{"id":"https://openalex.org/W4362521787","doi":"https://doi.org/10.1371/journal.pcbi.1010423","title":"Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies","display_name":"Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362521787","doi":"https://doi.org/10.1371/journal.pcbi.1010423","pmid":"https://pubmed.ncbi.nlm.nih.gov/37014904"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010423","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010423","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071676719","display_name":"Carolin Zitzmann","orcid":"https://orcid.org/0000-0001-5188-0042"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Carolin Zitzmann","raw_affiliation_strings":["Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany","Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]},{"raw_affiliation_string":"Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069743366","display_name":"Christopher D\u00e4chert","orcid":"https://orcid.org/0000-0001-6441-3099"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210165973","display_name":"Landscape Research Group","ror":"https://ror.org/05fpcda55","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210165973"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Christopher D\u00e4chert","raw_affiliation_strings":["Research Group \"Dynamics of Early Viral Infection and the Innate Antiviral Response\", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","Research Group"],"raw_orcid":"https://orcid.org/0000-0001-6441-3099","affiliations":[{"raw_affiliation_string":"Research Group \"Dynamics of Early Viral Infection and the Innate Antiviral Response\", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Research Group","institution_ids":["https://openalex.org/I4210165973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103722585","display_name":"Bianca Schmid","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bianca Schmid","raw_affiliation_strings":["Dept of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049978083","display_name":"Hilde M. van der Schaar","orcid":null},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Hilde van der Schaar","raw_affiliation_strings":["Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078257437","display_name":"Martijn J. van Hemert","orcid":"https://orcid.org/0000-0002-2617-9243"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Martijn van Hemert","raw_affiliation_strings":["Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058338534","display_name":"Alan S. Perelson","orcid":"https://orcid.org/0000-0002-2455-0002"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan S. Perelson","raw_affiliation_strings":["Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2455-0002","affiliations":[{"raw_affiliation_string":"Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040714564","display_name":"Frank J. M. van Kuppeveld","orcid":"https://orcid.org/0000-0001-5800-749X"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Frank J. M. van Kuppeveld","raw_affiliation_strings":["Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015740141","display_name":"Ralf Bartenschlager","orcid":"https://orcid.org/0000-0001-5601-9307"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Ralf Bartenschlager","raw_affiliation_strings":["Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands","German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042695802","display_name":"Marco Binder","orcid":"https://orcid.org/0000-0002-5805-6109"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210165973","display_name":"Landscape Research Group","ror":"https://ror.org/05fpcda55","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210165973"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Marco Binder","raw_affiliation_strings":["Research Group \"Dynamics of Early Viral Infection and the Innate Antiviral Response\", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","Research Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group \"Dynamics of Early Viral Infection and the Innate Antiviral Response\", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Research Group","institution_ids":["https://openalex.org/I4210165973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049849598","display_name":"Lars Kaderali","orcid":"https://orcid.org/0000-0002-2359-2294"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lars Kaderali","raw_affiliation_strings":["Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2359-2294","affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5015740141","https://openalex.org/A5040714564","https://openalex.org/A5042695802","https://openalex.org/A5049849598","https://openalex.org/A5049978083","https://openalex.org/A5058338534","https://openalex.org/A5069743366","https://openalex.org/A5071676719","https://openalex.org/A5078257437","https://openalex.org/A5103722585"],"corresponding_institution_ids":["https://openalex.org/I1343871089","https://openalex.org/I17937529","https://openalex.org/I193662353","https://openalex.org/I223822909","https://openalex.org/I2799318839","https://openalex.org/I2800006345","https://openalex.org/I4210115305","https://openalex.org/I4210165973"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2882,"currency":"EUR","value_usd":3108},"fwci":2.3773,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88937628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"4","first_page":"e1010423","last_page":"e1010423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.6384164094924927},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5336086750030518},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5195303559303284},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.516618549823761},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.5112521648406982},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.4674775302410126},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.439393550157547},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2907930016517639},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08875593543052673}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6384164094924927},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5336086750030518},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5195303559303284},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.516618549823761},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5112521648406982},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4674775302410126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.439393550157547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2907930016517639},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08875593543052673}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1010423","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010423","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37014904","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37014904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10104377","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10104377","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10104377/pdf/pcbi.1010423.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3715993","is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/3715993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010423&type=printable","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:doaj.org/article:e39053271cc943da86c1d0cfb984c664","is_oa":true,"landing_page_url":"https://doaj.org/article/e39053271cc943da86c1d0cfb984c664","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 4, p e1010423 (2023)","raw_type":"article"},{"id":"pmh:oai:osti.gov:1968339","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1968339","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1970049","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1970049","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1975019","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1975019","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010423","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010423","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G1222225840","display_name":null,"funder_award_id":"KA 2989/13-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1772065846","display_name":null,"funder_award_id":"R01-AI116868","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2400472844","display_name":null,"funder_award_id":"AI078881","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G759240754","display_name":null,"funder_award_id":"031A602A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8363525507","display_name":null,"funder_award_id":"R01-AI078881","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8659807574","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":164,"referenced_works":["https://openalex.org/W178187152","https://openalex.org/W1817957577","https://openalex.org/W1823300406","https://openalex.org/W1946374406","https://openalex.org/W1971212384","https://openalex.org/W1978716078","https://openalex.org/W1983108685","https://openalex.org/W1991400645","https://openalex.org/W1992970377","https://openalex.org/W1993072500","https://openalex.org/W1996903617","https://openalex.org/W2003277818","https://openalex.org/W2004506270","https://openalex.org/W2014092278","https://openalex.org/W2014903591","https://openalex.org/W2021199098","https://openalex.org/W2022098233","https://openalex.org/W2022802363","https://openalex.org/W2025278982","https://openalex.org/W2026407589","https://openalex.org/W2028194374","https://openalex.org/W2029483874","https://openalex.org/W2038163209","https://openalex.org/W2039620306","https://openalex.org/W2040154453","https://openalex.org/W2042135410","https://openalex.org/W2043519223","https://openalex.org/W2047382488","https://openalex.org/W2051269276","https://openalex.org/W2056274945","https://openalex.org/W2060078754","https://openalex.org/W2061146727","https://openalex.org/W2064164583","https://openalex.org/W2074958780","https://openalex.org/W2075266098","https://openalex.org/W2075335279","https://openalex.org/W2075477119","https://openalex.org/W2078491583","https://openalex.org/W2082615190","https://openalex.org/W2085598185","https://openalex.org/W2092333889","https://openalex.org/W2093577438","https://openalex.org/W2096815056","https://openalex.org/W2097375195","https://openalex.org/W2100371398","https://openalex.org/W2103164678","https://openalex.org/W2106120955","https://openalex.org/W2108353897","https://openalex.org/W2109977701","https://openalex.org/W2117951318","https://openalex.org/W2122848220","https://openalex.org/W2123799993","https://openalex.org/W2126153046","https://openalex.org/W2128962431","https://openalex.org/W2129300883","https://openalex.org/W2132316389","https://openalex.org/W2132492420","https://openalex.org/W2134812217","https://openalex.org/W2135121541","https://openalex.org/W2137293540","https://openalex.org/W2137729139","https://openalex.org/W2138387388","https://openalex.org/W2144407007","https://openalex.org/W2145530262","https://openalex.org/W2145605133","https://openalex.org/W2147095172","https://openalex.org/W2148214390","https://openalex.org/W2151898297","https://openalex.org/W2152665657","https://openalex.org/W2152803686","https://openalex.org/W2152952862","https://openalex.org/W2153621495","https://openalex.org/W2154098206","https://openalex.org/W2157309129","https://openalex.org/W2157458496","https://openalex.org/W2157510603","https://openalex.org/W2162645720","https://openalex.org/W2166235472","https://openalex.org/W2167340579","https://openalex.org/W2168648059","https://openalex.org/W2173211537","https://openalex.org/W2177381833","https://openalex.org/W2179083909","https://openalex.org/W2220853306","https://openalex.org/W2244397882","https://openalex.org/W2317312098","https://openalex.org/W2334046684","https://openalex.org/W2338936985","https://openalex.org/W2460922321","https://openalex.org/W2482626325","https://openalex.org/W2503826119","https://openalex.org/W2507267033","https://openalex.org/W2559875552","https://openalex.org/W2570973103","https://openalex.org/W2590198016","https://openalex.org/W2592647402","https://openalex.org/W2606696564","https://openalex.org/W2622450571","https://openalex.org/W2718090702","https://openalex.org/W2732356093","https://openalex.org/W2765157376","https://openalex.org/W2765461838","https://openalex.org/W2776479139","https://openalex.org/W2783209472","https://openalex.org/W2791607308","https://openalex.org/W2792939613","https://openalex.org/W2793987269","https://openalex.org/W2796064518","https://openalex.org/W2796452931","https://openalex.org/W2808362850","https://openalex.org/W2852166527","https://openalex.org/W2886793816","https://openalex.org/W2903773026","https://openalex.org/W2907156328","https://openalex.org/W2907433745","https://openalex.org/W2922757291","https://openalex.org/W2937039772","https://openalex.org/W2950594037","https://openalex.org/W2951890467","https://openalex.org/W2971386099","https://openalex.org/W2974212078","https://openalex.org/W2986347027","https://openalex.org/W2996456204","https://openalex.org/W2997594174","https://openalex.org/W2998418911","https://openalex.org/W3007704142","https://openalex.org/W3008203793","https://openalex.org/W3014426942","https://openalex.org/W3016829967","https://openalex.org/W3023683575","https://openalex.org/W3037869100","https://openalex.org/W3046026348","https://openalex.org/W3080678346","https://openalex.org/W3091955191","https://openalex.org/W3095872801","https://openalex.org/W3096967708","https://openalex.org/W3102859773","https://openalex.org/W3111086686","https://openalex.org/W3119992512","https://openalex.org/W3138473175","https://openalex.org/W3163640205","https://openalex.org/W3177919458","https://openalex.org/W3202031131","https://openalex.org/W3202265750","https://openalex.org/W3211547096","https://openalex.org/W4200469853","https://openalex.org/W4206526408","https://openalex.org/W4206758975","https://openalex.org/W4210993961","https://openalex.org/W4221121237","https://openalex.org/W4225015746","https://openalex.org/W4225357678","https://openalex.org/W4226405605","https://openalex.org/W4236541940","https://openalex.org/W4237142329","https://openalex.org/W4237212561","https://openalex.org/W4253697815","https://openalex.org/W6633345208","https://openalex.org/W6651727372","https://openalex.org/W6655920883","https://openalex.org/W6680265363","https://openalex.org/W6773860238","https://openalex.org/W6774209646","https://openalex.org/W6783875231"],"related_works":["https://openalex.org/W4205713785","https://openalex.org/W3016766501","https://openalex.org/W4398287560","https://openalex.org/W4398914716","https://openalex.org/W4398619072","https://openalex.org/W4398556994","https://openalex.org/W4398472861","https://openalex.org/W4398934068","https://openalex.org/W4398686282","https://openalex.org/W4398870170"],"abstract_inverted_index":{"Plus-strand":[0],"RNA":[1,20,32,66,240,248,260],"viruses":[2,21,33],"are":[3,10],"the":[4,35,53,58,69,80,93,118,143,158,164,169,196,252,268,276],"largest":[5],"group":[6,87],"of":[7,30,37,57,83,88,95,105,142,145,168,188,270],"viruses.":[8,89,171,261],"Many":[9],"human":[11],"pathogens":[12],"that":[13,152,195,237,265],"inflict":[14],"a":[15,49,138,209],"socio-economic":[16],"burden.":[17],"Interestingly,":[18],"plus-strand":[19,31,259],"share":[22],"remarkable":[23],"similarities":[24,75],"in":[25,79,117,157,165,213,233,277,282],"their":[26],"replication.":[27],"A":[28],"hallmark":[29],"is":[34],"remodeling":[36],"intracellular":[38,286],"membranes":[39],"to":[40,162,198,292],"establish":[41],"replication":[42,144,189,215,280],"organelles":[43],"(so-called":[44],"\"replication":[45],"factories\"),":[46],"which":[47,217],"provide":[48],"protected":[50],"environment":[51],"for":[52,64,212,257],"replicase":[54,271],"complex,":[55],"consisting":[56],"viral":[59,65,96,98,239,247,279,294],"genome":[60],"and":[61,76,100,113,123,148,150,185,235,246],"proteins":[62],"necessary":[63,161],"synthesis.":[67],"In":[68],"current":[70],"study,":[71],"we":[72,136,263],"investigate":[73],"pan-viral":[74],"virus-specific":[77,155,176],"differences":[78],"life":[81],"cycle":[82],"this":[84],"highly":[85],"relevant":[86],"We":[90,225],"first":[91],"measured":[92],"kinetics":[94,187],"RNA,":[97],"protein,":[99],"infectious":[101],"virus":[102,108,111],"particle":[103],"production":[104],"hepatitis":[106],"C":[107],"(HCV),":[109],"dengue":[110],"(DENV),":[112],"coxsackievirus":[114],"B3":[115],"(CVB3)":[116],"immuno-compromised":[119],"Huh7":[120],"cell":[121,181,204],"line":[122],"thus":[124],"without":[125],"perturbations":[126],"by":[127],"an":[128],"intrinsic":[129],"immune":[130],"response.":[131],"Based":[132],"on":[133],"these":[134],"measurements,":[135],"developed":[137],"detailed":[139],"mathematical":[140],"model":[141,159,173,193],"HCV,":[146],"DENV,":[147],"CVB3":[149],"showed":[151],"only":[153,267],"small":[154],"changes":[156],"were":[160],"describe":[163],"vitro":[166,214,278],"dynamics":[167],"different":[170,186],"Our":[172],"correctly":[174],"predicted":[175],"mechanisms":[177],"such":[178,242],"as":[179,243],"host":[180,203],"translation":[182,206],"shut":[183,201],"off":[184],"organelles.":[190],"Further,":[191],"our":[192],"suggests":[194],"ability":[197],"suppress":[199],"or":[200,222],"down":[202],"mRNA":[205],"may":[207,218,250,289],"be":[208,251],"key":[210],"factor":[211],"efficiency,":[216],"determine":[219],"acute":[220],"self-limited":[221],"chronic":[223],"infection.":[224],"further":[226],"analyzed":[227],"potential":[228],"broad-spectrum":[229],"antiviral":[230],"treatment":[231],"options":[232],"silico":[234],"found":[236,264],"targeting":[238,266],"translation,":[241],"polyprotein":[244],"cleavage":[245],"synthesis,":[249],"most":[253],"promising":[254],"drug":[255],"targets":[256],"all":[258],"Moreover,":[262],"formation":[269],"complexes":[272],"did":[273],"not":[274],"stop":[275],"early":[281],"infection,":[283],"while":[284],"inhibiting":[285],"trafficking":[287],"processes":[288],"even":[290],"lead":[291],"amplified":[293],"growth.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-21T07:57:09.225873","created_date":"2025-10-10T00:00:00"}