_name":"National Postdoctoral Program for Innovative Talents"},{"id":"https://openalex.org/G793667550","display_name":null,"funder_award_id":"KFJ-BRP-009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8050651220","display_name":null,"funder_award_id":"202101","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8099599964","display_name":null,"funder_award_id":"ZDBS-LY-SM016","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G8272864169","display_name":null,"funder_award_id":"2021YFF1200500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8801400471","display_name":null,"funder_award_id":"KFJ-BRP-009-005","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320335768","display_name":"National Postdoctoral Program for Innovative Talents","ror":null},{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336758","display_name":"Key Project of Frontier Science Research of Chinese Academy of Sciences","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376643074.pdf","grobid_xml":"https://content.openalex.org/works/W4376643074.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W190540197","https://openalex.org/W1202680985","https://openalex.org/W1500888647","https://openalex.org/W1588343339","https://openalex.org/W1759382455","https://openalex.org/W1803102843","https://openalex.org/W1964485754","https://openalex.org/W1965811910","https://openalex.org/W1965839094","https://openalex.org/W1967757651","https://openalex.org/W1969805461","https://openalex.org/W1970386034","https://openalex.org/W1972422447","https://openalex.org/W1975493568","https://openalex.org/W1979107226","https://openalex.org/W1985097226","https://openalex.org/W1985416514","https://openalex.org/W1988187251","https://openalex.org/W1988594072","https://openalex.org/W1991303432","https://openalex.org/W1995102273","https://openalex.org/W1999824974","https://openalex.org/W2007176538","https://openalex.org/W2009035529","https://openalex.org/W2013612636","https://openalex.org/W2013619747","https://openalex.org/W2023346730","https://openalex.org/W2027277404","https://openalex.org/W2031090875","https://openalex.org/W2032602147","https://openalex.org/W2044236886","https://openalex.org/W2056053405","https://openalex.org/W2057766174","https://openalex.org/W2057850803","https://openalex.org/W2059504647","https://openalex.org/W2060081344","https://openalex.org/W2062594082","https://openalex.org/W2065679186","https://openalex.org/W2065921821","https://openalex.org/W2066415386","https://openalex.org/W2073547003","https://openalex.org/W2074402828","https://openalex.org/W2077730872","https://openalex.org/W2078933645","https://openalex.org/W2080895748","https://openalex.org/W2091007201","https://openalex.org/W2092727330","https://openalex.org/W2092746448","https://openalex.org/W2101600846","https://openalex.org/W2106932184","https://openalex.org/W2111404134","https://openalex.org/W2111647009","https://openalex.org/W2111689333","https://openalex.org/W2112887820","https://openalex.org/W2114839447","https://openalex.org/W2126714764","https://openalex.org/W2127322768","https://openalex.org/W2129448726","https://openalex.org/W2130225062","https://openalex.org/W2131584678","https://openalex.org/W2131887397","https://openalex.org/W2132924229","https://openalex.org/W2138122982","https://openalex.org/W2145897869","https://openalex.org/W2151457629","https://openalex.org/W2155466666","https://openalex.org/W2157165549","https://openalex.org/W2157262350","https://openalex.org/W2166701319","https://openalex.org/W2167918062","https://openalex.org/W2177846120","https://openalex.org/W2229450847","https://openalex.org/W2315377404","https://openalex.org/W2316565238","https://openalex.org/W2376573086","https://openalex.org/W2557368150","https://openalex.org/W2561508218","https://openalex.org/W2566724977","https://openalex.org/W2582630110","https://openalex.org/W2598064261","https://openalex.org/W2602946330","https://openalex.org/W2614081736","https://openalex.org/W2758240400","https://openalex.org/W2772427550","https://openalex.org/W2784860954","https://openalex.org/W2792357121","https://openalex.org/W2808544125","https://openalex.org/W2885353677","https://openalex.org/W2885391792","https://openalex.org/W2890028217","https://openalex.org/W2898985696","https://openalex.org/W2936956377","https://openalex.org/W2948863660","https://openalex.org/W2949706399","https://openalex.org/W2950150251","https://openalex.org/W2950608592","https://openalex.org/W2951089481","https://openalex.org/W2974518325","https://openalex.org/W2980832688","https://openalex.org/W2982582384","https://openalex.org/W2983327530","https://openalex.org/W2991012415","https://openalex.org/W3085357237","https://openalex.org/W3090633600","https://openalex.org/W3091334475","https://openalex.org/W3095583226","https://openalex.org/W3112376646","https://openalex.org/W3114849352","https://openalex.org/W3152807587","https://openalex.org/W3155875946","https://openalex.org/W3159117888","https://openalex.org/W3159505833","https://openalex.org/W3161596995","https://openalex.org/W3162844431","https://openalex.org/W3177472573","https://openalex.org/W3197817645","https://openalex.org/W3213637877","https://openalex.org/W3217491883","https://openalex.org/W4226533065","https://openalex.org/W4234326204","https://openalex.org/W4256519993","https://openalex.org/W4284883537","https://openalex.org/W4288052398","https://openalex.org/W4294124094","https://openalex.org/W4294553991","https://openalex.org/W4296038329","https://openalex.org/W4309191898","https://openalex.org/W7074036442"],"related_works":["https://openalex.org/W2605190264","https://openalex.org/W2899474303","https://openalex.org/W2036521446","https://openalex.org/W2039465881","https://openalex.org/W2164809504","https://openalex.org/W1727089480","https://openalex.org/W2914535664","https://openalex.org/W2133328876","https://openalex.org/W367330046","https://openalex.org/W1998685667"],"abstract_inverted_index":{"Non-ribosomal":[0],"peptide":[1],"synthetase":[2],"(NRPS)":[3],"is":[4],"a":[5,25,44,69,128],"diverse":[6],"family":[7],"of":[8,14,24,65,72,95,134],"biosynthetic":[9],"enzymes":[10],"for":[11,28,47,62,139],"the":[12,22,77,90,115],"assembly":[13],"bioactive":[15],"peptides.":[16],"Despite":[17],"advances":[18],"in":[19,76,122],"microbial":[20],"sequencing,":[21],"lack":[23],"consistent":[26],"standard":[27],"annotating":[29],"NRPS":[30,73,123,135],"domains":[31],"and":[32,92,113,119,130],"modules":[33],"has":[34],"made":[35],"data-driven":[36,141],"discoveries":[37],"challenging.":[38],"To":[39],"address":[40],"this,":[41],"we":[42],"introduced":[43],"standardized":[45],"architecture":[46],"NRPS,":[48],"by":[49],"using":[50],"known":[51],"conserved":[52,97],"motifs":[53,98],"to":[54,85],"partition":[55],"typical":[56],"domains.":[57],"This":[58],"motif-and-intermotif":[59],"standardization":[60],"allowed":[61],"systematic":[63],"evaluations":[64],"sequence":[66],"properties":[67],"from":[68],"large":[70],"number":[71],"pathways,":[74],"resulting":[75],"most":[78],"comprehensive":[79,129],"cross-kingdom":[80],"C":[81],"domain":[82],"subtype":[83],"classifications":[84],"date,":[86],"as":[87,89],"well":[88],"discovery":[91],"experimental":[93],"validation":[94],"novel":[96],"with":[99,110],"functional":[100],"significance.":[101],"Furthermore,":[102],"our":[103],"coevolution":[104],"analysis":[105,133],"revealed":[106],"important":[107],"barriers":[108],"associated":[109],"re-engineering":[111],"NRPSs":[112],"uncovered":[114],"entanglement":[116],"between":[117],"phylogeny":[118],"substrate":[120],"specificity":[121],"sequences.":[124],"Our":[125],"findings":[126],"provide":[127],"statistically":[131],"insightful":[132],"sequences,":[136],"opening":[137],"avenues":[138],"future":[140],"discoveries.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}
