{"id":"https://openalex.org/W4312019610","doi":"https://doi.org/10.1371/journal.pcbi.1010607","title":"A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls","display_name":"A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls","publication_year":2022,"publication_date":"2022-12-20","ids":{"openalex":"https://openalex.org/W4312019610","doi":"https://doi.org/10.1371/journal.pcbi.1010607","pmid":"https://pubmed.ncbi.nlm.nih.gov/36538563"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010607","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010607","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043510125","display_name":"Melissa M. Stadt","orcid":"https://orcid.org/0000-0002-4215-8004"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Melissa M. Stadt","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4215-8004","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047625964","display_name":"Jessica Leete","orcid":"https://orcid.org/0000-0002-5211-1509"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Leete","raw_affiliation_strings":["Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5211-1509","affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022296371","display_name":"Sophia Devinyak","orcid":null},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sophia Devinyak","raw_affiliation_strings":["Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067659571","display_name":"Anita T. Layton","orcid":"https://orcid.org/0000-0002-1753-4063"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anita T. Layton","raw_affiliation_strings":["Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada","Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","Department of Biology, University of Waterloo, Waterloo, Ontario, Canada","Department of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Biology, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043510125"],"corresponding_institution_ids":["https://openalex.org/I151746483"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1301,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88817131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"e1010607","last_page":"e1010607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.6485996246337891},{"id":"https://openalex.org/keywords/homeostasis","display_name":"Homeostasis","score":0.6370724439620972},{"id":"https://openalex.org/keywords/potassium","display_name":"Potassium","score":0.4369596540927887},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36558210849761963},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3146553039550781},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.20356541872024536},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11646917462348938},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.11405178904533386}],"concepts":[{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.6485996246337891},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6370724439620972},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.4369596540927887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36558210849761963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3146553039550781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20356541872024536},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11646917462348938},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.11405178904533386},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010607","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36538563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36538563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:86d93b49fd644d028c2e0a55e01d9b6f","is_oa":true,"landing_page_url":"https://doaj.org/article/86d93b49fd644d028c2e0a55e01d9b6f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 12, p e1010607 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9812337","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9812337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010607","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3665882973","display_name":null,"funder_award_id":"RGPIN-2019-03916","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W154106180","https://openalex.org/W845777796","https://openalex.org/W1172355299","https://openalex.org/W1549507129","https://openalex.org/W1604267989","https://openalex.org/W1963514522","https://openalex.org/W1973854845","https://openalex.org/W1975508939","https://openalex.org/W1981036549","https://openalex.org/W1999111122","https://openalex.org/W2006720127","https://openalex.org/W2024434444","https://openalex.org/W2060635422","https://openalex.org/W2066970340","https://openalex.org/W2092221608","https://openalex.org/W2101284761","https://openalex.org/W2122152516","https://openalex.org/W2123893444","https://openalex.org/W2127575901","https://openalex.org/W2133790757","https://openalex.org/W2147621031","https://openalex.org/W2202991822","https://openalex.org/W2216918211","https://openalex.org/W2238160558","https://openalex.org/W2404788297","https://openalex.org/W2417442825","https://openalex.org/W2508550362","https://openalex.org/W2588279632","https://openalex.org/W2596324636","https://openalex.org/W2600167110","https://openalex.org/W2617822359","https://openalex.org/W2742226233","https://openalex.org/W2765815660","https://openalex.org/W2773438852","https://openalex.org/W2791322887","https://openalex.org/W2793180195","https://openalex.org/W2793466222","https://openalex.org/W2900373994","https://openalex.org/W2916864964","https://openalex.org/W2920410992","https://openalex.org/W2949599907","https://openalex.org/W2966664397","https://openalex.org/W2978272633","https://openalex.org/W2979523141","https://openalex.org/W2994427476","https://openalex.org/W3000704693","https://openalex.org/W3005870565","https://openalex.org/W3047259774","https://openalex.org/W3080233428","https://openalex.org/W3136637643","https://openalex.org/W3168270741","https://openalex.org/W3168692467","https://openalex.org/W4200357591","https://openalex.org/W4205679320","https://openalex.org/W4210494520","https://openalex.org/W4214542089","https://openalex.org/W4283213847","https://openalex.org/W4283755536","https://openalex.org/W4306898474","https://openalex.org/W4312131495"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Maintaining":[0],"normal":[1,251,280],"potassium":[2],"(K+)":[3],"concentrations":[4,248],"in":[5,93,113,134,145,178,250,253],"the":[6,44,69,131,172,192,198,223,235,242,265,271],"extra-":[7,25,243],"and":[8,26,30,58,107,174,202,209,244,258],"intracellular":[9,27],"fluid":[10,28,176,246],"is":[11,18,50,54,80],"critical":[12],"for":[13],"cell":[14],"function.":[15],"K+":[16,33,41,49,65,72,79,97,105,116,119,132,141,147,157,167,207,215,229,247,256,282,289],"homeostasis":[17,66],"achieved":[19],"by":[20,31,56,67,82],"ensuring":[21],"proper":[22],"distribution":[23],"between":[24],"compartments":[29,177],"matching":[32],"excretion":[34,142],"with":[35],"intake.":[36],"The":[37,60,169],"Na+-K+-ATPase":[38,52,206],"pump":[39],"facilitates":[40],"uptake":[42],"into":[43],"skeletal":[45,135],"muscle,":[46],"where":[47,130],"most":[48],"stored.":[51],"activity":[53],"stimulated":[55],"insulin":[57,201],"aldosterone.":[59],"kidneys":[61],"regulate":[62],"long":[63],"term":[64],"controlling":[68],"amount":[70],"of":[71,78,85,165,200,213,225,255,287],"excreted":[73],"through":[74],"urine.":[75],"Renal":[76],"handling":[77],"mediated":[81],"a":[83,108,122,162,179,185,277,285],"number":[84],"regulatory":[86,226,236],"mechanisms,":[87],"including":[88],"an":[89],"aldosterone-mediated":[90],"feedback":[91],"control,":[92],"which":[94,102,114],"high":[95,288],"extracellular":[96,146,175,281],"concentration":[98,133,283],"stimulates":[99],"aldosterone":[100,204,211],"secretion,":[101],"enhances":[103],"urine":[104,140],"excretion,":[106],"gastrointestinal":[109,193],"feedforward":[110,194],"control":[111,195],"mechanism,":[112,196],"dietary":[115],"intake":[117],"increases":[118],"excretion.":[120],"Recently,":[121],"muscle-kidney":[123,267],"cross":[124,268],"talk":[125,269],"signal":[126],"has":[127],"been":[128],"hypothesized,":[129],"muscle":[136],"cells":[137],"directly":[138],"affects":[139],"without":[143,264],"changes":[144],"concentration.":[148],"To":[149],"understand":[150],"how":[151,234],"these":[152],"mechanisms":[153,227,237],"coordinate":[154],"under":[155],"different":[156],"challenges,":[158],"we":[159,261],"have":[160],"developed":[161],"compartmental":[163],"model":[164,170,220,272],"whole-body":[166],"regulation.":[168],"represents":[171],"intra-":[173],"human":[180],"(male)":[181],"as":[182,184],"well":[183],"detailed":[186],"kidney":[187],"compartment.":[188],"We":[189,217],"included":[190],"(i)":[191],"(ii)":[197],"effect":[199],"(iii)":[203],"on":[205,228],"uptake,":[208],"(iv)":[210],"stimulation":[212],"renal":[214],"secretion.":[216],"used":[218],"this":[219],"to":[221,239,275,279],"investigate":[222],"impact":[224],"homeostasis.":[230],"Model":[231],"predictions":[232],"showed":[233],"synthesize":[238],"ensure":[240],"that":[241,263],"intracelluller":[245],"remain":[249],"range":[252],"times":[254],"loading":[257,290],"fasting.":[259],"Additionally,":[260],"predict":[262,276],"hypothesized":[266],"signal,":[270],"was":[273],"unable":[274],"return":[278],"after":[284],"period":[286],"or":[291],"depletion.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
