{"id":"https://openalex.org/W4298087487","doi":"https://doi.org/10.1371/journal.pcbi.1010267","title":"Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis","display_name":"Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis","publication_year":2022,"publication_date":"2022-09-30","ids":{"openalex":"https://openalex.org/W4298087487","doi":"https://doi.org/10.1371/journal.pcbi.1010267","pmid":"https://pubmed.ncbi.nlm.nih.gov/36178923"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010267","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010267","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010267&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010267&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075615651","display_name":"Fedor Shmarov","orcid":"https://orcid.org/0000-0002-3848-451X"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fedor Shmarov","raw_affiliation_strings":["Department of Computer Science, University of Manchester, Manchester, United Kingdom","School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3848-451X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052716174","display_name":"Graham R. Smith","orcid":"https://orcid.org/0000-0001-6967-7691"},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham R. Smith","raw_affiliation_strings":["Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6967-7691","affiliations":[{"raw_affiliation_string":"Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106128681","display_name":"Sophie Weatherhead","orcid":"https://orcid.org/0000-0002-8705-8867"},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophie C. Weatherhead","raw_affiliation_strings":["Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8705-8867","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I2801663869","https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029600332","display_name":"Nick J. Reynolds","orcid":"https://orcid.org/0000-0002-6484-825X"},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nick J. Reynolds","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6484-825X","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054022139","display_name":"Paolo Zuliani","orcid":"https://orcid.org/0000-0001-6033-5919"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paolo Zuliani","raw_affiliation_strings":["Department of Computer Science, University of Manchester, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6033-5919","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029600332","https://openalex.org/A5054022139"],"corresponding_institution_ids":["https://openalex.org/I28407311","https://openalex.org/I84884186"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.1697,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46725199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"18","issue":"9","first_page":"e1010267","last_page":"e1010267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9761999845504761,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"Psoriasis","score":0.9358190298080444},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6593515872955322},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6482945680618286},{"id":"https://openalex.org/keywords/psoriasis-area-and-severity-index","display_name":"Psoriasis Area and Severity Index","score":0.499222993850708},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.49878811836242676},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48773202300071716},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4623177647590637},{"id":"https://openalex.org/keywords/dermatology","display_name":"Dermatology","score":0.3685262203216553},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.262389600276947}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.9358190298080444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6593515872955322},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6482945680618286},{"id":"https://openalex.org/C2777011040","wikidata":"https://www.wikidata.org/wiki/Q390643","display_name":"Psoriasis Area and Severity Index","level":3,"score":0.499222993850708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49878811836242676},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48773202300071716},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4623177647590637},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3685262203216553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.262389600276947}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014467","descriptor_name":"Ultraviolet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014467","descriptor_name":"Ultraviolet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014467","descriptor_name":"Ultraviolet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010267","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010267","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010267&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36178923","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36178923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:305134050b6a4b008c778e6264415d85","is_oa":true,"landing_page_url":"https://doaj.org/article/305134050b6a4b008c778e6264415d85","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9, p e1010267 (2022)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1681038","is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1681038","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9524682","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9524682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010267","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010267","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010267&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3512349111","display_name":null,"funder_award_id":"(Senior Investigator Award) NIHR200168","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G976039981","display_name":"NIHR Senior Investigator Award","funder_award_id":"NIHR200168","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G988691230","display_name":null,"funder_award_id":"A1175","funder_id":"https://openalex.org/F4320320320","funder_display_name":"Rosetrees Trust"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320013","display_name":"British Skin Foundation","ror":"https://ror.org/02h7g2017"},{"id":"https://openalex.org/F4320320295","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320332071","display_name":"LEO Pharma","ror":null},{"id":"https://openalex.org/F4320335819","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4298087487.pdf","grobid_xml":"https://content.openalex.org/works/W4298087487.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W66443818","https://openalex.org/W200914752","https://openalex.org/W1568472039","https://openalex.org/W1606960717","https://openalex.org/W1821988420","https://openalex.org/W1965756947","https://openalex.org/W1975609097","https://openalex.org/W1975931490","https://openalex.org/W1979058179","https://openalex.org/W1981177225","https://openalex.org/W1983280412","https://openalex.org/W1988729643","https://openalex.org/W1991557802","https://openalex.org/W1992532837","https://openalex.org/W1993612200","https://openalex.org/W2002606293","https://openalex.org/W2003451722","https://openalex.org/W2013542144","https://openalex.org/W2015743406","https://openalex.org/W2025091340","https://openalex.org/W2029806813","https://openalex.org/W2040041622","https://openalex.org/W2042893569","https://openalex.org/W2044910634","https://openalex.org/W2057056202","https://openalex.org/W2061326479","https://openalex.org/W2061872792","https://openalex.org/W2063106526","https://openalex.org/W2069948046","https://openalex.org/W2080090843","https://openalex.org/W2090587274","https://openalex.org/W2093236527","https://openalex.org/W2107432039","https://openalex.org/W2109264320","https://openalex.org/W2110262269","https://openalex.org/W2121126920","https://openalex.org/W2127061621","https://openalex.org/W2143427896","https://openalex.org/W2149193200","https://openalex.org/W2151261149","https://openalex.org/W2153355648","https://openalex.org/W2158427148","https://openalex.org/W2171689947","https://openalex.org/W2211413238","https://openalex.org/W2336987877","https://openalex.org/W2791228900","https://openalex.org/W2791437944","https://openalex.org/W2811171873","https://openalex.org/W2887063969","https://openalex.org/W2896529504","https://openalex.org/W2897926103","https://openalex.org/W2899087954","https://openalex.org/W2900077869","https://openalex.org/W3000462768","https://openalex.org/W3038974679","https://openalex.org/W3098307890","https://openalex.org/W3120885077","https://openalex.org/W3124296497","https://openalex.org/W3138303272","https://openalex.org/W3139074489","https://openalex.org/W3143877554","https://openalex.org/W3160465618","https://openalex.org/W3177943111","https://openalex.org/W4211077900","https://openalex.org/W4243425586"],"related_works":["https://openalex.org/W3176363967","https://openalex.org/W3022724713","https://openalex.org/W2588369178","https://openalex.org/W2343185506","https://openalex.org/W2781166685","https://openalex.org/W4237828778","https://openalex.org/W1986850072","https://openalex.org/W2331246794","https://openalex.org/W2032633556","https://openalex.org/W2331028526"],"abstract_inverted_index":{"Despite":[0],"increased":[1],"understanding":[2],"about":[3],"psoriasis":[4,27,68],"pathophysiology,":[5],"currently":[6],"there":[7],"is":[8,180],"a":[9,17,106,127,221],"lack":[10],"of":[11,23,44,71,99,105,120,131,152,157,165,172,177,190,199,212],"predictive":[12],"computational":[13],"models.":[14],"We":[15],"developed":[16],"personalisable":[18],"ordinary":[19],"differential":[20],"equations":[21],"model":[22,90,101,179,219],"human":[24],"epidermis":[25,82],"and":[26,32,48,69,73,117,138,162,195,215,225],"that":[28,111],"incorporates":[29],"immune":[30,60,72,213],"cells":[31,75,214],"cytokine":[33],"stimuli":[34],"to":[35,67,84,93,115,192,202,223,228],"regulate":[36],"the":[37,81,85,103,148,158,163,170,209],"transition":[38,63],"between":[39],"two":[40],"stable":[41],"steady":[42],"states":[43],"clinically":[45],"healthy":[46,65,86],"(non-lesional)":[47],"disease":[49,95],"(lesional":[50],"psoriasis,":[51],"plaque)":[52],"skin.":[53],"In":[54,126],"line":[55],"with":[56],"experimental":[57],"data,":[58],"an":[59],"stimulus":[61],"initiated":[62],"from":[64],"skin":[66],"apoptosis":[70,116],"epidermal":[74,216],"induced":[76],"by":[77,207],"UVB":[78,136,153,193],"phototherapy":[79,200],"returned":[80],"back":[83],"state.":[87],"Notably,":[88],"our":[89,100,178,218],"was":[91],"able":[92],"distinguish":[94],"flares.":[96],"The":[97],"flexibility":[98],"permitted":[102],"development":[104],"patient-specific":[107],"\"UVB":[108,159],"sensitivity\"":[109,160],"parameter":[110,161],"reflected":[112],"subject-specific":[113],"sensitivity":[114],"enabled":[118],"simulation":[119],"individual":[121,135,166],"patients'":[122],"clinical":[123,129,139,185,204],"response":[124,140,191],"trajectory.":[125],"prospective":[128],"study":[130,224],"94":[132],"patients,":[133],"serial":[134],"doses":[137],"(Psoriasis":[141],"Area":[142],"Severity":[143],"Index)":[144],"values":[145],"collected":[146],"over":[147],"first":[149],"three":[150],"weeks":[151],"therapy":[154],"informed":[155],"estimation":[156],"prediction":[164],"patient":[167],"outcome":[168],"at":[169],"end":[171],"phototherapy.":[173],"An":[174],"important":[175],"advance":[176],"its":[181],"potential":[182],"for":[183,196],"direct":[184],"application":[186],"through":[187],"early":[188],"assessment":[189],"therapy,":[194],"individualised":[197],"optimisation":[198],"regimes":[201],"improve":[203],"outcome.":[205],"Additionally":[206],"incorporating":[208],"complex":[210],"interaction":[211],"keratinocytes,":[217],"provides":[220],"basis":[222],"predict":[226],"outcomes":[227],"biologic":[229],"therapies":[230],"in":[231],"psoriasis.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
