{"id":"https://openalex.org/W4283582505","doi":"https://doi.org/10.1371/journal.pcbi.1010203","title":"The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility","display_name":"The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283582505","doi":"https://doi.org/10.1371/journal.pcbi.1010203","pmid":"https://pubmed.ncbi.nlm.nih.gov/35759507"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010203","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010203","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000820276","display_name":"Ver\u00f3nica S. Mart\u00ednez","orcid":"https://orcid.org/0000-0003-2729-5278"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica S. Mart\u00ednez","raw_affiliation_strings":["ARC Training Centre for Biopharmaceutical Innovation (CBI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia"],"affiliations":[{"raw_affiliation_string":"ARC Training Centre for Biopharmaceutical Innovation (CBI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067817255","display_name":"Pedro A. Saa","orcid":"https://orcid.org/0000-0002-1659-9041"},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pedro A. Saa","raw_affiliation_strings":["Departamento de Ingenier\u00eda Qu\u00edmica y Bioprocesos, Escuela de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","Instituto de Ingenier\u00eda Matem\u00e1tica y Computacional, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"affiliations":[{"raw_affiliation_string":"Departamento de Ingenier\u00eda Qu\u00edmica y Bioprocesos, Escuela de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]},{"raw_affiliation_string":"Instituto de Ingenier\u00eda Matem\u00e1tica y Computacional, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040000318","display_name":"Jason Jooste","orcid":"https://orcid.org/0000-0002-2169-0552"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jason Jooste","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia"],"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060155832","display_name":"Kanupriya Tiwari","orcid":"https://orcid.org/0000-0003-3501-8924"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kanupriya Tiwari","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia"],"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030141585","display_name":"Lake\u2010Ee Quek","orcid":"https://orcid.org/0000-0002-9313-8740"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lake-Ee Quek","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","The Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, Australia"],"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061172047","display_name":"Lars K. Nielsen","orcid":"https://orcid.org/0000-0001-8191-3511"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["AU","DK"],"is_corresponding":true,"raw_author_name":"Lars K. Nielsen","raw_affiliation_strings":["ARC Training Centre for Biopharmaceutical Innovation (CBI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","Metabolomics Australia, The University of Queensland, Brisbane, Queensland, Australia","The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"ARC Training Centre for Biopharmaceutical Innovation (CBI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Metabolomics Australia, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061172047"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2801134892","https://openalex.org/I96673099"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6944,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66592147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"e1010203","last_page":"e1010203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.6848239302635193},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.5781828165054321},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5748087763786316},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.548467755317688},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5284338593482971},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5131505131721497},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.4441477656364441},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.410238653421402},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4098667502403259},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3202245831489563},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2276741862297058},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.1942015290260315},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17522206902503967},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16702499985694885},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.0918082594871521},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08395427465438843}],"concepts":[{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.6848239302635193},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.5781828165054321},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5748087763786316},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.548467755317688},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5284338593482971},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5131505131721497},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.4441477656364441},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.410238653421402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4098667502403259},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3202245831489563},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2276741862297058},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.1942015290260315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17522206902503967},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16702499985694885},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0918082594871521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08395427465438843},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010203","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010203","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35759507","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35759507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:8ee6253ece2b44098f1e3712b65e40d6","is_oa":true,"landing_page_url":"https://doaj.org/article/8ee6253ece2b44098f1e3712b65e40d6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1010203 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9269948","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9269948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/596e366c-6a99-477e-bcd6-e0168d6325b4","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/596e366c-6a99-477e-bcd6-e0168d6325b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mart\u00ednez , V S , Saa , P A , Jooste , J , Tiwari , K , Quek , L E &amp; Nielsen , L K 2022 , ' The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility ' , PLOS Computational Biology , vol. 18 , no. 6 , e1010203 . https://doi.org/10.1371/journal.pcbi.1010203","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010203","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010203","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth"}],"awards":[{"id":"https://openalex.org/G1127360030","display_name":null,"funder_award_id":"FONDAP","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G1278513833","display_name":null,"funder_award_id":"CENIA FB210017","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G2751394378","display_name":null,"funder_award_id":"20CC0035580","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3042249225","display_name":"CENTRO DE REGULACION DEL GENOMA (CRG)","funder_award_id":"15090007","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G346937527","display_name":null,"funder_award_id":"NNF14OC0009473","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3948645045","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G4019885841","display_name":null,"funder_award_id":"1190074","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G4159974099","display_name":null,"funder_award_id":"CENIA FB210017,","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G4592421031","display_name":null,"funder_award_id":"analysis","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G5215622454","display_name":null,"funder_award_id":"WRAP213-2019RD1","funder_id":"https://openalex.org/F4320335344","funder_display_name":"Advance Queensland"},{"id":"https://openalex.org/G6876882495","display_name":null,"funder_award_id":"15090007","funder_id":"https://openalex.org/F4320338206","funder_display_name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias"},{"id":"https://openalex.org/G7042228497","display_name":null,"funder_award_id":"NNF20CC0035580","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G7361212524","display_name":null,"funder_award_id":"NNF20CC0035580","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G7877382544","display_name":null,"funder_award_id":"FB210017","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8249311544","display_name":null,"funder_award_id":"IC160100027","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":null},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320335344","display_name":"Advance Queensland","ror":null},{"id":"https://openalex.org/F4320338206","display_name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W180513472","https://openalex.org/W754258627","https://openalex.org/W1994134392","https://openalex.org/W1998577003","https://openalex.org/W2000065954","https://openalex.org/W2000206290","https://openalex.org/W2003495172","https://openalex.org/W2008620264","https://openalex.org/W2018045523","https://openalex.org/W2022012525","https://openalex.org/W2031993452","https://openalex.org/W2046527060","https://openalex.org/W2057858265","https://openalex.org/W2065769502","https://openalex.org/W2070787626","https://openalex.org/W2075846943","https://openalex.org/W2076262841","https://openalex.org/W2077149408","https://openalex.org/W2083011190","https://openalex.org/W2085190689","https://openalex.org/W2085993965","https://openalex.org/W2087139200","https://openalex.org/W2094542248","https://openalex.org/W2099551325","https://openalex.org/W2103795997","https://openalex.org/W2107409961","https://openalex.org/W2108859156","https://openalex.org/W2117474489","https://openalex.org/W2120167281","https://openalex.org/W2124737787","https://openalex.org/W2126175129","https://openalex.org/W2133556195","https://openalex.org/W2141776893","https://openalex.org/W2142072523","https://openalex.org/W2142747156","https://openalex.org/W2162673839","https://openalex.org/W2163480486","https://openalex.org/W2171437346","https://openalex.org/W2296033497","https://openalex.org/W2342127666","https://openalex.org/W2345887956","https://openalex.org/W2418056440","https://openalex.org/W2461742269","https://openalex.org/W2555369234","https://openalex.org/W2616531040","https://openalex.org/W2617696743","https://openalex.org/W2737180538","https://openalex.org/W2749464300","https://openalex.org/W2796142352","https://openalex.org/W2810035723","https://openalex.org/W2952015518","https://openalex.org/W2963696287","https://openalex.org/W2980571433","https://openalex.org/W2993166334","https://openalex.org/W3103071483","https://openalex.org/W3104005457","https://openalex.org/W3192568929","https://openalex.org/W4211017114"],"related_works":["https://openalex.org/W2086397253","https://openalex.org/W2133122801","https://openalex.org/W4236696095","https://openalex.org/W600422426","https://openalex.org/W3143779693","https://openalex.org/W2626808643","https://openalex.org/W2004064826","https://openalex.org/W2007156430","https://openalex.org/W3103727510","https://openalex.org/W3081478936"],"abstract_inverted_index":{"The":[0],"topology":[1],"of":[2,17,26,33,42,118,125,153,155,174],"metabolic":[3,57,70,95],"networks":[4],"is":[5],"recognisably":[6],"modular":[7],"with":[8,55],"modules":[9,23,50,78],"weakly":[10],"connected":[11],"apart":[12],"from":[13,30],"sharing":[14],"a":[15,90,171],"pool":[16],"currency":[18,43],"metabolites.":[19,44],"Here,":[20],"we":[21,88],"defined":[22,106,160],"as":[24],"sets":[25],"reversible":[27,99,112,156],"reactions":[28,37,157],"isolated":[29],"the":[31,40,62,94,126,151,165],"rest":[32],"metabolism":[34],"by":[35,98,107],"irreversible":[36],"except":[38],"for":[39,128],"exchange":[41],"Our":[45],"approach":[46],"identifies":[47],"topologically":[48],"independent":[49],"under":[51],"specific":[52],"conditions":[53],"associated":[54],"different":[56],"functions.":[58],"As":[59],"case":[60],"studies,":[61],"E.coli":[63],"iJO1366":[64,129],"and":[65,76,145],"Human":[66],"Recon":[67],"2.2":[68],"genome-scale":[69],"models":[71],"were":[72],"split":[73],"in":[74,84,164],"103":[75],"321":[77],"respectively,":[79],"displaying":[80],"significant":[81],"correlation":[82],"patterns":[83],"expression":[85],"data.":[86],"Finally,":[87],"addressed":[89],"fundamental":[91],"question":[92],"about":[93],"flexibility":[96],"conferred":[97],"reactions:":[100],"\"Of":[101],"all":[102,111,122,162],"Directed":[103],"Topologies":[104],"(DTs)":[105],"fixing":[108],"directions":[109,163],"to":[110],"reactions,":[113],"how":[114],"many":[115],"are":[116],"capable":[117],"carrying":[119],"flux":[120,147],"through":[121],"reactions?\".":[123],"Enumeration":[124],"DTs":[127,141],"model":[130],"was":[131],"performed":[132],"using":[133],"an":[134],"efficient":[135],"depth-first":[136],"search":[137],"algorithm,":[138],"rejecting":[139],"infeasible":[140],"based":[142],"on":[143],"mass-imbalanced":[144],"loopy":[146],"patterns.":[148],"We":[149],"found":[150],"direction":[152],"79%":[154],"must":[158],"be":[159,168],"before":[161],"network":[166],"can":[167],"fixed,":[169],"granting":[170],"high":[172],"degree":[173],"flexibility.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
