{"id":"https://openalex.org/W3201192868","doi":"https://doi.org/10.1371/journal.pcbi.1010403","title":"Modeling age-specific incidence of colon cancer via niche competition","display_name":"Modeling age-specific incidence of colon cancer via niche competition","publication_year":2022,"publication_date":"2022-08-19","ids":{"openalex":"https://openalex.org/W3201192868","doi":"https://doi.org/10.1371/journal.pcbi.1010403","mag":"3201192868","pmid":"https://pubmed.ncbi.nlm.nih.gov/35984850"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010403","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010403","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010403&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010403&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070071976","display_name":"Steffen Lange","orcid":"https://orcid.org/0000-0002-0511-8011"},"institutions":[{"id":"https://openalex.org/I4210165059","display_name":"Hochschule f\u00fcr Technik und Wirtschaft Dresden \u2013 University of Applied Sciences","ror":"https://ror.org/05q5pk319","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210165059"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Steffen Lange","raw_affiliation_strings":["DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0511-8011","affiliations":[{"raw_affiliation_string":"DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]},{"raw_affiliation_string":"Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015648513","display_name":"Richard Mogwitz","orcid":"https://orcid.org/0000-0002-1621-5642"},"institutions":[{"id":"https://openalex.org/I4210165059","display_name":"Hochschule f\u00fcr Technik und Wirtschaft Dresden \u2013 University of Applied Sciences","ror":"https://ror.org/05q5pk319","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210165059"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Richard Mogwitz","raw_affiliation_strings":["Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1621-5642","affiliations":[{"raw_affiliation_string":"Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075500256","display_name":"Denis H\u00fcnniger","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165059","display_name":"Hochschule f\u00fcr Technik und Wirtschaft Dresden \u2013 University of Applied Sciences","ror":"https://ror.org/05q5pk319","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210165059"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denis H\u00fcnniger","raw_affiliation_strings":["DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]},{"raw_affiliation_string":"Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088968315","display_name":"Anja Voss\u2013B\u00f6hme","orcid":"https://orcid.org/0000-0001-6510-8694"},"institutions":[{"id":"https://openalex.org/I4210165059","display_name":"Hochschule f\u00fcr Technik und Wirtschaft Dresden \u2013 University of Applied Sciences","ror":"https://ror.org/05q5pk319","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210165059"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Vo\u00df-B\u00f6hme","raw_affiliation_strings":["DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6510-8694","affiliations":[{"raw_affiliation_string":"DataMedAssist, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]},{"raw_affiliation_string":"Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences, Dresden, Germany","institution_ids":["https://openalex.org/I4210165059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070071976"],"corresponding_institution_ids":["https://openalex.org/I4210165059"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2092,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5100291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"18","issue":"8","first_page":"e1010403","last_page":"e1010403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.7172192931175232},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6503434181213379},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.5737500190734863},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.5279697179794312},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.526838481426239},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"Tumor initiation","score":0.5199424028396606},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5175118446350098},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.43098723888397217},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.35410213470458984},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3238089084625244},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29221999645233154},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1968468427658081}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7172192931175232},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6503434181213379},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5737500190734863},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5279697179794312},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.526838481426239},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.5199424028396606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5175118446350098},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43098723888397217},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35410213470458984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3238089084625244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29221999645233154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1968468427658081},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010403","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010403","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010403&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35984850","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35984850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:2109.06031","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2109.06031","pdf_url":"https://arxiv.org/pdf/2109.06031","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:35cb3d4a731f48a399531726699a6444","is_oa":true,"landing_page_url":"https://doaj.org/article/35cb3d4a731f48a399531726699a6444","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1010403 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9432715","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9432715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010403","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010403","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010403&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G6976079997","display_name":null,"funder_award_id":"100382145","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"}],"funders":[{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201192868.pdf","grobid_xml":"https://content.openalex.org/works/W3201192868.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W221659336","https://openalex.org/W1552652587","https://openalex.org/W1567424149","https://openalex.org/W1748529216","https://openalex.org/W1965240747","https://openalex.org/W1965853112","https://openalex.org/W1971886549","https://openalex.org/W1988758354","https://openalex.org/W1988879680","https://openalex.org/W1992682395","https://openalex.org/W1998947396","https://openalex.org/W2001850356","https://openalex.org/W2008227339","https://openalex.org/W2009857926","https://openalex.org/W2010873488","https://openalex.org/W2012301659","https://openalex.org/W2019078072","https://openalex.org/W2023675208","https://openalex.org/W2024368570","https://openalex.org/W2029640961","https://openalex.org/W2045734186","https://openalex.org/W2047466546","https://openalex.org/W2058707933","https://openalex.org/W2059574805","https://openalex.org/W2061567460","https://openalex.org/W2065220128","https://openalex.org/W2066861312","https://openalex.org/W2076933987","https://openalex.org/W2102085111","https://openalex.org/W2104824960","https://openalex.org/W2106095214","https://openalex.org/W2128804917","https://openalex.org/W2130511906","https://openalex.org/W2132373340","https://openalex.org/W2134344399","https://openalex.org/W2137603189","https://openalex.org/W2141163897","https://openalex.org/W2147297736","https://openalex.org/W2150520316","https://openalex.org/W2153796518","https://openalex.org/W2154225779","https://openalex.org/W2154252184","https://openalex.org/W2157631035","https://openalex.org/W2164139230","https://openalex.org/W2168101538","https://openalex.org/W2197854826","https://openalex.org/W2260951263","https://openalex.org/W2282900526","https://openalex.org/W2294986496","https://openalex.org/W2346277289","https://openalex.org/W2414431533","https://openalex.org/W2589371072","https://openalex.org/W2592701528","https://openalex.org/W2596221930","https://openalex.org/W2799257871","https://openalex.org/W2804079254","https://openalex.org/W2883374138","https://openalex.org/W2894486342","https://openalex.org/W2923383156","https://openalex.org/W2950181793","https://openalex.org/W3003730688","https://openalex.org/W3004856249","https://openalex.org/W3048637028","https://openalex.org/W3105262056","https://openalex.org/W3132887244","https://openalex.org/W3139491653","https://openalex.org/W4205562661","https://openalex.org/W4206207828","https://openalex.org/W4248142848","https://openalex.org/W4298077380","https://openalex.org/W4322719806","https://openalex.org/W6608727978","https://openalex.org/W6681928485"],"related_works":["https://openalex.org/W2014135975","https://openalex.org/W1996126939","https://openalex.org/W2465265569","https://openalex.org/W2144836619","https://openalex.org/W1981307188","https://openalex.org/W2257030131","https://openalex.org/W1991110338","https://openalex.org/W2053989508","https://openalex.org/W2069344265","https://openalex.org/W4256045335"],"abstract_inverted_index":{"Cancer":[0],"development":[1,200],"is":[2,57,201,273],"a":[3,9,14,27,34,54,66,70,142,215,234],"multistep":[4],"process":[5],"often":[6],"starting":[7],"with":[8,73,158,176,184],"single":[10,35,67,235],"cell":[11,38,68],"in":[12,40,155,250],"which":[13,145,159,267],"number":[15],"of":[16,32,65,75,91,97,102,116,123,133,167,173,198,208,227,247,281],"epigenetic":[17],"and":[18,43,80,108,152,191,211],"genetic":[19],"alterations":[20],"have":[21],"accumulated":[22],"thus":[23],"transforming":[24],"it":[25],"into":[26],"tumor":[28,37,51,56,72,76,153,199,209,216,228],"cell.":[29],"The":[30,59,187],"progeny":[31],"such":[33,103],"benign":[36],"expands":[39],"the":[41,62,88,94,130,148,171,181,196,205,221,224,230,238,251,263,270,276],"tissue":[42],"can":[44],"at":[45],"some":[46],"point":[47],"progress":[48],"to":[49,69,129,138,220,258],"malignant":[50],"cells":[52,77,154,249],"until":[53],"detectable":[55,71],"formed.":[58],"dynamics":[60],"from":[61],"early":[63,206,225],"phase":[64,207,226],"billions":[74],"are":[78,105,161],"complex":[79],"still":[81],"not":[82,85],"fully":[83],"resolved,":[84],"even":[86],"for":[87],"well-known":[89],"prototype":[90],"multistage":[92],"carcinogenesis,":[93],"adenoma-adenocarcinoma":[95],"sequence":[96],"colorectal":[98],"cancer.":[99,169],"Mathematical":[100],"models":[101,136],"carcinogenesis":[104],"frequently":[106],"tested":[107],"calibrated":[109],"based":[110],"on":[111,147,223],"reported":[112,192],"age-specific":[113],"incidence":[114,165],"rates":[115,166],"cancer,":[117],"but":[118],"they":[119],"usually":[120],"require":[121],"calibration":[122],"four":[124],"or":[125],"more":[126],"parameters":[127],"due":[128],"wide":[131],"range":[132],"processes":[134,277],"these":[135],"aim":[137],"reflect.":[139],"We":[140,253],"present":[141],"cell-based":[143],"model,":[144],"focuses":[146],"competition":[149],"between":[150,189],"wild-type":[151],"colonic":[156],"crypts,":[157],"we":[160],"able":[162],"reproduce":[163],"epidemiological":[164],"colon":[168],"Additionally,":[170],"fraction":[172],"cancerous":[174],"tumors":[175],"precancerous":[177],"lesions":[178],"predicted":[179],"by":[180,204,242,275],"model":[182,190,231],"agree":[183],"clinical":[185],"estimates.":[186],"correspondence":[188],"data":[193],"suggests":[194],"that":[195,269],"fate":[197],"majorly":[202],"determined":[203],"growth":[210],"progression":[212],"long":[213],"before":[214],"becomes":[217],"detectable.":[218],"Due":[219],"focus":[222],"development,":[229],"has":[232],"only":[233],"fit":[236],"parameter,":[237],"time":[239,271],"scale":[240,272],"set":[241],"an":[243],"effective":[244,256],"replacement":[245,265],"rate":[246,257],"stem":[248],"crypt.":[252],"find":[254],"this":[255],"be":[259],"considerable":[260],"smaller":[261],"than":[262],"actual":[264],"rate,":[266],"implies":[268],"limited":[274],"succeeding":[278],"clonal":[279],"conversion":[280],"crypts.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}