{"id":"https://openalex.org/W4283716960","doi":"https://doi.org/10.1371/journal.pcbi.1010238","title":"Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning","display_name":"Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283716960","doi":"https://doi.org/10.1371/journal.pcbi.1010238","pmid":"https://pubmed.ncbi.nlm.nih.gov/35767567"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010238","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010238","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058985468","display_name":"Alex X. Lu","orcid":"https://orcid.org/0000-0001-9568-3155"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alex X. Lu","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348845","display_name":"Amy X. Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amy X. Lu","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033733724","display_name":"Iva Priti\u0161anac","orcid":"https://orcid.org/0000-0002-9152-6555"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Iva Priti\u0161anac","raw_affiliation_strings":["Department of Cell and Systems Biology, University of Toronto, Toronto, Canada","Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cell and Systems Biology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047578407","display_name":"Taraneh Zarin","orcid":"https://orcid.org/0000-0003-1253-3843"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Taraneh Zarin","raw_affiliation_strings":["Department of Cell and Systems Biology, University of Toronto, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cell and Systems Biology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087683429","display_name":"Julie D. Forman\u2010Kay","orcid":"https://orcid.org/0000-0001-8265-972X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie D. Forman-Kay","raw_affiliation_strings":["Department of Biochemistry, University of Toronto, Toronto, Canada","Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086545231","display_name":"Alan M Moses","orcid":"https://orcid.org/0000-0003-3118-3121"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Alan M. Moses","raw_affiliation_strings":["Department of Cell and Systems Biology, University of Toronto, Toronto, Canada","Department of Computer Science, University of Toronto, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cell and Systems Biology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5086545231"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.2528,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.95615691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"18","issue":"6","first_page":"e1010238","last_page":"e1010238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.8015673160552979},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7187727689743042},{"id":"https://openalex.org/keywords/human-proteome-project","display_name":"Human proteome project","score":0.611134946346283},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.5125955939292908},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47180691361427307},{"id":"https://openalex.org/keywords/structural-motif","display_name":"Structural motif","score":0.4676850438117981},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.46747279167175293},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.45871832966804504},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4493199586868286},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4423854649066925},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.4218204617500305},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3933263123035431},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3288240432739258},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.2946835458278656},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.28851351141929626},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12227004766464233},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07839187979698181}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8015673160552979},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7187727689743042},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.611134946346283},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.5125955939292908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47180691361427307},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.4676850438117981},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.46747279167175293},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.45871832966804504},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4493199586868286},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4423854649066925},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.4218204617500305},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3933263123035431},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3288240432739258},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2946835458278656},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.28851351141929626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12227004766464233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07839187979698181},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010238","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35767567","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35767567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:cb97a63ed41d4fd2a040177bf0b5297a","is_oa":true,"landing_page_url":"https://doaj.org/article/cb97a63ed41d4fd2a040177bf0b5297a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1010238 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9275697","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9275697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010238","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1020413421","display_name":null,"funder_award_id":"Project Scheme","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G1207874206","display_name":null,"funder_award_id":"NSERC-CGS","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G1597412403","display_name":null,"funder_award_id":"RGPIN-","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2165548363","display_name":null,"funder_award_id":"Canada","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2417676328","display_name":null,"funder_award_id":"RGPIN-2018-0","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2980479518","display_name":null,"funder_award_id":"RGPIN-2018","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3030655770","display_name":null,"funder_award_id":"Research Chair","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G3216283581","display_name":null,"funder_award_id":"RGPIN-201","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3512046080","display_name":null,"funder_award_id":"GPU academic seeding grand","funder_id":"https://openalex.org/F4320309480","funder_display_name":"Nvidia"},{"id":"https://openalex.org/G4324357226","display_name":null,"funder_award_id":"CGS Fellowship","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4389354971","display_name":null,"funder_award_id":"Research","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4515207065","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5265193246","display_name":null,"funder_award_id":"Canada Research Chair","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5463241825","display_name":null,"funder_award_id":"CGS grant","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5631553361","display_name":null,"funder_award_id":"RGPIN-2018-04924","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5784215521","display_name":null,"funder_award_id":"Chair","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6221715925","display_name":null,"funder_award_id":"RGPIN","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7136325465","display_name":null,"funder_award_id":"RGPIN-","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"},{"id":"https://openalex.org/G7426556402","display_name":null,"funder_award_id":"Canada Research Chairs","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8513938169","display_name":null,"funder_award_id":"PJT-14853","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8595721295","display_name":null,"funder_award_id":"NSERC","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"},{"id":"https://openalex.org/G919846122","display_name":null,"funder_award_id":"Chair","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"},{"id":"https://openalex.org/G978884283","display_name":null,"funder_award_id":"PJT-148532","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320309480","display_name":"Nvidia","ror":"https://ror.org/03jdj4y14"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W1019830208","https://openalex.org/W1522301498","https://openalex.org/W1845198418","https://openalex.org/W1895367194","https://openalex.org/W1912159341","https://openalex.org/W1964612763","https://openalex.org/W1971943180","https://openalex.org/W1972376083","https://openalex.org/W1973496588","https://openalex.org/W1981982138","https://openalex.org/W1994840640","https://openalex.org/W1996543580","https://openalex.org/W1996695017","https://openalex.org/W1999811798","https://openalex.org/W2000042427","https://openalex.org/W2009414370","https://openalex.org/W2009713859","https://openalex.org/W2015115860","https://openalex.org/W2016532044","https://openalex.org/W2031268938","https://openalex.org/W2038963685","https://openalex.org/W2040452705","https://openalex.org/W2040518083","https://openalex.org/W2040549215","https://openalex.org/W2041877620","https://openalex.org/W2047995544","https://openalex.org/W2067456654","https://openalex.org/W2074166146","https://openalex.org/W2076742999","https://openalex.org/W2079186703","https://openalex.org/W2085442947","https://openalex.org/W2091591127","https://openalex.org/W2098973407","https://openalex.org/W2100329853","https://openalex.org/W2102221598","https://openalex.org/W2102424972","https://openalex.org/W2107040871","https://openalex.org/W2107158607","https://openalex.org/W2114850508","https://openalex.org/W2126931884","https://openalex.org/W2127774996","https://openalex.org/W2138459937","https://openalex.org/W2141260639","https://openalex.org/W2144212668","https://openalex.org/W2158714788","https://openalex.org/W2162416481","https://openalex.org/W2162980545","https://openalex.org/W2164814636","https://openalex.org/W2166637863","https://openalex.org/W2168639701","https://openalex.org/W2169424993","https://openalex.org/W2345490732","https://openalex.org/W2345512687","https://openalex.org/W2519625972","https://openalex.org/W2566370974","https://openalex.org/W2586999231","https://openalex.org/W2593862218","https://openalex.org/W2606957126","https://openalex.org/W2613629789","https://openalex.org/W2730472814","https://openalex.org/W2770026599","https://openalex.org/W2786469974","https://openalex.org/W2786672974","https://openalex.org/W2792800146","https://openalex.org/W2803006006","https://openalex.org/W2806884808","https://openalex.org/W2808121690","https://openalex.org/W2810866092","https://openalex.org/W2884050383","https://openalex.org/W2890383569","https://openalex.org/W2896457183","https://openalex.org/W2898402099","https://openalex.org/W2919115771","https://openalex.org/W2923284745","https://openalex.org/W2938415845","https://openalex.org/W2948780424","https://openalex.org/W2951433247","https://openalex.org/W2952239877","https://openalex.org/W2955418283","https://openalex.org/W2955971475","https://openalex.org/W2971227267","https://openalex.org/W2971686199","https://openalex.org/W2980789587","https://openalex.org/W2987184424","https://openalex.org/W2988357750","https://openalex.org/W2995175313","https://openalex.org/W2995514860","https://openalex.org/W2995997429","https://openalex.org/W3005177895","https://openalex.org/W3005680577","https://openalex.org/W3011742814","https://openalex.org/W3023371261","https://openalex.org/W3024091520","https://openalex.org/W3045188402","https://openalex.org/W3083386021","https://openalex.org/W3092646203","https://openalex.org/W3093053585","https://openalex.org/W3098365587","https://openalex.org/W3105512395","https://openalex.org/W3108562892","https://openalex.org/W3114473647","https://openalex.org/W3115467785","https://openalex.org/W3119123814","https://openalex.org/W3127238141","https://openalex.org/W3128253898","https://openalex.org/W3129991888","https://openalex.org/W3130819465","https://openalex.org/W3136918052","https://openalex.org/W3146944767","https://openalex.org/W3156051371","https://openalex.org/W3157378145","https://openalex.org/W3158459025","https://openalex.org/W3173151551","https://openalex.org/W3184265853","https://openalex.org/W3194158938","https://openalex.org/W3195462907","https://openalex.org/W3203588026","https://openalex.org/W3210864467","https://openalex.org/W4200346882","https://openalex.org/W4205246014","https://openalex.org/W4205247356","https://openalex.org/W4229799243","https://openalex.org/W4252178616","https://openalex.org/W4255852734","https://openalex.org/W4297808394","https://openalex.org/W4379880437","https://openalex.org/W6631190155","https://openalex.org/W6631441373","https://openalex.org/W6684171462","https://openalex.org/W6763868836","https://openalex.org/W6770400242","https://openalex.org/W6770686123","https://openalex.org/W6791955017","https://openalex.org/W6811186411"],"related_works":["https://openalex.org/W3092794487","https://openalex.org/W2094752534","https://openalex.org/W2885268310","https://openalex.org/W2025055488","https://openalex.org/W2575115220","https://openalex.org/W2052894646","https://openalex.org/W2580329791","https://openalex.org/W2909412621","https://openalex.org/W3032536091","https://openalex.org/W2145037531"],"abstract_inverted_index":{"A":[0],"major":[1],"challenge":[2],"to":[3,92,155,166,188],"the":[4,15,22,61,88,106,123],"characterization":[5],"of":[6,24,30,85,101,128,158],"intrinsically":[7],"disordered":[8],"regions":[9,162],"(IDRs),":[10],"which":[11,55],"are":[12,67,163],"widespread":[13],"in":[14],"proteome,":[16],"but":[17],"relatively":[18],"poorly":[19,193],"understood,":[20],"is":[21,184],"identification":[23],"molecular":[25],"features":[26,66,127,139],"that":[27,63,122,130,149,177],"mediate":[28],"functions":[29],"these":[31],"regions,":[32],"such":[33],"as":[34,74,134],"short":[35],"motifs,":[36,135],"amino":[37,143],"acid":[38,144],"repeats":[39],"and":[40,116,120,161],"physicochemical":[41],"properties.":[42],"Here,":[43],"we":[44,56],"introduce":[45],"a":[46,75,83,95,113,185],"proteome-scale":[47],"feature":[48,178],"discovery":[49,179],"approach":[50],"for":[51,79,171],"IDRs.":[52,173],"Our":[53,174],"approach,":[54],"call":[57],"\"reverse":[58],"homology\",":[59],"exploits":[60],"principle":[62],"important":[64,165],"functional":[65],"conserved":[68,126],"over":[69],"evolution.":[70],"We":[71,108,146],"use":[72],"this":[73],"contrastive":[76],"learning":[77],"signal":[78],"deep":[80],"learning:":[81],"given":[82],"set":[84,100],"homologous":[86],"IDRs,":[87],"neural":[89,182],"network":[90,124],"has":[91],"correctly":[93],"choose":[94],"held-out":[96],"homolog":[97],"from":[98,105],"another":[99],"IDRs":[102,129],"sampled":[103],"randomly":[104],"proteome.":[107],"pair":[109],"reverse":[110],"homology":[111],"with":[112],"simple":[114],"architecture":[115],"standard":[117],"interpretation":[118],"techniques,":[119],"show":[121,148],"learns":[125],"can":[131,152],"be":[132,153],"interpreted":[133],"repeats,":[136],"or":[137,142],"bulk":[138],"like":[140],"charge":[141],"propensities.":[145],"also":[147],"our":[150],"model":[151],"used":[154],"produce":[156],"visualizations":[157],"what":[159],"residues":[160],"most":[164],"IDR":[167],"function,":[168],"generating":[169],"hypotheses":[170],"uncharacterized":[172],"results":[175],"suggest":[176],"using":[180],"unsupervised":[181],"networks":[183],"promising":[186],"avenue":[187],"gain":[189],"systematic":[190],"insight":[191],"into":[192],"understood":[194],"protein":[195],"sequences.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":4}],"updated_date":"2026-04-18T07:56:08.524223","created_date":"2025-10-10T00:00:00"}