{"id":"https://openalex.org/W4304092601","doi":"https://doi.org/10.1371/journal.pcbi.1010541","title":"Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar","display_name":"Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar","publication_year":2022,"publication_date":"2022-10-10","ids":{"openalex":"https://openalex.org/W4304092601","doi":"https://doi.org/10.1371/journal.pcbi.1010541","pmid":"https://pubmed.ncbi.nlm.nih.gov/36215228"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010541","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010541&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010541&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072590164","display_name":"Suran K. Galappaththige","orcid":"https://orcid.org/0000-0001-5268-1838"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suran Galappaththige","raw_affiliation_strings":["Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5268-1838","affiliations":[{"raw_affiliation_string":"Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013310955","display_name":"Richard A. Gray","orcid":"https://orcid.org/0000-0003-2798-6378"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Gray","raw_affiliation_strings":["Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059808191","display_name":"Caroline Mendon\u00e7a Costa","orcid":"https://orcid.org/0000-0002-9046-003X"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline Mendonca Costa","raw_affiliation_strings":["School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000435552","display_name":"Steven Niederer","orcid":"https://orcid.org/0000-0002-4612-6982"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Niederer","raw_affiliation_strings":["School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072917093","display_name":"Pras Pathmanathan","orcid":"https://orcid.org/0000-0003-2111-6689"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pras Pathmanathan","raw_affiliation_strings":["Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2111-6689","affiliations":[{"raw_affiliation_string":"Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072917093"],"corresponding_institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1335686170"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.3774,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.96763343,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"18","issue":"10","first_page":"e1010541","last_page":"e1010541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12495","display_name":"Electrostatic Discharge in Electronics","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/credibility","display_name":"Credibility","score":0.7732130289077759},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6721779108047485},{"id":"https://openalex.org/keywords/virtual-patient","display_name":"Virtual patient","score":0.6024718880653381},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4266558587551117},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34394359588623047},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3138693869113922}],"concepts":[{"id":"https://openalex.org/C2780224610","wikidata":"https://www.wikidata.org/wiki/Q1530061","display_name":"Credibility","level":2,"score":0.7732130289077759},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6721779108047485},{"id":"https://openalex.org/C2778533338","wikidata":"https://www.wikidata.org/wiki/Q7935148","display_name":"Virtual patient","level":2,"score":0.6024718880653381},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4266558587551117},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34394359588623047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3138693869113922},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010541","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010541&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36215228","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36215228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:6f718219ff2243e09d7560cc40456678","is_oa":true,"landing_page_url":"https://doaj.org/article/6f718219ff2243e09d7560cc40456678","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 10, p e1010541 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9d44eecc89db4fb2aa060d8f608c3e02","is_oa":true,"landing_page_url":"https://doaj.org/article/9d44eecc89db4fb2aa060d8f608c3e02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 10 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9550052","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9550052","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010541","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010541&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G8429837475","display_name":null,"funder_award_id":"EP/W000091/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304092601.pdf","grobid_xml":"https://content.openalex.org/works/W4304092601.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1072488465","https://openalex.org/W1593002915","https://openalex.org/W1599569911","https://openalex.org/W1970680757","https://openalex.org/W2003384163","https://openalex.org/W2046645682","https://openalex.org/W2061451182","https://openalex.org/W2077590638","https://openalex.org/W2078242986","https://openalex.org/W2080148075","https://openalex.org/W2104881731","https://openalex.org/W2105004070","https://openalex.org/W2107658445","https://openalex.org/W2115765852","https://openalex.org/W2130321115","https://openalex.org/W2132670047","https://openalex.org/W2140796340","https://openalex.org/W2163071496","https://openalex.org/W2256938810","https://openalex.org/W2272546316","https://openalex.org/W2367512715","https://openalex.org/W2487405781","https://openalex.org/W2511327285","https://openalex.org/W2624709875","https://openalex.org/W2724217199","https://openalex.org/W2738960554","https://openalex.org/W2793422464","https://openalex.org/W2794027666","https://openalex.org/W2796362334","https://openalex.org/W2802851452","https://openalex.org/W2888118590","https://openalex.org/W2895834009","https://openalex.org/W2920428737","https://openalex.org/W2925392792","https://openalex.org/W2953513972","https://openalex.org/W2954968983","https://openalex.org/W2965949845","https://openalex.org/W2969852609","https://openalex.org/W2979000069","https://openalex.org/W3009104639","https://openalex.org/W3010152544","https://openalex.org/W3032510290","https://openalex.org/W3037700092","https://openalex.org/W3037817333","https://openalex.org/W3039651212","https://openalex.org/W3093261009","https://openalex.org/W3093446383","https://openalex.org/W3104067275","https://openalex.org/W3106801472","https://openalex.org/W3120808464","https://openalex.org/W3153574682","https://openalex.org/W3158586821","https://openalex.org/W3185920181","https://openalex.org/W3196273051"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Reliable":[0],"and":[1,19,73,124,150,155,195,238,242,255,269],"robust":[2],"simulation":[3,20,167],"of":[4,13,29,60,66,83,97,110,118,175,191,215,226,259,267],"individual":[5],"patients":[6],"using":[7,132,169],"patient-specific":[8,133,177],"models":[9,96],"(PSMs)":[10],"is":[11,121],"one":[12],"the":[14,27,81,108,126,180,186,189,205,224,227],"next":[15],"frontiers":[16],"for":[17,39,62,79,130,232],"modeling":[18,137],"(M&S)":[21],"in":[22,63,85,193,198,248],"healthcare.":[23],"PSMs,":[24,274],"which":[25],"form":[26],"basis":[28],"digital":[30],"twins,":[31],"can":[32,217],"be":[33,54,218,263],"employed":[34],"as":[35,138,236],"clinical":[36,253],"tools":[37],"to,":[38],"example,":[40],"assess":[41],"disease":[42],"state,":[43],"predict":[44],"response":[45],"to":[46,56,106,122,146,160,210,265],"therapy,":[47],"or":[48,100],"optimize":[49],"therapy.":[50],"They":[51],"may":[52],"also":[53],"used":[55,145],"construct":[57],"virtual":[58,173,200],"cohorts":[59],"patients,":[61],"silico":[64],"evaluation":[65],"medical":[67,98,271],"product":[68],"safety":[69],"and/or":[70],"performance.":[71],"Methods":[72],"frameworks":[74],"have":[75,91],"recently":[76],"been":[77,93,114],"proposed":[78],"evaluating":[80],"credibility":[82,109,127,222],"M&S":[84],"healthcare":[86],"applications.":[87],"However,":[88],"such":[89,235],"efforts":[90],"generally":[92],"motivated":[94],"by":[95],"devices":[99],"generic":[101],"patient":[102],"models;":[103],"how":[104,152,212],"best":[105],"evaluate":[107],"PSMs":[111,131,149,216],"has":[112],"largely":[113],"unexplored.":[115],"The":[116,257],"aim":[117],"this":[119,260],"paper":[120,261],"understand":[123],"demonstrate":[125],"assessment":[128],"process":[129],"cardiac":[134,148,161,268],"electrophysiological":[135],"(EP)":[136],"an":[139],"exemplar.":[140],"We":[141,202],"first":[142,181],"review":[143],"approaches":[144],"generate":[147],"consider":[151],"verification,":[153],"validation,":[154,254],"uncertainty":[156,192,246],"quantification":[157,247],"(VVUQ)":[158],"apply":[159],"PSMs.":[162],"Next,":[163],"we":[164],"execute":[165],"two":[166],"studies":[168],"a":[170,182,199],"publicly":[171],"available":[172],"cohort":[174],"24":[176],"ventricular":[178],"models,":[179],"multi-patient":[183,241],"verification":[184],"study,":[185],"second":[187],"investigating":[188],"impact":[190],"personalized":[194,249],"non-personalized":[196,251],"inputs":[197],"cohort.":[201],"then":[203],"use":[204],"findings":[206],"from":[207],"our":[208],"analyses":[209],"identify":[211],"important":[213],"characteristics":[214],"considered":[219],"when":[220,275],"assessing":[221,276],"with":[223],"approach":[225],"ASME":[228],"V&V40":[229],"Standard,":[230],"accounting":[231],"PSM":[233,277],"concepts":[234],"inter-":[237],"intra-user":[239],"variability,":[240],"\"every-patient\"":[243],"error":[244],"estimation,":[245],"vs":[250],"inputs,":[252],"others.":[256],"results":[258],"will":[262],"useful":[264],"developers":[266],"other":[270],"image":[272],"based":[273],"credibility.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":3}],"updated_date":"2026-06-12T08:23:45.883708","created_date":"2025-10-10T00:00:00"}