{"id":"https://openalex.org/W4281729500","doi":"https://doi.org/10.1371/journal.pcbi.1010179","title":"Designing optimal allocations for cancer screening using queuing network models","display_name":"Designing optimal allocations for cancer screening using queuing network models","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4281729500","doi":"https://doi.org/10.1371/journal.pcbi.1010179","pmid":"https://pubmed.ncbi.nlm.nih.gov/35622852"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010179&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024629462","display_name":"Justin Dean","orcid":"https://orcid.org/0000-0003-4365-4912"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Dean","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049844279","display_name":"Evan Goldberg","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Goldberg","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091861581","display_name":"Franziska Michor","orcid":"https://orcid.org/0009-0003-8552-7767"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Franziska Michor","raw_affiliation_strings":["Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America","The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","The Ludwig Center at Harvard, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Ludwig Center at Harvard, Boston, Massachusetts, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091861581"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7392,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71396254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"18","issue":"5","first_page":"e1010179","last_page":"e1010179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6563969850540161},{"id":"https://openalex.org/keywords/queueing-theory","display_name":"Queueing theory","score":0.6103708744049072},{"id":"https://openalex.org/keywords/cancer-screening","display_name":"Cancer screening","score":0.544651448726654},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.49220791459083557},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.4116969704627991},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3932507634162903},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3806006610393524},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24301695823669434},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1559734046459198},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11049267649650574},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.08851519227027893}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6563969850540161},{"id":"https://openalex.org/C22684755","wikidata":"https://www.wikidata.org/wiki/Q847526","display_name":"Queueing theory","level":2,"score":0.6103708744049072},{"id":"https://openalex.org/C2776463041","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer screening","level":3,"score":0.544651448726654},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.49220791459083557},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4116969704627991},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3932507634162903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3806006610393524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24301695823669434},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1559734046459198},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11049267649650574},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08851519227027893},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35622852","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35622852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1010179","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010179","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0c568f05176a46fa9b333411d3d4eac0","is_oa":true,"landing_page_url":"https://doaj.org/article/0c568f05176a46fa9b333411d3d4eac0","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 5, p e1010179 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9182689","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9182689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281729500.pdf","grobid_xml":"https://content.openalex.org/works/W4281729500.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W119027141","https://openalex.org/W167176601","https://openalex.org/W1968812902","https://openalex.org/W1974799771","https://openalex.org/W1996210366","https://openalex.org/W2015840019","https://openalex.org/W2024670010","https://openalex.org/W2026105846","https://openalex.org/W2043342071","https://openalex.org/W2050410927","https://openalex.org/W2050468805","https://openalex.org/W2056597716","https://openalex.org/W2083030709","https://openalex.org/W2087194111","https://openalex.org/W2094055697","https://openalex.org/W2106504075","https://openalex.org/W2109341366","https://openalex.org/W2112474929","https://openalex.org/W2113622720","https://openalex.org/W2116685726","https://openalex.org/W2134344399","https://openalex.org/W2155585094","https://openalex.org/W2161107415","https://openalex.org/W2169895148","https://openalex.org/W2232858624","https://openalex.org/W2261667115","https://openalex.org/W2282197435","https://openalex.org/W2324732480","https://openalex.org/W2461966398","https://openalex.org/W2567093139","https://openalex.org/W2570618306","https://openalex.org/W2582875120","https://openalex.org/W2589223272","https://openalex.org/W2726542547","https://openalex.org/W2739145658","https://openalex.org/W2755742863","https://openalex.org/W2765264618","https://openalex.org/W2786387030","https://openalex.org/W2795996358","https://openalex.org/W2801970806","https://openalex.org/W2888026526","https://openalex.org/W2892147080","https://openalex.org/W2905273683","https://openalex.org/W2908923812","https://openalex.org/W2920187808","https://openalex.org/W2928740633","https://openalex.org/W2934463049","https://openalex.org/W2947020680","https://openalex.org/W2954319040","https://openalex.org/W2978007607","https://openalex.org/W3020301997","https://openalex.org/W3088519161","https://openalex.org/W3092071943","https://openalex.org/W3112170484","https://openalex.org/W3121892501","https://openalex.org/W3147514193","https://openalex.org/W4210685329","https://openalex.org/W4210774372","https://openalex.org/W4211203170","https://openalex.org/W4244249461","https://openalex.org/W4244578979","https://openalex.org/W4247230948","https://openalex.org/W6654949995"],"related_works":["https://openalex.org/W2365647353","https://openalex.org/W4294163344","https://openalex.org/W2481385346","https://openalex.org/W97763332","https://openalex.org/W4385401023","https://openalex.org/W2044363610","https://openalex.org/W2363056536","https://openalex.org/W2029548118","https://openalex.org/W2295575944","https://openalex.org/W2072421453"],"abstract_inverted_index":{"Cancer":[0],"is":[1,21,101,113],"one":[2],"of":[3,7,41,69,77,115,124,127,139],"the":[4,39,67,75,108,122,137,148,159],"leading":[5],"causes":[6],"death,":[8],"but":[9],"mortality":[10],"can":[11,82],"be":[12,83],"reduced":[13],"by":[14,142],"detecting":[15],"tumors":[16],"earlier":[17],"so":[18],"that":[19,161],"treatment":[20],"initiated":[22],"at":[23],"a":[24,47,61],"less":[25],"aggressive":[26],"stage.":[27],"The":[28],"tradeoff":[29],"between":[30],"costs":[31],"associated":[32],"with":[33],"screening":[34,53,78,88,130,164,179],"and":[35,45,90,112,129,132,151,181,190],"its":[36,183],"benefit":[37],"makes":[38],"decision":[40],"whom":[42],"to":[43,85,91,103,145,168,175],"screen":[44],"when":[46],"challenge.":[48],"To":[49],"enable":[50],"comparisons":[51],"across":[52],"strategies":[54],"for":[55,73,95,110,186],"any":[56,187],"cancer":[57,188],"type,":[58],"we":[59],"demonstrate":[60,136],"mathematical":[62],"modeling":[63],"platform":[64],"based":[65],"on":[66],"theory":[68],"queuing":[70],"networks":[71],"designed":[72],"quantifying":[74,117],"benefits":[76,94,160],"strategies.":[79],"Our":[80,99,156],"methodology":[81,141],"used":[84],"design":[86],"optimal":[87,178],"protocols":[89],"estimate":[92],"their":[93],"specific":[96],"patient":[97,170],"populations.":[98],"method":[100],"amenable":[102],"exact":[104],"analysis,":[105],"thus":[106,172],"circumventing":[107],"need":[109],"simulations,":[111],"capable":[114],"exactly":[116],"outcomes":[118],"given":[119],"variability":[120],"in":[121],"age":[123],"diagnosis,":[125],"rate":[126],"progression,":[128],"sensitivity":[131],"intervention":[133],"outcomes.":[134],"We":[135],"power":[138],"this":[140],"applying":[143],"it":[144],"data":[146],"from":[147],"Surveillance,":[149],"Epidemiology":[150],"End":[152],"Results":[153],"(SEER)":[154],"program.":[155],"approach":[157],"estimates":[158],"various":[162],"novel":[163],"programs":[165],"would":[166],"confer":[167],"different":[169],"populations,":[171],"enabling":[173],"us":[174],"formulate":[176],"an":[177],"allocation":[180],"quantify":[182],"potential":[184],"effects":[185],"type":[189],"intervention.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}