{"id":"https://openalex.org/W4300690657","doi":"https://doi.org/10.1371/journal.pcbi.1010092","title":"Spatial models of pattern formation during phagocytosis","display_name":"Spatial models of pattern formation during phagocytosis","publication_year":2022,"publication_date":"2022-10-03","ids":{"openalex":"https://openalex.org/W4300690657","doi":"https://doi.org/10.1371/journal.pcbi.1010092","pmid":"https://pubmed.ncbi.nlm.nih.gov/36190993"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010092&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091846659","display_name":"J. Cody Herron","orcid":"https://orcid.org/0000-0001-6240-9950"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Cody Herron","raw_affiliation_strings":["Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044954439","display_name":"Shiqiong Hu","orcid":"https://orcid.org/0000-0001-8882-6859"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiqiong Hu","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084929153","display_name":"Bei Liu","orcid":"https://orcid.org/0000-0001-5979-3082"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bei Liu","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086804597","display_name":"Takashi Watanabe","orcid":"https://orcid.org/0000-0002-9015-5246"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Watanabe","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032731476","display_name":"Klaus M. Hahn","orcid":"https://orcid.org/0000-0002-1970-7562"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus M. Hahn","raw_affiliation_strings":["Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002387944","display_name":"Timothy C. Elston","orcid":"https://orcid.org/0000-0002-4601-2117"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy C. Elston","raw_affiliation_strings":["Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002387944"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2844,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76627461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"18","issue":"10","first_page":"e1010092","last_page":"e1010092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phagocytosis","display_name":"Phagocytosis","score":0.6858399510383606},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.68217933177948},{"id":"https://openalex.org/keywords/cdc42","display_name":"CDC42","score":0.5660939812660217},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5618252754211426},{"id":"https://openalex.org/keywords/podosome","display_name":"Podosome","score":0.5351762175559998},{"id":"https://openalex.org/keywords/rosette","display_name":"Rosette (schizont appearance)","score":0.5089564323425293},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5044883489608765},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.42791634798049927},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.42280250787734985},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34630894660949707},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.33574378490448},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.3076797127723694},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21255603432655334},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.20034551620483398},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.19476774334907532}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.6858399510383606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.68217933177948},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.5660939812660217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5618252754211426},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.5351762175559998},{"id":"https://openalex.org/C2781414804","wikidata":"https://www.wikidata.org/wiki/Q7368701","display_name":"Rosette (schizont appearance)","level":2,"score":0.5089564323425293},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5044883489608765},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.42791634798049927},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.42280250787734985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34630894660949707},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33574378490448},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3076797127723694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21255603432655334},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20034551620483398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19476774334907532}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36190993","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36190993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f7ee124af7934947bb6a3ae023d5663b","is_oa":true,"landing_page_url":"https://doaj.org/article/f7ee124af7934947bb6a3ae023d5663b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 10, p e1010092 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9560619","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9560619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1495302769","display_name":null,"funder_award_id":"GM067553","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2032071810","display_name":null,"funder_award_id":"R35GM127145","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3477252937","display_name":null,"funder_award_id":"U01 EB018816","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4433549427","display_name":null,"funder_award_id":"5T32 GM067553","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G502471280","display_name":null,"funder_award_id":"R35GM122596","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7408713538","display_name":null,"funder_award_id":"GM127145","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G971106953","display_name":null,"funder_award_id":"R35GM1225","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4300690657.pdf","grobid_xml":"https://content.openalex.org/works/W4300690657.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1628017834","https://openalex.org/W1871204376","https://openalex.org/W1964458331","https://openalex.org/W1965530701","https://openalex.org/W1977489066","https://openalex.org/W1980661496","https://openalex.org/W1985482228","https://openalex.org/W1993356393","https://openalex.org/W1995583822","https://openalex.org/W1995882349","https://openalex.org/W1997478649","https://openalex.org/W1999583932","https://openalex.org/W2000124962","https://openalex.org/W2015159529","https://openalex.org/W2019731805","https://openalex.org/W2031239234","https://openalex.org/W2039305326","https://openalex.org/W2042629182","https://openalex.org/W2054571151","https://openalex.org/W2056241473","https://openalex.org/W2069738082","https://openalex.org/W2071544114","https://openalex.org/W2074798811","https://openalex.org/W2081386033","https://openalex.org/W2089840306","https://openalex.org/W2089996830","https://openalex.org/W2098456336","https://openalex.org/W2109042184","https://openalex.org/W2110546082","https://openalex.org/W2112048948","https://openalex.org/W2115993724","https://openalex.org/W2129322844","https://openalex.org/W2132847744","https://openalex.org/W2133769266","https://openalex.org/W2134178604","https://openalex.org/W2136722399","https://openalex.org/W2144203350","https://openalex.org/W2148534890","https://openalex.org/W2152235865","https://openalex.org/W2152511989","https://openalex.org/W2157293287","https://openalex.org/W2162689493","https://openalex.org/W2164950092","https://openalex.org/W2167834648","https://openalex.org/W2266150212","https://openalex.org/W2340916214","https://openalex.org/W2405819699","https://openalex.org/W2429042322","https://openalex.org/W2510220479","https://openalex.org/W2512505748","https://openalex.org/W2581076644","https://openalex.org/W2582835905","https://openalex.org/W2601714044","https://openalex.org/W2763645127","https://openalex.org/W2775062021","https://openalex.org/W2781823456","https://openalex.org/W2791625137","https://openalex.org/W2944878488","https://openalex.org/W2949637625","https://openalex.org/W2950442623","https://openalex.org/W2950465077","https://openalex.org/W2950560399","https://openalex.org/W2950635409","https://openalex.org/W2951495812","https://openalex.org/W2954247282","https://openalex.org/W2983217157","https://openalex.org/W3001424757","https://openalex.org/W3003257820","https://openalex.org/W3034804330","https://openalex.org/W3043572320","https://openalex.org/W3082124340","https://openalex.org/W3101826276","https://openalex.org/W3103145119","https://openalex.org/W3134083665","https://openalex.org/W3159507420","https://openalex.org/W3174822025","https://openalex.org/W3206620110","https://openalex.org/W3210478861","https://openalex.org/W4283019933","https://openalex.org/W4288068574","https://openalex.org/W6676279030"],"related_works":["https://openalex.org/W399366602","https://openalex.org/W2046831018","https://openalex.org/W2133227578","https://openalex.org/W2416132370","https://openalex.org/W2101862679","https://openalex.org/W2060537876","https://openalex.org/W2156393369","https://openalex.org/W2099689616","https://openalex.org/W1986259688","https://openalex.org/W2889331747"],"abstract_inverted_index":{"Phagocytosis,":[0],"the":[1,18,47,50,58,62,90,97,107,114,152,165,185,198,229,235],"biological":[2],"process":[3],"in":[4,79,119,139],"which":[5,201],"cells":[6,68],"ingest":[7],"large":[8],"particles":[9],"such":[10],"as":[11],"bacteria,":[12],"is":[13,26,100,133],"a":[14,41,111,137,192],"key":[15],"component":[16],"of":[17,49,57,74,84,109,113,117,125,129,154,170,194,220],"innate":[19],"immune":[20],"response.":[21],"Fc\u03b3":[22],"receptor":[23,126],"(Fc\u03b3R)-mediated":[24],"phagocytosis":[25,81],"initiated":[27],"when":[28],"these":[29,161],"receptors":[30],"are":[31,225],"activated":[32,227],"after":[33],"binding":[34],"immunoglobulin":[35],"G":[36],"(IgG).":[37],"Receptor":[38],"activation":[39],"initiates":[40],"signaling":[42],"cascade":[43],"that":[44,77,95,105,174,224],"leads":[45],"to":[46,70,135,160,237,240],"formation":[48,177,214],"phagocytic":[51],"cup":[52],"and":[53,132,157],"culminates":[54],"with":[55],"ingestion":[56],"foreign":[59],"particle.":[60],"In":[61,184],"experimental":[63],"system":[64],"termed":[65],"\"frustrated":[66],"phagocytosis\",":[67],"attempt":[69],"internalize":[71],"micropatterned":[72],"disks":[73],"IgG.":[75],"Cells":[76],"engage":[78],"frustrated":[80],"form":[82],"\"rosettes\"":[83],"actin-enriched":[85],"structures":[86],"called":[87],"podosomes":[88],"around":[89,197],"IgG":[91,199,230],"disk.":[92],"The":[93,206],"mechanism":[94,208],"generates":[96],"rosette":[98,168,204],"pattern":[99,120,169,176],"unknown.":[101],"We":[102,149,172],"present":[103],"data":[104],"supports":[106],"involvement":[108],"Cdc42,":[110],"member":[112],"Rho":[115],"family":[116],"GTPases,":[118],"formation.":[121],"Cdc42":[122],"acts":[123],"downstream":[124],"activation,":[127],"upstream":[128],"actin":[130],"polymerization,":[131],"known":[134],"play":[136],"role":[138],"polarity":[140],"establishment.":[141],"Reaction-diffusion":[142],"models":[143,162,236],"for":[144],"GTPase":[145],"spatiotemporal":[146],"dynamics":[147],"exist.":[148],"demonstrate":[150],"how":[151],"addition":[153],"negative":[155],"feedback":[156],"minor":[158],"changes":[159],"can":[163,178],"generate":[164],"experimentally":[166],"observed":[167],"podosomes.":[171],"show":[173],"this":[175],"occur":[179],"through":[180],"two":[181],"general":[182],"mechanisms.":[183],"first":[186],"mechanism,":[187],"an":[188],"intermediate":[189,221],"species":[190,223],"forms":[191],"ring":[193,213],"high":[195],"activity":[196],"disk,":[200],"then":[202],"promotes":[203],"organization.":[205],"second":[207],"does":[209],"not":[210],"require":[211],"initial":[212],"but":[215],"relies":[216],"on":[217],"spatial":[218],"gradients":[219],"chemical":[222],"selectively":[226],"over":[228],"patch.":[231],"Finally,":[232],"we":[233],"analyze":[234],"suggest":[238],"experiments":[239],"test":[241],"their":[242],"validity.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}