{"id":"https://openalex.org/W4212960609","doi":"https://doi.org/10.1371/journal.pcbi.1009833","title":"Evidence for the emergence of \u03b2-trefoils by \u2018Peptide Budding\u2019 from an IgG-like \u03b2-sandwich","display_name":"Evidence for the emergence of \u03b2-trefoils by \u2018Peptide Budding\u2019 from an IgG-like \u03b2-sandwich","publication_year":2022,"publication_date":"2022-02-14","ids":{"openalex":"https://openalex.org/W4212960609","doi":"https://doi.org/10.1371/journal.pcbi.1009833","pmid":"https://pubmed.ncbi.nlm.nih.gov/35157697"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009833","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009833&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009833&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053003299","display_name":"Liam M. Longo","orcid":"https://orcid.org/0000-0002-1773-0611"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]},{"id":"https://openalex.org/I4210111488","display_name":"Life Science Institute","ror":"https://ror.org/01yeyd808","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111488"]},{"id":"https://openalex.org/I4210144256","display_name":"Blue Marble Space","ror":"https://ror.org/03dewsa74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144256"]},{"id":"https://openalex.org/I4210154041","display_name":"Blue Marble Space Institute of Science","ror":"https://ror.org/04yhya597","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Liam M. Longo","raw_affiliation_strings":["Blue Marble Space Institute of Science, Seattle, Washington, United States of America","Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Marble Space Institute of Science, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]},{"raw_affiliation_string":"Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210111488","https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039615104","display_name":"Rachel Kolodny","orcid":"https://orcid.org/0000-0001-8523-1614"},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Rachel Kolodny","raw_affiliation_strings":["Department of Computer Science, University of Haifa, Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0001-8523-1614","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Haifa, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077229931","display_name":"Shawn E. McGlynn","orcid":"https://orcid.org/0000-0002-8199-7011"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]},{"id":"https://openalex.org/I4210111488","display_name":"Life Science Institute","ror":"https://ror.org/01yeyd808","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111488"]},{"id":"https://openalex.org/I4210144256","display_name":"Blue Marble Space","ror":"https://ror.org/03dewsa74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144256"]},{"id":"https://openalex.org/I4210154041","display_name":"Blue Marble Space Institute of Science","ror":"https://ror.org/04yhya597","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Shawn E. McGlynn","raw_affiliation_strings":["Blue Marble Space Institute of Science, Seattle, Washington, United States of America","Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8199-7011","affiliations":[{"raw_affiliation_string":"Blue Marble Space Institute of Science, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]},{"raw_affiliation_string":"Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210111488","https://openalex.org/I114531698"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039615104","https://openalex.org/A5053003299","https://openalex.org/A5077229931"],"corresponding_institution_ids":["https://openalex.org/I114531698","https://openalex.org/I4210111488","https://openalex.org/I4210144256","https://openalex.org/I4210154041","https://openalex.org/I91203450"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2151,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77404352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"18","issue":"2","first_page":"e1009833","last_page":"e1009833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trefoil","display_name":"Trefoil","score":0.8150562047958374},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6777400374412537},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5308132171630859},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.4798823893070221},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.44510433077812195},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39816761016845703},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10206517577171326}],"concepts":[{"id":"https://openalex.org/C2776971509","wikidata":"https://www.wikidata.org/wiki/Q905612","display_name":"Trefoil","level":2,"score":0.8150562047958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6777400374412537},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5308132171630859},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4798823893070221},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.44510433077812195},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39816761016845703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10206517577171326},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070116","descriptor_name":"Lotus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071162","descriptor_name":"Trefoil Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000071162","descriptor_name":"Trefoil Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000071162","descriptor_name":"Trefoil Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009833","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009833&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35157697","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35157697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009833","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009833","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9bccdd6f8ba340e490e0f0b1d59d2993","is_oa":true,"landing_page_url":"https://doaj.org/article/9bccdd6f8ba340e490e0f0b1d59d2993","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009833 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8880906","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8880906","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009833","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009833&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G7136500954","display_name":null,"funder_award_id":"1724300","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4212960609.pdf","grobid_xml":"https://content.openalex.org/works/W4212960609.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1539855354","https://openalex.org/W1659313070","https://openalex.org/W1965827393","https://openalex.org/W1978113501","https://openalex.org/W1985007883","https://openalex.org/W1985603295","https://openalex.org/W2009247363","https://openalex.org/W2026097376","https://openalex.org/W2030831143","https://openalex.org/W2034477756","https://openalex.org/W2035282842","https://openalex.org/W2041481056","https://openalex.org/W2051210555","https://openalex.org/W2062226826","https://openalex.org/W2064809817","https://openalex.org/W2071161999","https://openalex.org/W2090441795","https://openalex.org/W2115167726","https://openalex.org/W2115540209","https://openalex.org/W2141920771","https://openalex.org/W2145961091","https://openalex.org/W2147199176","https://openalex.org/W2168171702","https://openalex.org/W2168825646","https://openalex.org/W2211953232","https://openalex.org/W2213029892","https://openalex.org/W2345957401","https://openalex.org/W2557595285","https://openalex.org/W2559738700","https://openalex.org/W2767095293","https://openalex.org/W2902051551","https://openalex.org/W2918063357","https://openalex.org/W2964153518","https://openalex.org/W3000287747","https://openalex.org/W3009817199","https://openalex.org/W3018526736","https://openalex.org/W3034771393","https://openalex.org/W3035872707","https://openalex.org/W3042578179","https://openalex.org/W3113219874","https://openalex.org/W3118204244","https://openalex.org/W3122018424","https://openalex.org/W3125294413","https://openalex.org/W3199322743","https://openalex.org/W6636901474","https://openalex.org/W6646494498","https://openalex.org/W6661220816","https://openalex.org/W6684993928","https://openalex.org/W6688314194","https://openalex.org/W6760022898","https://openalex.org/W6830619977"],"related_works":["https://openalex.org/W2654359665","https://openalex.org/W1554470851","https://openalex.org/W2920061786","https://openalex.org/W4389300316","https://openalex.org/W2625912121","https://openalex.org/W2621246910","https://openalex.org/W4379055781","https://openalex.org/W2136345656","https://openalex.org/W4404556479","https://openalex.org/W2791437416"],"abstract_inverted_index":{"As":[0],"sequence":[1,41,100,133],"and":[2,81,102,204],"structure":[3,43,136],"comparison":[4],"algorithms":[5],"gain":[6],"sensitivity,":[7],"the":[8,12,64,69,84,90,112,124,140,163,166,188],"intrinsic":[9],"interconnectedness":[10],"of":[11,86,111,123,165,190,202],"protein":[13,34,91,119,210],"universe":[14],"has":[15,147],"become":[16],"increasingly":[17],"apparent.":[18],"Despite":[19],"this":[20],"general":[21],"trend,":[22],"\u03b2-trefoils":[23,52],"have":[24,48],"emerged":[25],"as":[26,143,146],"an":[27,32,180,206],"uncommon":[28],"counterexample:":[29],"They":[30],"are":[31],"isolated":[33],"lineage":[35,71],"for":[36],"which":[37],"few,":[38],"if":[39],"any,":[40],"or":[42,135],"associations":[44],"to":[45,82],"other":[46],"lineages":[47,211],"been":[49,148],"identified.":[50],"If":[51],"are,":[53],"in":[54,58,115,128],"fact,":[55],"remote":[56],"islands":[57],"sequence-structure":[59],"space,":[60],"it":[61,171],"implies":[62],"that":[63,67,170],"oligomerizing":[65],"peptide":[66,196],"founded":[68],"\u03b2-trefoil":[70,79,113,132,141,167],"itself":[72],"arose":[73],"de":[74],"novo.":[75],"To":[76],"better":[77],"understand":[78],"evolution,":[80],"probe":[83],"limits":[85],"fragment":[87],"sharing":[88],"across":[89],"universe,":[92],"we":[93],"identified":[94],"both":[95],"'\u03b2-trefoil":[96],"bridging":[97],"themes'":[98],"(evolutionarily-related":[99],"segments)":[101],"'\u03b2-trefoil-like":[103],"motifs'":[104],"(structure":[105],"motifs":[106,137],"with":[107],"a":[108,144,159,173,191,195,200],"hallmark":[109],"feature":[110],"architecture)":[114],"multiple,":[116],"ostensibly":[117],"unrelated,":[118],"lineages.":[120],"The":[121,151],"success":[122],"present":[125],"approach":[126],"stems,":[127],"part,":[129],"from":[130,179,194],"considering":[131],"segments":[134],"rather":[138],"than":[139],"architecture":[142],"whole,":[145],"done":[149],"previously.":[150],"newly":[152],"uncovered":[153],"inter-lineage":[154],"connections":[155],"presented":[156],"here":[157],"suggest":[158],"novel":[160],"hypothesis":[161],"about":[162],"origins":[164],"fold":[168,175],"itself-namely,":[169],"is":[172],"derived":[174],"formed":[176],"by":[177],"'budding'":[178],"Immunoglobulin-like":[181],"\u03b2-sandwich":[182],"protein.":[183],"These":[184],"results":[185],"demonstrate":[186],"how":[187],"evolution":[189],"folded":[192],"domain":[193],"need":[197],"not":[198],"be":[199],"signature":[201],"antiquity":[203],"underpin":[205],"emerging":[207],"truth:":[208],"few":[209],"escape":[212],"nature's":[213],"sewing":[214],"table.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2025-10-10T00:00:00"}
