{"id":"https://openalex.org/W4377115691","doi":"https://doi.org/10.1371/journal.pcbi.1010694","title":"Stochastic modelling of a three-dimensional glycogen granule synthesis and impact of the branching enzyme","display_name":"Stochastic modelling of a three-dimensional glycogen granule synthesis and impact of the branching enzyme","publication_year":2023,"publication_date":"2023-05-19","ids":{"openalex":"https://openalex.org/W4377115691","doi":"https://doi.org/10.1371/journal.pcbi.1010694","pmid":"https://pubmed.ncbi.nlm.nih.gov/37205718"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010694","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010694","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010694&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010694&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075070307","display_name":"Yvan Rousset","orcid":"https://orcid.org/0000-0002-9118-7178"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Yvan Rousset","raw_affiliation_strings":["Institute for Computational Cell Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany","Institute for Quantitative and Theoretical Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Computational Cell Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute for Quantitative and Theoretical Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026460206","display_name":"Oliver Ebenh\u00f6h","orcid":"https://orcid.org/0000-0002-7229-7398"},"institutions":[{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oliver Ebenh\u00f6h","raw_affiliation_strings":["Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D\u00fcsseldorf, Germany","Institute for Quantitative and Theoretical Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210126213","https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute for Quantitative and Theoretical Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050021188","display_name":"Ad\u00e9la\u00efde Raguin","orcid":"https://orcid.org/0000-0003-0057-7021"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ad\u00e9la\u00efde Raguin","raw_affiliation_strings":["Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D\u00fcsseldorf, Germany","Institute for Computational Cell Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210126213","https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute for Computational Cell Biology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026460206","https://openalex.org/A5050021188","https://openalex.org/A5075070307"],"corresponding_institution_ids":["https://openalex.org/I4210126213","https://openalex.org/I44260953"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2746,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80200661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"19","issue":"5","first_page":"e1010694","last_page":"e1010694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-branching-enzyme","display_name":"Glycogen branching enzyme","score":0.8745661973953247},{"id":"https://openalex.org/keywords/glycogen","display_name":"Glycogen","score":0.8068965673446655},{"id":"https://openalex.org/keywords/branching","display_name":"Branching (polymer chemistry)","score":0.7511618137359619},{"id":"https://openalex.org/keywords/glycogen-synthase","display_name":"Glycogen synthase","score":0.5816270709037781},{"id":"https://openalex.org/keywords/granule","display_name":"Granule (geology)","score":0.5298649668693542},{"id":"https://openalex.org/keywords/branching-process","display_name":"Branching process","score":0.47271794080734253},{"id":"https://openalex.org/keywords/glycogen-debranching-enzyme","display_name":"Glycogen debranching enzyme","score":0.4595206677913666},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.4570567309856415},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39349132776260376},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3810063302516937},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3744126856327057},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.34659677743911743},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3416277766227722},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3411616086959839},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.26323264837265015},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1825692355632782},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.07647338509559631}],"concepts":[{"id":"https://openalex.org/C9262364","wikidata":"https://www.wikidata.org/wiki/Q161537","display_name":"Glycogen branching enzyme","level":4,"score":0.8745661973953247},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.8068965673446655},{"id":"https://openalex.org/C206175624","wikidata":"https://www.wikidata.org/wiki/Q595731","display_name":"Branching (polymer chemistry)","level":2,"score":0.7511618137359619},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.5816270709037781},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.5298649668693542},{"id":"https://openalex.org/C177255742","wikidata":"https://www.wikidata.org/wiki/Q4109953","display_name":"Branching process","level":2,"score":0.47271794080734253},{"id":"https://openalex.org/C78245214","wikidata":"https://www.wikidata.org/wiki/Q1532471","display_name":"Glycogen debranching enzyme","level":4,"score":0.4595206677913666},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4570567309856415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39349132776260376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3810063302516937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3744126856327057},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34659677743911743},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3416277766227722},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3411616086959839},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.26323264837265015},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1825692355632782},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07647338509559631},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015061","descriptor_name":"1,4-alpha-Glucan Branching Enzyme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010694","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010694","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010694&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37205718","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37205718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10198547","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10198547","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10198547/pdf/pcbi.1010694.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bcd98bf1cab6459eb7506be6fad1d8cb","is_oa":true,"landing_page_url":"https://doaj.org/article/bcd98bf1cab6459eb7506be6fad1d8cb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 5, p e1010694 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010694","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010694","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010694&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[{"id":"https://openalex.org/G1655541775","display_name":null,"funder_award_id":"Professorinnenprogramm","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G1974542962","display_name":null,"funder_award_id":"Sk\u0142odowska","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2689612763","display_name":null,"funder_award_id":"Marie","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4956428346","display_name":null,"funder_award_id":"Horizon 2020 research and innovatio","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5036817778","display_name":null,"funder_award_id":"European Union's Horizon 2020 research and innov","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5245769629","display_name":null,"funder_award_id":"No 81616","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G6285993314","display_name":null,"funder_award_id":"Excellence Strategy EXC 2048/1, Project ID: 390686111","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8633428685","display_name":null,"funder_award_id":"European Union's Horizon 2020 research and innovat","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377115691.pdf","grobid_xml":"https://content.openalex.org/works/W4377115691.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W43127145","https://openalex.org/W110565935","https://openalex.org/W594633362","https://openalex.org/W1253276357","https://openalex.org/W1498418139","https://openalex.org/W1521390995","https://openalex.org/W1579118669","https://openalex.org/W1878895845","https://openalex.org/W1978647781","https://openalex.org/W1980234998","https://openalex.org/W1980395922","https://openalex.org/W1989487994","https://openalex.org/W2004360704","https://openalex.org/W2005031851","https://openalex.org/W2005525419","https://openalex.org/W2016779478","https://openalex.org/W2021490051","https://openalex.org/W2022090985","https://openalex.org/W2031702559","https://openalex.org/W2040605486","https://openalex.org/W2042321087","https://openalex.org/W2044736201","https://openalex.org/W2051584393","https://openalex.org/W2053564624","https://openalex.org/W2070892016","https://openalex.org/W2072444025","https://openalex.org/W2073585463","https://openalex.org/W2076163976","https://openalex.org/W2080062518","https://openalex.org/W2081683581","https://openalex.org/W2085733261","https://openalex.org/W2088819408","https://openalex.org/W2091609267","https://openalex.org/W2104802276","https://openalex.org/W2120867050","https://openalex.org/W2129810925","https://openalex.org/W2132886799","https://openalex.org/W2143531882","https://openalex.org/W2146047637","https://openalex.org/W2147227257","https://openalex.org/W2153091256","https://openalex.org/W2155418451","https://openalex.org/W2171513176","https://openalex.org/W2261945294","https://openalex.org/W2276262061","https://openalex.org/W2342065134","https://openalex.org/W2619940596","https://openalex.org/W2791486327","https://openalex.org/W2801457683","https://openalex.org/W2942938364","https://openalex.org/W3209984045","https://openalex.org/W4244613995","https://openalex.org/W4248059810","https://openalex.org/W4304182778"],"related_works":["https://openalex.org/W1557918944","https://openalex.org/W2016779478","https://openalex.org/W2064255685","https://openalex.org/W2071961392","https://openalex.org/W1973201825","https://openalex.org/W1977169791","https://openalex.org/W2133948569","https://openalex.org/W4388500120","https://openalex.org/W2084228516","https://openalex.org/W2056502033"],"abstract_inverted_index":{"In":[0,87],"humans,":[1],"glycogen":[2,23,58,70,146,204,219,299,313],"storage":[3,314],"diseases":[4],"result":[5],"from":[6],"metabolic":[7],"inborn":[8],"errors,":[9],"and":[10,16,42,72,81,95,118,167,292,302],"can":[11,216,294],"lead":[12],"to":[13,27,83,133,190,269,297,307],"severe":[14],"phenotypes":[15],"lethal":[17],"conditions.":[18],"Besides":[19],"these":[20,184,200],"rare":[21],"diseases,":[22],"is":[24,36,77],"also":[25,187,235],"associated":[26],"widely":[28],"spread":[29],"societal":[30],"burdens":[31],"such":[32],"as":[33],"diabetes.":[34],"Glycogen":[35],"a":[37,45,92,104,266],"branched":[38,100],"glucose":[39],"polymer":[40,101],"synthesised":[41],"degraded":[43],"by":[44],"complex":[46],"set":[47],"of":[48,57,99,114,123,145,157,165,181,253,279],"enzymes.":[49],"Over":[50],"the":[51,55,64,67,73,112,115,121,124,143,155,158,163,208,244,251,271,280,285,309],"past":[52],"50":[53],"years,":[54],"structure":[56,71,156],"has":[59],"been":[60],"intensively":[61],"investigated.":[62],"Yet,":[63],"interplay":[65],"between":[66],"detailed":[68],"three-dimensional":[69],"related":[74],"enzyme":[75,150],"activity":[76],"only":[78,174],"partially":[79],"characterised":[80],"still":[82],"be":[84,256,295],"fully":[85],"understood.":[86],"this":[88,232],"article,":[89],"we":[90,176,215,248],"develop":[91],"stochastic":[93],"coarse-grained":[94],"spatially":[96],"resolved":[97],"model":[98,125,209,264,291],"biosynthesis":[102],"following":[103],"Gillespie":[105],"algorithm.":[106],"Our":[107,289],"study":[108],"largely":[109],"focusses":[110],"on":[111,284],"role":[113],"branching":[116,149,166,254,281],"enzyme,":[117,282],"first":[119],"investigates":[120],"properties":[122,229],"with":[126,210,239],"generic":[127,290],"parameter":[128],"values,":[129],"before":[130],"comparing":[131],"it":[132,169],"in":[134,138,223,236,243,277,304],"vivo":[135],"experimental":[136,211,245],"data":[137,212,300],"mice.":[139,226],"It":[140],"arises":[141],"that":[142,214,250,273],"ratio":[144],"synthase":[147],"over":[148],"reaction":[151],"rates":[152],"drastically":[153],"impacts":[154],"granule.":[159],"We":[160,193],"deeply":[161],"investigate":[162],"mechanism":[164,252],"parametrise":[168],"using":[170],"distinct":[171,188],"lengths.":[172],"Not":[173],"do":[175],"consider":[177],"various":[178,197],"possible":[179],"sets":[180],"values":[182,198,242],"for":[183,199,231,312],"lengths,":[185],"but":[186],"rules":[189],"apply":[191],"them.":[192],"show":[194],"how":[195],"combining":[196],"lengths":[201],"finely":[202],"tunes":[203],"macromolecular":[205],"structure.":[206],"Comparing":[207],"confirms":[213],"accurately":[217],"reproduce":[218],"chain":[220,286],"length":[221,287],"distributions":[222],"wild":[224],"type":[225],"Additional":[227],"granule":[228],"obtained":[230],"fit":[233],"are":[234],"good":[237],"agreement":[238],"typically":[240],"reported":[241],"literature.":[246],"Nonetheless,":[247],"find":[249],"must":[255],"more":[257],"flexible":[258],"than":[259],"usually":[260],"reported.":[261],"Overall,":[262],"our":[263],"provides":[265],"theoretical":[267],"basis":[268],"quantify":[270],"effect":[272],"single":[274],"enzymatic":[275],"parameters,":[276],"particular":[278,305],"have":[283],"distribution.":[288],"methods":[293],"applied":[296],"any":[298],"set,":[301],"could":[303],"contribute":[306],"characterise":[308],"mechanisms":[310],"responsible":[311],"disorders.":[315]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}
