{"id":"https://openalex.org/W4280505930","doi":"https://doi.org/10.1371/journal.pcbi.1009839","title":"Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing","display_name":"Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing","publication_year":2022,"publication_date":"2022-05-13","ids":{"openalex":"https://openalex.org/W4280505930","doi":"https://doi.org/10.1371/journal.pcbi.1009839","pmid":"https://pubmed.ncbi.nlm.nih.gov/35559958"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009839&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031268756","display_name":"Etienne Baratchart","orcid":"https://orcid.org/0000-0002-6944-3569"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Etienne Baratchart","raw_affiliation_strings":["Integrated Mathematical Oncology Department, SRB4, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6944-3569","affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology Department, SRB4, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083342481","display_name":"Chen Hao Lo","orcid":"https://orcid.org/0000-0001-8848-2507"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Hao Lo","raw_affiliation_strings":["Cancer Biology Ph.D. Program, Department of Cell Biology Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, United States of America","Tumor Biology Department, SRB3, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8848-2507","affiliations":[{"raw_affiliation_string":"Cancer Biology Ph.D. Program, Department of Cell Biology Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Tumor Biology Department, SRB3, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005942374","display_name":"Conor C. Lynch","orcid":"https://orcid.org/0000-0002-4506-6244"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Conor C. Lynch","raw_affiliation_strings":["Cancer Biology Ph.D. Program, Department of Cell Biology Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Ph.D. Program, Department of Cell Biology Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003774553","display_name":"David Basanta","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Basanta","raw_affiliation_strings":["Integrated Mathematical Oncology Department, SRB4, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8527-0776","affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology Department, SRB4, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003774553","https://openalex.org/A5005942374"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5769,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8929808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"18","issue":"5","first_page":"e1009839","last_page":"e1009839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclast","display_name":"Osteoclast","score":0.8328737616539001},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6321614980697632},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6264311075210571},{"id":"https://openalex.org/keywords/monocyte","display_name":"Monocyte","score":0.5666857957839966},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.5184599757194519},{"id":"https://openalex.org/keywords/macrophage","display_name":"Macrophage","score":0.4990804195404053},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"Macrophage polarization","score":0.495693564414978},{"id":"https://openalex.org/keywords/bone-healing","display_name":"Bone healing","score":0.4707487225532532},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4570990800857544},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.39154088497161865},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.2614944577217102},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.08548057079315186},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0811299979686737}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.8328737616539001},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6321614980697632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6264311075210571},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5666857957839966},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5184599757194519},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4990804195404053},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.495693564414978},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4707487225532532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4570990800857544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39154088497161865},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2614944577217102},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08548057079315186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0811299979686737},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35559958","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35559958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:265fb605d8ab446dbbe717f21781d987","is_oa":true,"landing_page_url":"https://doaj.org/article/265fb605d8ab446dbbe717f21781d987","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 5, p e1009839 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:763292d69e5147148784965daa20c1ce","is_oa":true,"landing_page_url":"https://doaj.org/article/763292d69e5147148784965daa20c1ce","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 5 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9106165","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9106165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2021782124","display_name":null,"funder_award_id":"U01CA202958","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G597233881","display_name":null,"funder_award_id":"U01CA244101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280505930.pdf","grobid_xml":"https://content.openalex.org/works/W4280505930.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W1567210565","https://openalex.org/W1684025987","https://openalex.org/W1797422316","https://openalex.org/W1802397357","https://openalex.org/W1822656157","https://openalex.org/W1823574256","https://openalex.org/W1848678928","https://openalex.org/W1953179980","https://openalex.org/W1956258286","https://openalex.org/W1965696823","https://openalex.org/W1973336682","https://openalex.org/W1973849127","https://openalex.org/W1976199086","https://openalex.org/W1978172024","https://openalex.org/W1981805995","https://openalex.org/W1984654699","https://openalex.org/W1988699576","https://openalex.org/W1991083334","https://openalex.org/W1997794453","https://openalex.org/W2000077738","https://openalex.org/W2001094576","https://openalex.org/W2005528887","https://openalex.org/W2007284300","https://openalex.org/W2007945453","https://openalex.org/W2011772406","https://openalex.org/W2012976204","https://openalex.org/W2014679360","https://openalex.org/W2019221616","https://openalex.org/W2019451761","https://openalex.org/W2020330911","https://openalex.org/W2020545615","https://openalex.org/W2022436869","https://openalex.org/W2023447635","https://openalex.org/W2025104440","https://openalex.org/W2025494633","https://openalex.org/W2026067651","https://openalex.org/W2026561031","https://openalex.org/W2028543411","https://openalex.org/W2032579180","https://openalex.org/W2032879966","https://openalex.org/W2033793521","https://openalex.org/W2035904396","https://openalex.org/W2037544158","https://openalex.org/W2037716466","https://openalex.org/W2039712973","https://openalex.org/W2041581343","https://openalex.org/W2042207589","https://openalex.org/W2045891124","https://openalex.org/W2046923162","https://openalex.org/W2053296436","https://openalex.org/W2054472394","https://openalex.org/W2054738820","https://openalex.org/W2055404740","https://openalex.org/W2055763817","https://openalex.org/W2057035809","https://openalex.org/W2061095868","https://openalex.org/W2067033131","https://openalex.org/W2070825285","https://openalex.org/W2072100512","https://openalex.org/W2072462631","https://openalex.org/W2073034575","https://openalex.org/W2073380079","https://openalex.org/W2081141707","https://openalex.org/W2081374651","https://openalex.org/W2083337908","https://openalex.org/W2087692142","https://openalex.org/W2089573422","https://openalex.org/W2089836937","https://openalex.org/W2090230271","https://openalex.org/W2092004666","https://openalex.org/W2094524631","https://openalex.org/W2095537212","https://openalex.org/W2096407919","https://openalex.org/W2100128950","https://openalex.org/W2104904898","https://openalex.org/W2105054044","https://openalex.org/W2105156168","https://openalex.org/W2105933619","https://openalex.org/W2109293470","https://openalex.org/W2109853011","https://openalex.org/W2110062192","https://openalex.org/W2111967308","https://openalex.org/W2112130807","https://openalex.org/W2118278569","https://openalex.org/W2120988911","https://openalex.org/W2123303185","https://openalex.org/W2124797640","https://openalex.org/W2125378419","https://openalex.org/W2127738873","https://openalex.org/W2129381039","https://openalex.org/W2130594874","https://openalex.org/W2132933661","https://openalex.org/W2136722399","https://openalex.org/W2136878411","https://openalex.org/W2138810805","https://openalex.org/W2139183953","https://openalex.org/W2140380746","https://openalex.org/W2142242761","https://openalex.org/W2142820105","https://openalex.org/W2147596501","https://openalex.org/W2148851290","https://openalex.org/W2149813574","https://openalex.org/W2150362511","https://openalex.org/W2153406260","https://openalex.org/W2154434805","https://openalex.org/W2155920085","https://openalex.org/W2159992335","https://openalex.org/W2162166699","https://openalex.org/W2162707559","https://openalex.org/W2164839146","https://openalex.org/W2168376037","https://openalex.org/W2168484418","https://openalex.org/W2168669893","https://openalex.org/W2170607629","https://openalex.org/W2171154327","https://openalex.org/W2171519949","https://openalex.org/W2255879554","https://openalex.org/W2271567759","https://openalex.org/W2291522985","https://openalex.org/W2293430956","https://openalex.org/W2299138507","https://openalex.org/W2319967189","https://openalex.org/W2342035050","https://openalex.org/W2471500324","https://openalex.org/W2493810914","https://openalex.org/W2502848651","https://openalex.org/W2512881232","https://openalex.org/W2513866232","https://openalex.org/W2516952220","https://openalex.org/W2517745633","https://openalex.org/W2518285474","https://openalex.org/W2519022826","https://openalex.org/W2537319471","https://openalex.org/W2548414910","https://openalex.org/W2582686270","https://openalex.org/W2592069713","https://openalex.org/W2623014794","https://openalex.org/W2626120438","https://openalex.org/W2736337012","https://openalex.org/W2763530312","https://openalex.org/W2766359205","https://openalex.org/W2768045238","https://openalex.org/W2768721130","https://openalex.org/W2772514947","https://openalex.org/W2779193814","https://openalex.org/W2801347649","https://openalex.org/W2807629723","https://openalex.org/W2897945399","https://openalex.org/W2900693075","https://openalex.org/W2909659447","https://openalex.org/W2939670601","https://openalex.org/W2943405011","https://openalex.org/W2951486507","https://openalex.org/W2957835797","https://openalex.org/W2962804036","https://openalex.org/W3136455867","https://openalex.org/W3186932594","https://openalex.org/W4251104453","https://openalex.org/W4256073489","https://openalex.org/W6668944194"],"related_works":["https://openalex.org/W4386033951","https://openalex.org/W2348217469","https://openalex.org/W3143279666","https://openalex.org/W2985630013","https://openalex.org/W2144857713","https://openalex.org/W2806617632","https://openalex.org/W3197706278","https://openalex.org/W3029971791","https://openalex.org/W1853146561","https://openalex.org/W1983073898"],"abstract_inverted_index":{"Myeloid-derived":[0],"monocyte":[1],"and":[2,14,22,27,45,54,83,134,166,246],"macrophages":[3,159,172],"are":[4,160,173],"key":[5,161],"cells":[6],"in":[7,67,81,84,125,130,175,255,266,272],"the":[8,51,60,89,101,198,204,212,215,249,256],"bone":[9,127,139,177,243],"that":[10,240,247],"contribute":[11],"to":[12,124,132,147,222,236,269],"remodeling":[13],"injury":[15,128,244],"repair.":[16],"However,":[17],"their":[18],"temporal":[19,57],"polarization":[20,46],"status":[21],"control":[23],"of":[24,42,62,91,103,214],"bone-resorbing":[25],"osteoclasts":[26],"bone-forming":[28],"osteoblasts":[29,181],"responses":[30],"is":[31,73],"largely":[32],"unknown.":[33],"In":[34,207],"this":[35,229],"study,":[36],"we":[37,109,209],"focused":[38],"on":[39],"two":[40,190,205],"aspects":[41],"monocyte/macrophage":[43],"dynamics":[44,253],"states":[47],"over":[48],"time:":[49],"1)":[50,157],"injury-triggered":[52],"pro-":[53,63],"anti-inflammatory":[55,65,158,199],"monocytes/macrophages":[56,66,187],"profiles,":[58],"2)":[59,170],"contributions":[61],"versus":[64],"coordinating":[68],"healing":[69,72],"response.":[70],"Bone":[71],"a":[74],"complex":[75,273],"multicellular":[76,274],"dynamic":[77],"process.":[78,257],"While":[79],"traditional":[80],"vitro":[82],"vivo":[85,126],"experimentation":[86],"may":[87],"capture":[88],"behavior":[90,102],"select":[92],"populations":[93,141],"with":[94],"high":[95],"resolution,":[96],"they":[97],"cannot":[98],"simultaneously":[99],"track":[100],"multiple":[104,121],"populations.":[105],"To":[106],"address":[107],"this,":[108],"have":[110],"used":[111,265],"an":[112,223],"integrated":[113],"coupled":[114,250],"ordinary":[115],"differential":[116],"equations":[117],"(ODEs)-based":[118],"framework":[119,233],"describing":[120],"cellular":[122,251],"species":[123],"data":[129,245],"order":[131],"identify":[133,237],"test":[135],"various":[136],"hypotheses":[137],"regarding":[138],"cell":[140],"dynamics.":[142],"Our":[143],"approach":[144],"allowed":[145,234],"us":[146,235],"infer":[148],"several":[149],"biological":[150,238],"insights":[151],"including,":[152],"but":[153],"not":[154],"limited":[155],"to,:":[156],"for":[162],"early":[163],"osteoclast":[164,176,183],"inhibition":[165,201],"pro-inflammatory":[167,171],"macrophage":[168],"suppression,":[169],"involved":[174,254],"resorptive":[178],"activity,":[179],"whereas":[180],"promote":[182],"differentiation,":[184],"3)":[185],"Pro-inflammatory":[186],"rise":[188],"during":[189],"expansion":[191],"waves,":[192],"which":[193],"can":[194],"be":[195,264],"explained":[196],"by":[197,218],"macrophages-mediated":[200],"phase":[202],"between":[203],"waves.":[206],"addition,":[208],"further":[210],"tested":[211],"robustness":[213],"mathematical":[216,232],"model":[217],"comparing":[219],"simulation":[220],"results":[221],"independent":[224],"experimental":[225],"dataset.":[226],"Taken":[227],"together,":[228],"novel":[230],"comprehensive":[231],"mechanisms":[239,271],"best":[241],"recapitulate":[242],"explain":[248],"population":[252],"Furthermore,":[258],"our":[259],"hypothesis":[260],"testing":[261],"methodology":[262],"could":[263],"other":[267],"contexts":[268],"decipher":[270],"processes.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
