{"id":"https://openalex.org/W4293469963","doi":"https://doi.org/10.1371/journal.pcbi.1010436","title":"Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits","display_name":"Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits","publication_year":2022,"publication_date":"2022-08-29","ids":{"openalex":"https://openalex.org/W4293469963","doi":"https://doi.org/10.1371/journal.pcbi.1010436","pmid":"https://pubmed.ncbi.nlm.nih.gov/36037215"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010436","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010436","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038013237","display_name":"Naoto Kubota","orcid":"https://orcid.org/0000-0003-0612-2300"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Kubota","raw_affiliation_strings":["Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0612-2300","affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053074141","display_name":"Mikita Suyama","orcid":"https://orcid.org/0000-0001-9526-3193"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mikita Suyama","raw_affiliation_strings":["Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9526-3193","affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053074141"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5208,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61810087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"18","issue":"8","first_page":"e1010436","last_page":"e1010436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.9029040336608887},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7595669031143188},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.6633093357086182},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6162738800048828},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.6116658449172974},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5586515069007874},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5539857745170593},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.44566240906715393},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.43126511573791504},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42088523507118225},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.2124466896057129},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.13259363174438477}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.9029040336608887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7595669031143188},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6633093357086182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6162738800048828},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6116658449172974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5586515069007874},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5539857745170593},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44566240906715393},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.43126511573791504},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42088523507118225},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2124466896057129},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13259363174438477}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010436","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010436","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36037215","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36037215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c993564f9b3c408ca68444ce81d9234e","is_oa":true,"landing_page_url":"https://doaj.org/article/c993564f9b3c408ca68444ce81d9234e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1010436 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0sh2j6xj","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0sh2j6xj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 18, iss 8","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9462676","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9462676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010436","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010436","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1014257459","https://openalex.org/W1947333330","https://openalex.org/W1973022936","https://openalex.org/W1986911601","https://openalex.org/W1991376447","https://openalex.org/W1997222931","https://openalex.org/W2005243425","https://openalex.org/W2008797552","https://openalex.org/W2014938226","https://openalex.org/W2025943989","https://openalex.org/W2036594436","https://openalex.org/W2038874082","https://openalex.org/W2044286001","https://openalex.org/W2051161717","https://openalex.org/W2062566852","https://openalex.org/W2065096062","https://openalex.org/W2066961060","https://openalex.org/W2073109785","https://openalex.org/W2076154138","https://openalex.org/W2078111650","https://openalex.org/W2084891010","https://openalex.org/W2088637291","https://openalex.org/W2104549677","https://openalex.org/W2114104545","https://openalex.org/W2117028091","https://openalex.org/W2124999415","https://openalex.org/W2129688995","https://openalex.org/W2132926880","https://openalex.org/W2138207763","https://openalex.org/W2143625465","https://openalex.org/W2144961623","https://openalex.org/W2161633633","https://openalex.org/W2164531600","https://openalex.org/W2165454946","https://openalex.org/W2165700891","https://openalex.org/W2169456326","https://openalex.org/W2171808845","https://openalex.org/W2185693210","https://openalex.org/W2259938310","https://openalex.org/W2323326409","https://openalex.org/W2341539131","https://openalex.org/W2409451325","https://openalex.org/W2519244818","https://openalex.org/W2529838505","https://openalex.org/W2553059833","https://openalex.org/W2559028527","https://openalex.org/W2571503386","https://openalex.org/W2588635522","https://openalex.org/W2592811885","https://openalex.org/W2765741842","https://openalex.org/W2768013244","https://openalex.org/W2770378609","https://openalex.org/W2791747812","https://openalex.org/W2805712258","https://openalex.org/W2889056149","https://openalex.org/W2899616402","https://openalex.org/W2917404003","https://openalex.org/W2950044823","https://openalex.org/W2951912016","https://openalex.org/W2952375549","https://openalex.org/W2952701000","https://openalex.org/W2952947531","https://openalex.org/W2953336103","https://openalex.org/W2971958993","https://openalex.org/W2973702082","https://openalex.org/W2991384483","https://openalex.org/W2995527562","https://openalex.org/W3042068575","https://openalex.org/W3046196569","https://openalex.org/W3083664261","https://openalex.org/W3094967361","https://openalex.org/W3133859624","https://openalex.org/W3199307135","https://openalex.org/W3202212354","https://openalex.org/W4281790889","https://openalex.org/W4286218496","https://openalex.org/W4289638000"],"related_works":["https://openalex.org/W104925310","https://openalex.org/W2464196154","https://openalex.org/W2150283886","https://openalex.org/W1995613491","https://openalex.org/W2115836816","https://openalex.org/W2951751247","https://openalex.org/W2143143063","https://openalex.org/W4384126845","https://openalex.org/W2112543488","https://openalex.org/W4323567910"],"abstract_inverted_index":{"Genomic":[0],"variations":[1,139,232],"are":[2,9],"associated":[3,40,79,170],"with":[4,41,80,171,192],"gene":[5,22,141,228],"expression":[6,11,23,56],"levels,":[7],"which":[8,137,177],"called":[10,83],"quantitative":[12,86],"trait":[13,87],"loci":[14,39,78,88,169],"(eQTL).":[15],"Most":[16],"eQTL":[17,51,154,180],"may":[18],"affect":[19],"the":[20,34,54,100,108,121,134,172,178,205,214,217],"total":[21,55],"levels":[24,57],"by":[25,59,153,230],"regulating":[26],"transcriptional":[27],"activities":[28,43],"of":[29,37,62,104,127,174,204,208,216,219],"a":[30,72],"specific":[31],"promoter.":[32],"However,":[33],"direct":[35],"exploration":[36],"genomic":[38,77,138,168,231],"promoter":[42,81,84,113],"using":[44,90],"RNA-seq":[45,92,97,221],"data":[46],"has":[47],"been":[48],"challenging":[49],"because":[50],"analyses":[52],"treat":[53],"estimated":[58],"summing":[60],"those":[61],"all":[63],"isoforms":[64],"transcribed":[65],"from":[66,99,107],"distinct":[67],"promoters.":[68],"Here":[69],"we":[70,111,166],"propose":[71],"new":[73],"method":[74],"for":[75],"identifying":[76],"activities,":[82],"usage":[85],"(puQTL),":[89],"conventional":[91],"data.":[93],"By":[94],"leveraging":[95],"public":[96,220],"datasets":[98,222],"lymphoblastoid":[101],"cell":[102],"lines":[103],"438":[105],"individuals":[106],"GEUVADIS":[109],"project,":[110],"obtained":[112],"activity":[114,173],"estimates":[115],"and":[116,233],"mapped":[117],"2,592":[118],"puQTL":[119,128,147,188],"at":[120,193],"10%":[122],"FDR":[123],"level.":[124],"The":[125],"results":[126,212],"mapping":[129],"enabled":[130],"us":[131],"to":[132,223,236],"interpret":[133],"manner":[135],"in":[136],"regulate":[140],"expression.":[142],"We":[143,184],"found":[144,185],"that":[145,157,186],"310":[146],"genes":[148],"(16.1%)":[149],"were":[150,190],"not":[151],"detected":[152],"analysis,":[155],"suggesting":[156],"our":[158],"pipeline":[159],"can":[160],"identify":[161],"novel":[162,202,225],"variant-gene":[163],"associations.":[164],"Furthermore,":[165],"identified":[167],"\"hidden\"":[175],"promoters,":[176],"standard":[179],"studies":[181],"have":[182],"ignored.":[183],"most":[187],"signals":[189],"concordant":[191],"least":[194],"one":[195],"genome-wide":[196],"association":[197],"study":[198],"(GWAS)":[199],"signal,":[200],"enabling":[201],"interpretations":[203],"molecular":[206],"mechanisms":[207],"complex":[209,237],"traits.":[210,238],"Our":[211],"emphasize":[213],"importance":[215],"re-analysis":[218],"obtain":[224],"insights":[226],"into":[227],"regulation":[229],"their":[234],"contributions":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}