{"id":"https://openalex.org/W4224227704","doi":"https://doi.org/10.1371/journal.pcbi.1010071","title":"Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons","display_name":"Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons","publication_year":2022,"publication_date":"2022-04-22","ids":{"openalex":"https://openalex.org/W4224227704","doi":"https://doi.org/10.1371/journal.pcbi.1010071","pmid":"https://pubmed.ncbi.nlm.nih.gov/35452457"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010071","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010071","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010071&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010071&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057420531","display_name":"Daniele Linaro","orcid":"https://orcid.org/0000-0001-8751-0350"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Daniele Linaro","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8751-0350","affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025729892","display_name":"Matthew J. Levy","orcid":"https://orcid.org/0000-0002-3502-0605"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Levy","raw_affiliation_strings":["Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United State of America"],"raw_orcid":"https://orcid.org/0000-0002-3502-0605","affiliations":[{"raw_affiliation_string":"Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038365863","display_name":"David Hunt","orcid":"https://orcid.org/0000-0002-7567-5649"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Hunt","raw_affiliation_strings":["Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, United State of America"],"raw_orcid":"https://orcid.org/0000-0002-7567-5649","affiliations":[{"raw_affiliation_string":"Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038365863","https://openalex.org/A5057420531"],"corresponding_institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I93860229"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6483,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82614492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"4","first_page":"e1010071","last_page":"e1010071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.546038031578064},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.531990647315979},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5008471012115479},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4613935947418213},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4600294828414917},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4541475474834442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4347190856933594},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.2845080494880676},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09094449877738953}],"concepts":[{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.546038031578064},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.531990647315979},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5008471012115479},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4613935947418213},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4600294828414917},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4541475474834442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4347190856933594},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2845080494880676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09094449877738953},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056654","descriptor_name":"CA3 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056654","descriptor_name":"CA3 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056654","descriptor_name":"CA3 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010071","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010071","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010071&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35452457","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35452457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1010071","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010071","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:57cde475e7044fcebd9ecef8797289b0","is_oa":true,"landing_page_url":"https://doaj.org/article/57cde475e7044fcebd9ecef8797289b0","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 4, p e1010071 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9089861","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9089861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010071","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010071","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010071&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224227704.pdf","grobid_xml":"https://content.openalex.org/works/W4224227704.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W954230352","https://openalex.org/W1543878663","https://openalex.org/W1606104224","https://openalex.org/W1770958704","https://openalex.org/W1781851852","https://openalex.org/W1836848727","https://openalex.org/W1875306972","https://openalex.org/W1921182138","https://openalex.org/W1940417817","https://openalex.org/W1966907489","https://openalex.org/W1968687601","https://openalex.org/W1970716201","https://openalex.org/W1975117887","https://openalex.org/W1989932452","https://openalex.org/W1999838582","https://openalex.org/W2000066873","https://openalex.org/W2004921550","https://openalex.org/W2008027377","https://openalex.org/W2017957151","https://openalex.org/W2024721108","https://openalex.org/W2025687881","https://openalex.org/W2033125075","https://openalex.org/W2038603307","https://openalex.org/W2041507388","https://openalex.org/W2065188087","https://openalex.org/W2068904459","https://openalex.org/W2076524128","https://openalex.org/W2083604548","https://openalex.org/W2095478325","https://openalex.org/W2100260601","https://openalex.org/W2101234009","https://openalex.org/W2102509567","https://openalex.org/W2107165322","https://openalex.org/W2109042184","https://openalex.org/W2111162236","https://openalex.org/W2114771311","https://openalex.org/W2124354910","https://openalex.org/W2125421120","https://openalex.org/W2127389037","https://openalex.org/W2129902114","https://openalex.org/W2132854652","https://openalex.org/W2133128074","https://openalex.org/W2149246533","https://openalex.org/W2154323800","https://openalex.org/W2163294786","https://openalex.org/W2164811687","https://openalex.org/W2166181456","https://openalex.org/W2168025484","https://openalex.org/W2168267501","https://openalex.org/W2179438025","https://openalex.org/W2238721744","https://openalex.org/W2278712272","https://openalex.org/W2338375276","https://openalex.org/W2561068888","https://openalex.org/W2751166226","https://openalex.org/W2800392236","https://openalex.org/W2805469146","https://openalex.org/W2807113328","https://openalex.org/W2808556497","https://openalex.org/W2889897651","https://openalex.org/W2890638274","https://openalex.org/W2897249806","https://openalex.org/W2902652978","https://openalex.org/W2911737192","https://openalex.org/W2914346278","https://openalex.org/W2940712369","https://openalex.org/W2951043812","https://openalex.org/W2963554196","https://openalex.org/W2963620174","https://openalex.org/W2982679883","https://openalex.org/W3015385604","https://openalex.org/W3028320395","https://openalex.org/W3099967679","https://openalex.org/W3106188259","https://openalex.org/W3110917833","https://openalex.org/W3162218953","https://openalex.org/W3205424648","https://openalex.org/W4214775604","https://openalex.org/W4290769203","https://openalex.org/W6675354045","https://openalex.org/W6676279030"],"related_works":["https://openalex.org/W2035947495","https://openalex.org/W2093087336","https://openalex.org/W2042263265","https://openalex.org/W1507350045","https://openalex.org/W2061212356","https://openalex.org/W2802231275","https://openalex.org/W851926024","https://openalex.org/W2804329247","https://openalex.org/W1971280907","https://openalex.org/W2897057615"],"abstract_inverted_index":{"The":[0],"transformation":[1],"of":[2,19,28,43,74,102,106,127,196,207,217,240],"synaptic":[3,201],"input":[4,202],"into":[5],"action":[6],"potential":[7],"output":[8,198],"is":[9],"a":[10,80,94,215,241],"fundamental":[11],"single-cell":[12,172],"computation":[13],"resulting":[14],"from":[15],"the":[16,24,33,41,44,69,114,125,137,144,149,155,160,176,187,194,224,229,238],"complex":[17],"interaction":[18],"distinct":[20],"cellular":[21,34,75,230],"morphology":[22],"and":[23,88,130,142,233],"unique":[25],"expression":[26],"profile":[27],"ion":[29,168],"channels":[30],"that":[31,119,132,154,222],"define":[32,223],"phenotype.":[35],"Experimental":[36],"studies":[37],"aimed":[38],"at":[39],"uncovering":[40],"mechanisms":[42,221],"transfer":[45,210,231],"function":[46,232],"have":[47],"led":[48],"to":[49,67,98,185,227],"important":[50],"insights,":[51],"yet":[52],"are":[53,163],"limited":[54],"in":[55,71,148,171,193,237,245],"scope":[56],"by":[57,83,159,200],"technical":[58],"feasibility,":[59],"making":[60],"biophysical":[61,190,220],"simulations":[62,213],"an":[63,204],"attractive":[64],"complementary":[65],"approach":[66,82,134],"push":[68],"boundaries":[70],"our":[72,133],"understanding":[73],"computation.":[76],"Here":[77],"we":[78,152],"take":[79],"data-driven":[81],"utilizing":[84],"high-resolution":[85],"morphological":[86],"reconstructions":[87],"patch-clamp":[89],"electrophysiology":[90],"data":[91,174],"together":[92],"with":[93,165],"multi-objective":[95],"optimization":[96,161],"algorithm":[97,162],"build":[99],"two":[100,115,177],"populations":[101],"biophysically":[103],"detailed":[104],"models":[105,129,184],"murine":[107],"hippocampal":[108],"CA3":[109,246],"pyramidal":[110],"neurons":[111],"based":[112],"on":[113],"principal":[116],"cell":[117,138,178,188,218],"types":[118],"comprise":[120],"this":[121],"region.":[122],"We":[123,180],"evaluated":[124],"performance":[126],"these":[128,183,235],"find":[131],"quantitatively":[135],"matches":[136],"type-specific":[139,189,219],"firing":[140],"phenotypes":[141],"recapitulate":[143],"intrinsic":[145],"population-level":[146],"variability":[147],"data.":[150],"Moreover,":[151],"confirm":[153],"conductance":[156],"values":[157],"found":[158],"consistent":[164],"differentially":[166],"expressed":[167],"channel":[169],"genes":[170],"transcriptomic":[173],"for":[175,243],"types.":[179],"then":[181],"use":[182],"investigate":[186],"properties":[191],"involved":[192],"generation":[195],"complex-spiking":[197],"driven":[199],"through":[203],"information-theoretic":[205],"treatment":[206],"their":[208],"respective":[209],"functions.":[211],"Our":[212],"identify":[214],"host":[216],"morpho-functional":[225],"phenotype":[226],"shape":[228],"place":[234],"findings":[236],"context":[239],"role":[242],"bursting":[244],"recurrent":[247],"network":[248],"synchronization":[249],"dynamics.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}