{"id":"https://openalex.org/W4296328663","doi":"https://doi.org/10.1371/journal.pcbi.1010524","title":"On the incongruence of genotype-phenotype and fitness landscapes","display_name":"On the incongruence of genotype-phenotype and fitness landscapes","publication_year":2022,"publication_date":"2022-09-19","ids":{"openalex":"https://openalex.org/W4296328663","doi":"https://doi.org/10.1371/journal.pcbi.1010524","pmid":"https://pubmed.ncbi.nlm.nih.gov/36121840"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010524","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010524","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010524","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011036860","display_name":"Malvika Srivastava","orcid":"https://orcid.org/0000-0003-0757-4990"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Malvika Srivastava","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0757-4990","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074476792","display_name":"Joshua L. Payne","orcid":"https://orcid.org/0000-0002-2978-8423"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Joshua L. Payne","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2978-8423","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011036860","https://openalex.org/A5074476792"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2688,"currency":"EUR","value_usd":2899},"fwci":3.1934,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.92371639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"9","first_page":"e1010524","last_page":"e1010524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.8681375980377197},{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.8427281975746155},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7297887802124023},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7081818580627441},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5995082855224609},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.598383903503418},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5217764973640442},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.4981095790863037},{"id":"https://openalex.org/keywords/genetic-fitness","display_name":"Genetic Fitness","score":0.44831377267837524},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39552491903305054},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32779544591903687},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.16363900899887085},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07950586080551147}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.8681375980377197},{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.8427281975746155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7297887802124023},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7081818580627441},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5995082855224609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.598383903503418},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5217764973640442},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4981095790863037},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.44831377267837524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39552491903305054},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32779544591903687},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.16363900899887085},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07950586080551147},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010524","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010524","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36121840","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36121840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:6e53cde1f0aa4412966ba1d6d1f615e3","is_oa":true,"landing_page_url":"https://doaj.org/article/6e53cde1f0aa4412966ba1d6d1f615e3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9, p e1010524 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9521842","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9521842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010524","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010524","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1893454185","display_name":null,"funder_award_id":"PP00P3_170604","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G226506748","display_name":null,"funder_award_id":"310030_192541","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8005194274","display_name":null,"funder_award_id":"PP00P3_160604","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W1498410508","https://openalex.org/W1510121895","https://openalex.org/W1600814660","https://openalex.org/W1762301290","https://openalex.org/W1964778231","https://openalex.org/W1965991910","https://openalex.org/W1969012077","https://openalex.org/W1972792790","https://openalex.org/W1983153145","https://openalex.org/W1983658594","https://openalex.org/W1993405220","https://openalex.org/W1994122295","https://openalex.org/W1998756227","https://openalex.org/W2002964220","https://openalex.org/W2004778468","https://openalex.org/W2005983216","https://openalex.org/W2007106381","https://openalex.org/W2008545863","https://openalex.org/W2011759634","https://openalex.org/W2012404898","https://openalex.org/W2013449615","https://openalex.org/W2019632428","https://openalex.org/W2022891974","https://openalex.org/W2026107823","https://openalex.org/W2032433599","https://openalex.org/W2033169664","https://openalex.org/W2042310235","https://openalex.org/W2042392223","https://openalex.org/W2047919241","https://openalex.org/W2051853521","https://openalex.org/W2057414337","https://openalex.org/W2063028997","https://openalex.org/W2064015405","https://openalex.org/W2064164319","https://openalex.org/W2065362852","https://openalex.org/W2068872007","https://openalex.org/W2072409782","https://openalex.org/W2073734048","https://openalex.org/W2076469310","https://openalex.org/W2081531630","https://openalex.org/W2096145529","https://openalex.org/W2097955805","https://openalex.org/W2098920163","https://openalex.org/W2106837952","https://openalex.org/W2112068999","https://openalex.org/W2113557726","https://openalex.org/W2118265845","https://openalex.org/W2122452605","https://openalex.org/W2126304668","https://openalex.org/W2126643167","https://openalex.org/W2140542639","https://openalex.org/W2143172590","https://openalex.org/W2145674897","https://openalex.org/W2151670888","https://openalex.org/W2151907070","https://openalex.org/W2153367920","https://openalex.org/W2156469654","https://openalex.org/W2160465883","https://openalex.org/W2165327448","https://openalex.org/W2177081463","https://openalex.org/W2266201493","https://openalex.org/W2304402346","https://openalex.org/W2308616703","https://openalex.org/W2336101408","https://openalex.org/W2345943684","https://openalex.org/W2357558255","https://openalex.org/W2379594833","https://openalex.org/W2462656404","https://openalex.org/W2483469645","https://openalex.org/W2508444502","https://openalex.org/W2508698766","https://openalex.org/W2531753895","https://openalex.org/W2547075996","https://openalex.org/W2560097163","https://openalex.org/W2572573235","https://openalex.org/W2593075177","https://openalex.org/W2610903912","https://openalex.org/W2615193235","https://openalex.org/W2620848075","https://openalex.org/W2622846400","https://openalex.org/W2768474856","https://openalex.org/W2783734371","https://openalex.org/W2790509526","https://openalex.org/W2795719151","https://openalex.org/W2800231751","https://openalex.org/W2801395517","https://openalex.org/W2810754857","https://openalex.org/W2810811976","https://openalex.org/W2890052694","https://openalex.org/W2898806520","https://openalex.org/W2901329381","https://openalex.org/W2902290256","https://openalex.org/W2905701416","https://openalex.org/W2944831967","https://openalex.org/W2946722611","https://openalex.org/W2950721626","https://openalex.org/W2951701224","https://openalex.org/W2952730289","https://openalex.org/W2953058007","https://openalex.org/W2959963856","https://openalex.org/W2962952282","https://openalex.org/W2970136167","https://openalex.org/W2990395719","https://openalex.org/W2992478931","https://openalex.org/W3027041747","https://openalex.org/W3033043045","https://openalex.org/W3090460189","https://openalex.org/W3098920008","https://openalex.org/W3106874121","https://openalex.org/W3128786636","https://openalex.org/W3133917645","https://openalex.org/W3145085575","https://openalex.org/W3161462675","https://openalex.org/W3197200418","https://openalex.org/W3199464923","https://openalex.org/W4200570526","https://openalex.org/W4246887724","https://openalex.org/W4251042002","https://openalex.org/W4297795096","https://openalex.org/W6666533934"],"related_works":["https://openalex.org/W4295749382","https://openalex.org/W4225153397","https://openalex.org/W4226215149","https://openalex.org/W2892105358","https://openalex.org/W2801395517","https://openalex.org/W2105313632","https://openalex.org/W2098920163","https://openalex.org/W2781796898","https://openalex.org/W2126304668","https://openalex.org/W2118609795"],"abstract_inverted_index":{"The":[0],"mapping":[1],"from":[2],"genotype":[3],"to":[4,6,25,76,96,159,174,207,222,230],"phenotype":[5],"fitness":[7,32,57,74,104,161,176,204],"typically":[8,191],"involves":[9],"multiple":[10],"nonlinearities":[11],"that":[12,45,146,170,178],"can":[13,48],"transform":[14],"the":[15,52,78,99,116,183,198,203,213,223],"effects":[16,30],"of":[17,44,55,82,101,123,217],"mutations.":[18],"For":[19,126],"example,":[20,127],"mutations":[21],"may":[22,33,228],"contribute":[23],"additively":[24],"a":[26,39,56,71,109,121],"phenotype,":[27],"but":[28,187],"their":[29],"on":[31,92],"combine":[34],"non-additively":[35],"because":[36,197],"selection":[37,107,128,172],"favors":[38,108],"low":[40,110,130],"or":[41,111,131],"intermediate":[42,112,132],"value":[43],"phenotype.":[46],"This":[47],"cause":[49],"incongruence":[50,100],"between":[51],"topographical":[53],"properties":[54],"landscape":[58,205],"and":[59,80,89,103,234],"its":[60],"underlying":[61,184],"genotype-phenotype":[62,65,102,147,185,225],"landscape.":[63],"Yet,":[64],"landscapes":[66,75,105,148,162,177],"are":[67,179,239],"often":[68],"used":[69],"as":[70,210,212],"proxy":[72],"for":[73,129],"study":[77,98],"dynamics":[79],"predictability":[81],"evolution.":[83],"Here,":[84],"we":[85,119,168],"use":[86],"theoretical":[87,117],"models":[88],"empirical":[90,224],"data":[91],"transcription":[93,236],"factor-DNA":[94,237],"interactions":[95,238],"systematically":[97],"when":[106],"phenotypic":[113,133],"value.":[114],"Using":[115],"models,":[118],"prove":[120],"number":[122],"fundamental":[124],"results.":[125],"values":[134],"does":[135,192],"not":[136,193],"change":[137],"simple":[138,151],"sign":[139,143,152],"epistasis":[140,153],"into":[141],"reciprocal":[142],"epistasis,":[144],"implying":[145],"with":[149],"only":[150],"motifs":[154],"will":[155],"always":[156],"give":[157],"rise":[158],"single-peaked":[160],"under":[163],"such":[164,171],"selection.":[165],"More":[166],"broadly,":[167],"show":[169],"tends":[173],"create":[175],"more":[180],"rugged":[181],"than":[182],"landscape,":[186],"this":[188],"increased":[189],"ruggedness":[190],"frustrate":[194],"adaptive":[195,200],"evolution":[196],"local":[199],"peaks":[201],"in":[202,242],"tend":[206],"be":[208],"nearly":[209],"tall":[211],"global":[214],"peak.":[215],"Many":[216],"these":[218],"results":[219],"carry":[220],"forward":[221],"landscapes,":[226],"which":[227],"help":[229],"explain":[231],"why":[232],"low-":[233],"intermediate-affinity":[235],"so":[240],"prevalent":[241],"eukaryotic":[243],"gene":[244],"regulation.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}