{"id":"https://openalex.org/W4309600436","doi":"https://doi.org/10.1371/journal.pcbi.1010738","title":"Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites","display_name":"Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites","publication_year":2022,"publication_date":"2022-11-22","ids":{"openalex":"https://openalex.org/W4309600436","doi":"https://doi.org/10.1371/journal.pcbi.1010738","pmid":"https://pubmed.ncbi.nlm.nih.gov/36413575"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010738","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010738","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101661807","display_name":"Rong Gao","orcid":"https://orcid.org/0000-0002-9245-4952"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Gao","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080861862","display_name":"Samantha E. Brokaw","orcid":"https://orcid.org/0009-0003-0754-983X"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha E. Brokaw","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049419810","display_name":"Zeyue Li","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeyue Li","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007395322","display_name":"Libby J. Helfant","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Libby J. Helfant","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053596221","display_name":"Ti Wu","orcid":"https://orcid.org/0000-0001-6427-6418"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ti Wu","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103159827","display_name":"Muhammad Imran Malik","orcid":"https://orcid.org/0000-0002-8079-5119"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Malik","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039365328","display_name":"Ann Stock","orcid":"https://orcid.org/0000-0002-0446-8079"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann M. Stock","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0446-8079","affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039365328"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0839,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.4241349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"18","issue":"11","first_page":"e1010738","last_page":"e1010738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.779821515083313},{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.7764337658882141},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.6126668453216553},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.493113249540329},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4741896092891693},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4691803753376007},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.4633190333843231},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.46218785643577576},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.43807631731033325},{"id":"https://openalex.org/keywords/dna-binding-protein","display_name":"DNA-binding protein","score":0.43545252084732056},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4194096624851227},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34913498163223267},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3448938727378845},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3240361213684082},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32303673028945923},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.2979293465614319},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.11601081490516663}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.779821515083313},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7764337658882141},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6126668453216553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.493113249540329},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4741896092891693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4691803753376007},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.4633190333843231},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46218785643577576},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.43807631731033325},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.43545252084732056},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4194096624851227},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34913498163223267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3448938727378845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3240361213684082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32303673028945923},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2979293465614319},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11601081490516663},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010738","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36413575","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36413575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ef8fddb0f181419faeb25366f933def1","is_oa":false,"landing_page_url":"https://doaj.org/article/ef8fddb0f181419faeb25366f933def1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 11, p e1010738 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9725139","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9725139","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010738","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.46000000834465027,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G4100482095","display_name":null,"funder_award_id":"R35GM131727","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5802050902","display_name":null,"funder_award_id":"R35 GM131727","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7822834426","display_name":null,"funder_award_id":"R35GM131727","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W179059320","https://openalex.org/W1525087137","https://openalex.org/W1905737356","https://openalex.org/W1953863407","https://openalex.org/W1970661255","https://openalex.org/W1971496855","https://openalex.org/W1972890383","https://openalex.org/W1975818668","https://openalex.org/W2000566667","https://openalex.org/W2012046093","https://openalex.org/W2015523481","https://openalex.org/W2021076430","https://openalex.org/W2025423467","https://openalex.org/W2031859095","https://openalex.org/W2048842389","https://openalex.org/W2052154287","https://openalex.org/W2056879222","https://openalex.org/W2061425021","https://openalex.org/W2061659241","https://openalex.org/W2066253471","https://openalex.org/W2069282518","https://openalex.org/W2071731040","https://openalex.org/W2081929574","https://openalex.org/W2083632051","https://openalex.org/W2091607609","https://openalex.org/W2104123948","https://openalex.org/W2105264930","https://openalex.org/W2110699703","https://openalex.org/W2117011728","https://openalex.org/W2123660300","https://openalex.org/W2124980889","https://openalex.org/W2129149800","https://openalex.org/W2133083422","https://openalex.org/W2134027489","https://openalex.org/W2135326887","https://openalex.org/W2137464895","https://openalex.org/W2145661401","https://openalex.org/W2153695031","https://openalex.org/W2155264370","https://openalex.org/W2155798202","https://openalex.org/W2159443864","https://openalex.org/W2162416324","https://openalex.org/W2169675068","https://openalex.org/W2191824721","https://openalex.org/W2262666557","https://openalex.org/W2338885502","https://openalex.org/W2377905161","https://openalex.org/W2462893633","https://openalex.org/W2497459305","https://openalex.org/W2508353644","https://openalex.org/W2792156998","https://openalex.org/W2887573668","https://openalex.org/W2888611975","https://openalex.org/W2890535935","https://openalex.org/W2904118784","https://openalex.org/W2909818156","https://openalex.org/W2924932674","https://openalex.org/W3032859417","https://openalex.org/W3070186272","https://openalex.org/W3105214764","https://openalex.org/W3107622259","https://openalex.org/W3121102348","https://openalex.org/W3174607828","https://openalex.org/W3193916265","https://openalex.org/W3207414512","https://openalex.org/W3214469586","https://openalex.org/W4200317157","https://openalex.org/W4200350396","https://openalex.org/W4214934434","https://openalex.org/W4225996430","https://openalex.org/W7066938423"],"related_works":["https://openalex.org/W2036927633","https://openalex.org/W2153561273","https://openalex.org/W2079197459","https://openalex.org/W2152664145","https://openalex.org/W2165899269","https://openalex.org/W2236968607","https://openalex.org/W2090848290","https://openalex.org/W2146393977","https://openalex.org/W2009673058","https://openalex.org/W2039285586"],"abstract_inverted_index":{"Binding":[0],"of":[1,15,25,35,37,41,54,62,68,95,121,124,130,160,169,184,226],"transcription":[2,26,163],"factor":[3],"(TF)":[4],"proteins":[5,98,150],"to":[6,12,20,44,102,213],"regulatory":[7,97],"DNA":[8],"sites":[9,47,57],"is":[10,28,48,84],"key":[11],"accurate":[13],"control":[14,88],"gene":[16],"expression":[17],"in":[18,118,199,233],"response":[19,83],"environmental":[21],"stimuli.":[22],"Theoretical":[23],"modeling":[24],"regulation":[27],"often":[29],"focused":[30],"on":[31],"a":[32,69,81,180,186,195],"limited":[33],"set":[34],"genes":[36],"interest,":[38],"while":[39],"binding":[40,56],"the":[42,60,90,96,108,119,131,154,161,191,219,234],"TF":[43,55,63,70,149,188],"other":[45],"genomic":[46],"seldom":[49],"considered.":[50],"The":[51],"total":[52],"number":[53],"(TFBSs)":[58],"affects":[59],"availability":[61],"protein":[64,143,201],"molecules":[65],"and":[66],"sequestration":[67],"by":[71,151],"TFBSs":[72,152],"can":[73,176],"promote":[74],"bistability.":[75,104],"For":[76,145],"many":[77],"signaling":[78,134,200],"systems":[79,116],"where":[80],"graded":[82,216],"desirable":[85],"for":[86,112,148,156,190,211],"continuous":[87],"over":[89],"input":[91],"range,":[92],"biochemical":[93],"parameters":[94],"need":[99],"be":[100,177],"tuned":[101],"avoid":[103],"Here":[105],"we":[106],"analyze":[107],"mono-/bistable":[109],"parameter":[110,221],"range":[111,222],"positively":[113],"autoregulated":[114,162,192],"two-component":[115],"(TCSs)":[117],"presence":[120],"different":[122],"numbers":[123],"competing":[125],"TFBSs.":[126],"TCS":[127,170],"signaling,":[128],"one":[129],"major":[132],"bacterial":[133],"strategies,":[135],"couples":[136],"signal":[137],"perception":[138],"with":[139,179],"output":[140],"responses":[141],"via":[142],"phosphorylation.":[144],"bistability,":[146],"competition":[147],"lowers":[153],"requirement":[155],"high":[157,166,187],"fold":[158,197],"change":[159,198],"but":[164],"demands":[165],"phosphorylation":[167,182],"activities":[168],"proteins.":[171],"We":[172],"show":[173],"that":[174],"bistability":[175],"avoided":[178],"low":[181,196],"capacity":[183],"TCSs,":[185],"affinity":[189],"promoter":[193],"or":[194],"levels":[202],"upon":[203],"induction.":[204],"These":[205],"may":[206],"represent":[207],"general":[208],"design":[209],"rules":[210],"TCSs":[212],"ensure":[214],"uniform":[215],"responses.":[217],"Examining":[218],"mono-/bistability":[220],"allows":[223],"qualitative":[224],"prediction":[225],"steady-state":[227],"responses,":[228],"which":[229],"are":[230],"experimentally":[231],"validated":[232],"E.":[235],"coli":[236],"CusRS":[237],"system.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}