{"id":"https://openalex.org/W4366463408","doi":"https://doi.org/10.1371/journal.pcbi.1010988","title":"Bridging the gap between mechanistic biological models and machine learning surrogates","display_name":"Bridging the gap between mechanistic biological models and machine learning surrogates","publication_year":2023,"publication_date":"2023-04-20","ids":{"openalex":"https://openalex.org/W4366463408","doi":"https://doi.org/10.1371/journal.pcbi.1010988","pmid":"https://pubmed.ncbi.nlm.nih.gov/37079494"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010988","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010988&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010988&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017518655","display_name":"Ioana M. Gherman","orcid":"https://orcid.org/0000-0002-4042-0435"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ioana M. Gherman","raw_affiliation_strings":["Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4042-0435","affiliations":[{"raw_affiliation_string":"Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025272350","display_name":"Zahraa S. Abdallah","orcid":"https://orcid.org/0000-0002-1291-2918"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zahraa S. Abdallah","raw_affiliation_strings":["Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081644845","display_name":"Wei Pang","orcid":"https://orcid.org/0000-0002-1761-6659"},"institutions":[{"id":"https://openalex.org/I32062511","display_name":"Heriot-Watt University","ror":"https://ror.org/04mghma93","country_code":"GB","type":"education","lineage":["https://openalex.org/I32062511"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Wei Pang","raw_affiliation_strings":["School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I32062511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000195963","display_name":"Thomas E. Gorochowski","orcid":"https://orcid.org/0000-0003-1702-786X"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thomas E. Gorochowski","raw_affiliation_strings":["School of Biological Sciences, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029076189","display_name":"Claire Grierson","orcid":"https://orcid.org/0000-0002-4000-0975"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claire S. Grierson","raw_affiliation_strings":["School of Biological Sciences, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060401447","display_name":"Lucia Marucci","orcid":"https://orcid.org/0000-0002-7553-6358"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lucia Marucci","raw_affiliation_strings":["Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000195963","https://openalex.org/A5017518655","https://openalex.org/A5025272350","https://openalex.org/A5029076189","https://openalex.org/A5060401447","https://openalex.org/A5081644845"],"corresponding_institution_ids":["https://openalex.org/I32062511","https://openalex.org/I36234482"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":10.8021,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.98803298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"4","first_page":"e1010988","last_page":"e1010988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bridging","display_name":"Bridging (networking)","score":0.7734872102737427},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7307190299034119},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.6580057740211487},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.5684890151023865},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5388270616531372},{"id":"https://openalex.org/keywords/scope","display_name":"Scope (computer science)","score":0.5301024913787842},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4640779495239258},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4545814096927643},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.38147538900375366},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10059720277786255}],"concepts":[{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.7734872102737427},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7307190299034119},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.6580057740211487},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.5684890151023865},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5388270616531372},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.5301024913787842},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4640779495239258},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4545814096927643},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.38147538900375366},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10059720277786255},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1010988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010988","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010988&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37079494","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37079494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:research-information.bris.ac.uk:publications/13db3ce8-a455-4cad-9ee9-777461f52f4a","is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/13db3ce8-a455-4cad-9ee9-777461f52f4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gherman, I M, Marucci, L, Gorochowski, T E, Abdallah, Z S, Grierson, C S & Pang, W 2023, 'Bridging the gap between mechanistic biological models and machine learning surrogates', PLOS Computational Biology, vol. 19, no. 4, e1010988, pp. e1010988. https://doi.org/10.1371/journal.pcbi.1010988","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:10118077","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10118077","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10118077/pdf/pcbi.1010988.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1010988","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010988","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c4c8a58fa00c4437b06968a41f641a69","is_oa":true,"landing_page_url":"https://doaj.org/article/c4c8a58fa00c4437b06968a41f641a69","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 4, p e1010988 (2023)","raw_type":"article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/13db3ce8-a455-4cad-9ee9-777461f52f4a","is_oa":true,"landing_page_url":"https://hdl.handle.net/1983/13db3ce8-a455-4cad-9ee9-777461f52f4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gherman, I M, Marucci, L, Gorochowski, T E, Abdallah, Z S, Grierson, C S & Pang, W 2023, 'Bridging the gap between mechanistic biological models and machine learning surrogates', PLOS Computational Biology, vol. 19, no. 4, e1010988, pp. e1010988. https://doi.org/10.1371/journal.pcbi.1010988","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010988","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010988&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.4699999988079071,"display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G1393776984","display_name":null,"funder_award_id":"EP/S01876X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1633672591","display_name":null,"funder_award_id":"N510129","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2734201728","display_name":null,"funder_award_id":"URF\\R\\221008","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G3314637109","display_name":null,"funder_award_id":"UF160357","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G3855435662","display_name":null,"funder_award_id":"N510129","funder_id":"https://openalex.org/F4320313467","funder_display_name":"Alan Turing Institute"},{"id":"https://openalex.org/G4019402016","display_name":null,"funder_award_id":"BB/W013959/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4072067573","display_name":null,"funder_award_id":"EP/N510129/1","funder_id":"https://openalex.org/F4320313467","funder_display_name":"Alan Turing Institute"},{"id":"https://openalex.org/G4148060743","display_name":"BrisEngBio: From Synthetic to Engineering Biology at Bristol","funder_award_id":"BB/W013959/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G444630160","display_name":null,"funder_award_id":"EP/N510129/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4500485203","display_name":"The Alan Turing Institute","funder_award_id":"EP/N510129/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4631897923","display_name":null,"funder_award_id":"BB/W013959/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5349518980","display_name":null,"funder_award_id":"UF160357 and URF\\R\\221008","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G5947308196","display_name":"21ENGBIO Reprogramming bacterial cells using whole-cell models","funder_award_id":"BB/W012235/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6285227557","display_name":null,"funder_award_id":"BB/W013770/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6775709800","display_name":null,"funder_award_id":"BB/W012235/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7132250322","display_name":null,"funder_award_id":"BB/W013770/1 and BB/X511997/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7664310867","display_name":"COMBO: CONTROL-BASED BIODESIGN OF MAMMALIAN CELL DYNAMICS","funder_award_id":"EP/S01876X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G777199097","display_name":null,"funder_award_id":"EPSRC grant EP/N510129/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8751587367","display_name":"21EBTA: EB-AI Consortium for Bioengineered Cells &amp; Systems (AI-4-EB)","funder_award_id":"BB/W013770/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320313467","display_name":"Alan Turing Institute","ror":"https://ror.org/035dkdb55"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366463408.pdf","grobid_xml":"https://content.openalex.org/works/W4366463408.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W569276703","https://openalex.org/W1523157856","https://openalex.org/W1530806320","https://openalex.org/W1650849552","https://openalex.org/W1830293097","https://openalex.org/W1934203468","https://openalex.org/W1946550961","https://openalex.org/W1996749840","https://openalex.org/W2000996567","https://openalex.org/W2009894386","https://openalex.org/W2015185311","https://openalex.org/W2016381905","https://openalex.org/W2023590177","https://openalex.org/W2028067548","https://openalex.org/W2036919025","https://openalex.org/W2038625140","https://openalex.org/W2038952578","https://openalex.org/W2051118439","https://openalex.org/W2064675550","https://openalex.org/W2080654988","https://openalex.org/W2081781433","https://openalex.org/W2089613060","https://openalex.org/W2101647774","https://openalex.org/W2104276184","https://openalex.org/W2122175455","https://openalex.org/W2134704464","https://openalex.org/W2143592315","https://openalex.org/W2168059482","https://openalex.org/W2183868163","https://openalex.org/W2293809279","https://openalex.org/W2309832917","https://openalex.org/W2328214874","https://openalex.org/W2338065342","https://openalex.org/W2339557529","https://openalex.org/W2410931147","https://openalex.org/W2555077524","https://openalex.org/W2557183043","https://openalex.org/W2592453717","https://openalex.org/W2604944342","https://openalex.org/W2763371835","https://openalex.org/W2781074607","https://openalex.org/W2785071288","https://openalex.org/W2799828736","https://openalex.org/W2805376876","https://openalex.org/W2806054145","https://openalex.org/W2806157403","https://openalex.org/W2807294233","https://openalex.org/W2887761650","https://openalex.org/W2888186677","https://openalex.org/W2892035503","https://openalex.org/W2901072570","https://openalex.org/W2910249264","https://openalex.org/W2916035624","https://openalex.org/W2924104858","https://openalex.org/W2952015518","https://openalex.org/W2952773158","https://openalex.org/W2955219525","https://openalex.org/W2956016460","https://openalex.org/W2962858109","https://openalex.org/W2964716450","https://openalex.org/W2965156580","https://openalex.org/W2974861367","https://openalex.org/W2975605169","https://openalex.org/W2976185208","https://openalex.org/W2981731882","https://openalex.org/W2982857584","https://openalex.org/W2982936646","https://openalex.org/W3000025696","https://openalex.org/W3011249019","https://openalex.org/W3026223623","https://openalex.org/W3044339796","https://openalex.org/W3048283750","https://openalex.org/W3048421397","https://openalex.org/W3081873517","https://openalex.org/W3097352266","https://openalex.org/W3105098767","https://openalex.org/W3109365969","https://openalex.org/W3112570229","https://openalex.org/W3115948762","https://openalex.org/W3119784999","https://openalex.org/W3156276054","https://openalex.org/W3214434028","https://openalex.org/W4200380646","https://openalex.org/W4205371438","https://openalex.org/W4211225168","https://openalex.org/W4213357108","https://openalex.org/W4289021499","https://openalex.org/W4292302479","https://openalex.org/W6640567031","https://openalex.org/W6758101381"],"related_works":["https://openalex.org/W4388870064","https://openalex.org/W4235186151","https://openalex.org/W178231042","https://openalex.org/W2360028903","https://openalex.org/W4280543773","https://openalex.org/W2054685365","https://openalex.org/W2272354214","https://openalex.org/W2366083136","https://openalex.org/W2120383820","https://openalex.org/W2387622493"],"abstract_inverted_index":{"Mechanistic":[0],"models":[1,20,48,131,149],"have":[2,24,111],"been":[3,112],"used":[4,51,113],"for":[5],"centuries":[6],"to":[7,52,114,130,154],"describe":[8],"complex":[9,57,159],"interconnected":[10],"processes,":[11],"including":[12],"biological":[13,133,160],"ones.":[14],"As":[15],"the":[16,54,78,90,92,96,101,152,156],"scope":[17],"of":[18,56,69,77,100,158],"these":[19,125],"has":[21],"widened,":[22],"so":[23],"their":[25,32,63],"computational":[26,64],"demands.":[27],"This":[28,72],"complexity":[29],"can":[30,49,127],"limit":[31],"suitability":[33],"when":[34,39],"running":[35],"many":[36],"simulations":[37],"or":[38],"real-time":[40],"results":[41],"are":[42,66],"required.":[43],"Surrogate":[44],"machine":[45],"learning":[46],"(ML)":[47],"be":[50,128],"approximate":[53,115],"behaviour":[55],"mechanistic":[58,117],"models,":[59],"and":[60,85,98,141,144],"once":[61],"built,":[62],"demands":[65],"several":[67],"orders":[68],"magnitude":[70],"lower.":[71],"paper":[73,93],"provides":[74],"an":[75,83],"overview":[76],"relevant":[79],"literature,":[80],"both":[81],"from":[82],"applicability":[84],"a":[86,121,164],"theoretical":[87],"perspective.":[88],"For":[89],"latter,":[91],"focuses":[94],"on":[95,123],"design":[97],"training":[99],"underlying":[102],"ML":[103,109,148],"models.":[104,118],"Application-wise,":[105],"we":[106],"show":[107,145],"how":[108,124],"surrogates":[110],"different":[116],"We":[119],"present":[120],"perspective":[122],"approaches":[126],"applied":[129],"representing":[132],"processes":[134],"with":[135],"potential":[136],"industrial":[137],"applications":[138],"(e.g.,":[139],"metabolism":[140],"whole-cell":[142],"modelling)":[143],"why":[146],"surrogate":[147],"may":[150],"hold":[151],"key":[153],"making":[155],"simulation":[157],"systems":[161],"possible":[162],"using":[163],"typical":[165],"desktop":[166],"computer.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":7}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}
