{"id":"https://openalex.org/W4214657749","doi":"https://doi.org/10.1371/journal.pcbi.1009918","title":"In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms","display_name":"In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms","publication_year":2022,"publication_date":"2022-02-28","ids":{"openalex":"https://openalex.org/W4214657749","doi":"https://doi.org/10.1371/journal.pcbi.1009918","pmid":"https://pubmed.ncbi.nlm.nih.gov/35226669"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009918","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009918","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053897573","display_name":"Matteo D\u2019Antonio","orcid":"https://orcid.org/0000-0001-5844-6433"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matteo D\u2019Antonio","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5844-6433","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018731463","display_name":"Jennifer Nguyen","orcid":"https://orcid.org/0000-0001-7019-0311"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer P. Nguyen","raw_affiliation_strings":["Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, United States of America","Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7019-0311","affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040806177","display_name":"Timothy D. Arthur","orcid":"https://orcid.org/0000-0002-3393-1691"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy D. Arthur","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, United States of America","Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3393-1691","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110186603","display_name":"Hiroko Matsui","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroko Matsui","raw_affiliation_strings":["Institute of Genomic Medicine, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genomic Medicine, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060468814","display_name":"Margaret K. R. Donovan","orcid":"https://orcid.org/0000-0001-5240-4216"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret K. R. Donovan","raw_affiliation_strings":["Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, United States of America","Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087501884","display_name":"Agnieszka D\u2019Antonio\u2010Chronowska","orcid":"https://orcid.org/0000-0003-1653-4106"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnieszka D\u2019Antonio-Chronowska","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1653-4106","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083421459","display_name":"Kelly A. Frazer","orcid":"https://orcid.org/0000-0002-6060-8902"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kelly A. Frazer","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America","Institute of Genomic Medicine, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6060-8902","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Genomic Medicine, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5083421459"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.4718,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.93875164,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"e1009918","last_page":"e1009918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.795304536819458},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7374435067176819},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.6613633036613464},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6199448108673096},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.5905947089195251},{"id":"https://openalex.org/keywords/fetus","display_name":"Fetus","score":0.5835039615631104},{"id":"https://openalex.org/keywords/heart-development","display_name":"Heart development","score":0.5696284770965576},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.5372910499572754},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4589709937572479},{"id":"https://openalex.org/keywords/rna-binding-protein","display_name":"RNA-binding protein","score":0.4295167624950409},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4272557497024536},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.37854188680648804},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3581794202327728},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2856435477733612},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2850431799888611},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15918675065040588}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.795304536819458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7374435067176819},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6613633036613464},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6199448108673096},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5905947089195251},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5835039615631104},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.5696284770965576},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5372910499572754},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4589709937572479},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4295167624950409},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4272557497024536},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.37854188680648804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3581794202327728},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2856435477733612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2850431799888611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15918675065040588},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009918","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009918","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35226669","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35226669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:9db7d6f61c9c4402989534ec503a0a50","is_oa":true,"landing_page_url":"https://doaj.org/article/9db7d6f61c9c4402989534ec503a0a50","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009918 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3tn2d5mk","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3tn2d5mk","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 18, iss 2","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8912908","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8912908","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009918","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009918","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"awards":[{"id":"https://openalex.org/G1413867369","display_name":null,"funder_award_id":"HG008118","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2007589374","display_name":null,"funder_award_id":"1728497","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G2564695853","display_name":null,"funder_award_id":"GC1R-06673","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"},{"id":"https://openalex.org/G3467074946","display_name":null,"funder_award_id":"1728497","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4568296995","display_name":null,"funder_award_id":"HL107442","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4806452686","display_name":null,"funder_award_id":"HG008118","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5547883867","display_name":null,"funder_award_id":"F31HL158198","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5642672705","display_name":null,"funder_award_id":"T15LM011271","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6512042090","display_name":null,"funder_award_id":"1728497","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"},{"id":"https://openalex.org/G6975055142","display_name":null,"funder_award_id":"GC1R-06673-B","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"},{"id":"https://openalex.org/G7724644928","display_name":null,"funder_award_id":"T15LM011271","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8514233497","display_name":null,"funder_award_id":"HL107442","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G932654426","display_name":null,"funder_award_id":"F31HL158198","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1669479280","https://openalex.org/W1907511822","https://openalex.org/W1938218641","https://openalex.org/W1968919723","https://openalex.org/W1970288681","https://openalex.org/W1980176728","https://openalex.org/W1992481904","https://openalex.org/W1999574084","https://openalex.org/W1999932351","https://openalex.org/W2001045428","https://openalex.org/W2002365858","https://openalex.org/W2008746873","https://openalex.org/W2010136740","https://openalex.org/W2014677321","https://openalex.org/W2019928317","https://openalex.org/W2021812886","https://openalex.org/W2030796951","https://openalex.org/W2052959842","https://openalex.org/W2059060273","https://openalex.org/W2059603567","https://openalex.org/W2065756643","https://openalex.org/W2066828912","https://openalex.org/W2067244481","https://openalex.org/W2078948712","https://openalex.org/W2086294280","https://openalex.org/W2087368781","https://openalex.org/W2102071784","https://openalex.org/W2105694586","https://openalex.org/W2111814811","https://openalex.org/W2117476795","https://openalex.org/W2117565279","https://openalex.org/W2121996218","https://openalex.org/W2122358139","https://openalex.org/W2122760939","https://openalex.org/W2124144440","https://openalex.org/W2124631820","https://openalex.org/W2128505445","https://openalex.org/W2130116522","https://openalex.org/W2130410032","https://openalex.org/W2139834186","https://openalex.org/W2141287548","https://openalex.org/W2148134248","https://openalex.org/W2157286838","https://openalex.org/W2161633633","https://openalex.org/W2168235673","https://openalex.org/W2168324813","https://openalex.org/W2169456326","https://openalex.org/W2170874249","https://openalex.org/W2189596073","https://openalex.org/W2285541813","https://openalex.org/W2325022937","https://openalex.org/W2415174329","https://openalex.org/W2465917013","https://openalex.org/W2500316083","https://openalex.org/W2528173482","https://openalex.org/W2555508223","https://openalex.org/W2559791563","https://openalex.org/W2570362976","https://openalex.org/W2582453508","https://openalex.org/W2604155358","https://openalex.org/W2605339538","https://openalex.org/W2612976808","https://openalex.org/W2621066222","https://openalex.org/W2632422275","https://openalex.org/W2671227891","https://openalex.org/W2738013061","https://openalex.org/W2742750831","https://openalex.org/W2747877289","https://openalex.org/W2782360860","https://openalex.org/W2788579133","https://openalex.org/W2791289934","https://openalex.org/W2791414150","https://openalex.org/W2791628775","https://openalex.org/W2794480084","https://openalex.org/W2796473433","https://openalex.org/W2855985248","https://openalex.org/W2883480695","https://openalex.org/W2894291799","https://openalex.org/W2894687190","https://openalex.org/W2898598946","https://openalex.org/W2900644541","https://openalex.org/W2942610007","https://openalex.org/W2950239555","https://openalex.org/W2950891099","https://openalex.org/W2952100718","https://openalex.org/W2958340383","https://openalex.org/W2963977057","https://openalex.org/W2966017196","https://openalex.org/W2972319909","https://openalex.org/W2976869240","https://openalex.org/W2981886509","https://openalex.org/W2992352308","https://openalex.org/W2994994786","https://openalex.org/W2997442991","https://openalex.org/W3004299218","https://openalex.org/W3008983522","https://openalex.org/W3017283277","https://openalex.org/W3025989739","https://openalex.org/W3029402610","https://openalex.org/W3033728751","https://openalex.org/W3046003662","https://openalex.org/W3087692064","https://openalex.org/W3119971867","https://openalex.org/W3133859624","https://openalex.org/W3216158734","https://openalex.org/W4226263545"],"related_works":["https://openalex.org/W2941210649","https://openalex.org/W2904939684","https://openalex.org/W2321791250","https://openalex.org/W2012312817","https://openalex.org/W4213427798","https://openalex.org/W2081598294","https://openalex.org/W3010322897","https://openalex.org/W2056672569","https://openalex.org/W2090969926","https://openalex.org/W4385462331"],"abstract_inverted_index":{"Reactivation":[0],"of":[1,31,62,77,98,105,114,220],"fetal-specific":[2,106,116,157],"genes":[3,227],"and":[4,15,47,59,87,89,110,126,182,203,224,228,234],"isoforms":[5,132,158],"occurs":[6,24],"during":[7,205],"heart":[8,48,82,124,143,206,225,243],"failure.":[9,244],"However,":[10],"the":[11,16,20,74,99,111,120,146],"underlying":[12],"molecular":[13],"mechanisms":[14],"extent":[17],"to":[18,119,145,163,170,209,238],"which":[19,230],"fetal":[21,63,196],"program":[22],"switch":[23],"remains":[25],"unclear.":[26],"Limitations":[27],"hindering":[28],"transcriptome-wide":[29],"analyses":[30],"alternative":[32],"splicing":[33],"differences":[34,122],"(i.e.":[35],"isoform":[36],"switching)":[37],"in":[38,142],"cardiovascular":[39,92],"system":[40],"(CVS)":[41],"tissues":[42],"between":[43,123],"fetal,":[44],"healthy":[45,84,127,194],"adult":[46,85,128],"failure":[49,125,144,207],"have":[50,72,164,175],"included":[51],"both":[52],"cellular":[53,75],"heterogeneity":[54],"across":[55],"bulk":[56],"RNA-seq":[57,79],"samples":[58,80],"limited":[60],"availability":[61],"tissue":[64,198],"for":[65,133,242],"research.":[66],"To":[67],"overcome":[68],"these":[69],"limitations,":[70],"we":[71,216],"deconvoluted":[73],"compositions":[76],"996":[78],"representing":[81],"failure,":[83],"(heart":[86],"arteria),":[88],"fetal-like":[90,147],"(iPSC-derived":[91],"progenitor":[93],"cells)":[94],"CVS":[95],"tissues.":[96],"Comparison":[97],"expression":[100,148],"profiles":[101],"revealed":[102],"that":[103,140,161,191,204],"reactivation":[104],"RNA-binding":[107],"proteins":[108,160],"(RBPs),":[109],"accompanied":[112],"re-expression":[113],"1,523":[115],"isoforms,":[117,156,229],"contribute":[118],"transcriptome":[121],"heart.":[129],"Of":[130],"note,":[131],"20":[134],"different":[135],"RBPs":[136],"were":[137],"among":[138],"those":[139],"reverted":[141],"pattern.":[149],"We":[150],"determined":[151],"that,":[152],"compared":[153,192],"with":[154,193],"adult-specific":[155],"encode":[159],"tend":[162],"more":[165,168],"functions,":[166],"are":[167,231],"likely":[169],"harbor":[171],"RBP":[172],"binding":[173],"sites,":[174,181],"canonical":[176],"sequences":[177],"at":[178],"their":[179],"splice":[180],"contain":[183],"typical":[184],"upstream":[185],"polypyrimidine":[186],"tracts.":[187],"Our":[188],"study":[189],"suggests":[190],"adult,":[195],"cardiac":[197,221],"requires":[199],"stricter":[200,211],"transcriptional":[201,212],"regulation,":[202],"reversion":[208],"this":[210],"regulation":[213],"occurs.":[214],"Furthermore,":[215],"provide":[217],"a":[218],"resource":[219],"developmental":[222],"stage-specific":[223],"failure-associated":[226],"largely":[232],"unexplored":[233],"can":[235],"be":[236],"exploited":[237],"investigate":[239],"novel":[240],"therapeutics":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}