{"id":"https://openalex.org/W4281946838","doi":"https://doi.org/10.1371/journal.pcbi.1010226","title":"Non-monotonic effects of GABAergic synaptic inputs on neuronal firing","display_name":"Non-monotonic effects of GABAergic synaptic inputs on neuronal firing","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281946838","doi":"https://doi.org/10.1371/journal.pcbi.1010226","pmid":"https://pubmed.ncbi.nlm.nih.gov/35666719"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010226","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010226","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010226&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010226&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078325696","display_name":"Aghil Abed Zadeh","orcid":"https://orcid.org/0000-0002-7721-7094"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aghil Abed Zadeh","raw_affiliation_strings":["Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7721-7094","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061274157","display_name":"Brandon D. Turner","orcid":"https://orcid.org/0000-0002-2887-1719"},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon D. Turner","raw_affiliation_strings":["Department of Neurology, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085465113","display_name":"Nicole Calakos","orcid":"https://orcid.org/0000-0002-9918-3294"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Calakos","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America","Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","Department of Neurology, Duke University Medical Center, Durham, North Carolina, United States of America","Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210153043"]},{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210153043"]},{"raw_affiliation_string":"Department of Neurology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047235486","display_name":"Nicolas Brunel","orcid":"https://orcid.org/0000-0002-2272-3248"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Brunel","raw_affiliation_strings":["Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","Department of Physics, Duke University, Durham, North Carolina, United States of America","Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2272-3248","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210153043"]},{"raw_affiliation_string":"Department of Physics, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078325696"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210153043"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0919,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.31014218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"e1010226","last_page":"e1010226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabaergic","display_name":"GABAergic","score":0.8169341087341309},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7274083495140076},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.6728461980819702},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6563072800636292},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.5249257683753967},{"id":"https://openalex.org/keywords/gamma-aminobutyric-acid","display_name":"gamma-Aminobutyric acid","score":0.51249098777771},{"id":"https://openalex.org/keywords/reversal-potential","display_name":"Reversal potential","score":0.45120537281036377},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3344285488128662},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.26412755250930786},{"id":"https://openalex.org/keywords/patch-clamp","display_name":"Patch clamp","score":0.16090688109397888},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.04963481426239014}],"concepts":[{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.8169341087341309},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7274083495140076},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6728461980819702},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6563072800636292},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5249257683753967},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.51249098777771},{"id":"https://openalex.org/C2778071365","wikidata":"https://www.wikidata.org/wiki/Q3089249","display_name":"Reversal potential","level":4,"score":0.45120537281036377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3344285488128662},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.26412755250930786},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.16090688109397888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04963481426239014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010226","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010226","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010226&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35666719","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35666719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9203025","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9203025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:db4c4c38c9d2425e990fac6016cc90e9","is_oa":true,"landing_page_url":"https://doaj.org/article/db4c4c38c9d2425e990fac6016cc90e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1010226 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010226","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010226","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010226&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1108229486","display_name":"Striatal Plasticity in Habit Formation as a Platform to Deconstruct Adaptive Learning","funder_award_id":"5r01ns110059-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3224074059","display_name":null,"funder_award_id":"R01 NS110059","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281946838.pdf","grobid_xml":"https://content.openalex.org/works/W4281946838.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W316919195","https://openalex.org/W1489519230","https://openalex.org/W1521194061","https://openalex.org/W1540301663","https://openalex.org/W1633786496","https://openalex.org/W1965453664","https://openalex.org/W1965959842","https://openalex.org/W1973004621","https://openalex.org/W1975302642","https://openalex.org/W1987664075","https://openalex.org/W1995831678","https://openalex.org/W2010621915","https://openalex.org/W2011154084","https://openalex.org/W2011857818","https://openalex.org/W2012064273","https://openalex.org/W2019306960","https://openalex.org/W2020587316","https://openalex.org/W2020887697","https://openalex.org/W2021454300","https://openalex.org/W2034808029","https://openalex.org/W2035498160","https://openalex.org/W2045839462","https://openalex.org/W2047925020","https://openalex.org/W2054234898","https://openalex.org/W2057724638","https://openalex.org/W2059754952","https://openalex.org/W2064363302","https://openalex.org/W2065344452","https://openalex.org/W2069241799","https://openalex.org/W2069586118","https://openalex.org/W2078654278","https://openalex.org/W2079086000","https://openalex.org/W2084658148","https://openalex.org/W2093301371","https://openalex.org/W2107081816","https://openalex.org/W2108502510","https://openalex.org/W2109251081","https://openalex.org/W2119350525","https://openalex.org/W2134218486","https://openalex.org/W2137730912","https://openalex.org/W2139471530","https://openalex.org/W2141166794","https://openalex.org/W2143788747","https://openalex.org/W2145718412","https://openalex.org/W2146611606","https://openalex.org/W2150032800","https://openalex.org/W2154914851","https://openalex.org/W2157338202","https://openalex.org/W2158060752","https://openalex.org/W2212326032","https://openalex.org/W2254149533","https://openalex.org/W2296983774","https://openalex.org/W2320983896","https://openalex.org/W2416630006","https://openalex.org/W2535706923","https://openalex.org/W2554698846","https://openalex.org/W2602352603","https://openalex.org/W2620906303","https://openalex.org/W2750749867","https://openalex.org/W2752784673","https://openalex.org/W2922544041","https://openalex.org/W2952426443","https://openalex.org/W3020380091","https://openalex.org/W3030060774","https://openalex.org/W3083432548","https://openalex.org/W3088841699","https://openalex.org/W3088934399","https://openalex.org/W3122088591","https://openalex.org/W4256020708"],"related_works":["https://openalex.org/W2084829611","https://openalex.org/W2035152577","https://openalex.org/W2095958730","https://openalex.org/W2792813395","https://openalex.org/W2473939969","https://openalex.org/W1988117871","https://openalex.org/W2179189279","https://openalex.org/W2020824087","https://openalex.org/W2400893902","https://openalex.org/W2097142850"],"abstract_inverted_index":{"GABA":[0,43,79,112,120,139,214],"is":[1],"generally":[2],"known":[3],"as":[4,75,135,186,188],"the":[5,10,28,39,45,108,151,157,189,192,211],"principal":[6],"inhibitory":[7,124],"neurotransmitter":[8],"in":[9,215],"nervous":[11],"system,":[12],"usually":[13],"acting":[14],"by":[15],"hyperpolarizing":[16],"membrane":[17],"potential.":[18],"However,":[19],"GABAergic":[20,63,133,176,204],"currents":[21],"sometimes":[22],"exhibit":[23,70],"non-inhibitory":[24],"effects,":[25],"depending":[26],"on":[27,44,180],"brain":[29],"region,":[30],"developmental":[31],"stage":[32],"or":[33],"pathological":[34],"condition.":[35],"Here,":[36],"we":[37],"investigate":[38],"diverse":[40],"effects":[41,134,174,202,212],"of":[42,48,78,105,131,138,153,169,175,191,200,203,213],"firing":[46,68,95],"rate":[47,69],"several":[49],"single":[50],"neuron":[51],"models,":[52],"using":[53],"both":[54],"analytical":[55],"calculations":[56],"and":[57,66,98,142,218],"numerical":[58],"simulations.":[59],"We":[60,126,145,163],"find":[61,146],"that":[62,147],"synaptic":[64,205],"conductance":[65],"output":[67],"three":[71],"qualitatively":[72],"different":[73,132],"regimes":[74],"a":[76,99,128,136,166,197],"function":[77,137],"reversal":[80,140],"potential,":[81],"EGABA:":[82],"monotonically":[83,90],"decreasing":[84],"for":[85,92,102,155,209],"sufficiently":[86],"low":[87],"EGABA":[88,93,154],"(inhibitory),":[89],"increasing":[91],"above":[94],"threshold":[96],"(excitatory);":[97],"non-monotonic":[100,109,158],"region":[101],"intermediate":[103],"values":[104],"EGABA.":[106],"In":[107],"regime,":[110],"small":[111],"conductances":[113,121],"have":[114],"an":[115,123],"excitatory":[116],"effect":[117,159],"while":[118],"large":[119],"show":[122],"effect.":[125],"provide":[127],"phase":[129],"diagram":[130],"potential":[141],"glutamate":[143],"conductance.":[144],"noisy":[148],"inputs":[149],"increase":[150],"range":[152],"which":[156],"can":[160],"be":[161],"observed.":[162],"also":[164],"construct":[165],"micro-circuit":[167],"model":[168],"striatum":[170],"to":[171],"explain":[172],"observed":[173],"fast":[177],"spiking":[178],"interneurons":[179],"spiny":[181],"projection":[182],"neurons,":[183],"including":[184],"non-monotonicity,":[185],"well":[187],"heterogeneity":[190],"effects.":[193],"Our":[194],"work":[195],"provides":[196],"mechanistic":[198],"explanation":[199],"paradoxical":[201],"inputs,":[206],"with":[207],"implications":[208],"understanding":[210],"neural":[216],"computation":[217],"development.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2022-06-13T00:00:00"}