{"id":"https://openalex.org/W4312066257","doi":"https://doi.org/10.1371/journal.pcbi.1010794","title":"Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant","display_name":"Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant","publication_year":2022,"publication_date":"2022-12-21","ids":{"openalex":"https://openalex.org/W4312066257","doi":"https://doi.org/10.1371/journal.pcbi.1010794","pmid":"https://pubmed.ncbi.nlm.nih.gov/36542668"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010794","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007294687","display_name":"Tingting Zhao","orcid":"https://orcid.org/0000-0001-8429-2239"},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Zhao","raw_affiliation_strings":["Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8429-2239","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I178169726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029581064","display_name":"Nischal Karki","orcid":"https://orcid.org/0000-0002-3325-4256"},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nischal Karki","raw_affiliation_strings":["Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I178169726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060360100","display_name":"Brian D. Zoltowski","orcid":"https://orcid.org/0000-0001-6749-0743"},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Zoltowski","raw_affiliation_strings":["Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I178169726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019062687","display_name":"Devin A. Matthews","orcid":"https://orcid.org/0000-0003-2795-5483"},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Devin A. Matthews","raw_affiliation_strings":["Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I178169726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019062687"],"corresponding_institution_ids":["https://openalex.org/I178169726"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1503,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8073036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"18","issue":"12","first_page":"e1010794","last_page":"e1010794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.9108355045318604},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.7855658531188965},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.556021511554718},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.407844603061676},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.39861607551574707},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3916645050048828},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3637731671333313},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.3272992968559265},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2990654408931732},{"id":"https://openalex.org/keywords/proto-oncogene-tyrosine-protein-kinase-src","display_name":"Proto-oncogene tyrosine-protein kinase Src","score":0.25453051924705505},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.16294234991073608}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9108355045318604},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.7855658531188965},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.556021511554718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.407844603061676},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39861607551574707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3916645050048828},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3637731671333313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3272992968559265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2990654408931732},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.25453051924705505},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16294234991073608}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010794","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36542668","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36542668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1010794","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9330d525e6bc44c6a2c8c7a083cb93b1","is_oa":true,"landing_page_url":"https://doaj.org/article/9330d525e6bc44c6a2c8c7a083cb93b1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 12, p e1010794 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9815575","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9815575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010794","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"awards":[{"id":"https://openalex.org/G7462042259","display_name":null,"funder_award_id":"1753167","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320318036","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1548640328","https://openalex.org/W1978525564","https://openalex.org/W1978564046","https://openalex.org/W1988537554","https://openalex.org/W1991275114","https://openalex.org/W2017212715","https://openalex.org/W2030947664","https://openalex.org/W2032848879","https://openalex.org/W2043188148","https://openalex.org/W2044227662","https://openalex.org/W2046265191","https://openalex.org/W2054596855","https://openalex.org/W2058006865","https://openalex.org/W2060872117","https://openalex.org/W2089468765","https://openalex.org/W2093464262","https://openalex.org/W2093694964","https://openalex.org/W2101234009","https://openalex.org/W2103667952","https://openalex.org/W2114775462","https://openalex.org/W2132629607","https://openalex.org/W2139372772","https://openalex.org/W2147988069","https://openalex.org/W2158236694","https://openalex.org/W2160341881","https://openalex.org/W2168240189","https://openalex.org/W2170209094","https://openalex.org/W2170711116","https://openalex.org/W2209179188","https://openalex.org/W2226825552","https://openalex.org/W2232614234","https://openalex.org/W2238529566","https://openalex.org/W2510475640","https://openalex.org/W2783073729","https://openalex.org/W2786987313","https://openalex.org/W2796750185","https://openalex.org/W2802520483","https://openalex.org/W2807148066","https://openalex.org/W2883727702","https://openalex.org/W2900314239","https://openalex.org/W2983017086","https://openalex.org/W2983057821","https://openalex.org/W3006076839","https://openalex.org/W3046751266","https://openalex.org/W3049559440","https://openalex.org/W3111446677","https://openalex.org/W3112376646","https://openalex.org/W4239632189","https://openalex.org/W4251529734","https://openalex.org/W6675354045","https://openalex.org/W6787264416"],"related_works":["https://openalex.org/W2046450796","https://openalex.org/W2939998722","https://openalex.org/W2169750653","https://openalex.org/W1971782741","https://openalex.org/W2195592873","https://openalex.org/W3005062988","https://openalex.org/W4211217675","https://openalex.org/W2075777827","https://openalex.org/W2911329269","https://openalex.org/W2592466923"],"abstract_inverted_index":{"Signal":[0],"Transducer":[1],"and":[2,15,76,108,110,142,147,164,179,186,236,244,269,276],"Activator":[3],"of":[4,32,53,74,85,114,145,177,251,264,273],"Transcription":[5],"3":[6],"(STAT3)":[7],"plays":[8],"a":[9,18,27,38,72,229,249],"crucial":[10],"role":[11],"in":[12,158,196,267],"cancer":[13,22],"development":[14,52],"thus":[16],"is":[17,92,135],"viable":[19],"target":[20,40,57],"for":[21,41,130,200,213],"treatment.":[23],"STAT3":[24,146,178,221,268,274],"functions":[25],"as":[26],"dimer":[28],"mediated":[29,227],"by":[30,67,183,228],"phosphorylation":[31],"the":[33,51,58,68,88,112,128,149,153,180,197,201,219,234,240,262],"SRC-homology":[34],"2":[35],"(SH2)":[36],"domain,":[37,60],"key":[39],"therapeutic":[42],"drugs.":[43],"While":[44],"great":[45],"efforts":[46],"have":[47,80,101],"been":[48,65,102],"employed":[49,172],"towards":[50],"compounds":[54],"that":[55,82],"directly":[56],"SH2":[59,86,106,131,198,237],"no":[61],"compound":[62],"has":[63,121],"yet":[64],"approved":[66],"FDA":[69],"due":[70],"to":[71,104,152,160,173,225],"lack":[73],"specificity":[75,275],"pharmacologic":[77],"efficacy.":[78],"Studies":[79],"shown":[81,103],"allosteric":[83,166,207,256],"regulation":[84,132],"via":[87,133,239],"coiled-coil":[89],"domain":[90,199,242],"(CCD)":[91],"an":[93],"alternative":[94],"drug":[95,119],"design":[96],"strategy.":[97],"Several":[98],"CCD":[99,134,235],"effectors":[100],"modulate":[105],"binding":[107],"affinity,":[109],"at":[111,116],"time":[113],"writing":[115],"least":[117],"one":[118],"candidate":[120],"entered":[122],"phase":[123],"I":[124],"clinical":[125],"trials.":[126],"However,":[127],"mechanism":[129,257],"poorly":[136],"understood.":[137],"Here,":[138],"we":[139],"investigate":[140],"structural":[141],"dynamic":[143,187],"features":[144],"compare":[148],"wild":[150],"type":[151],"reduced":[154],"function":[155],"variant":[156],"D170A":[157,202],"order":[159],"delineate":[161],"mechanistic":[162],"differences":[163],"propose":[165],"pathways.":[167],"Molecular":[168],"dynamics":[169],"simulations":[170],"were":[171],"explore":[174],"conformational":[175,194,246],"space":[176],"variant,":[181,203],"followed":[182],"structural,":[184],"conformation,":[185],"analysis.":[188],"The":[189,254],"trajectories":[190],"explored":[191],"show":[192],"distinctive":[193],"changes":[195,247],"indicating":[204],"long":[205,214],"range":[206,215],"effects.":[208],"Multiple":[209],"analyses":[210],"provide":[211],"evidence":[212],"communication":[216],"pathways":[217],"between":[218],"two":[220],"domains,":[222],"which":[223,232],"seem":[224],"be":[226],"rigid":[230],"core":[231],"connects":[233],"domains":[238],"linker":[241],"(LD)":[243],"transmits":[245],"through":[248],"network":[250],"short-range":[252],"interactions.":[253],"proposed":[255],"provides":[258],"new":[259],"insight":[260],"into":[261],"understanding":[263],"intramolecular":[265],"signaling":[266],"potential":[270],"pharmaceutical":[271],"control":[272],"activity.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}