{"id":"https://openalex.org/W4289637391","doi":"https://doi.org/10.1371/journal.pcbi.1010407","title":"Neural networks for self-adjusting mutation rate estimation when the recombination rate is unknown","display_name":"Neural networks for self-adjusting mutation rate estimation when the recombination rate is unknown","publication_year":2022,"publication_date":"2022-08-03","ids":{"openalex":"https://openalex.org/W4289637391","doi":"https://doi.org/10.1371/journal.pcbi.1010407","pmid":"https://pubmed.ncbi.nlm.nih.gov/35921376"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010407","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062573008","display_name":"Klara Elisabeth Burger","orcid":null},"institutions":[{"id":"https://openalex.org/I4210133934","display_name":"Bernstein Center for Computational Neuroscience T\u00fcbingen","ror":"https://ror.org/03kfnwp54","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210092532","https://openalex.org/I4210133934"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klara Elisabeth Burger","raw_affiliation_strings":["Cluster of Excellence \"Machine Learning: New Perspectives for Science\", University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cluster of Excellence \"Machine Learning: New Perspectives for Science\", University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210133934","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091710048","display_name":"Peter Pfaffelhuber","orcid":"https://orcid.org/0000-0002-6421-5460"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Pfaffelhuber","raw_affiliation_strings":["Department of Mathematical Stochastics, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Stochastics, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080984432","display_name":"Franz Baumdicker","orcid":"https://orcid.org/0000-0001-9106-7259"},"institutions":[{"id":"https://openalex.org/I4210133934","display_name":"Bernstein Center for Computational Neuroscience T\u00fcbingen","ror":"https://ror.org/03kfnwp54","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210092532","https://openalex.org/I4210133934"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Franz Baumdicker","raw_affiliation_strings":["Cluster of Excellence \"Controlling Microbes to Fight Infections\", Mathematical and Computational Population Genetics, University of T\u00fcbingen, T\u00fcbingen, Germany","Cluster of Excellence \"Machine Learning: New Perspectives for Science\", University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9106-7259","affiliations":[{"raw_affiliation_string":"Cluster of Excellence \"Controlling Microbes to Fight Infections\", Mathematical and Computational Population Genetics, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Cluster of Excellence \"Machine Learning: New Perspectives for Science\", University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210133934","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080984432"],"corresponding_institution_ids":["https://openalex.org/I4210133934","https://openalex.org/I8087733"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2577,"currency":"EUR","value_usd":2779},"fwci":2.8177,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.9108999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"18","issue":"8","first_page":"e1010407","last_page":"e1010407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.8508948087692261},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5374581813812256},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5270785689353943},{"id":"https://openalex.org/keywords/recombination","display_name":"Recombination","score":0.5234500765800476},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5147385597229004},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.4480941891670227},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.42176252603530884},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4131360650062561},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3693433105945587},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3363836407661438},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3357716500759125},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3091840147972107},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2843477427959442},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1984393298625946}],"concepts":[{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.8508948087692261},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5374581813812256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5270785689353943},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5234500765800476},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5147385597229004},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4480941891670227},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42176252603530884},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4131360650062561},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3693433105945587},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3363836407661438},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3357716500759125},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3091840147972107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2843477427959442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1984393298625946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35921376","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35921376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e99a03ea298b4b88ab9e51a19855df54","is_oa":true,"landing_page_url":"https://doaj.org/article/e99a03ea298b4b88ab9e51a19855df54","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1010407 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9377634","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9377634","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1341008233","display_name":null,"funder_award_id":"EXC 2064/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2036822895","display_name":null,"funder_award_id":"EXC 2124","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2358734255","display_name":null,"funder_award_id":"EXC 2124 - 390838134","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2856364404","display_name":null,"funder_award_id":"EXC 2064/1 - 390727645","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4771072336","display_name":null,"funder_award_id":"390838134","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7907426250","display_name":null,"funder_award_id":"390727645","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8128963897","display_name":null,"funder_award_id":"EXC 2064","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8915364236","display_name":null,"funder_award_id":"2064/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1710947543","https://openalex.org/W1772281102","https://openalex.org/W1825691109","https://openalex.org/W1965175390","https://openalex.org/W2019956985","https://openalex.org/W2036599383","https://openalex.org/W2074164491","https://openalex.org/W2082967637","https://openalex.org/W2114632170","https://openalex.org/W2119279196","https://openalex.org/W2135818404","https://openalex.org/W2140686356","https://openalex.org/W2142254004","https://openalex.org/W2152832004","https://openalex.org/W2165974744","https://openalex.org/W2257979135","https://openalex.org/W2441671549","https://openalex.org/W2474518231","https://openalex.org/W2544062746","https://openalex.org/W2585671443","https://openalex.org/W2618851150","https://openalex.org/W2783880833","https://openalex.org/W2788628106","https://openalex.org/W2950327064","https://openalex.org/W2951641704","https://openalex.org/W2952978770","https://openalex.org/W2953082877","https://openalex.org/W2962862931","https://openalex.org/W2963306315","https://openalex.org/W2973043487","https://openalex.org/W2977922357","https://openalex.org/W2989915159","https://openalex.org/W2996212123","https://openalex.org/W2998768917","https://openalex.org/W2998859599","https://openalex.org/W3008479721","https://openalex.org/W3037441421","https://openalex.org/W3042023486","https://openalex.org/W3175542337","https://openalex.org/W4246522342","https://openalex.org/W4247464444","https://openalex.org/W4249446031","https://openalex.org/W6929334658"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369","https://openalex.org/W2097774084","https://openalex.org/W2606677068","https://openalex.org/W2120838291"],"abstract_inverted_index":{"Estimating":[0],"the":[1,35,96,99,104,119,132,154,162,167,170,200,214,221],"mutation":[2,100],"rate,":[3],"or":[4,20,134],"equivalently":[5],"effective":[6],"population":[7,14,87],"size,":[8],"is":[9,18,40,70,73,177],"a":[10,181,204,231],"common":[11],"task":[12],"in":[13,62,86,230],"genetics.":[15,88],"If":[16],"recombination":[17,33,196,210,225,236],"low":[19,193],"high,":[21],"optimal":[22,38],"linear":[23],"estimation":[24,97,206],"methods":[25],"are":[26,82,240],"known":[27],"and":[28,51,108,128,140,157,194,198],"well":[29,78,188],"understood.":[30],"For":[31,115],"intermediate":[32,209],"rates,":[34,197],"calculation":[36],"of":[37,98,169],"estimators":[39,61,121,150,164,191],"more":[41],"challenging.":[42],"As":[43],"an":[44],"alternative":[45],"to":[46,58,75,165,179,216],"model-based":[47,113,120,163,190],"estimation,":[48],"neural":[49,93,146],"networks":[50,94,147],"other":[52],"machine":[53],"learning":[54],"tools":[55,81],"could":[56],"help":[57],"develop":[59],"good":[60],"these":[63,80,149],"involved":[64],"scenarios.":[65],"However,":[66],"if":[67,151],"no":[68,139],"benchmark":[69],"available":[71],"it":[72],"difficult":[74],"assess":[76],"how":[77],"suited":[79],"for":[83,95,138,192,208],"different":[84],"applications":[85],"Here":[89],"we":[90,117],"investigate":[91],"feedforward":[92],"rate":[101],"based":[102,219],"on":[103,220],"site":[105],"frequency":[106],"spectrum":[107],"compare":[109],"their":[110],"performance":[111],"with":[112,153],"estimators.":[114],"this":[116],"use":[118],"introduced":[122],"by":[123],"Fu,":[124],"Futschik":[125],"et":[126],"al.,":[127],"Watterson":[129],"that":[130,145,184],"minimize":[131],"variance":[133],"mean":[135],"squared":[136],"error":[137],"free":[141],"recombination.":[142],"We":[143,212],"find":[144],"reproduce":[148],"provided":[152],"appropriate":[155],"features":[156],"training":[158,171],"sets.":[159],"Remarkably,":[160],"using":[161],"adjust":[166],"weights":[168],"data,":[172],"only":[173],"one":[174],"hidden":[175],"layer":[176],"necessary":[178],"obtain":[180],"single":[182],"estimator":[183],"performs":[185],"almost":[186],"as":[187,189],"high":[195],"at":[199],"same":[201],"time":[202],"provides":[203],"superior":[205],"method":[207,215],"rates.":[211],"apply":[213],"simulated":[217],"data":[218],"human":[222],"chromosome":[223],"2":[224],"map,":[226],"highlighting":[227],"its":[228],"robustness":[229],"realistic":[232],"setting":[233],"where":[234],"local":[235],"rates":[237],"vary":[238],"and/or":[239],"unknown.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}