{"id":"https://openalex.org/W4214836883","doi":"https://doi.org/10.1371/journal.pcbi.1009844","title":"Autocrine signaling can explain the emergence of Allee effects in cancer cell populations","display_name":"Autocrine signaling can explain the emergence of Allee effects in cancer cell populations","publication_year":2022,"publication_date":"2022-03-03","ids":{"openalex":"https://openalex.org/W4214836883","doi":"https://doi.org/10.1371/journal.pcbi.1009844","pmid":"https://pubmed.ncbi.nlm.nih.gov/35239640"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009844","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009844","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009844&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009844&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060674598","display_name":"Philip Gerlee","orcid":null},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Philip Gerlee","raw_affiliation_strings":["Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068929470","display_name":"Philipp M. Altrock","orcid":"https://orcid.org/0000-0001-7731-3345"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Philipp M. Altrock","raw_affiliation_strings":["Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Pl\u00f6n, Germany","Department of Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Pl\u00f6n, Germany","institution_ids":["https://openalex.org/I4210152351"]},{"raw_affiliation_string":"Department of Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480598","display_name":"A. Malik","orcid":"https://orcid.org/0000-0003-1356-9039"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Adam Malik","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065107314","display_name":"Cecilia Krona","orcid":"https://orcid.org/0000-0001-6458-1949"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Cecilia Krona","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051667380","display_name":"Sven Nelander","orcid":"https://orcid.org/0000-0003-1758-1262"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sven Nelander","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060674598"],"corresponding_institution_ids":["https://openalex.org/I66862912","https://openalex.org/I881427289"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2261,"currency":"EUR","value_usd":2438},"fwci":2.7345,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90354928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"18","issue":"3","first_page":"e1009844","last_page":"e1009844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allee-effect","display_name":"Allee effect","score":0.9722945690155029},{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.8806849718093872},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.6166842579841614},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5861067175865173},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5614916682243347},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4978973865509033},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.44845008850097656},{"id":"https://openalex.org/keywords/population-growth","display_name":"Population growth","score":0.43571674823760986},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.42077505588531494},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3505299389362335},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.1806659996509552},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15898507833480835},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.12685871124267578}],"concepts":[{"id":"https://openalex.org/C10958125","wikidata":"https://www.wikidata.org/wiki/Q2301505","display_name":"Allee effect","level":3,"score":0.9722945690155029},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.8806849718093872},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6166842579841614},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5861067175865173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5614916682243347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4978973865509033},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44845008850097656},{"id":"https://openalex.org/C77352025","wikidata":"https://www.wikidata.org/wiki/Q386191","display_name":"Population growth","level":3,"score":0.43571674823760986},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42077505588531494},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3505299389362335},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1806659996509552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15898507833480835},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.12685871124267578},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004463","descriptor_name":"Ecology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004463","descriptor_name":"Ecology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004463","descriptor_name":"Ecology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011156","descriptor_name":"Population Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011156","descriptor_name":"Population Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011156","descriptor_name":"Population Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011157","descriptor_name":"Population Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011157","descriptor_name":"Population Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011157","descriptor_name":"Population Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009844","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009844","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009844&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35239640","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35239640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:DiVA.org:uu-470567","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470567","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article in journal"},{"id":"pmh:oai:doaj.org/article:e0f7c0e08e3b4820bf9811e8e9bce0c8","is_oa":true,"landing_page_url":"https://doaj.org/article/e0f7c0e08e3b4820bf9811e8e9bce0c8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 3, p e1009844 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8923455","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8923455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research.chalmers.se:529162","is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/529162","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009844","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009844","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009844&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320333647","display_name":"Kite Pharma","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4214836883.pdf","grobid_xml":"https://content.openalex.org/works/W4214836883.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W657833124","https://openalex.org/W1225649966","https://openalex.org/W1533539415","https://openalex.org/W1786281163","https://openalex.org/W1989187943","https://openalex.org/W2003345727","https://openalex.org/W2007614382","https://openalex.org/W2018288777","https://openalex.org/W2022488821","https://openalex.org/W2025237524","https://openalex.org/W2035988720","https://openalex.org/W2045484383","https://openalex.org/W2081084899","https://openalex.org/W2097248959","https://openalex.org/W2114836982","https://openalex.org/W2117974455","https://openalex.org/W2125378172","https://openalex.org/W2129269004","https://openalex.org/W2157247642","https://openalex.org/W2161567884","https://openalex.org/W2162290846","https://openalex.org/W2175637278","https://openalex.org/W2179429273","https://openalex.org/W2343285928","https://openalex.org/W2521906657","https://openalex.org/W2611476281","https://openalex.org/W2753965489","https://openalex.org/W2754522606","https://openalex.org/W2770635892","https://openalex.org/W2911509322","https://openalex.org/W2954031524","https://openalex.org/W2956132396","https://openalex.org/W2965758825","https://openalex.org/W2981532786","https://openalex.org/W3015646919","https://openalex.org/W3087506723","https://openalex.org/W3089210563","https://openalex.org/W3138656858","https://openalex.org/W6670945296"],"related_works":["https://openalex.org/W2735032095","https://openalex.org/W2107190886","https://openalex.org/W2187747741","https://openalex.org/W2774394389","https://openalex.org/W8757030","https://openalex.org/W2600193926","https://openalex.org/W2396018591","https://openalex.org/W2068425564","https://openalex.org/W2148180014","https://openalex.org/W1984799333"],"abstract_inverted_index":{"In":[0],"many":[1],"human":[2],"cancers,":[3],"the":[4,12,15,31,50,71,81,121],"rate":[5,117],"of":[6,14,61,74,123,170],"cell":[7,17,65,105,124,145,161],"growth":[8,23,77,116],"depends":[9,118],"crucially":[10],"on":[11,120,130],"size":[13],"tumor":[16,144],"population.":[18],"Low,":[19],"zero,":[20],"or":[21,112],"negative":[22,109],"at":[24,148],"low":[25,104],"population":[26],"densities":[27,106],"is":[28,135],"known":[29],"as":[30],"Allee":[32,101,177],"effect;":[33],"this":[34],"effect":[35],"has":[36],"been":[37],"studied":[38],"extensively":[39],"in":[40,49,63],"ecology,":[41],"but":[42],"so":[43],"far":[44],"lacks":[45],"a":[46],"good":[47],"explanation":[48],"cancer":[51,82,171],"setting.":[52],"Here,":[53],"we":[54],"formulate":[55],"and":[56,88,99,128,156,173],"analyze":[57],"an":[58,75],"individual-based":[59],"model":[60,134],"cancer,":[62],"which":[64],"division":[66],"rates":[67],"are":[68],"increased":[69],"by":[70,80,89],"local":[72],"concentration":[73],"autocrine":[76,92],"factor":[78],"produced":[79],"cells":[83],"themselves.":[84],"We":[85,151],"show,":[86],"analytically":[87],"simulation,":[90],"that":[91,153],"signaling":[93],"suffices":[94],"to":[95,108,126],"cause":[96],"both":[97],"strong":[98],"weak":[100],"effects.":[102],"Whether":[103],"lead":[107],"(strong":[110],"effect)":[111,115],"reduced":[113],"(weak":[114],"directly":[119],"ratio":[122],"death":[125],"proliferation,":[127],"indirectly":[129],"cellular":[131],"dispersal.":[132],"Our":[133],"consistent":[136],"with":[137],"experimental":[138],"observations":[139],"from":[140],"three":[141],"patient-derived":[142],"brain":[143],"lines":[146],"grown":[147],"different":[149],"densities.":[150],"propose":[152],"further":[154],"studying":[155],"quantifying":[157],"population-wide":[158],"feedback,":[159],"impacting":[160],"growth,":[162],"will":[163],"be":[164],"central":[165],"for":[166,179],"advancing":[167],"our":[168],"understanding":[169],"dynamics":[172],"treatment,":[174],"potentially":[175],"exploiting":[176],"effects":[178],"therapy.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}