{"id":"https://openalex.org/W4210730147","doi":"https://doi.org/10.1371/journal.pcbi.1009847","title":"Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cycle","display_name":"Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cycle","publication_year":2022,"publication_date":"2022-01-28","ids":{"openalex":"https://openalex.org/W4210730147","doi":"https://doi.org/10.1371/journal.pcbi.1009847","pmid":"https://pubmed.ncbi.nlm.nih.gov/35089921"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009847","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009847","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009847&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009847&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038554155","display_name":"Chunrui Xu","orcid":"https://orcid.org/0000-0002-4755-1593"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunrui Xu","raw_affiliation_strings":["Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107975570","display_name":"Henry Hollis","orcid":"https://orcid.org/0000-0002-6088-2792"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Hollis","raw_affiliation_strings":["Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017133045","display_name":"Michelle Dai","orcid":"https://orcid.org/0000-0001-7659-4544"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Dai","raw_affiliation_strings":["Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106942780","display_name":"Xiangyu Yao","orcid":"https://orcid.org/0000-0003-0804-1061"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangyu Yao","raw_affiliation_strings":["Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108116806","display_name":"Layne T. Watson","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Layne T. Watson","raw_affiliation_strings":["Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022834433","display_name":"Yang Cao","orcid":"https://orcid.org/0000-0001-9336-3748"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Cao","raw_affiliation_strings":["Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048086973","display_name":"Minghan Chen","orcid":"https://orcid.org/0000-0002-7321-8962"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minghan Chen","raw_affiliation_strings":["Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Wake Forest University, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048086973"],"corresponding_institution_ids":["https://openalex.org/I47251452"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7475,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73705022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"e1009847","last_page":"e1009847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caulobacter-crescentus","display_name":"Caulobacter crescentus","score":0.9978187680244446},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.68410325050354},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.6115550398826599},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.5737959146499634},{"id":"https://openalex.org/keywords/dnaa","display_name":"DnaA","score":0.49922895431518555},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46477916836738586},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4376230537891388},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.4134024381637573},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.4130380153656006},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30645325779914856},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.285388320684433},{"id":"https://openalex.org/keywords/control-of-chromosome-duplication","display_name":"Control of chromosome duplication","score":0.11092075705528259},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10575971007347107}],"concepts":[{"id":"https://openalex.org/C2778767192","wikidata":"https://www.wikidata.org/wiki/Q2943106","display_name":"Caulobacter crescentus","level":4,"score":0.9978187680244446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.68410325050354},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6115550398826599},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5737959146499634},{"id":"https://openalex.org/C107827726","wikidata":"https://www.wikidata.org/wiki/Q673206","display_name":"DnaA","level":5,"score":0.49922895431518555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46477916836738586},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4376230537891388},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4134024381637573},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4130380153656006},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30645325779914856},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.285388320684433},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.11092075705528259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10575971007347107}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016935","descriptor_name":"Caulobacter crescentus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009847","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009847","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009847&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35089921","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35089921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f6fcfb6aad84406e9d00a5ba291e726d","is_oa":true,"landing_page_url":"https://doaj.org/article/f6fcfb6aad84406e9d00a5ba291e726d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 1, p e1009847 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8865702","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8865702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009847","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009847","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009847&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.46000000834465027}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210730147.pdf","grobid_xml":"https://content.openalex.org/works/W4210730147.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1927893666","https://openalex.org/W1967926188","https://openalex.org/W1976563265","https://openalex.org/W1979750491","https://openalex.org/W1980645074","https://openalex.org/W1985253447","https://openalex.org/W1993927879","https://openalex.org/W2001078622","https://openalex.org/W2002467143","https://openalex.org/W2003512951","https://openalex.org/W2004814352","https://openalex.org/W2015172896","https://openalex.org/W2019650206","https://openalex.org/W2020073817","https://openalex.org/W2027407693","https://openalex.org/W2046489364","https://openalex.org/W2050478109","https://openalex.org/W2062134022","https://openalex.org/W2065719622","https://openalex.org/W2068568312","https://openalex.org/W2072096103","https://openalex.org/W2077643009","https://openalex.org/W2088597183","https://openalex.org/W2091786047","https://openalex.org/W2093336806","https://openalex.org/W2097160953","https://openalex.org/W2113557404","https://openalex.org/W2118875492","https://openalex.org/W2126105956","https://openalex.org/W2131288254","https://openalex.org/W2142895432","https://openalex.org/W2153098264","https://openalex.org/W2156365508","https://openalex.org/W2160765784","https://openalex.org/W2161257009","https://openalex.org/W2162314382","https://openalex.org/W2168421163","https://openalex.org/W2169032295","https://openalex.org/W2220831328","https://openalex.org/W2346143383","https://openalex.org/W2463500520","https://openalex.org/W2501857680","https://openalex.org/W2537009135","https://openalex.org/W2616413311","https://openalex.org/W2749932109","https://openalex.org/W2770910920","https://openalex.org/W2950559407","https://openalex.org/W2961699287","https://openalex.org/W3004505503","https://openalex.org/W3036331919","https://openalex.org/W3091028401","https://openalex.org/W3192439553","https://openalex.org/W4282007651","https://openalex.org/W7017178448"],"related_works":["https://openalex.org/W2792904350","https://openalex.org/W1483119271","https://openalex.org/W1256885807","https://openalex.org/W2156382630","https://openalex.org/W2138531864","https://openalex.org/W2012511424","https://openalex.org/W2073451711","https://openalex.org/W2971578741","https://openalex.org/W2057273013","https://openalex.org/W1539789276"],"abstract_inverted_index":{"The":[0,37,122],"cell":[1,13,33,55,75,113],"cycle":[2,56,76],"of":[3,21,39,54,74,91,108,116,125,137,145,149,162,180,191],"Caulobacter":[4,25,44,150],"crescentus":[5],"involves":[6],"the":[7,50,71,80,142,153,178,189],"polar":[8],"morphogenesis":[9],"and":[10,19,35,86,101,140,175],"an":[11,26,134,184],"asymmetric":[12],"division":[14],"driven":[15],"by":[16],"precise":[17],"interactions":[18],"regulations":[20],"proteins,":[22],"which":[23,170],"makes":[24],"ideal":[27],"model":[28,67,155],"organism":[29],"for":[30,167],"investigating":[31],"bacterial":[32],"development":[34],"differentiation.":[36],"abundance":[38],"molecular":[40],"data":[41],"accumulated":[42],"on":[43,79],"motivates":[45],"system":[46],"biologists":[47],"to":[48,68,131,159,173,187],"analyze":[49],"complex":[51],"regulatory":[52,94],"network":[53],"via":[57],"quantitative":[58],"modeling.":[59],"In":[60],"this":[61],"paper,":[62],"We":[63],"propose":[64],"a":[65],"comprehensive":[66],"accurately":[69],"characterize":[70],"underlying":[72],"mechanisms":[73],"regulation":[77],"based":[78],"study":[81,188],"of:":[82],"a)":[83],"chromosome":[84],"replication":[85],"methylation;":[87],"b)":[88],"interactive":[89],"pathways":[90],"five":[92],"master":[93],"proteins":[95,192],"including":[96],"DnaA,":[97],"GcrA,":[98],"CcrM,":[99],"CtrA,":[100],"SciP,":[102],"as":[103,105],"well":[104],"novel":[106],"consideration":[107],"their":[109],"corresponding":[110],"mRNAs;":[111],"c)":[112],"cycle-dependent":[114],"proteolysis":[115,182],"CtrA":[117],"through":[118],"hierarchical":[119],"protease":[120],"complexes.":[121],"temporal":[123],"dynamics":[124],"our":[126],"simulation":[127],"results":[128],"are":[129,171],"able":[130],"closely":[132],"replicate":[133],"extensive":[135],"set":[136],"experimental":[138],"observations":[139],"capture":[141],"main":[143],"phenotype":[144],"seven":[146],"mutant":[147,164],"strains":[148,169],"crescentus.":[151],"Collectively,":[152],"proposed":[154],"can":[156],"be":[157],"used":[158],"predict":[160],"phenotypes":[161],"other":[163],"cases,":[165],"especially":[166],"nonviable":[168],"hard":[172],"cultivate":[174],"observe.":[176],"Moreover,":[177],"module":[179],"cyclic":[181],"is":[183],"efficient":[185],"tool":[186],"metabolism":[190],"with":[193],"similar":[194],"mechanisms.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
