{"id":"https://openalex.org/W4308555765","doi":"https://doi.org/10.1371/journal.pcbi.1010687","title":"Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis","display_name":"Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis","publication_year":2022,"publication_date":"2022-11-08","ids":{"openalex":"https://openalex.org/W4308555765","doi":"https://doi.org/10.1371/journal.pcbi.1010687","pmid":"https://pubmed.ncbi.nlm.nih.gov/36346808"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010687","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010687","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033292408","display_name":"Mubasher Rashid","orcid":null},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]},{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mubasher Rashid","raw_affiliation_strings":["Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India","Present affiliation: Department of Mathematics and Statistics, Indian Institute of Technology Kanpur, Kanpur, India"],"raw_orcid":"https://orcid.org/0000-0003-2790-6147","affiliations":[{"raw_affiliation_string":"Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Present affiliation: Department of Mathematics and Statistics, Indian Institute of Technology Kanpur, Kanpur, India","institution_ids":["https://openalex.org/I94234084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000547526","display_name":"Kishore Hari","orcid":"https://orcid.org/0000-0001-5655-9039"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kishore Hari","raw_affiliation_strings":["Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056491712","display_name":"John Thampi","orcid":null},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"John Thampi","raw_affiliation_strings":["BS-MS Programme, Indian Institute of Science Education and Research, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BS-MS Programme, Indian Institute of Science Education and Research, Pune, India","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080992504","display_name":"Nived Krishnan Santhosh","orcid":"https://orcid.org/0000-0003-2879-9187"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nived Krishnan Santhosh","raw_affiliation_strings":["BS-MS Programme, Indian Institute of Science, Bangalore, India"],"raw_orcid":"https://orcid.org/0000-0003-2879-9187","affiliations":[{"raw_affiliation_string":"BS-MS Programme, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083772852","display_name":"Mohit Kumar Jolly","orcid":"https://orcid.org/0000-0002-6631-2109"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mohit Kumar Jolly","raw_affiliation_strings":["Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":"https://orcid.org/0000-0002-6631-2109","affiliations":[{"raw_affiliation_string":"Center for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083772852"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0915,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89379491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"11","first_page":"e1010687","last_page":"e1010687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6912024617195129},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.5378100275993347},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5107858180999756},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47725722193717957},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.44204720854759216},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.4373798966407776},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.42341750860214233},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38657820224761963},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3268303871154785},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.2618448734283447},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.24652573466300964},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2191525399684906},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18807116150856018},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.15206274390220642},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14802119135856628}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6912024617195129},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5378100275993347},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5107858180999756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47725722193717957},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44204720854759216},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.4373798966407776},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.42341750860214233},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38657820224761963},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3268303871154785},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.2618448734283447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24652573466300964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2191525399684906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18807116150856018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15206274390220642},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14802119135856628},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010687","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36346808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36346808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:40a244ef69b445e98e16b921737aae77","is_oa":true,"landing_page_url":"https://doaj.org/article/40a244ef69b445e98e16b921737aae77","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 11, p e1010687 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9674141","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9674141","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010687","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322753","display_name":"Infosys Foundation","ror":"https://ror.org/03bs18y54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1495945591","https://openalex.org/W1970661255","https://openalex.org/W1980561748","https://openalex.org/W2010292117","https://openalex.org/W2016382979","https://openalex.org/W2019237060","https://openalex.org/W2020838623","https://openalex.org/W2082239705","https://openalex.org/W2093921289","https://openalex.org/W2115436106","https://openalex.org/W2140937954","https://openalex.org/W2146950091","https://openalex.org/W2164052505","https://openalex.org/W2167198989","https://openalex.org/W2177744475","https://openalex.org/W2192807450","https://openalex.org/W2240026504","https://openalex.org/W2266814182","https://openalex.org/W2302083974","https://openalex.org/W2338391827","https://openalex.org/W2593940162","https://openalex.org/W2600259521","https://openalex.org/W2668710393","https://openalex.org/W2756978353","https://openalex.org/W2771542157","https://openalex.org/W2798231099","https://openalex.org/W2804945220","https://openalex.org/W2815567807","https://openalex.org/W2884268198","https://openalex.org/W2898174520","https://openalex.org/W2905431641","https://openalex.org/W2905491238","https://openalex.org/W2949145420","https://openalex.org/W2950783290","https://openalex.org/W2951629157","https://openalex.org/W2963504961","https://openalex.org/W2973842082","https://openalex.org/W2989983430","https://openalex.org/W2991007371","https://openalex.org/W2998926303","https://openalex.org/W3004771246","https://openalex.org/W3015231394","https://openalex.org/W3024005153","https://openalex.org/W3084047541","https://openalex.org/W3092452814","https://openalex.org/W3126881157","https://openalex.org/W3137958277","https://openalex.org/W3165561581","https://openalex.org/W3186940301","https://openalex.org/W3202556172","https://openalex.org/W4211233744","https://openalex.org/W4213236321","https://openalex.org/W4225932655","https://openalex.org/W4307037012"],"related_works":["https://openalex.org/W1797702204","https://openalex.org/W4376112453","https://openalex.org/W4376112202","https://openalex.org/W4224737743","https://openalex.org/W2485516716","https://openalex.org/W2464515224","https://openalex.org/W4224326768","https://openalex.org/W4376112403","https://openalex.org/W4376112235","https://openalex.org/W4319461675"],"abstract_inverted_index":{"Epithelial":[0,9,26],"to":[1,8,23,61,95,179,228,231,236],"Mesenchymal":[2,28],"Transition":[3,10],"(EMT)":[4],"and":[5,30,36,49,55,107,114,150,160,176],"its":[6],"reverse-Mesenchymal":[7],"(MET)":[11],"are":[12,45],"hallmarks":[13],"of":[14,103,117,145,203,218],"metastasis.":[15,71,238],"Cancer":[16],"cells":[17,44,65],"use":[18],"this":[19],"reversible":[20],"cellular":[21],"programming":[22],"switch":[24],"among":[25,172],"(E),":[27],"(M),":[29],"hybrid":[31,63,91,132,165,204,233],"Epithelial/Mesenchymal":[32],"(hybrid":[33],"E/M)":[34],"state(s)":[35],"seed":[37],"tumors":[38],"at":[39],"distant":[40],"sites.":[41],"Hybrid":[42],"E/M":[43,64,92,205,234],"often":[46],"more":[47,127,136,181],"aggressive":[48],"metastatic":[50],"than":[51],"the":[52,101,115,122,201,232],"\"pure\"":[53],"E":[54],"M":[56],"cells.":[57],"Thus,":[58],"identifying":[59,87],"mechanisms":[60],"inhibit":[62],"can":[66,193,213],"be":[67,96,180],"promising":[68],"in":[69,207,216,222],"curtailing":[70],"While":[72,124],"multiple":[73],"gene":[74],"regulatory":[75],"networks":[76,125,134],"(GRNs)":[77],"based":[78],"mathematical":[79],"models":[80],"for":[81],"EMT/MET":[82],"have":[83,214],"been":[84],"developed":[85],"recently,":[86],"topological":[88],"signatures":[89,191],"enriching":[90],"phenotypes":[93,166],"remains":[94],"done.":[97],"Here,":[98],"we":[99],"investigate":[100],"dynamics":[102],"13":[104],"different":[105],"GRNs":[106,208,223],"report":[108],"an":[109],"interesting":[110],"association":[111],"between":[112,158],"\"hybridness\"":[113,159],"number":[116],"negative/positive":[118],"feedback":[119,129,138],"loops":[120,130,139],"across":[121],"networks.":[123],"having":[126,135],"negative":[128],"favor":[131],"phenotype(s),":[133],"positive":[137],"(PFLs)":[140],"or":[141],"many":[142],"HiLoops-specific":[143],"combinations":[144],"PFLs,":[146],"support":[147],"terminal":[148],"(E":[149],"M)":[151],"phenotypes.":[152],"We":[153],"also":[154],"establish":[155],"a":[156,225],"connection":[157],"network-frustration":[161],"by":[162],"showing":[163],"that":[164,192],"likely":[167],"result":[168],"from":[169],"non-reinforcing":[170],"interactions":[171,221],"network":[173,189],"nodes":[174],"(genes)":[175],"therefore":[177],"tend":[178],"frustrated":[182],"(less":[183],"stable).":[184],"Our":[185,211],"analysis,":[186],"thus,":[187],"identifies":[188],"topology-based":[190],"give":[194],"rise":[195],"to,":[196],"as":[197,199,224],"well":[198],"prevent,":[200],"emergence":[202],"phenotype":[206],"underlying":[209],"EMP.":[210],"results":[212],"implications":[215],"terms":[217],"targeting":[219],"specific":[220],"potent":[226],"way":[227],"restrict":[229],"switching":[230],"phenotype(s)":[235],"curtail":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-02-01T03:34:12.195049","created_date":"2022-11-12T00:00:00"}