{"id":"https://openalex.org/W4220773386","doi":"https://doi.org/10.1371/journal.pcbi.1010030","title":"Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design","display_name":"Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4220773386","doi":"https://doi.org/10.1371/journal.pcbi.1010030","pmid":"https://pubmed.ncbi.nlm.nih.gov/35363778"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010030","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010030&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010030&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091848896","display_name":"Damiano Fassina","orcid":"https://orcid.org/0000-0002-0560-6111"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Damiano Fassina","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, United Kingdom","School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059808191","display_name":"Caroline Mendon\u00e7a Costa","orcid":"https://orcid.org/0000-0002-9046-003X"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline M. Costa","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071305139","display_name":"Stefano Longobardi","orcid":"https://orcid.org/0000-0002-0111-0047"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefano Longobardi","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086347334","display_name":"Elias Karabelas","orcid":"https://orcid.org/0000-0002-4496-1933"},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Elias Karabelas","raw_affiliation_strings":["Institute of Mathematics & Scientific Computing, University of Graz, Graz, Austria"],"affiliations":[{"raw_affiliation_string":"Institute of Mathematics & Scientific Computing, University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012616951","display_name":"Gernot Plank","orcid":"https://orcid.org/0000-0002-7380-6908"},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gernot Plank","raw_affiliation_strings":["Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division Biophysics, Medical University of Graz, Graz, Austria"],"affiliations":[{"raw_affiliation_string":"Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division Biophysics, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055266997","display_name":"Si\u00e2n E. Harding","orcid":"https://orcid.org/0000-0002-3651-6354"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sian E. Harding","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000435552","display_name":"Steven Niederer","orcid":"https://orcid.org/0000-0002-4612-6982"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven A. Niederer","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5091848896"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.4863,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.92968906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"4","first_page":"e1010030","last_page":"e1010030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5517786741256714},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.5435031652450562},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5243228673934937},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.5053194165229797},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.4692763090133667},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.4686051607131958},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4623810648918152},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.4293265640735626},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3686695694923401},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29621368646621704},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2660590410232544},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.19229811429977417}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5517786741256714},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5435031652450562},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5243228673934937},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5053194165229797},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4692763090133667},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.4686051607131958},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4623810648918152},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4293265640735626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3686695694923401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29621368646621704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2660590410232544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19229811429977417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1010030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010030","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010030&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35363778","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35363778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/566dd228-e9cb-4044-87d0-027db6aae962","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/566dd228-e9cb-4044-87d0-027db6aae962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fassina, D, Costa, C M, Longobardi, S, Karabelas, E, Plank, G, Harding, S E & Niederer, S A 2022, 'Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design', PLoS Computational Biology, vol. 18, no. 4, e1010030. https://doi.org/10.1371/journal.pcbi.1010030","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:5fbdad1b48774d249685a288a0322e37","is_oa":true,"landing_page_url":"https://doaj.org/article/5fbdad1b48774d249685a288a0322e37","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 4, p e1010030 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9007348","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9007348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010030","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010030&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.550000011920929,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1251496372","display_name":null,"funder_award_id":"EP/P01268X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1322964166","display_name":null,"funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2702669842","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G3870200508","display_name":null,"funder_award_id":"A000049","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G427633563","display_name":null,"funder_award_id":"SP/18/6/33805","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5061473542","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G5808058046","display_name":null,"funder_award_id":"MR/L012618/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5907639349","display_name":null,"funder_award_id":"203148","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6597195141","display_name":null,"funder_award_id":"RM/17/1/33377","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G677384440","display_name":null,"funder_award_id":"20314","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G7044186993","display_name":null,"funder_award_id":"PG/15/91/31812","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7533812842","display_name":null,"funder_award_id":"PG/13/37/30280","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7650934720","display_name":null,"funder_award_id":"EP/M012492/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7967443389","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G799444527","display_name":null,"funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G8433875941","display_name":null,"funder_award_id":"BHF RM/17/1/33377","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320321058","display_name":"King's Health Partners","ror":"https://ror.org/01xcsye48"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220773386.pdf","grobid_xml":"https://content.openalex.org/works/W4220773386.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W1514256992","https://openalex.org/W1577789931","https://openalex.org/W1902126572","https://openalex.org/W1974119618","https://openalex.org/W1975550208","https://openalex.org/W1976419485","https://openalex.org/W1982880087","https://openalex.org/W1991288228","https://openalex.org/W1996092871","https://openalex.org/W2006277797","https://openalex.org/W2008168419","https://openalex.org/W2009316106","https://openalex.org/W2014514899","https://openalex.org/W2015172641","https://openalex.org/W2021903123","https://openalex.org/W2025900960","https://openalex.org/W2048015545","https://openalex.org/W2055747608","https://openalex.org/W2057774981","https://openalex.org/W2064227310","https://openalex.org/W2069397448","https://openalex.org/W2070722083","https://openalex.org/W2074789845","https://openalex.org/W2078242986","https://openalex.org/W2080192524","https://openalex.org/W2081212418","https://openalex.org/W2081498718","https://openalex.org/W2088765131","https://openalex.org/W2096237299","https://openalex.org/W2098044063","https://openalex.org/W2098276166","https://openalex.org/W2101589741","https://openalex.org/W2104881731","https://openalex.org/W2106649982","https://openalex.org/W2107124153","https://openalex.org/W2112279366","https://openalex.org/W2115765852","https://openalex.org/W2118478353","https://openalex.org/W2124929662","https://openalex.org/W2125987139","https://openalex.org/W2127787997","https://openalex.org/W2127883447","https://openalex.org/W2128085444","https://openalex.org/W2130321115","https://openalex.org/W2132670047","https://openalex.org/W2137543837","https://openalex.org/W2138203975","https://openalex.org/W2149516335","https://openalex.org/W2161810647","https://openalex.org/W2174396676","https://openalex.org/W2244501064","https://openalex.org/W2280539066","https://openalex.org/W2477853234","https://openalex.org/W2552242055","https://openalex.org/W2558042067","https://openalex.org/W2581103430","https://openalex.org/W2729331518","https://openalex.org/W2752348623","https://openalex.org/W2761278051","https://openalex.org/W2763140785","https://openalex.org/W2781937105","https://openalex.org/W2791281444","https://openalex.org/W2794616878","https://openalex.org/W2797243013","https://openalex.org/W2799792856","https://openalex.org/W2799881750","https://openalex.org/W2802139387","https://openalex.org/W2803772876","https://openalex.org/W2885264717","https://openalex.org/W2892304681","https://openalex.org/W2898458682","https://openalex.org/W2901531538","https://openalex.org/W2911534815","https://openalex.org/W2912164115","https://openalex.org/W2925392792","https://openalex.org/W2927449931","https://openalex.org/W2954018739","https://openalex.org/W2962098197","https://openalex.org/W2973147083","https://openalex.org/W2999317379","https://openalex.org/W3026223623","https://openalex.org/W3046823956","https://openalex.org/W3091565618","https://openalex.org/W3111407427","https://openalex.org/W3164422518","https://openalex.org/W3190928756","https://openalex.org/W3212410380","https://openalex.org/W4240747920","https://openalex.org/W4306319652","https://openalex.org/W6679245879","https://openalex.org/W6764929632"],"related_works":["https://openalex.org/W2274750791","https://openalex.org/W2055549109","https://openalex.org/W1968555577","https://openalex.org/W2748521320","https://openalex.org/W2006154469","https://openalex.org/W203924752","https://openalex.org/W2119568772","https://openalex.org/W2070106059","https://openalex.org/W4235186062","https://openalex.org/W651281245"],"abstract_inverted_index":{"Application":[0],"of":[1,83,99,123,128,155,161,246,255,459],"epicardial":[2,138],"patches":[3,35,365],"constructed":[4],"from":[5,294],"human-induced":[6],"pluripotent":[7],"stem":[8],"cell-":[9],"derived":[10],"cardiomyocytes":[11],"(hiPSC-CMs)":[12],"has":[13],"been":[14],"proposed":[15],"as":[16,152,325,421],"a":[17,41,45,76,124,145,153,159,199,336],"long-term":[18],"therapy":[19],"to":[20,56,62,70,79,104,204,250,284,296,313,329,341,346],"treat":[21],"scarred":[22],"hearts":[23],"post":[24],"myocardial":[25],"infarction":[26],"(MI).":[27],"Understanding":[28],"electrical":[29,52,87],"interaction":[30,360],"between":[31,361,386],"engineered":[32],"heart":[33,59],"tissue":[34,60,377],"(EHT)":[36],"and":[37,109,144,166,170,188,223,231,258,267,305,317,363,376,379,389,416,457],"host":[38,58,129,362],"myocardium":[39],"represents":[40],"key":[42],"step":[43],"toward":[44],"successful":[46],"patch":[47,84,101,139,149,167,235,395],"engraftment.":[48],"EHT":[49,234,278,292,315,321,343,364,394,411,419,435],"retain":[50],"different":[51,100],"properties":[53,108,412],"with":[54,158],"respect":[55],"the":[57,63,81,90,111,141,206,212,219,226,233,238,244,282,320,359,406,418,422],"due":[61],"hiPSC-CMs":[64,451],"immature":[65],"phenotype,":[66],"which":[67,277],"may":[68,440,461],"lead":[69],"increased":[71,342,347],"arrhythmia":[72,310,338],"risk.":[73,114],"We":[74,93,115,179,197,242,261,275,351,371,427],"developed":[75,116],"modelling":[77],"framework":[78,356],"examine":[80],"influence":[82],"design":[85,102,279],"on":[86,397,450],"activation":[88,107,301,414,432,464],"at":[89],"engraftment":[91],"site.":[92],"performed":[94,198],"an":[95,117,134,137,326],"in":[96,118,302,367,368],"silico":[97,119],"investigation":[98],"approaches":[103],"restore":[105,285,462],"pre-MI":[106,463],"evaluated":[110],"associated":[112],"arrhythmic":[113,442],"cardiac":[120],"electrophysiology":[121],"model":[122,132,177,182,401,446],"transmural":[125,409],"cross":[126],"section":[127],"myocardium.":[130,260],"The":[131,148],"featured":[133],"infarct":[135,142],"region,":[136],"spanning":[140],"region":[143],"bath":[146],"region.":[147],"is":[150,215,228,240,408,437],"modelled":[151],"layer":[154,160],"hiPSC-CM,":[156],"combined":[157],"conductive":[162],"polymer":[163],"(CP).":[164],"Tissue":[165],"geometrical":[168],"dimensions":[169],"conductivities":[171],"were":[172],"incorporated":[173],"through":[174],"10":[175],"modifiable":[176],"parameters.":[178],"validated":[180],"our":[181,354,445],"against":[183],"4":[184],"independent":[185],"experimental":[186],"studies":[187,249],"showed":[189,372],"that":[190,211,263,290,353,373,403,429,448],"it":[191],"can":[192],"qualitatively":[193],"reproduce":[194],"their":[195],"findings.":[196],"global":[200],"sensitivity":[201,269],"analysis":[202],"(GSA)":[203],"isolate":[205],"most":[207],"important":[208],"parameters,":[209],"showing":[210],"stimulus":[213,264],"propagation":[214,265],"mainly":[216],"governed":[217],"by":[218,232,252,433],"scar":[220,227,239,407],"depth,":[221],"radius":[222],"conductivity":[224,236,293,316,344,420,436],"when":[225,237,405],"not":[229,392,466],"transmural,":[230],"transmural.":[241],"assessed":[243,309],"relevance":[245],"small":[247,380,387],"animal":[248],"humans":[251,390],"comparing":[253],"simulations":[254],"rat,":[256,303],"rabbit":[257,304],"human":[259],"found":[262],"paths":[266],"GSA":[268],"indices":[270],"are":[271],"consistent":[272],"across":[273],"species.":[274],"explored":[276],"variables":[280],"have":[281],"potential":[283,454],"physiological":[286,300,431],"propagation.":[287,426],"Simulations":[288],"predict":[289],"increasing":[291,314,319],"0.28":[295],"1-1.1":[297],"S/m":[298],"recovered":[299],"human.":[306],"Finally,":[307,444],"we":[308],"risk":[311,339],"related":[312],"tested":[318],"Na+":[322,348],"channel":[323,349],"density":[324],"alternative":[327],"strategy":[328],"match":[330],"healthy":[331],"activation.":[332],"Our":[333,400],"results":[334],"revealed":[335,402],"greater":[337],"linked":[340],"compared":[345],"density.":[350],"demonstrated":[352],"modeling":[355],"could":[357],"capture":[358],"observed":[366],"vitro":[369],"experiments.":[370],"large":[374],"(patch":[375],"dimensions)":[378],"(cardiac":[381],"myocyte":[382],"electrophysiology)":[383],"scale":[384],"differences":[385],"animals":[388],"do":[391,410],"alter":[393],"effect":[396],"infarcted":[398],"tissue.":[399],"only":[404],"impact":[413],"times":[415],"isolated":[417],"main":[423],"parameter":[424],"influencing":[425],"predicted":[428],"restoring":[430],"tuning":[434],"possible":[438],"but":[439],"promote":[441],"behavior.":[443],"suggests":[447],"acting":[449],"low":[452],"action":[453],"upstroke":[455],"velocity":[456],"lack":[458],"IK1":[460],"while":[465],"promoting":[467],"arrhythmia.":[468]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
