{"id":"https://openalex.org/W4312064942","doi":"https://doi.org/10.1371/journal.pcbi.1010787","title":"Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins","display_name":"Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins","publication_year":2022,"publication_date":"2022-12-21","ids":{"openalex":"https://openalex.org/W4312064942","doi":"https://doi.org/10.1371/journal.pcbi.1010787","pmid":"https://pubmed.ncbi.nlm.nih.gov/36542665"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010787&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011075421","display_name":"Jakub W. Wojciechowski","orcid":"https://orcid.org/0000-0001-5289-653X"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jakub W. Wojciechowski","raw_affiliation_strings":["Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0001-5289-653X","affiliations":[{"raw_affiliation_string":"Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050204967","display_name":"Emirhan Tekoglu","orcid":"https://orcid.org/0000-0001-5723-8480"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL","TR"],"is_corresponding":false,"raw_author_name":"Emirhan Tekoglu","raw_affiliation_strings":["Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc, Y\u0131ld\u0131z Teknik \u00dcniversitesi, \u0130stanbul, Turkey","Wydzia\u0142 Chemiczny, Politechnika Wroc\u0142awska, Poland","YTU - Yildiz Technical University (Barbaros Bulvar\u0131 34349 Y\u0131ld\u0131z-\u0130stanbul - Turkey)","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0001-5723-8480","affiliations":[{"raw_affiliation_string":"Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc, Y\u0131ld\u0131z Teknik \u00dcniversitesi, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4101805"]},{"raw_affiliation_string":"Wydzia\u0142 Chemiczny, Politechnika Wroc\u0142awska, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"YTU - Yildiz Technical University (Barbaros Bulvar\u0131 34349 Y\u0131ld\u0131z-\u0130stanbul - Turkey)","institution_ids":["https://openalex.org/I4101805"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059977094","display_name":"Marlena G\u0105sior\u2010G\u0142ogowska","orcid":"https://orcid.org/0000-0002-7835-7523"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marlena G\u0105sior-G\u0142ogowska","raw_affiliation_strings":["Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0002-7835-7523","affiliations":[{"raw_affiliation_string":"Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008283036","display_name":"Virginie Coustou","orcid":"https://orcid.org/0000-0002-6327-2113"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Coustou","raw_affiliation_strings":["Institut de Biochimie et de G\u00e9n\u00e9tique Cellulaire, UMR 5095 CNRS, Universit\u00e9 de Bordeaux, Bordeaux, France","IBGC - Institut de biochimie et g\u00e9n\u00e9tique cellulaires (1 Rue Camille Saint-Saens 33077 BORDEAUX CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biochimie et de G\u00e9n\u00e9tique Cellulaire, UMR 5095 CNRS, Universit\u00e9 de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I4210140961","https://openalex.org/I15057530","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"IBGC - Institut de biochimie et g\u00e9n\u00e9tique cellulaires (1 Rue Camille Saint-Saens 33077 BORDEAUX CEDEX - France)","institution_ids":["https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045659226","display_name":"Natalia Szulc","orcid":"https://orcid.org/0000-0003-2951-1827"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Natalia Szulc","raw_affiliation_strings":["Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0003-2951-1827","affiliations":[{"raw_affiliation_string":"Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020091838","display_name":"Monika Szefczyk","orcid":"https://orcid.org/0000-0003-4779-6395"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Szefczyk","raw_affiliation_strings":["Katedra Chemii Bioorganicznej, Wydzia\u0142 Chemiczny, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0003-4779-6395","affiliations":[{"raw_affiliation_string":"Katedra Chemii Bioorganicznej, Wydzia\u0142 Chemiczny, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021996292","display_name":"Marta Kopaczy\u0144ska","orcid":"https://orcid.org/0000-0003-2160-5773"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Kopaczy\u0144ska","raw_affiliation_strings":["Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076009017","display_name":"Sven J. Saupe","orcid":"https://orcid.org/0000-0002-5589-721X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sven J. Saupe","raw_affiliation_strings":["Institut de Biochimie et de G\u00e9n\u00e9tique Cellulaire, UMR 5095 CNRS, Universit\u00e9 de Bordeaux, Bordeaux, France","IBGC - Institut de biochimie et g\u00e9n\u00e9tique cellulaires (1 Rue Camille Saint-Saens 33077 BORDEAUX CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biochimie et de G\u00e9n\u00e9tique Cellulaire, UMR 5095 CNRS, Universit\u00e9 de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I4210140961","https://openalex.org/I15057530","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"IBGC - Institut de biochimie et g\u00e9n\u00e9tique cellulaires (1 Rue Camille Saint-Saens 33077 BORDEAUX CEDEX - France)","institution_ids":["https://openalex.org/I4210140961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058156708","display_name":"Witold Dyrka","orcid":"https://orcid.org/0000-0002-2683-077X"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]},{"id":"https://openalex.org/I686019","display_name":"AGH University of Krakow","ror":"https://ror.org/00bas1c41","country_code":"PL","type":"education","lineage":["https://openalex.org/I686019"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Witold Dyrka","raw_affiliation_strings":["Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)"],"raw_orcid":"https://orcid.org/0000-0002-2683-077X","affiliations":[{"raw_affiliation_string":"Katedra In\u017cynierii Biomedycznej, Wydzia\u0142 Podstawowych Problem\u00f3w Techniki, Politechnika Wroc\u0142awska, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Wroc\u0142aw University of Science and Technology = Politechnika Wroclawska [Wroc\u0142aw] (Wybrze\u017ce Wyspia\u0144skiego 27\r\n50-370 Wroc\u0142aw - Poland)","institution_ids":["https://openalex.org/I11923345","https://openalex.org/I686019"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5058156708","https://openalex.org/A5076009017"],"corresponding_institution_ids":["https://openalex.org/I11923345","https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961","https://openalex.org/I686019"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.0007,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93250907,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"e1010787","last_page":"e1010787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9797000288963318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7651530504226685},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.6668879985809326},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6472139954566956},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.622963011264801},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.46289342641830444},{"id":"https://openalex.org/keywords/architecture-domain","display_name":"Architecture domain","score":0.449863463640213},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4422861933708191},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.41829216480255127},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32661765813827515},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2800614833831787},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09859591722488403},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.08247938752174377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7651530504226685},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6668879985809326},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6472139954566956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.622963011264801},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.46289342641830444},{"id":"https://openalex.org/C194167682","wikidata":"https://www.wikidata.org/wiki/Q4787088","display_name":"Architecture domain","level":5,"score":0.449863463640213},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4422861933708191},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.41829216480255127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32661765813827515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2800614833831787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09859591722488403},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08247938752174377},{"id":"https://openalex.org/C163352659","wikidata":"https://www.wikidata.org/wiki/Q5380367","display_name":"Enterprise architecture management","level":4,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C10590034","wikidata":"https://www.wikidata.org/wiki/Q1048431","display_name":"Enterprise architecture","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070576","descriptor_name":"NLR Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070576","descriptor_name":"NLR Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070576","descriptor_name":"NLR Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1010787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36542665","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36542665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04295229v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04295229","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-734X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1010787","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010787","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:cdm21054.contentdm.oclc.org:IR/11152","is_oa":false,"landing_page_url":"http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/11152","pdf_url":null,"source":{"id":"https://openalex.org/S4306401341","display_name":"Digital Collections portal (Ko\u00e7 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1351752","host_organization_name":"Ko\u00e7 University","host_organization_lineage":["https://openalex.org/I1351752"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:20da7749729543e6904b2828fb499ec3","is_oa":true,"landing_page_url":"https://doaj.org/article/20da7749729543e6904b2828fb499ec3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 12, p e1010787 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9815663","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9815663","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1004479585","display_name":null,"funder_award_id":"SFAS, R-17-CE11-0035","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6379412426","display_name":null,"funder_award_id":"2019/35/B/NZ2/03997","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"},{"id":"https://openalex.org/G6798147722","display_name":null,"funder_award_id":"POWR.03.02.00-00-I003/16","funder_id":"https://openalex.org/F4320335039","funder_display_name":"Narodowe Centrum Bada\u0144 i Rozwoju"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320323564","display_name":"Politechnika Wroc\u0142awska","ror":"https://ror.org/008fyn775"},{"id":"https://openalex.org/F4320335039","display_name":"Narodowe Centrum Bada\u0144 i Rozwoju","ror":"https://ror.org/05pwfyy15"},{"id":"https://openalex.org/F4320335596","display_name":"Wroclawskie Centrum Sieciowo-Superkomputerowe, Politechnika Wroclawska","ror":null},{"id":"https://openalex.org/F4320338463","display_name":"CHIST-ERA","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312064942.pdf","grobid_xml":"https://content.openalex.org/works/W4312064942.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W985591611","https://openalex.org/W1507905236","https://openalex.org/W1562298285","https://openalex.org/W1592870802","https://openalex.org/W1779124439","https://openalex.org/W1967919877","https://openalex.org/W1970462135","https://openalex.org/W1972624882","https://openalex.org/W1993823146","https://openalex.org/W1994415899","https://openalex.org/W1996386189","https://openalex.org/W1998262071","https://openalex.org/W1998983498","https://openalex.org/W2001914359","https://openalex.org/W2002637016","https://openalex.org/W2004191416","https://openalex.org/W2011301426","https://openalex.org/W2013463247","https://openalex.org/W2015444119","https://openalex.org/W2016820866","https://openalex.org/W2020207222","https://openalex.org/W2023189893","https://openalex.org/W2026258231","https://openalex.org/W2033649150","https://openalex.org/W2033833965","https://openalex.org/W2036860469","https://openalex.org/W2038149917","https://openalex.org/W2044485528","https://openalex.org/W2051210555","https://openalex.org/W2053023958","https://openalex.org/W2055987716","https://openalex.org/W2057709942","https://openalex.org/W2069663555","https://openalex.org/W2071769268","https://openalex.org/W2072179322","https://openalex.org/W2072613948","https://openalex.org/W2077291291","https://openalex.org/W2093508880","https://openalex.org/W2094046685","https://openalex.org/W2096525273","https://openalex.org/W2102245393","https://openalex.org/W2102461176","https://openalex.org/W2107303661","https://openalex.org/W2109606373","https://openalex.org/W2110894701","https://openalex.org/W2111344528","https://openalex.org/W2111402143","https://openalex.org/W2112004950","https://openalex.org/W2114499303","https://openalex.org/W2115185894","https://openalex.org/W2115888213","https://openalex.org/W2117624357","https://openalex.org/W2118038164","https://openalex.org/W2120257250","https://openalex.org/W2127322768","https://openalex.org/W2131172331","https://openalex.org/W2133821029","https://openalex.org/W2138122982","https://openalex.org/W2140373863","https://openalex.org/W2141147511","https://openalex.org/W2144356753","https://openalex.org/W2144535585","https://openalex.org/W2145268834","https://openalex.org/W2146151607","https://openalex.org/W2147306275","https://openalex.org/W2156125289","https://openalex.org/W2157009395","https://openalex.org/W2158714788","https://openalex.org/W2160378127","https://openalex.org/W2160829101","https://openalex.org/W2164516405","https://openalex.org/W2170747616","https://openalex.org/W2224056471","https://openalex.org/W2287080039","https://openalex.org/W2329428957","https://openalex.org/W2330959820","https://openalex.org/W2332428172","https://openalex.org/W2342249984","https://openalex.org/W2376573086","https://openalex.org/W2414307244","https://openalex.org/W2510854709","https://openalex.org/W2519821319","https://openalex.org/W2557595285","https://openalex.org/W2558438718","https://openalex.org/W2568381790","https://openalex.org/W2574254622","https://openalex.org/W2765497440","https://openalex.org/W2765943536","https://openalex.org/W2774178591","https://openalex.org/W2788464082","https://openalex.org/W2799940490","https://openalex.org/W2804752712","https://openalex.org/W2889944714","https://openalex.org/W2894453768","https://openalex.org/W2912246834","https://openalex.org/W2918063357","https://openalex.org/W2924139971","https://openalex.org/W2940752472","https://openalex.org/W2950954328","https://openalex.org/W2978988678","https://openalex.org/W2990575322","https://openalex.org/W2991012415","https://openalex.org/W3003569240","https://openalex.org/W3014109989","https://openalex.org/W3025885307","https://openalex.org/W3029801758","https://openalex.org/W3034801370","https://openalex.org/W3035232037","https://openalex.org/W3035579699","https://openalex.org/W3044695778","https://openalex.org/W3045213859","https://openalex.org/W3092891813","https://openalex.org/W3097708790","https://openalex.org/W3101509328","https://openalex.org/W3102041518","https://openalex.org/W3102588302","https://openalex.org/W3107611715","https://openalex.org/W3110584530","https://openalex.org/W3112170103","https://openalex.org/W3112376646","https://openalex.org/W3112440234","https://openalex.org/W3116044544","https://openalex.org/W3128431212","https://openalex.org/W3133798886","https://openalex.org/W3150635270","https://openalex.org/W3158576172","https://openalex.org/W3158652447","https://openalex.org/W3160440937","https://openalex.org/W3163855438","https://openalex.org/W3172741708","https://openalex.org/W3177828909","https://openalex.org/W4205773061","https://openalex.org/W4210298079","https://openalex.org/W4210454423","https://openalex.org/W4210617542","https://openalex.org/W4220673930","https://openalex.org/W4220838810","https://openalex.org/W4220996810","https://openalex.org/W4225832917","https://openalex.org/W4238387639","https://openalex.org/W4243601081","https://openalex.org/W4280649038","https://openalex.org/W4281790889","https://openalex.org/W4293298428"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W1530034981","https://openalex.org/W2985427592","https://openalex.org/W4320492283","https://openalex.org/W4214695225","https://openalex.org/W2783284266","https://openalex.org/W2153919606","https://openalex.org/W3197607994","https://openalex.org/W4285199176"],"abstract_inverted_index":{"NLR":[0,103,162],"proteins":[1],"are":[2,20],"intracellular":[3],"receptors":[4],"constituting":[5],"a":[6],"conserved":[7],"component":[8],"of":[9,14,25,29,38,43,90,101,127,131,173],"the":[10,35,74,80,87,97,128,145,161],"innate":[11],"immune":[12],"system":[13],"cellular":[15],"organisms.":[16],"In":[17,69],"fungi,":[18],"NLRs":[19,45],"characterized":[21],"by":[22],"high":[23],"diversity":[24],"architectures":[26,163],"and":[27,40,61,85,93,121,124,135,158,164,170],"presence":[28],"amyloid":[30,115,147,165],"signaling.":[31],"Here,":[32],"we":[33,110],"explore":[34],"diverse":[36],"world":[37],"effector":[39],"signaling":[41,148,166],"domains":[42,84,95],"fungal":[44,102],"using":[46],"state-of-the-art":[47],"bioinformatic":[48],"methods":[49],"including":[50,118],"MMseqs2":[51],"for":[52,58,66],"fast":[53],"clustering,":[54],"probabilistic":[55],"context-free":[56],"grammars":[57],"sequence":[59],"analysis,":[60],"AlphaFold2":[62],"deep":[63],"neural":[64],"networks":[65],"structure":[67],"prediction.":[68],"addition":[70],"to":[71,107],"substantially":[72],"improving":[73],"overall":[75],"annotation,":[76],"especially":[77],"in":[78,133,136,142,151,160,167],"basidiomycetes,":[79],"study":[81],"identifies":[82],"novel":[83,119],"reveals":[86],"structural":[88],"similarity":[89],"MLKL-related":[91],"HeLo-":[92],"Goodbye-like":[94],"forming":[96],"most":[98,129],"abundant":[99,130],"superfamily":[100],"effectors.":[104],"Moreover,":[105],"compared":[106],"previous":[108],"studies,":[109],"found":[111],"several":[112],"times":[113],"more":[114],"motif":[116],"instances,":[117],"families,":[120],"validated":[122],"aggregating":[123],"prion-forming":[125],"properties":[126],"them":[132],"vitro":[134],"vivo.":[137],"Also,":[138],"through":[139],"an":[140],"extensive":[141],"silico":[143],"search,":[144],"NLR-associated":[146],"was":[149],"identified":[150],"basidiomycetes.":[152],"The":[153],"emerging":[154],"picture":[155],"highlights":[156],"similarities":[157],"differences":[159],"ascomycetes,":[168],"basidiomycetes":[169],"other":[171],"branches":[172],"life.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
