{"id":"https://openalex.org/W4295901863","doi":"https://doi.org/10.1371/journal.pcbi.1010414","title":"Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization","display_name":"Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization","publication_year":2022,"publication_date":"2022-09-15","ids":{"openalex":"https://openalex.org/W4295901863","doi":"https://doi.org/10.1371/journal.pcbi.1010414","pmid":"https://pubmed.ncbi.nlm.nih.gov/36107837"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010414","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010414","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110636527","display_name":"Michael A. Kelley","orcid":null},"institutions":[{"id":"https://openalex.org/I167576493","display_name":"Colorado School of Mines","ror":"https://ror.org/04raf6v53","country_code":"US","type":"education","lineage":["https://openalex.org/I167576493"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Kelley","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, Colorado, United States of America","institution_ids":["https://openalex.org/I167576493"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019746951","display_name":"Karin Leiderman","orcid":"https://orcid.org/0000-0002-4188-1305"},"institutions":[{"id":"https://openalex.org/I167576493","display_name":"Colorado School of Mines","ror":"https://ror.org/04raf6v53","country_code":"US","type":"education","lineage":["https://openalex.org/I167576493"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karin Leiderman","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, Colorado, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4188-1305","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, Colorado, United States of America","institution_ids":["https://openalex.org/I167576493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019746951","https://openalex.org/A5110636527"],"corresponding_institution_ids":["https://openalex.org/I167576493"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7607,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72519783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"18","issue":"9","first_page":"e1010414","last_page":"e1010414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrin","display_name":"Fibrin","score":0.9409711360931396},{"id":"https://openalex.org/keywords/thrombin","display_name":"Thrombin","score":0.9382858276367188},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"Fibrinogen","score":0.8275517821311951},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5431933999061584},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.520440399646759},{"id":"https://openalex.org/keywords/polymerization","display_name":"Polymerization","score":0.5037800669670105},{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.4870052933692932},{"id":"https://openalex.org/keywords/discovery-and-development-of-direct-thrombin-inhibitors","display_name":"Discovery and development of direct thrombin inhibitors","score":0.4118189513683319},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3791433274745941},{"id":"https://openalex.org/keywords/platelet","display_name":"Platelet","score":0.25323525071144104},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2199719250202179},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17255672812461853},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1642622947692871},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1340733766555786},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.057121217250823975},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.0554729700088501}],"concepts":[{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.9409711360931396},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.9382858276367188},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.8275517821311951},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5431933999061584},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.520440399646759},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.5037800669670105},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4870052933692932},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.4118189513683319},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3791433274745941},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.25323525071144104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2199719250202179},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17255672812461853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1642622947692871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1340733766555786},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.057121217250823975},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0554729700088501}],"mesh":[{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010414","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36107837","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36107837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:160afdd7441442488de61d1134be9121","is_oa":true,"landing_page_url":"https://doaj.org/article/160afdd7441442488de61d1134be9121","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9, p e1010414 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a4d7d25f06da40a59a70b0f8ae545728","is_oa":true,"landing_page_url":"https://doaj.org/article/a4d7d25f06da40a59a70b0f8ae545728","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9477365","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9477365","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010414","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1168023769","display_name":null,"funder_award_id":"R01 HL120728","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1652930883","display_name":null,"funder_award_id":"1848221","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1660312822","display_name":null,"funder_award_id":"R01HL120728","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G276693304","display_name":null,"funder_award_id":"R01HL151984","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3693324169","display_name":null,"funder_award_id":"CAREER DMS-1848221","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5015318866","display_name":null,"funder_award_id":"ARO-12369656","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G5154725139","display_name":null,"funder_award_id":"DMS-1848221","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5388882251","display_name":null,"funder_award_id":"R01 HL151984","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6003866290","display_name":null,"funder_award_id":"12369656","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7489865666","display_name":null,"funder_award_id":"DMS-1848221","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W188309080","https://openalex.org/W297821776","https://openalex.org/W1483922672","https://openalex.org/W1487236423","https://openalex.org/W1514449664","https://openalex.org/W1711208506","https://openalex.org/W1867300921","https://openalex.org/W1909740408","https://openalex.org/W1963508326","https://openalex.org/W1964088851","https://openalex.org/W1972112385","https://openalex.org/W1980398280","https://openalex.org/W1982669495","https://openalex.org/W1990693205","https://openalex.org/W1992952287","https://openalex.org/W1998529033","https://openalex.org/W1998762602","https://openalex.org/W2000044487","https://openalex.org/W2003843472","https://openalex.org/W2004021726","https://openalex.org/W2007077437","https://openalex.org/W2017466351","https://openalex.org/W2026230149","https://openalex.org/W2027141031","https://openalex.org/W2042208046","https://openalex.org/W2045334963","https://openalex.org/W2068289427","https://openalex.org/W2077375327","https://openalex.org/W2078132464","https://openalex.org/W2091859469","https://openalex.org/W2095486848","https://openalex.org/W2118409138","https://openalex.org/W2127133496","https://openalex.org/W2138849164","https://openalex.org/W2154400398","https://openalex.org/W2280879333","https://openalex.org/W2335231905","https://openalex.org/W2337841764","https://openalex.org/W2394695278","https://openalex.org/W2409296984","https://openalex.org/W2428993745","https://openalex.org/W2508432438","https://openalex.org/W2572149156","https://openalex.org/W2608928161","https://openalex.org/W2762806006","https://openalex.org/W2795698891","https://openalex.org/W2799520713","https://openalex.org/W2803425666","https://openalex.org/W2965587010","https://openalex.org/W2972399534","https://openalex.org/W3045981737","https://openalex.org/W3138074963","https://openalex.org/W3198821933","https://openalex.org/W3202050621","https://openalex.org/W3215023436","https://openalex.org/W4200386728","https://openalex.org/W4210663131","https://openalex.org/W4229675254","https://openalex.org/W4324262907"],"related_works":["https://openalex.org/W621194568","https://openalex.org/W2945127487","https://openalex.org/W1972585653","https://openalex.org/W2082498220","https://openalex.org/W2395336416","https://openalex.org/W3036624957","https://openalex.org/W2022775994","https://openalex.org/W2017506418","https://openalex.org/W2027443037","https://openalex.org/W2413494355"],"abstract_inverted_index":{"Thrombin":[0,18,70],"is":[1,9,42,71,90,104],"an":[2,28],"enzyme":[3],"produced":[4],"during":[5,101,145,220,247],"blood":[6],"coagulation":[7],"that":[8,89,117,153],"crucial":[10],"to":[11,74,160,163,167,178,201,223],"the":[12,33,43,96,119,150,165,168,173,182,188,193,212,231],"formation":[13],"of":[14,39,84,98,114,176,195,233],"a":[15,57,87,111,204,224],"stable":[16],"clot.":[17,35],"cleaves":[19],"soluble":[20],"fibrinogen":[21,41,177],"into":[22],"fibrin,":[23,125],"which":[24,46,170],"polymerizes":[25],"and":[26,54,66,124,141,241,249],"forms":[27],"insoluble,":[29],"stabilizing":[30],"gel":[31],"around":[32],"growing":[34],"A":[36],"small":[37],"fraction":[38],"circulating":[40],"variant":[44],"\u03b3A/\u03b3',":[45],"has":[47],"been":[48],"associated":[49],"with":[50,128,252],"high-affinity":[51],"thrombin":[52,138,161,166,198,210,229],"binding":[53,135,159,190,219],"implicated":[55],"as":[56,203,230],"risk":[58],"factor":[59],"for":[60,81,143,217,244],"myocardial":[61],"infarctions,":[62],"deep":[63],"vein":[64],"thrombosis,":[65],"coronary":[67],"artery":[68],"disease.":[69],"also":[72],"known":[73],"be":[75],"strongly":[76],"sequestered":[77],"by":[78,93],"polymerized":[79],"fibrin":[80,102,115,146,156,183,196],"extended":[82],"periods":[83],"time":[85],"in":[86,155,227],"way":[88],"partially":[91],"regulated":[92],"\u03b3A/\u03b3'.":[94,129],"However,":[95],"role":[97,216],"\u03b3A/\u03b3'-thrombin":[99],"interactions":[100,120,246],"polymerization":[103,116,221,248],"not":[105],"fully":[106,185],"understood.":[107],"Here,":[108],"we":[109],"present":[110],"mathematical":[112],"model":[113,151,238],"considered":[118],"between":[121],"thrombin,":[122],"fibrinogen,":[123],"including":[126],"those":[127],"In":[130],"our":[131],"model,":[132],"bivalent":[133],"thrombin-fibrin":[134],"greatly":[136],"increased":[137],"residency":[139],"times":[140],"allowed":[142],"thrombin-trapping":[144],"polymerization.":[147],"Results":[148],"from":[149,211],"showed":[152],"early":[154],"polymerization,":[157],"\u03b3'":[158,234],"served":[162],"localize":[164],"fibrin(ogen),":[169],"effectively":[171],"enhanced":[172],"enzymatic":[174],"conversion":[175],"fibrin.":[179],"When":[180],"all":[181,208],"was":[184,235],"generated,":[186],"however,":[187],"fibrin-thrombin":[189,245],"persisted":[191],"but":[192],"effect":[194],"on":[197],"switched":[199],"quickly":[200],"serve":[202],"sink,":[205],"essentially":[206],"removing":[207],"free":[209],"system.":[213],"This":[214],"dual":[215],"\u03b3'-thrombin":[218],"led":[222],"paradoxical":[225],"decrease":[226],"trapped":[228],"amount":[232],"increased.":[236],"The":[237],"highlighted":[239],"biochemical":[240],"biophysical":[242],"roles":[243],"agreed":[250],"well":[251],"experimental":[253],"observations.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
