{"id":"https://openalex.org/W4300689221","doi":"https://doi.org/10.1371/journal.pcbi.1010576","title":"Variant calling enhances the identification of cancer cells in single-cell RNA sequencing data","display_name":"Variant calling enhances the identification of cancer cells in single-cell RNA sequencing data","publication_year":2022,"publication_date":"2022-10-03","ids":{"openalex":"https://openalex.org/W4300689221","doi":"https://doi.org/10.1371/journal.pcbi.1010576","pmid":"https://pubmed.ncbi.nlm.nih.gov/36191033"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010576","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010576&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010576&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051342427","display_name":"William Gasper","orcid":null},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Gasper","raw_affiliation_strings":["School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, United States of America","institution_ids":["https://openalex.org/I122266389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101669833","display_name":"Francesca Rossi","orcid":"https://orcid.org/0000-0001-7327-6364"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Rossi","raw_affiliation_strings":["Department of Surgery, University of Texas Southwestern, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Texas Southwestern, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074086190","display_name":"Matteo Ligorio","orcid":"https://orcid.org/0000-0001-8865-0881"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matteo Ligorio","raw_affiliation_strings":["Department of Surgery, University of Texas Southwestern, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Texas Southwestern, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013370423","display_name":"Dario Ghersi","orcid":"https://orcid.org/0000-0002-0630-0843"},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dario Ghersi","raw_affiliation_strings":["School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, United States of America","institution_ids":["https://openalex.org/I122266389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013370423","https://openalex.org/A5074086190"],"corresponding_institution_ids":["https://openalex.org/I122266389","https://openalex.org/I867280407"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2847,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50385265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"18","issue":"10","first_page":"e1010576","last_page":"e1010576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.7256039977073669},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6743267774581909},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5896358489990234},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5625351071357727},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.5589432716369629},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5272936820983887},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.508841335773468},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.498152494430542},{"id":"https://openalex.org/keywords/single-cell-sequencing","display_name":"Single cell sequencing","score":0.4658556580543518},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.45869913697242737},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.4583721458911896},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4496304988861084},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3987804651260376},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.3574540615081787},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.2764487862586975},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.19576972723007202},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.16407519578933716}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7256039977073669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6743267774581909},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5896358489990234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5625351071357727},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.5589432716369629},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5272936820983887},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.508841335773468},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.498152494430542},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.4658556580543518},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45869913697242737},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4583721458911896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4496304988861084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3987804651260376},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3574540615081787},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2764487862586975},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.19576972723007202},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.16407519578933716}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010576","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010576&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36191033","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36191033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:80fd1041f4f1452cb8d5043f7e110277","is_oa":true,"landing_page_url":"https://doaj.org/article/80fd1041f4f1452cb8d5043f7e110277","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 10, p e1010576 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9560611","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9560611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010576","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010576&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1421797890","display_name":null,"funder_award_id":"RR200023","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G617247599","display_name":null,"funder_award_id":"5R37CA242070","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4300689221.pdf","grobid_xml":"https://content.openalex.org/works/W4300689221.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W808646684","https://openalex.org/W1496181682","https://openalex.org/W1969556504","https://openalex.org/W1989298969","https://openalex.org/W1991064719","https://openalex.org/W2008870230","https://openalex.org/W2030017878","https://openalex.org/W2034269086","https://openalex.org/W2035853334","https://openalex.org/W2036897871","https://openalex.org/W2083087817","https://openalex.org/W2088470456","https://openalex.org/W2091052259","https://openalex.org/W2099019742","https://openalex.org/W2103441770","https://openalex.org/W2106578986","https://openalex.org/W2112713769","https://openalex.org/W2117692326","https://openalex.org/W2130410032","https://openalex.org/W2149441684","https://openalex.org/W2161112598","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2201797518","https://openalex.org/W2214074259","https://openalex.org/W2253928581","https://openalex.org/W2294446650","https://openalex.org/W2342435575","https://openalex.org/W2558217573","https://openalex.org/W2585175142","https://openalex.org/W2606495925","https://openalex.org/W2613784923","https://openalex.org/W2614443510","https://openalex.org/W2758559111","https://openalex.org/W2766676715","https://openalex.org/W2767281692","https://openalex.org/W2774506962","https://openalex.org/W2785610956","https://openalex.org/W2785713700","https://openalex.org/W2807848287","https://openalex.org/W2810475801","https://openalex.org/W2889213939","https://openalex.org/W2889721546","https://openalex.org/W2915160617","https://openalex.org/W2921113926","https://openalex.org/W2946295060","https://openalex.org/W2947811794","https://openalex.org/W2951506174","https://openalex.org/W2963310788","https://openalex.org/W2997123690","https://openalex.org/W3006211741","https://openalex.org/W3037016372","https://openalex.org/W3086823661","https://openalex.org/W3087223457","https://openalex.org/W3087730663","https://openalex.org/W3115113339","https://openalex.org/W3123988232","https://openalex.org/W3128997041","https://openalex.org/W3131055609","https://openalex.org/W3134442664","https://openalex.org/W3155669323","https://openalex.org/W4221030787","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W4394359997","https://openalex.org/W4362511652","https://openalex.org/W4362511917","https://openalex.org/W4362511922","https://openalex.org/W4362485688","https://openalex.org/W4362530184","https://openalex.org/W4362530193","https://openalex.org/W2904597490","https://openalex.org/W4362485661","https://openalex.org/W4394365953"],"abstract_inverted_index":{"Single-cell":[0],"RNA-sequencing":[1],"is":[2],"an":[3],"invaluable":[4],"research":[5],"tool":[6],"that":[7,22,95,113,135,158,176],"allows":[8],"for":[9,49,74,123],"the":[10,36,40,71,87,136,171],"investigation":[11],"of":[12,43,89,116,138,173,184],"gene":[13],"expression":[14,61],"in":[15,20,32,78,102,118,150,181],"heterogeneous":[16],"cancer":[17,33,51,76],"cell":[18],"populations":[19],"ways":[21],"bulk":[23],"RNA-seq":[24,45,80,104,188],"cannot.":[25],"However,":[26],"normal":[27,53,130],"(i.e.,":[28],"non":[29],"tumor)":[30],"cells":[31,54,77,117,175],"samples":[34,81,120],"have":[35],"potential":[37],"to":[38,69,129],"confound":[39],"downstream":[41,182],"analysis":[42,168],"single-cell":[44,79,103,185],"data.":[46],"Existing":[47],"methods":[48,163],"identifying":[50,75],"and":[52,63,86,111,142,167],"include":[55],"copy":[56,144],"number":[57,137,145,172],"variation":[58,146],"inference,":[59],"marker-gene":[60],"analysis,":[62],"expression-based":[64],"clustering.":[65],"This":[66],"work":[67],"aims":[68],"extend":[70],"existing":[72,160],"approaches":[73],"by":[82],"incorporating":[83],"variant":[84,165],"calling":[85,166],"identification":[88],"putative":[90,96,124,139],"driver":[91,97,125,140],"alterations.":[92],"We":[93],"found":[94],"alterations":[98,126,141],"can":[99,169,177],"be":[100,178],"detected":[101],"data":[105],"obtained":[106],"with":[107,164],"full-length":[108,186],"transcript":[109,187],"technologies":[110],"noticed":[112],"a":[114],"subset":[115],"tumor":[119,174],"are":[121,147],"enriched":[122],"as":[127],"compared":[128],"cells.":[131],"Furthermore,":[132],"we":[133],"show":[134],"inferred":[143],"not":[148],"correlated":[149],"all":[151],"samples.":[152],"Taken":[153],"together,":[154],"our":[155],"findings":[156],"suggest":[157],"augmenting":[159],"cancer-cell":[161],"filtering":[162],"increase":[170],"confidently":[179],"included":[180],"analyses":[183],"datasets.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
