{"id":"https://openalex.org/W4290852275","doi":"https://doi.org/10.1371/journal.pcbi.1010366","title":"De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks","display_name":"De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks","publication_year":2022,"publication_date":"2022-08-12","ids":{"openalex":"https://openalex.org/W4290852275","doi":"https://doi.org/10.1371/journal.pcbi.1010366","pmid":"https://pubmed.ncbi.nlm.nih.gov/35960757"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010366","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010366","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017056980","display_name":"Sergio Marco Salas","orcid":"https://orcid.org/0000-0002-4636-0322"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sergio Marco Salas","raw_affiliation_strings":["Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden"],"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101532496","display_name":"Xiao Yuan","orcid":"https://orcid.org/0000-0001-9788-7717"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xiao Yuan","raw_affiliation_strings":["Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002207055","display_name":"Christer Sylv\u00e9n","orcid":"https://orcid.org/0000-0003-1017-7849"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christer Sylven","raw_affiliation_strings":["Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002137026","display_name":"Mats Nilsson","orcid":"https://orcid.org/0000-0001-9985-0387"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Mats Nilsson","raw_affiliation_strings":["Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden"],"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028372092","display_name":"Carolina W\u00e4hlby","orcid":"https://orcid.org/0000-0002-4139-7003"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Carolina W\u00e4hlby","raw_affiliation_strings":["Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087265062","display_name":"Gabriele Partel","orcid":"https://orcid.org/0000-0002-4482-3119"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","SE"],"is_corresponding":true,"raw_author_name":"Gabriele Partel","raw_affiliation_strings":["Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden","Laboratory of Multi-omic Integrative Bioinformatics, Department of Human Genetics, KU Leuven, Leuven, Belgium","VIB-KU Leuven Center for Brain & Disease Research, Laboratory of Computational Biology, Department of Human Genetics, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]},{"raw_affiliation_string":"Laboratory of Multi-omic Integrative Bioinformatics, Department of Human Genetics, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB-KU Leuven Center for Brain & Disease Research, Laboratory of Computational Biology, Department of Human Genetics, Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002137026","https://openalex.org/A5028372092","https://openalex.org/A5087265062"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I161593684","https://openalex.org/I2800139495","https://openalex.org/I4210153928","https://openalex.org/I99464096"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2604,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5206397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"18","issue":"8","first_page":"e1010366","last_page":"e1010366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9693999886512756,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6370164752006531},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.6144344210624695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5725675821304321},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.5504810810089111},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4522670805454254},{"id":"https://openalex.org/keywords/functional-diversity","display_name":"Functional diversity","score":0.42774030566215515},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.39719265699386597},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38071420788764954},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26840606331825256},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20844930410385132}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6370164752006531},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.6144344210624695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5725675821304321},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5504810810089111},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4522670805454254},{"id":"https://openalex.org/C2988890453","wikidata":"https://www.wikidata.org/wiki/Q5508815","display_name":"Functional diversity","level":2,"score":0.42774030566215515},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39719265699386597},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38071420788764954},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26840606331825256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20844930410385132},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1010366","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010366","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35960757","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35960757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/705133","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/705133","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Plos Computational Biology, vol. 18 (8), Art.No. ARTN e1010366","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:DiVA.org:uu-512255","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512255","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6dcd79603c5c473eb053649c29d706ec","is_oa":true,"landing_page_url":"https://doaj.org/article/6dcd79603c5c473eb053649c29d706ec","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1010366 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9401155","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9401155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010366","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010366","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2252777492","display_name":null,"funder_award_id":"VR-RFI 2019-00217","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2742414913","display_name":null,"funder_award_id":"2018.0172","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G4656236572","display_name":null,"funder_award_id":"KAW 2018.0172","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G4819674707","display_name":null,"funder_award_id":"2019-00217","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5202584736","display_name":null,"funder_award_id":"BD150008","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G5918438204","display_name":null,"funder_award_id":"VR-RFI 2019-00217","funder_id":"https://openalex.org/F4320325677","funder_display_name":"Science for Life Laboratory"},{"id":"https://openalex.org/G6796527211","display_name":null,"funder_award_id":"SVCF 2017-173964","funder_id":"https://openalex.org/F4320315474","funder_display_name":"Chan Zuckerberg Initiative"},{"id":"https://openalex.org/G7155443499","display_name":null,"funder_award_id":"2019-01238","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7228997265","display_name":null,"funder_award_id":"Vetenskapsr\u00e5","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8683756101","display_name":null,"funder_award_id":"support","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"}],"funders":[{"id":"https://openalex.org/F4320306192","display_name":"Silicon Valley Community Foundation","ror":"https://ror.org/001ader08"},{"id":"https://openalex.org/F4320309793","display_name":"Familjen Erling-Perssons Stiftelse","ror":"https://ror.org/04sfsy924"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1972618510","https://openalex.org/W2066040738","https://openalex.org/W2072162746","https://openalex.org/W2094049138","https://openalex.org/W2098590189","https://openalex.org/W2102212449","https://openalex.org/W2120856680","https://openalex.org/W2131266444","https://openalex.org/W2135937351","https://openalex.org/W2471536144","https://openalex.org/W2766959028","https://openalex.org/W2792537872","https://openalex.org/W2913611220","https://openalex.org/W2922020904","https://openalex.org/W2942880491","https://openalex.org/W2950372712","https://openalex.org/W2955754489","https://openalex.org/W2983354807","https://openalex.org/W2996171578","https://openalex.org/W3001963866","https://openalex.org/W3028450988","https://openalex.org/W3082160892","https://openalex.org/W3087138957","https://openalex.org/W3087998689","https://openalex.org/W3090542854","https://openalex.org/W3106188259","https://openalex.org/W3109948114","https://openalex.org/W3120342826","https://openalex.org/W3171488579","https://openalex.org/W3208940117","https://openalex.org/W4313455851","https://openalex.org/W6745439786","https://openalex.org/W6959663221"],"related_works":["https://openalex.org/W4307993920","https://openalex.org/W1898241694","https://openalex.org/W2930001795","https://openalex.org/W4390695629","https://openalex.org/W2036616013","https://openalex.org/W3157307916","https://openalex.org/W2141091415","https://openalex.org/W2786822253","https://openalex.org/W4401169882","https://openalex.org/W4386916799"],"abstract_inverted_index":{"With":[0,124],"the":[1,9,12,27,66,160],"emergence":[2],"of":[3,11,17,30,88,107,163,199],"high":[4],"throughput":[5],"single":[6,33,55,152],"cell":[7,34,45,49,56,121,153],"techniques,":[8],"understanding":[10],"molecular":[13,132],"and":[14,60,84,99,136,139,192],"cellular":[15,86],"diversity":[16,68,87,133],"mammalian":[18],"organs":[19],"have":[20],"rapidly":[21],"increased.":[22],"In":[23],"order":[24],"to":[25,42,81,112],"understand":[26],"spatial":[28,40,104,169],"organization":[29],"this":[31],"diversity,":[32],"data":[35,41,57,92],"is":[36],"often":[37],"integrated":[38],"with":[39,147],"create":[43],"probabilistic":[44,120],"maps.":[46],"However,":[47],"targeted":[48],"typing":[50,122],"approaches":[51],"relying":[52],"on":[53,171],"existing":[54],"achieve":[58],"incomplete":[59],"biased":[61,118],"maps":[62,106],"that":[63],"could":[64,128],"mask":[65],"true":[67],"present":[69],"in":[70,89,151,174,188],"a":[71,77,167,179,193],"tissue":[72,190],"slide.":[73],"Here":[74],"we":[75,127],"applied":[76],"de":[78,184],"novo":[79,185],"technique":[80,181],"spatially":[82],"resolve":[83],"characterize":[85,129],"situ":[90],"sequencing":[91,155],"during":[93,202],"human":[94],"heart":[95,203],"development.":[96],"We":[97,157],"obtained":[98],"made":[100],"accessible":[101],"well":[102],"defined":[103],"cell-type":[105,200],"fetal":[108],"hearts":[109],"from":[110],"4.5":[111],"9":[113],"post":[114],"conception":[115],"weeks,":[116],"not":[117],"by":[119],"approaches.":[123],"our":[125,176],"analysis,":[126],"previously":[130],"unreported":[131],"within":[134],"cardiomyocytes":[135],"epicardial":[137,164],"cells":[138],"identified":[140],"their":[141],"characteristic":[142],"expression":[143],"signatures,":[144],"comparing":[145],"them":[146],"specific":[148],"subpopulations":[149],"found":[150],"RNA":[154],"datasets.":[156],"further":[158],"characterized":[159],"differentiation":[161,201],"trajectories":[162],"cells,":[165],"identifying":[166],"clear":[168],"component":[170],"it.":[172],"All":[173],"all,":[175],"study":[177],"provides":[178],"novel":[180],"for":[182,196],"conducting":[183],"spatial-temporal":[186],"analyses":[187],"developmental":[189],"samples":[191],"useful":[194],"resource":[195],"online":[197],"exploration":[198],"development":[204],"at":[205],"sub-cellular":[206],"image":[207],"resolution.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2022-08-12T00:00:00"}