{"id":"https://openalex.org/W4363645562","doi":"https://doi.org/10.1371/journal.pcbi.1010923","title":"Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies","display_name":"Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4363645562","doi":"https://doi.org/10.1371/journal.pcbi.1010923","pmid":"https://pubmed.ncbi.nlm.nih.gov/37036839"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010923","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010923","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010923&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010923&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033664827","display_name":"Tomer Mann","orcid":"https://orcid.org/0000-0002-8239-0123"},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Tomer D. Mann","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel","Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0002-8239-0123","affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037132858","display_name":"Eli Kopel","orcid":"https://orcid.org/0000-0002-3235-1644"},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Eli Kopel","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084507913","display_name":"Eli Eisenberg","orcid":"https://orcid.org/0000-0001-8681-3202"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Eli Eisenberg","raw_affiliation_strings":["Raymond and Beverly Sackler School of Physics and Astronomy and Sagol School of Neuroscience, Tel Aviv, University, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0001-8681-3202","affiliations":[{"raw_affiliation_string":"Raymond and Beverly Sackler School of Physics and Astronomy and Sagol School of Neuroscience, Tel Aviv, University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076478183","display_name":"Erez Y. Levanon","orcid":"https://orcid.org/0000-0002-3641-4198"},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Erez Y. Levanon","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel","The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033664827","https://openalex.org/A5037132858","https://openalex.org/A5076478183","https://openalex.org/A5084507913"],"corresponding_institution_ids":["https://openalex.org/I13955877","https://openalex.org/I16391192","https://openalex.org/I2799807261"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5563,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.89585712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"4","first_page":"e1010923","last_page":"e1010923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.9168887138366699},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.6686434149742126},{"id":"https://openalex.org/keywords/adar","display_name":"ADAR","score":0.6528131365776062},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.60603928565979},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.46673429012298584},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.46350544691085815},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.44327208399772644},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.41502779722213745},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4005787670612335},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3802246153354645},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36670178174972534},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.15531304478645325}],"concepts":[{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.9168887138366699},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6686434149742126},{"id":"https://openalex.org/C2778323267","wikidata":"https://www.wikidata.org/wiki/Q21118028","display_name":"ADAR","level":5,"score":0.6528131365776062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.60603928565979},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.46673429012298584},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.46350544691085815},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.44327208399772644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41502779722213745},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4005787670612335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3802246153354645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36670178174972534},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.15531304478645325}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010923","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010923","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010923&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37036839","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37036839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10085048","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10085048","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10085048/pdf/pcbi.1010923.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4fc29ed28e8a47918044fd39ea67cf26","is_oa":true,"landing_page_url":"https://doaj.org/article/4fc29ed28e8a47918044fd39ea67cf26","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 4, p e1010923 (2023)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f138dfb7defd40e09beafd617e9e8b23","is_oa":true,"landing_page_url":"https://doaj.org/article/f138dfb7defd40e09beafd617e9e8b23","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 4 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010923","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010923","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010923&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G2519273060","display_name":null,"funder_award_id":"1945/18","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G3601111394","display_name":null,"funder_award_id":"231/21","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G7510730424","display_name":null,"funder_award_id":"2673/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4363645562.pdf","grobid_xml":"https://content.openalex.org/works/W4363645562.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1816176398","https://openalex.org/W1828537510","https://openalex.org/W1965089560","https://openalex.org/W2004590033","https://openalex.org/W2012800815","https://openalex.org/W2018838463","https://openalex.org/W2035938509","https://openalex.org/W2046641567","https://openalex.org/W2056025481","https://openalex.org/W2082632613","https://openalex.org/W2094042342","https://openalex.org/W2103350275","https://openalex.org/W2113224683","https://openalex.org/W2115221577","https://openalex.org/W2120276739","https://openalex.org/W2137983259","https://openalex.org/W2144134250","https://openalex.org/W2147736027","https://openalex.org/W2156538352","https://openalex.org/W2156891661","https://openalex.org/W2162758488","https://openalex.org/W2169456326","https://openalex.org/W2173666904","https://openalex.org/W2175136759","https://openalex.org/W2470212121","https://openalex.org/W2508597987","https://openalex.org/W2512481987","https://openalex.org/W2518166184","https://openalex.org/W2538460872","https://openalex.org/W2581130118","https://openalex.org/W2582821178","https://openalex.org/W2592811885","https://openalex.org/W2598176747","https://openalex.org/W2753498475","https://openalex.org/W2756894029","https://openalex.org/W2762506271","https://openalex.org/W2791581835","https://openalex.org/W2792855672","https://openalex.org/W2794989402","https://openalex.org/W2885420192","https://openalex.org/W2896431240","https://openalex.org/W2901071040","https://openalex.org/W2903746377","https://openalex.org/W2904139947","https://openalex.org/W2911475378","https://openalex.org/W2928944963","https://openalex.org/W2941053556","https://openalex.org/W2943242055","https://openalex.org/W2950663303","https://openalex.org/W2958340383","https://openalex.org/W2981114707","https://openalex.org/W2990258266","https://openalex.org/W2995709710","https://openalex.org/W3020644307","https://openalex.org/W3023273801","https://openalex.org/W3025513698","https://openalex.org/W3035022847","https://openalex.org/W3088401235","https://openalex.org/W3118302893","https://openalex.org/W3133886385","https://openalex.org/W4214885856","https://openalex.org/W4236789083","https://openalex.org/W4282018017","https://openalex.org/W4283365719","https://openalex.org/W4289637911"],"related_works":["https://openalex.org/W2998988912","https://openalex.org/W2410226897","https://openalex.org/W3027254392","https://openalex.org/W2982292153","https://openalex.org/W3102334290","https://openalex.org/W161920910","https://openalex.org/W3024172273","https://openalex.org/W2762862477","https://openalex.org/W3069287001","https://openalex.org/W1990667116"],"abstract_inverted_index":{"Adenosine-to-inosine":[0],"RNA":[1,19,54,106,218,243],"editing":[2,41,55,82,107,172,185,210,219],"is":[3,69,96,157,191,220,225],"essential":[4],"to":[5,118],"prevent":[6],"undesired":[7],"immune":[8],"activation.":[9],"This":[10,183],"diverse":[11],"process":[12],"alters":[13],"the":[14,18,87,92,109,119,139,188,194],"genetic":[15],"content":[16],"of":[17,121,134,143,193,209,242,247],"and":[20,27,30,49,51,67,111,113,123,129,141,146,164,174,201,224,239,249],"may":[21],"recode":[22],"proteins,":[23],"change":[24],"splice":[25],"sites":[26,198],"miRNA":[28],"targets,":[29],"mimic":[31],"genomic":[32],"mutations.":[33],"Recent":[34],"studies":[35],"have":[36,60],"associated":[37],"or":[38],"implicated":[39],"aberrant":[40],"with":[42,161],"pathological":[43],"conditions,":[44],"including":[45,86],"cancer,":[46],"autoimmune":[47],"diseases,":[48],"neurological":[50],"psychiatric":[52],"conditions.":[53,231],"patterns":[56],"in":[57,75,83,100,108,159,187,211,222,227],"cardiovascular":[58,230],"tissues":[59],"not":[61],"been":[62],"investigated":[63],"systematically":[64],"so":[65],"far,":[66],"little":[68],"known":[70],"about":[71],"its":[72],"potential":[73],"role":[74,117],"cardiac":[76,144],"diseases.":[77],"Some":[78],"hints":[79],"suggest":[80,175],"robust":[81],"this":[84],"system,":[85],"fact":[88],"that":[89,150,217],"ADARB1":[90],"(ADAR2),":[91],"main":[93],"coding-sequence":[94],"editor,":[95],"most":[97],"highly":[98],"expressed":[99],"these":[101,212],"tissues.":[102],"Here":[103],"we":[104,148,202],"characterized":[105],"heart":[110,126,140,165],"arteries":[112,142,223],"examined":[114],"a":[115,169,178,235,245],"contributory":[116],"development":[120],"atherosclerosis":[122,248],"two":[124],"structural":[125],"diseases":[127],"-Ischemic":[128],"Dilated":[130],"Cardiomyopathies.":[131],"Analyzing":[132],"hundreds":[133],"RNA-seq":[135],"samples":[136],"taken":[137],"from":[138],"patients":[145,160],"controls,":[147],"find":[149],"global":[151],"editing,":[152],"alongside":[153],"inflammatory":[154],"gene":[155,190],"expression,":[156],"increased":[158,207],"atherosclerosis,":[162],"cardiomyopathies,":[163],"failure.":[166],"We":[167],"describe":[168],"single":[170],"recoding":[171,184],"site":[173,186],"it":[176,204],"as":[177,244],"target":[179],"for":[180,237],"focused":[181],"research.":[182],"IGFBP7":[189],"one":[192],"only":[195],"evolutionary":[196],"conserved":[197],"between":[199],"mammals,":[200],"found":[203],"exhibits":[205],"consistently":[206],"levels":[208],"patients.":[213],"Our":[214],"findings":[215],"reveal":[216],"abundant":[221],"elevated":[226],"several":[228],"key":[229],"They":[232],"thus":[233],"provide":[234],"roadmap":[236],"basic":[238],"translational":[240],"research":[241],"mediator":[246],"non-genetic":[250],"cardiomyopathies.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}