{"id":"https://openalex.org/W4383216587","doi":"https://doi.org/10.1371/journal.pcbi.1010774","title":"DAPTEV: Deep aptamer evolutionary modelling for COVID-19 drug design","display_name":"DAPTEV: Deep aptamer evolutionary modelling for COVID-19 drug design","publication_year":2023,"publication_date":"2023-07-05","ids":{"openalex":"https://openalex.org/W4383216587","doi":"https://doi.org/10.1371/journal.pcbi.1010774","pmid":"https://pubmed.ncbi.nlm.nih.gov/37406007"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010774","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010774&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010774&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085468809","display_name":"Cameron Andress","orcid":"https://orcid.org/0000-0002-0613-3029"},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Cameron Andress","raw_affiliation_strings":["Department of Computer Science, Brock University, St. Catharines, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Brock University, St. Catharines, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074365776","display_name":"Kalli Kappel","orcid":"https://orcid.org/0000-0002-2129-199X"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kalli Kappel","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023652432","display_name":"Marcus Elbert Villena","orcid":null},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marcus Elbert Villena","raw_affiliation_strings":["Department of Biological Sciences, Brock University, St. Catharines, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Brock University, St. Catharines, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022450803","display_name":"Miroslava \u010cuperlovi\u0107\u2010Culf","orcid":"https://orcid.org/0000-0002-9483-8159"},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Miroslava Cuperlovic-Culf","raw_affiliation_strings":["Digital Technologies Research Centre, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Digital Technologies Research Centre, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000070759","display_name":"Hongbin Yan","orcid":"https://orcid.org/0000-0002-9087-0493"},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Hongbin Yan","raw_affiliation_strings":["Department of Chemistry, Brock University, St. Catharines, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brock University, St. Catharines, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033510515","display_name":"Yifeng Li","orcid":"https://orcid.org/0000-0002-4873-6928"},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Yifeng Li","raw_affiliation_strings":["Department of Biological Sciences, Brock University, St. Catharines, Canada","Department of Computer Science, Brock University, St. Catharines, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Brock University, St. Catharines, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Department of Computer Science, Brock University, St. Catharines, Canada","institution_ids":["https://openalex.org/I186803428"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000070759","https://openalex.org/A5022450803","https://openalex.org/A5023652432","https://openalex.org/A5033510515","https://openalex.org/A5074365776","https://openalex.org/A5085468809"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I186803428","https://openalex.org/I4210159778"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.725,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84393947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"7","first_page":"e1010774","last_page":"e1010774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.9928950667381287},{"id":"https://openalex.org/keywords/systematic-evolution-of-ligands-by-exponential-enrichment","display_name":"Systematic evolution of ligands by exponential enrichment","score":0.8824936747550964},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6900316476821899},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.635985791683197},{"id":"https://openalex.org/keywords/selex-aptamer-technique","display_name":"SELEX Aptamer Technique","score":0.551763117313385},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.5481321811676025},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.4727811813354492},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.45139098167419434},{"id":"https://openalex.org/keywords/binding-affinities","display_name":"Binding affinities","score":0.43228524923324585},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39720749855041504},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.36884742975234985},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.33409300446510315},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.25944983959198},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17565003037452698},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11819320917129517},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07607561349868774}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9928950667381287},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.8824936747550964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6900316476821899},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.635985791683197},{"id":"https://openalex.org/C2911215874","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"SELEX Aptamer Technique","level":5,"score":0.551763117313385},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5481321811676025},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4727811813354492},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.45139098167419434},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.43228524923324585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39720749855041504},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.36884742975234985},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33409300446510315},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25944983959198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17565003037452698},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11819320917129517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07607561349868774},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010774","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010774&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37406007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37406007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:9cf619e9-ec28-4d2a-b640-51e6f28ce339","is_oa":true,"landing_page_url":"https://nrc-publications.canada.ca/eng/view/object/?id=9cf619e9-ec28-4d2a-b640-51e6f28ce339","pdf_url":"https://nrc-publications.canada.ca/eng/view/ft/?id=9cf619e9-ec28-4d2a-b640-51e6f28ce339","source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10351721","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10351721","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10351721/pdf/pcbi.1010774.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010774","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010774&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G187451341","display_name":null,"funder_award_id":"Fellow","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G2128070193","display_name":null,"funder_award_id":"AI4D-108-2","funder_id":"https://openalex.org/F4320334601","funder_display_name":"National Research Council Canada"},{"id":"https://openalex.org/G2733759975","display_name":null,"funder_award_id":"Hanna H. Gray","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G3414865127","display_name":null,"funder_award_id":"AI4D-108","funder_id":"https://openalex.org/F4320334601","funder_display_name":"National Research Council Canada"},{"id":"https://openalex.org/G7187994468","display_name":null,"funder_award_id":"RGPIN 2021-03879","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320323140","display_name":"Brock University","ror":"https://ror.org/056am2717"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334601","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383216587.pdf","grobid_xml":"https://content.openalex.org/works/W4383216587.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W51469642","https://openalex.org/W1019830208","https://openalex.org/W1981021420","https://openalex.org/W2007081196","https://openalex.org/W2019381697","https://openalex.org/W2025820428","https://openalex.org/W2029667189","https://openalex.org/W2050271637","https://openalex.org/W2056511887","https://openalex.org/W2066074720","https://openalex.org/W2075848246","https://openalex.org/W2079321730","https://openalex.org/W2099207551","https://openalex.org/W2119342775","https://openalex.org/W2122410182","https://openalex.org/W2130479394","https://openalex.org/W2169947235","https://openalex.org/W2250539671","https://openalex.org/W2286350386","https://openalex.org/W2405777378","https://openalex.org/W2410986655","https://openalex.org/W2495359280","https://openalex.org/W2529996553","https://openalex.org/W2594639291","https://openalex.org/W2652705574","https://openalex.org/W2741817639","https://openalex.org/W2919115771","https://openalex.org/W2920083709","https://openalex.org/W2924334974","https://openalex.org/W2952396359","https://openalex.org/W2953667108","https://openalex.org/W2996812727","https://openalex.org/W2999955472","https://openalex.org/W2999998283","https://openalex.org/W3009335299","https://openalex.org/W3011537081","https://openalex.org/W3014067025","https://openalex.org/W3024765662","https://openalex.org/W3029765016","https://openalex.org/W3032032947","https://openalex.org/W3034680516","https://openalex.org/W3096628760","https://openalex.org/W3098269892","https://openalex.org/W3128346632","https://openalex.org/W3133171587","https://openalex.org/W3141159078","https://openalex.org/W3153413248","https://openalex.org/W3174909509","https://openalex.org/W3201055938","https://openalex.org/W4214747244","https://openalex.org/W4214852353","https://openalex.org/W4283802707","https://openalex.org/W4289131272","https://openalex.org/W4293475204","https://openalex.org/W4300861274","https://openalex.org/W6739901393"],"related_works":["https://openalex.org/W4282964019","https://openalex.org/W2943446673","https://openalex.org/W2165900404","https://openalex.org/W1939162951","https://openalex.org/W96566440","https://openalex.org/W3027502831","https://openalex.org/W1502158823","https://openalex.org/W4283324873","https://openalex.org/W2112239026","https://openalex.org/W4389028830"],"abstract_inverted_index":{"Typical":[0],"drug":[1,114],"discovery":[2,115],"and":[3,10,27,47,83,107,116],"development":[4,57],"processes":[5],"are":[6,17,88],"costly,":[7,77],"time":[8],"consuming":[9],"often":[11,84],"biased":[12],"by":[13,71],"expert":[14],"opinion.":[15],"Aptamers":[16],"short,":[18],"single-stranded":[19],"oligonucleotides":[20],"(RNA/DNA)":[21],"that":[22,87,130],"bind":[23,38],"to":[24,39,111,134],"target":[25,53],"proteins":[26],"other":[28],"types":[29],"of":[30,69],"biomolecules.":[31],"Compared":[32],"with":[33,42,51,139],"small-molecule":[34],"drugs,":[35],"aptamers":[36,60,86,138],"can":[37],"their":[40],"targets":[41],"high":[43],"affinity":[44],"(binding":[45],"strength)":[46],"specificity":[48],"(uniquely":[49],"interacting":[50],"the":[52,119],"only).":[54],"The":[55],"conventional":[56],"process":[58,64],"for":[59,105],"utilizes":[61],"a":[62,124],"manual":[63],"known":[65],"as":[66,123],"Systematic":[67],"Evolution":[68],"Ligands":[70],"Exponential":[72],"Enrichment":[73],"(SELEX),":[74],"which":[75],"is":[76,132],"slow,":[78],"dependent":[79],"on":[80],"library":[81],"choice":[82],"produces":[85],"not":[89],"optimized.":[90],"To":[91],"address":[92],"these":[93],"challenges,":[94],"in":[95],"this":[96],"research,":[97],"we":[98],"create":[99],"an":[100],"intelligent":[101],"approach,":[102],"named":[103],"DAPTEV,":[104],"generating":[106],"evolving":[108],"aptamer":[109],"sequences":[110],"support":[112],"aptamer-based":[113],"development.":[117],"Using":[118],"COVID-19":[120],"spike":[121],"protein":[122],"target,":[125],"our":[126],"computational":[127],"results":[128],"suggest":[129],"DAPTEV":[131],"able":[133],"produce":[135],"structurally":[136],"complex":[137],"strong":[140],"binding":[141],"affinities.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-16T09:10:04.655348","created_date":"2025-10-10T00:00:00"}
