{"id":"https://openalex.org/W4307180476","doi":"https://doi.org/10.1371/journal.pcbi.1010153","title":"Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis","display_name":"Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis","publication_year":2022,"publication_date":"2022-10-24","ids":{"openalex":"https://openalex.org/W4307180476","doi":"https://doi.org/10.1371/journal.pcbi.1010153","pmid":"https://pubmed.ncbi.nlm.nih.gov/36279309"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010153","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010153","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006557939","display_name":"Rebecca G. Zitnay","orcid":"https://orcid.org/0000-0002-8911-9029"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca G. Zitnay","raw_affiliation_strings":["Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","Huntsman Cancer Institute, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8911-9029","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068160117","display_name":"Michael R. Herron","orcid":"https://orcid.org/0000-0002-6660-2464"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Herron","raw_affiliation_strings":["Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6660-2464","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019884370","display_name":"Keith R. Carney","orcid":null},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith R. Carney","raw_affiliation_strings":["Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073311385","display_name":"Scott Potter","orcid":"https://orcid.org/0000-0002-5641-1007"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Potter","raw_affiliation_strings":["Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America","Huntsman Cancer Institute, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5641-1007","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055819685","display_name":"Lyska L. Emerson","orcid":"https://orcid.org/0000-0002-2367-6578"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyska L. Emerson","raw_affiliation_strings":["Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America","Huntsman Cancer Institute, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2367-6578","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054820125","display_name":"Jeffrey A. Weiss","orcid":"https://orcid.org/0000-0002-7264-2454"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey A. Weiss","raw_affiliation_strings":["Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","Scientific Computing and Imaging Institute, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7264-2454","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Scientific Computing and Imaging Institute, Salt Lake City, Utah, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075201122","display_name":"Michelle C. Mendoza","orcid":"https://orcid.org/0000-0002-6490-1794"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle C. Mendoza","raw_affiliation_strings":["Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America","Huntsman Cancer Institute, Salt Lake City, Utah, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6490-1794","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Huntsman Cancer Institute, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5054820125","https://openalex.org/A5075201122"],"corresponding_institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5842,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61609788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"18","issue":"10","first_page":"e1010153","last_page":"e1010153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.7015405893325806},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.6470741629600525},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6020776033401489},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5539690852165222},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.5482029914855957},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5072972178459167},{"id":"https://openalex.org/keywords/alveolar-wall","display_name":"Alveolar Wall","score":0.49898648262023926},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.41552498936653137},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.41365963220596313},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37802982330322266},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26665520668029785},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.24793586134910583},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07520073652267456}],"concepts":[{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.7015405893325806},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6470741629600525},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6020776033401489},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5539690852165222},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5482029914855957},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5072972178459167},{"id":"https://openalex.org/C2908807708","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar Wall","level":3,"score":0.49898648262023926},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.41552498936653137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41365963220596313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37802982330322266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26665520668029785},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24793586134910583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07520073652267456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010153","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010153","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36279309","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36279309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ead9c3eff93c4d7e9bd85610e613f347","is_oa":true,"landing_page_url":"https://doaj.org/article/ead9c3eff93c4d7e9bd85610e613f347","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 10, p e1010153 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9632844","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9632844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010153","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010153","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1524521139","display_name":null,"funder_award_id":"Award Number P30CA042014","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3842455803","display_name":null,"funder_award_id":"U24EB029007","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4007174616","display_name":null,"funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G499401144","display_name":null,"funder_award_id":"RSG CSM130435","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G5241747136","display_name":null,"funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G5863154916","display_name":null,"funder_award_id":"R01GM083925","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8411495483","display_name":null,"funder_award_id":"CSM130435","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G8785564348","display_name":null,"funder_award_id":"R01CA255790","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1519294355","https://openalex.org/W1566703732","https://openalex.org/W1788732318","https://openalex.org/W1890402826","https://openalex.org/W1911732078","https://openalex.org/W1921845417","https://openalex.org/W1961544337","https://openalex.org/W1966871331","https://openalex.org/W1973767497","https://openalex.org/W1975132186","https://openalex.org/W1975727847","https://openalex.org/W1977381126","https://openalex.org/W1978164308","https://openalex.org/W1982268629","https://openalex.org/W1989095124","https://openalex.org/W1993099542","https://openalex.org/W1996505814","https://openalex.org/W2003305342","https://openalex.org/W2017950984","https://openalex.org/W2020817345","https://openalex.org/W2024722383","https://openalex.org/W2032019019","https://openalex.org/W2034261911","https://openalex.org/W2049674541","https://openalex.org/W2050694778","https://openalex.org/W2059569751","https://openalex.org/W2065432613","https://openalex.org/W2079347556","https://openalex.org/W2086244192","https://openalex.org/W2099052265","https://openalex.org/W2100331015","https://openalex.org/W2101728107","https://openalex.org/W2102052626","https://openalex.org/W2104947426","https://openalex.org/W2116043657","https://openalex.org/W2118997818","https://openalex.org/W2120645483","https://openalex.org/W2125766343","https://openalex.org/W2129270987","https://openalex.org/W2144611337","https://openalex.org/W2153010576","https://openalex.org/W2159566721","https://openalex.org/W2159731793","https://openalex.org/W2165845169","https://openalex.org/W2168139169","https://openalex.org/W2175915054","https://openalex.org/W2180481128","https://openalex.org/W2180503361","https://openalex.org/W2309573236","https://openalex.org/W2337773432","https://openalex.org/W2343408491","https://openalex.org/W2479062276","https://openalex.org/W2488256128","https://openalex.org/W2555999948","https://openalex.org/W2572293469","https://openalex.org/W2587816384","https://openalex.org/W2691615730","https://openalex.org/W2734318655","https://openalex.org/W2740909954","https://openalex.org/W2741543122","https://openalex.org/W2762514399","https://openalex.org/W2788966615","https://openalex.org/W2789065958","https://openalex.org/W2838855305","https://openalex.org/W2904211489","https://openalex.org/W2911188335","https://openalex.org/W2916599080","https://openalex.org/W2943990749","https://openalex.org/W2951696890","https://openalex.org/W2988699331","https://openalex.org/W3006010054","https://openalex.org/W3007255686","https://openalex.org/W3119767525","https://openalex.org/W3133793054","https://openalex.org/W3135187369","https://openalex.org/W3162089523","https://openalex.org/W3181829673","https://openalex.org/W3204985733","https://openalex.org/W4200581443","https://openalex.org/W6633658626"],"related_works":["https://openalex.org/W1967821671","https://openalex.org/W3030842346","https://openalex.org/W4307869277","https://openalex.org/W1969795570","https://openalex.org/W2125789691","https://openalex.org/W2063781606","https://openalex.org/W4290263427","https://openalex.org/W2060097039","https://openalex.org/W2055789824","https://openalex.org/W2788712402"],"abstract_inverted_index":{"Early":[0],"lung":[1,33,45,135,209,233],"cancer":[2,34],"lesions":[3,51,210],"develop":[4],"within":[5],"a":[6,232],"unique":[7],"microenvironment":[8],"that":[9,57,203,226,245],"undergoes":[10],"constant":[11],"cyclic":[12],"stretch":[13],"from":[14],"respiration.":[15],"While":[16],"tumor":[17,24,105,120,158,200,217,223,234,248],"stiffening":[18,75],"is":[19,35],"an":[20,58],"established":[21],"driver":[22],"of":[23,28,44,80,115,123,134,183,215,231],"progression,":[25],"the":[26,66,70,78,81,84,90,95,100,104,110,119,124,143,157,163,169,216,229],"contribution":[27],"stress":[29],"and":[30,88,130,222,235],"strain":[31,67,82,91,101,164,180,204,242],"to":[32,47,142,149,168,178],"unknown.":[36],"We":[37,55,186],"developed":[38],"tissue":[39,46],"scale":[40],"finite":[41],"element":[42],"models":[43],"test":[48],"how":[49],"early":[50,59,208],"alter":[52],"respiration-induced":[53],"strain.":[54,150],"found":[56],"tumor,":[60],"represented":[61],"as":[62],"alveolar":[63,72,86,125,152,238],"filling,":[64],"amplified":[65,179],"experienced":[68,102],"in":[69,83,103,128,176,190,206,236],"adjacent":[71,85,141,171],"walls.":[73,185],"Tumor":[74],"further":[76],"increased":[77,241],"amplitude":[79],"walls":[87,161,239],"extended":[89],"amplification":[92,116,165,205],"deeper":[93],"into":[94],"normal":[96],"lung.":[97],"In":[98],"contrast,":[99],"proper":[106],"was":[107],"less":[108],"than":[109],"applied":[111],"strain,":[112],"although":[113],"regions":[114],"appeared":[117],"at":[118,228],"edge.":[121],"Measurements":[122],"wall":[126,139,153],"thickness":[127],"clinical":[129,192],"mouse":[131],"model":[132],"samples":[133],"adenocarcinoma":[136],"(LUAD)":[137],"showed":[138],"thickening":[140,154,175],"tumors,":[144],"consistent":[145],"with":[146,159,198],"cellular":[147],"response":[148,177],"Modeling":[151],"by":[155],"encircling":[156],"thickened":[160,184],"moved":[162],"radially":[166],"outward,":[167],"next":[170],"alveolus.":[172],"Simulating":[173],"iterative":[174],"produced":[181],"tracks":[182,189,195],"observed":[187],"such":[188],"early-stage":[191],"samples.":[193],"The":[194,219],"were":[196],"populated":[197],"invading":[199],"cells,":[201],"suggesting":[202],"very":[207],"could":[211,246],"guide":[212],"pro-invasive":[213],"remodeling":[214],"microenvironment.":[218],"simulation":[220],"results":[221],"measurements":[224],"suggest":[225],"cells":[227],"edge":[230],"surrounding":[237],"experience":[240],"during":[243],"respiration":[244],"promote":[247],"progression.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
