{"id":"https://openalex.org/W4281780934","doi":"https://doi.org/10.1371/journal.pcbi.1010165","title":"CellDynaMo\u2013stochastic reaction-diffusion-dynamics model: Application to search-and-capture process of mitotic spindle assembly","display_name":"CellDynaMo\u2013stochastic reaction-diffusion-dynamics model: Application to search-and-capture process of mitotic spindle assembly","publication_year":2022,"publication_date":"2022-06-03","ids":{"openalex":"https://openalex.org/W4281780934","doi":"https://doi.org/10.1371/journal.pcbi.1010165","pmid":"https://pubmed.ncbi.nlm.nih.gov/35657997"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010165&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054009790","display_name":"Evgenii Kliuchnikov","orcid":"https://orcid.org/0000-0002-2410-2138"},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evgenii Kliuchnikov","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America","institution_ids":["https://openalex.org/I133738476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083809468","display_name":"Artem Zhmurov","orcid":"https://orcid.org/0000-0002-4414-8352"},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Artem Zhmurov","raw_affiliation_strings":["KTH Royal Institute of Technology, Stockholm, Sweden"],"affiliations":[{"raw_affiliation_string":"KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113740075","display_name":"Kenneth A. Marx","orcid":null},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth A. Marx","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America","institution_ids":["https://openalex.org/I133738476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035607641","display_name":"Alex Mogilner","orcid":"https://orcid.org/0000-0001-5302-2404"},"institutions":[{"id":"https://openalex.org/I36672615","display_name":"Courant Institute of Mathematical Sciences","ror":"https://ror.org/037tm7f56","country_code":"US","type":"education","lineage":["https://openalex.org/I36672615","https://openalex.org/I57206974"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex Mogilner","raw_affiliation_strings":["Courant Institute for Mathematical Sciences and Department of Biology, New York University, New York, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Courant Institute for Mathematical Sciences and Department of Biology, New York University, New York, New York, United States of America","institution_ids":["https://openalex.org/I36672615","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027517667","display_name":"Valeri Barsegov","orcid":"https://orcid.org/0000-0003-1994-3917"},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valeri Barsegov","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts, Lowell, Massachusetts, United States of America","institution_ids":["https://openalex.org/I133738476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027517667","https://openalex.org/A5035607641","https://openalex.org/A5054009790","https://openalex.org/A5083809468","https://openalex.org/A5113740075"],"corresponding_institution_ids":["https://openalex.org/I133738476","https://openalex.org/I36672615","https://openalex.org/I57206974","https://openalex.org/I86987016"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2853,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.75970124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"e1010165","last_page":"e1010165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetochore","display_name":"Kinetochore","score":0.9058864116668701},{"id":"https://openalex.org/keywords/spindle-apparatus","display_name":"Spindle apparatus","score":0.662095308303833},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"Chromosome segregation","score":0.6475392580032349},{"id":"https://openalex.org/keywords/mitosis","display_name":"Mitosis","score":0.5795623660087585},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.5643329620361328},{"id":"https://openalex.org/keywords/centromere","display_name":"Centromere","score":0.5379546284675598},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.4590117335319519},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.4578685760498047},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39542460441589355},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3929691016674042},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36061811447143555},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35256415605545044},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3272217810153961},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.23790207505226135},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.21612539887428284},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16613554954528809},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.10670149326324463}],"concepts":[{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.9058864116668701},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.662095308303833},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.6475392580032349},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5795623660087585},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5643329620361328},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.5379546284675598},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4590117335319519},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4578685760498047},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39542460441589355},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3929691016674042},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36061811447143555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35256415605545044},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3272217810153961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23790207505226135},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.21612539887428284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16613554954528809},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10670149326324463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35657997","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35657997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e0fcfa62cf59455aae8171f4d44bc293","is_oa":true,"landing_page_url":"https://doaj.org/article/e0fcfa62cf59455aae8171f4d44bc293","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1010165 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9200364","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9200364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6399999856948853,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G5029822828","display_name":null,"funder_award_id":"R01HL148227","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5512787694","display_name":null,"funder_award_id":"DMS1953430","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5612561338","display_name":null,"funder_award_id":"MCB-2027530","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7048678561","display_name":null,"funder_award_id":"2027530","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8603510745","display_name":"Multipronged Modeling of Subcellular Self-Organization","funder_award_id":"1953430","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281780934.pdf","grobid_xml":"https://content.openalex.org/works/W4281780934.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1561240970","https://openalex.org/W1837364200","https://openalex.org/W1933219102","https://openalex.org/W1946177469","https://openalex.org/W1964523091","https://openalex.org/W1967696278","https://openalex.org/W1975648894","https://openalex.org/W1978319180","https://openalex.org/W1981343650","https://openalex.org/W1982903250","https://openalex.org/W1985499212","https://openalex.org/W1986789040","https://openalex.org/W1988791304","https://openalex.org/W1989582949","https://openalex.org/W1989925383","https://openalex.org/W1990300808","https://openalex.org/W1991721210","https://openalex.org/W1992487208","https://openalex.org/W1995940821","https://openalex.org/W2009228694","https://openalex.org/W2010310052","https://openalex.org/W2012737437","https://openalex.org/W2014089330","https://openalex.org/W2014765011","https://openalex.org/W2015005644","https://openalex.org/W2022178479","https://openalex.org/W2027329338","https://openalex.org/W2028436548","https://openalex.org/W2035482871","https://openalex.org/W2042321087","https://openalex.org/W2045658203","https://openalex.org/W2046451925","https://openalex.org/W2052801874","https://openalex.org/W2063334772","https://openalex.org/W2063766478","https://openalex.org/W2070333171","https://openalex.org/W2073881036","https://openalex.org/W2074413263","https://openalex.org/W2075909204","https://openalex.org/W2079987996","https://openalex.org/W2086461420","https://openalex.org/W2089736751","https://openalex.org/W2093508765","https://openalex.org/W2102673682","https://openalex.org/W2111053500","https://openalex.org/W2113613128","https://openalex.org/W2115378800","https://openalex.org/W2117177914","https://openalex.org/W2120375547","https://openalex.org/W2121182271","https://openalex.org/W2122087743","https://openalex.org/W2125659595","https://openalex.org/W2131113110","https://openalex.org/W2132680465","https://openalex.org/W2132898564","https://openalex.org/W2133553176","https://openalex.org/W2142226910","https://openalex.org/W2142430376","https://openalex.org/W2151643303","https://openalex.org/W2154513960","https://openalex.org/W2155418451","https://openalex.org/W2158469604","https://openalex.org/W2159412636","https://openalex.org/W2165822768","https://openalex.org/W2166080650","https://openalex.org/W2167127135","https://openalex.org/W2176681227","https://openalex.org/W2217038394","https://openalex.org/W2234920034","https://openalex.org/W2319282836","https://openalex.org/W2341109105","https://openalex.org/W2342161828","https://openalex.org/W2345583633","https://openalex.org/W2345911676","https://openalex.org/W2396522587","https://openalex.org/W2537573351","https://openalex.org/W2577847218","https://openalex.org/W2582965622","https://openalex.org/W2792238040","https://openalex.org/W2797454477","https://openalex.org/W2808597451","https://openalex.org/W2910305526","https://openalex.org/W2949763289","https://openalex.org/W2950765255","https://openalex.org/W3006399487","https://openalex.org/W3088192487","https://openalex.org/W3121738285","https://openalex.org/W3137233314","https://openalex.org/W3146913000","https://openalex.org/W3195659979","https://openalex.org/W3196320965","https://openalex.org/W3199283527","https://openalex.org/W4210331257","https://openalex.org/W4243666696","https://openalex.org/W4255712990","https://openalex.org/W4281567539"],"related_works":["https://openalex.org/W2002037873","https://openalex.org/W1586174670","https://openalex.org/W2009362775","https://openalex.org/W2002402022","https://openalex.org/W2075749722","https://openalex.org/W2495570492","https://openalex.org/W2473044667","https://openalex.org/W2944032129","https://openalex.org/W2088365533","https://openalex.org/W2154020701"],"abstract_inverted_index":{"We":[0,70,168],"introduce":[1],"a":[2,208],"Stochastic":[3],"Reaction-Diffusion-Dynamics":[4],"Model":[5],"(SRDDM)":[6],"for":[7,37,155],"simulations":[8],"of":[9,60,62,76,79,91,101,119,125,133,142,158,176,183,220,226,234],"cellular":[10],"mechanochemical":[11],"processes":[12],"with":[13,105],"high":[14],"spatial":[15,87],"and":[16,40,99,108,117,136,161,204,216,229],"temporal":[17],"resolution.":[18],"The":[19,131],"SRDDM":[20,72,113],"is":[21,172],"mapped":[22],"into":[23],"the":[24,29,44,58,77,112,115,128,143,150,156,181,184,194,213,221,224,232],"CellDynaMo":[25],"package,":[26],"which":[27,146,179],"couples":[28],"spatially":[30],"inhomogeneous":[31],"reaction-diffusion":[32],"master":[33],"equation":[34],"to":[35,49,73,127,191],"account":[36],"biochemical":[38],"reactions":[39,157],"molecular":[41,63],"transport":[42],"within":[43],"Langevin":[45],"Dynamics":[46],"(LD)":[47],"framework":[48],"describe":[50],"dynamic":[51,89],"mechanical":[52],"processes.":[53],"This":[54],"computational":[55],"infrastructure":[56],"allows":[57],"simulation":[59],"hours":[61],"machine":[64],"dynamics":[65],"in":[66,85,95,149],"reasonable":[67],"wall-clock":[68],"time.":[69],"apply":[71],"test":[74],"performance":[75],"Search-and-Capture":[78],"mitotic":[80],"spindle":[81,235],"assembly":[82],"by":[83,152,196],"simulating,":[84],"three":[86],"dimensions,":[88],"instability":[90],"elastic":[92],"microtubules":[93,126,222],"anchored":[94],"two":[96],"centrosomes,":[97],"movement":[98],"deformations":[100,206],"geometrically":[102],"realistic":[103],"centromeres":[104],"flexible":[106],"kinetochores":[107,192],"chromosome":[109,185,189,199],"arms.":[110],"Furthermore,":[111],"describes":[114],"mechanics":[116],"kinetics":[118],"Ndc80":[120,144],"linkers":[121],"mediating":[122],"transient":[123],"attachments":[124,135],"chromosomal":[129],"kinetochores.":[130],"rates":[132,225],"these":[134],"detachments":[137,178],"depend":[138],"upon":[139],"phosphorylation":[140],"states":[141],"linkers,":[145],"are":[147],"regulated":[148],"model":[151],"explicitly":[153],"accounting":[154],"Aurora":[159,202],"A":[160,203],"B":[162],"kinase":[163],"enzymes":[164],"undergoing":[165],"restricted":[166],"diffusion.":[167],"find":[169],"that":[170,187,201,217],"there":[171],"an":[173],"optimal":[174],"rate":[175],"microtubule-kinetochore":[177],"maximizes":[180],"accuracy":[182,195,233],"connections,":[186],"adding":[188],"arms":[190],"improve":[193,231],"slowing":[197],"down":[198],"movements,":[200],"kinetochore":[205,227],"have":[207],"small":[209],"positive":[210],"effect":[211],"on":[212],"attachment":[214],"accuracy,":[215],"thermal":[218],"fluctuations":[219],"increase":[223],"capture":[228],"also":[230],"assembly.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}