{"id":"https://openalex.org/W4295880393","doi":"https://doi.org/10.1371/journal.pcbi.1010488","title":"A quantitative modelling approach for DNA repair on a population scale","display_name":"A quantitative modelling approach for DNA repair on a population scale","publication_year":2022,"publication_date":"2022-09-12","ids":{"openalex":"https://openalex.org/W4295880393","doi":"https://doi.org/10.1371/journal.pcbi.1010488","pmid":"https://pubmed.ncbi.nlm.nih.gov/36094963"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010488","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010488","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010488&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010488&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044533871","display_name":"Leo Zeitler","orcid":"https://orcid.org/0000-0001-6667-4663"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Leo Zeitler","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0001-6667-4663","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210106617","https://openalex.org/I277688954","https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025174656","display_name":"Cyril Denby Wilkes","orcid":"https://orcid.org/0000-0003-3932-5294"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Denby Wilkes","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-3932-5294","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210106617","https://openalex.org/I277688954","https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053305582","display_name":"Arach Goldar","orcid":"https://orcid.org/0000-0003-4139-247X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arach Goldar","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-4139-247X","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210106617","https://openalex.org/I277688954","https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I2738703131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010841814","display_name":"Julie Soutourina","orcid":"https://orcid.org/0000-0001-5218-2350"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julie Soutourina","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0001-5218-2350","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210106617","https://openalex.org/I277688954","https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I2738703131"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010841814"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210128565"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2608,"currency":"EUR","value_usd":2812},"fwci":0.2604,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52434041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"18","issue":"9","first_page":"e1010488","last_page":"e1010488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7013466358184814},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5970798134803772},{"id":"https://openalex.org/keywords/nucleosome","display_name":"Nucleosome","score":0.5653952956199646},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.551780104637146},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5395135283470154},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4755128026008606},{"id":"https://openalex.org/keywords/budding-yeast","display_name":"Budding yeast","score":0.426960825920105},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4098505973815918},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40110692381858826},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3907593786716461},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35734784603118896},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.2672068476676941},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.24480140209197998}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7013466358184814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5970798134803772},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.5653952956199646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.551780104637146},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5395135283470154},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4755128026008606},{"id":"https://openalex.org/C2992884146","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Budding yeast","level":4,"score":0.426960825920105},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4098505973815918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40110692381858826},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3907593786716461},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35734784603118896},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.2672068476676941},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.24480140209197998},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010488","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010488","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010488&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36094963","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36094963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1010488","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010488","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8d1831405b1d41e389648e0a1362b0ec","is_oa":true,"landing_page_url":"https://doaj.org/article/8d1831405b1d41e389648e0a1362b0ec","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9, p e1010488 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9499311","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9499311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010488","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010488","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010488&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2444547639","display_name":"International PhD programme in NUMERICal Simulation","funder_award_id":"800945","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6007769398","display_name":null,"funder_award_id":"PGA1 RF20170205342","funder_id":"https://openalex.org/F4320322361","funder_display_name":"Fondation ARC pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G8095742631","display_name":null,"funder_award_id":"PGA1 RF20170205342","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G8468091303","display_name":null,"funder_award_id":"800945","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295880393.pdf","grobid_xml":"https://content.openalex.org/works/W4295880393.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1572098237","https://openalex.org/W1964284289","https://openalex.org/W1972122075","https://openalex.org/W1974736523","https://openalex.org/W1980887180","https://openalex.org/W1984353960","https://openalex.org/W1988510430","https://openalex.org/W2009331672","https://openalex.org/W2013727278","https://openalex.org/W2024908520","https://openalex.org/W2048228139","https://openalex.org/W2056320034","https://openalex.org/W2059901912","https://openalex.org/W2070312296","https://openalex.org/W2072980863","https://openalex.org/W2084369408","https://openalex.org/W2084451754","https://openalex.org/W2090732497","https://openalex.org/W2112090753","https://openalex.org/W2128066858","https://openalex.org/W2148983475","https://openalex.org/W2169506226","https://openalex.org/W2399619985","https://openalex.org/W2503637244","https://openalex.org/W2505939414","https://openalex.org/W2525528836","https://openalex.org/W2526788217","https://openalex.org/W2559939046","https://openalex.org/W2565394605","https://openalex.org/W2625176645","https://openalex.org/W2793725693","https://openalex.org/W2951694241","https://openalex.org/W2961424399","https://openalex.org/W2978212472","https://openalex.org/W2997804167","https://openalex.org/W3009266182","https://openalex.org/W3016886916","https://openalex.org/W3210151835","https://openalex.org/W4200630259","https://openalex.org/W6894051565"],"related_works":["https://openalex.org/W2464479560","https://openalex.org/W2528336156","https://openalex.org/W2979355489","https://openalex.org/W2169256639","https://openalex.org/W2171263406","https://openalex.org/W2767387010","https://openalex.org/W1494361266","https://openalex.org/W1917144541","https://openalex.org/W1600255339","https://openalex.org/W146465756"],"abstract_inverted_index":{"The":[0,124,144],"great":[1],"advances":[2],"of":[3,11,77,109,151],"sequencing":[4,65],"technologies":[5],"allow":[6],"the":[7,75,96,130],"in":[8,39,55],"vivo":[9],"measurement":[10],"nuclear":[12,152],"processes-such":[13],"as":[14,67,74,85],"DNA":[15],"repair":[16,51,84,104],"after":[17],"UV":[18],"exposure-over":[19],"entire":[20],"cell":[21],"populations.":[22],"However,":[23],"data":[24],"sets":[25],"usually":[26],"contain":[27],"only":[28],"a":[29,45,86,91,107,148,155],"few":[30],"samples":[31],"over":[32,53],"several":[33],"hours,":[34],"missing":[35],"possibly":[36],"important":[37],"information":[38],"between":[40],"time":[41,54],"points.":[42],"We":[43,102],"developed":[44],"data-driven":[46],"approach":[47],"to":[48,60,106,115,141],"analyse":[49],"CPD":[50],"kinetics":[52],"Saccharomyces":[56],"cerevisiae.":[57],"In":[58],"contrast":[59],"other":[61],"studies":[62],"that":[63,112],"consider":[64],"signals":[66,78],"an":[68],"average":[69],"behaviour,":[70],"we":[71,89],"understand":[72],"them":[73],"superposition":[76],"from":[79],"independent":[80],"cells.":[81],"By":[82],"motivating":[83],"stochastic":[87],"process,":[88],"derive":[90],"minimal":[92],"model":[93],"for":[94,129,138],"which":[95,134],"parameters":[97,105],"can":[98],"be":[99],"conveniently":[100],"estimated.":[101],"correlate":[103],"variety":[108],"genomic":[110],"features":[111],"are":[113],"assumed":[114],"influence":[116],"repair,":[117],"including":[118],"transcription":[119,131],"rate":[120],"and":[121],"nucleosome":[122],"density.":[123],"clearest":[125],"link":[126],"was":[127],"found":[128],"unit":[132],"length,":[133],"has":[135],"been":[136],"unreported":[137],"budding":[139],"yeast":[140],"our":[142],"knowledge.":[143],"framework":[145],"hence":[146],"allows":[147],"comprehensive":[149],"analysis":[150],"processes":[153],"on":[154],"population":[156],"scale.":[157]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2025-10-10T00:00:00"}