{"id":"https://openalex.org/W4292636472","doi":"https://doi.org/10.1371/journal.pcbi.1010438","title":"Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling","display_name":"Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling","publication_year":2022,"publication_date":"2022-08-22","ids":{"openalex":"https://openalex.org/W4292636472","doi":"https://doi.org/10.1371/journal.pcbi.1010438","pmid":"https://pubmed.ncbi.nlm.nih.gov/35994503"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010438&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044156409","display_name":"Alina Batzilla","orcid":"https://orcid.org/0000-0003-3893-8355"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alina Batzilla","raw_affiliation_strings":["Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3893-8355","affiliations":[{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077710470","display_name":"Junyan Lu","orcid":"https://orcid.org/0000-0002-9211-0746"},"institutions":[{"id":"https://openalex.org/I1303691731","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I1303691731"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Junyan Lu","raw_affiliation_strings":["Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany","Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9211-0746","affiliations":[{"raw_affiliation_string":"Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]},{"raw_affiliation_string":"Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany","institution_ids":["https://openalex.org/I1303691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060298368","display_name":"Jarno Kivioja","orcid":"https://orcid.org/0000-0002-4046-0963"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jarno Kivioja","raw_affiliation_strings":["Department of Medical Oncology and Hematology, University Hospital Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, University Hospital Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210100468","https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037201118","display_name":"Kerstin Putzker","orcid":"https://orcid.org/0000-0001-8375-5908"},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Putzker","raw_affiliation_strings":["Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8375-5908","affiliations":[{"raw_affiliation_string":"Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041510189","display_name":"Joe Lewis","orcid":"https://orcid.org/0000-0002-9926-1328"},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joe Lewis","raw_affiliation_strings":["Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000098098","display_name":"Thorsten Zenz","orcid":"https://orcid.org/0000-0001-7890-9845"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Thorsten Zenz","raw_affiliation_strings":["Department of Medical Oncology and Hematology, University Hospital Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, University Hospital Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210100468","https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029601108","display_name":"Wolfgang Huber","orcid":"https://orcid.org/0000-0002-0474-2218"},"institutions":[{"id":"https://openalex.org/I1303691731","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I1303691731"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang Huber","raw_affiliation_strings":["Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0474-2218","affiliations":[{"raw_affiliation_string":"Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]},{"raw_affiliation_string":"Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany","institution_ids":["https://openalex.org/I1303691731"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5000098098","https://openalex.org/A5029601108","https://openalex.org/A5077710470"],"corresponding_institution_ids":["https://openalex.org/I1303691731","https://openalex.org/I202697423","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100468","https://openalex.org/I4210138560"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4587,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65033076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"18","issue":"8","first_page":"e1010438","last_page":"e1010438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6288121342658997},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5119441747665405},{"id":"https://openalex.org/keywords/ponatinib","display_name":"Ponatinib","score":0.5066633820533752},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5046371221542358},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.48865726590156555},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.4840216338634491},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.4831625819206238},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.46569666266441345},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4230196475982666},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.4126896560192108},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40260910987854004},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.3976060152053833},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.3787878155708313},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35021430253982544},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3273022174835205},{"id":"https://openalex.org/keywords/dasatinib","display_name":"Dasatinib","score":0.3194279670715332},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20823821425437927},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19207537174224854},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.17676526308059692}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6288121342658997},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5119441747665405},{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.5066633820533752},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5046371221542358},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.48865726590156555},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.4840216338634491},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4831625819206238},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.46569666266441345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4230196475982666},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4126896560192108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40260910987854004},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3976060152053833},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3787878155708313},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35021430253982544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3273022174835205},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.3194279670715332},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20823821425437927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19207537174224854},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17676526308059692},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35994503","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35994503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:195db4ad367c435b910eb09f4fb511e9","is_oa":true,"landing_page_url":"https://doaj.org/article/195db4ad367c435b910eb09f4fb511e9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1010438 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9436053","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9436053","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1339929833","display_name":null,"funder_award_id":"031L0212E","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G1637071432","display_name":null,"funder_award_id":"031L0171A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2591741566","display_name":null,"funder_award_id":"161L0213","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3968725559","display_name":null,"funder_award_id":"KFS-4439-02-2018","funder_id":"https://openalex.org/F4320327373","funder_display_name":"Schweizerische Arbeitsgemeinschaft f\u00fcr Klinische Krebsforschung"},{"id":"https://openalex.org/G6912708956","display_name":null,"funder_award_id":"KFS-4439-02-2018","funder_id":"https://openalex.org/F4320327941","funder_display_name":"Swiss Cancer Research Foundation"},{"id":"https://openalex.org/G7558587260","display_name":null,"funder_award_id":"031L0171A","funder_id":"https://openalex.org/F4320322001","funder_display_name":"Ministry of Foreign Affairs"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322001","display_name":"Ministry of Foreign Affairs","ror":"https://ror.org/03bgwd624"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320325738","display_name":"Universit\u00e4tsspital Z\u00fcrich","ror":null},{"id":"https://openalex.org/F4320327373","display_name":"Schweizerische Arbeitsgemeinschaft f\u00fcr Klinische Krebsforschung","ror":"https://ror.org/04rtrpb08"},{"id":"https://openalex.org/F4320327941","display_name":"Swiss Cancer Research Foundation","ror":"https://ror.org/022wnsy59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292636472.pdf","grobid_xml":"https://content.openalex.org/works/W4292636472.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1243376384","https://openalex.org/W1840311687","https://openalex.org/W1993345471","https://openalex.org/W1998025025","https://openalex.org/W1999390452","https://openalex.org/W2000585061","https://openalex.org/W2014557438","https://openalex.org/W2022054497","https://openalex.org/W2024264816","https://openalex.org/W2033403400","https://openalex.org/W2064186732","https://openalex.org/W2067036696","https://openalex.org/W2067656626","https://openalex.org/W2072763778","https://openalex.org/W2073928244","https://openalex.org/W2074306827","https://openalex.org/W2097360283","https://openalex.org/W2103385435","https://openalex.org/W2108068107","https://openalex.org/W2124971246","https://openalex.org/W2130410032","https://openalex.org/W2134493631","https://openalex.org/W2141393790","https://openalex.org/W2146512944","https://openalex.org/W2151918127","https://openalex.org/W2170202162","https://openalex.org/W2179438025","https://openalex.org/W2211564719","https://openalex.org/W2214074259","https://openalex.org/W2318933236","https://openalex.org/W2350389426","https://openalex.org/W2395185160","https://openalex.org/W2411238967","https://openalex.org/W2461427403","https://openalex.org/W2533139534","https://openalex.org/W2565920990","https://openalex.org/W2603632157","https://openalex.org/W2611446801","https://openalex.org/W2741508285","https://openalex.org/W2756562465","https://openalex.org/W2766768871","https://openalex.org/W2770695743","https://openalex.org/W2771855639","https://openalex.org/W2773242491","https://openalex.org/W2794329191","https://openalex.org/W2896480326","https://openalex.org/W2909346948","https://openalex.org/W2923142485","https://openalex.org/W2936686072","https://openalex.org/W2941706209","https://openalex.org/W2946259536","https://openalex.org/W2952121859","https://openalex.org/W2987480925","https://openalex.org/W3036853145","https://openalex.org/W3039462624","https://openalex.org/W3107299541","https://openalex.org/W3181052965","https://openalex.org/W3189949217","https://openalex.org/W4210508051","https://openalex.org/W4294541781","https://openalex.org/W4399538195"],"related_works":["https://openalex.org/W4206613547","https://openalex.org/W4366390701","https://openalex.org/W4280598799","https://openalex.org/W4283524715","https://openalex.org/W4230002713","https://openalex.org/W2802017747","https://openalex.org/W4210861756","https://openalex.org/W3213158727","https://openalex.org/W4245885852","https://openalex.org/W175647981"],"abstract_inverted_index":{"The":[0,15,177,196],"development":[1,50],"of":[2,11,45,72,93,121,130,152,169,184,192,211],"cancer":[3,37,124],"therapies":[4],"may":[5],"be":[6,32],"improved":[7],"by":[8,54],"the":[9,55,118,127,139,143,148,185,209],"discovery":[10],"tumor-specific":[12],"molecular":[13,70,205],"dependencies.":[14],"requisite":[16],"tools":[17],"include":[18],"genetic":[19],"and":[20,27,47,103,138],"chemical":[21,59],"perturbations,":[22],"each":[23],"with":[24,135],"its":[25],"strengths":[26],"limitations.":[28],"Chemical":[29],"perturbations":[30],"can":[31],"readily":[33],"applied":[34],"to":[35,63,198],"primary":[36],"samples":[38],"at":[39],"large":[40],"scale,":[41],"but":[42],"mechanistic":[43],"understanding":[44],"hits":[46],"further":[48],"pharmaceutical":[49],"is":[51],"often":[52],"complicated":[53],"fact":[56],"that":[57,87],"a":[58,84,99,165,181,189],"compound":[60],"has":[61],"affinities":[62],"multiple":[64],"proteins.":[65],"To":[66],"computationally":[67],"infer":[68],"specific":[69],"dependencies":[71,141,187,206],"individual":[73],"cancers":[74],"from":[75],"their":[76],"ex":[77],"vivo":[78],"drug":[79,105,213],"sensitivity":[80],"profiles,":[81],"we":[82],"developed":[83],"mathematical":[85],"model":[86],"deconvolutes":[88],"these":[89],"data":[90],"using":[91],"measurements":[92],"protein-drug":[94],"affinity":[95],"profiles.":[96],"Through":[97],"integrating":[98],"drug-kinase":[100],"profiling":[101],"dataset":[102],"several":[104],"response":[106,214],"datasets,":[107],"our":[108,158],"method,":[109],"DepInfeR,":[110],"correctly":[111],"identified":[112],"known":[113],"protein":[114],"kinase":[115,174,186],"dependencies,":[116,163],"including":[117,164],"EGFR":[119],"dependence":[120,129,168],"HER2+":[122],"breast":[123],"cell":[125],"lines,":[126],"FLT3":[128],"acute":[131],"myeloid":[132],"leukemia":[133,155],"(AML)":[134],"FLT3-ITD":[136],"mutations":[137],"differential":[140],"on":[142,172],"B-cell":[144],"receptor":[145],"pathway":[146],"in":[147,188],"two":[149],"major":[150],"subtypes":[151],"chronic":[153],"lymphocytic":[154],"(CLL).":[156],"Furthermore,":[157],"method":[159,178],"uncovered":[160],"new":[161],"subgroup-specific":[162],"previously":[166],"unreported":[167],"high-risk":[170],"CLL":[171,194],"Checkpoint":[173],"1":[175],"(CHEK1).":[176],"also":[179],"produced":[180],"detailed":[182],"map":[183],"heterogeneous":[190],"set":[191],"117":[193],"samples.":[195],"ability":[197],"deconvolute":[199],"polypharmacological":[200],"phenotypes":[201],"into":[202],"underlying":[203],"causal":[204],"should":[207],"increase":[208],"utility":[210],"high-throughput":[212],"assays":[215],"for":[216],"functional":[217],"precision":[218],"oncology.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}