{"id":"https://openalex.org/W4210966978","doi":"https://doi.org/10.1371/journal.pcbi.1009811","title":"Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts","display_name":"Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts","publication_year":2022,"publication_date":"2022-02-10","ids":{"openalex":"https://openalex.org/W4210966978","doi":"https://doi.org/10.1371/journal.pcbi.1009811","pmid":"https://pubmed.ncbi.nlm.nih.gov/35143483"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009811","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028977024","display_name":"Robert Mines","orcid":"https://orcid.org/0000-0001-7637-9991"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Mines","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024103451","display_name":"Tomasz Lipniacki","orcid":"https://orcid.org/0000-0002-3488-2561"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Tomasz Lipniacki","raw_affiliation_strings":["Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023687769","display_name":"Xiling Shen","orcid":"https://orcid.org/0000-0002-4978-3531"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiling Shen","raw_affiliation_strings":["Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","Woo Center for Big Data and Precision Health, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Woo Center for Big Data and Precision Health, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023687769","https://openalex.org/A5024103451"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210119410","https://openalex.org/I99542240"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9533,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.72248461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"18","issue":"2","first_page":"e1009811","last_page":"e1009811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleosome","display_name":"Nucleosome","score":0.8471797704696655},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.6066058874130249},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39046019315719604},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3734481930732727},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.29299479722976685},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24637430906295776},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.12228745222091675}],"concepts":[{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.8471797704696655},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.6066058874130249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39046019315719604},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3734481930732727},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.29299479722976685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24637430906295776},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12228745222091675}],"mesh":[{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009811","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35143483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35143483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009811","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009811","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ba554f8c2e234e8594b12da16034d413","is_oa":true,"landing_page_url":"https://doaj.org/article/ba554f8c2e234e8594b12da16034d413","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009811 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8865691","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8865691","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009811","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.75,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G1002378658","display_name":null,"funder_award_id":"GM1224","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5417929130","display_name":null,"funder_award_id":"DGE-1644868","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6894402473","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7219468342","display_name":null,"funder_award_id":"DGE-1644868","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8720611893","display_name":null,"funder_award_id":"R35GM122465","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8795230287","display_name":null,"funder_award_id":"1644868","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1494502909","https://openalex.org/W1522996100","https://openalex.org/W1531821806","https://openalex.org/W1537236879","https://openalex.org/W1925000049","https://openalex.org/W1971687743","https://openalex.org/W1978514520","https://openalex.org/W2002078856","https://openalex.org/W2002144533","https://openalex.org/W2003470745","https://openalex.org/W2005361347","https://openalex.org/W2006855885","https://openalex.org/W2017721918","https://openalex.org/W2033246134","https://openalex.org/W2038894647","https://openalex.org/W2040921271","https://openalex.org/W2045485743","https://openalex.org/W2060101754","https://openalex.org/W2061413646","https://openalex.org/W2070273691","https://openalex.org/W2071759249","https://openalex.org/W2073717849","https://openalex.org/W2077052198","https://openalex.org/W2099793004","https://openalex.org/W2108141605","https://openalex.org/W2108648156","https://openalex.org/W2110725132","https://openalex.org/W2114870653","https://openalex.org/W2137088684","https://openalex.org/W2138891173","https://openalex.org/W2144983532","https://openalex.org/W2146080904","https://openalex.org/W2149118429","https://openalex.org/W2150682710","https://openalex.org/W2154731166","https://openalex.org/W2155418451","https://openalex.org/W2168221215","https://openalex.org/W2171280873","https://openalex.org/W2176036947","https://openalex.org/W2193868205","https://openalex.org/W2279123229","https://openalex.org/W2284566144","https://openalex.org/W2300489152","https://openalex.org/W2338186631","https://openalex.org/W2346509327","https://openalex.org/W2491614679","https://openalex.org/W2543492720","https://openalex.org/W2607272609","https://openalex.org/W2617905560","https://openalex.org/W2621349699","https://openalex.org/W2623740927","https://openalex.org/W2624331686","https://openalex.org/W2770511295","https://openalex.org/W2782738830","https://openalex.org/W2784103660","https://openalex.org/W2805692480","https://openalex.org/W2884391785","https://openalex.org/W2889881062","https://openalex.org/W2913609388","https://openalex.org/W2916138631","https://openalex.org/W2952938648","https://openalex.org/W2956837899","https://openalex.org/W2987232531","https://openalex.org/W2989630699","https://openalex.org/W2994747368","https://openalex.org/W2999194912","https://openalex.org/W3003495620","https://openalex.org/W3083460832","https://openalex.org/W3084779500","https://openalex.org/W3103441470","https://openalex.org/W3105595740","https://openalex.org/W3105907097","https://openalex.org/W3106157409","https://openalex.org/W3165729689","https://openalex.org/W4211059059","https://openalex.org/W4237787829","https://openalex.org/W4239629847"],"related_works":["https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W3084825885","https://openalex.org/W2298861036","https://openalex.org/W3148032049","https://openalex.org/W2271181815"],"abstract_inverted_index":{"Nucleosomes":[0],"are":[1,150,261,290],"recognized":[2],"as":[3],"key":[4],"regulators":[5],"of":[6,47,72,83,93,103,106,136,218,236,285],"transcription.":[7,73],"However,":[8],"the":[9,32,45,81,94,100,104,125,137,143,151,171,175,189,208,215,225,234,240,243,252,258,269,282],"relationship":[10],"between":[11],"slow":[12,56],"nucleosome":[13,57,67,95,181],"unwrapping":[14],"dynamics":[15,58,177],"and":[16,80,127,148,153,180,197,201,223,287],"bulk":[17],"transcriptional":[18,51],"properties":[19],"has":[20],"not":[21],"been":[22],"thoroughly":[23],"explored.":[24],"Here,":[25],"an":[26],"agent-based":[27],"model":[28],"that":[29,173,207,224,294],"we":[30,157],"call":[31],"dynamic":[33,288,295],"defect":[34],"Totally":[35],"Asymmetric":[36],"Simple":[37],"Exclusion":[38],"Process":[39],"(ddTASEP)":[40],"was":[41],"constructed":[42],"to":[43,55,70,124,131,142,292],"investigate":[44],"effects":[46,105,284],"nucleosome-induced":[48,107],"pausing":[49,108,302],"on":[50,109,281],"dynamics.":[52,112],"Pausing":[53],"due":[54],"induced":[59],"RNAPII":[60,190,210],"convoy":[61],"formation,":[62],"which":[63],"would":[64],"cooperatively":[65],"prevent":[66],"rebinding":[68],"leading":[69],"bursts":[71,266],"The":[74,113],"mean":[75,114],"first":[76,84,115],"passage":[77,85,116],"time":[78,86],"(MFPT)":[79],"variance":[82],"(VFPT)":[87],"were":[88],"analytically":[89],"expressed":[90],"in":[91,170],"terms":[92],"rate":[96,118,195,254],"constants,":[97],"allowing":[98,264],"for":[99,160,188],"direct":[101],"quantification":[102],"pioneering":[110],"polymerase":[111],"elongation":[117,194],"\u03b3(hc,":[119],"ho)":[120],"is":[121,165,276],"inversely":[122],"proportional":[123],"MFPT":[126],"can":[128,297],"be":[129,132],"considered":[130],"a":[133,166,219,248],"new":[134],"axis":[135],"ddTASEP":[138,176],"phase":[139],"diagram,":[140],"orthogonal":[141],"classical":[144],"\u03b1\u03b2-plane":[145],"(where":[146],"\u03b1":[147],"\u03b2":[149,161],"initiation":[152],"termination":[154],"rates).":[155],"Subsequently,":[156],"showed":[158],"that,":[159],"=":[162],"1,":[163],"there":[164],"novel":[167],"jamming":[168],"transition":[169],"\u03b1\u03b3-plane":[172],"separates":[174],"into":[178],"initiation-limited":[179],"pausing-limited":[182],"regions.":[183],"We":[184,205],"propose":[185],"analytical":[186],"estimates":[187],"density":[191],"\u03c1,":[192],"average":[193,226,244,270],"v,":[196],"transcription":[198],"flux":[199,221],"J":[200],"verified":[202],"them":[203],"numerically.":[204],"demonstrate":[206],"intra-burst":[209],"waiting":[211],"times":[212],"tin":[213],"follow":[214],"time-headway":[216],"distribution":[217],"max":[220],"TASEP":[222],"inter-burst":[227],"interval":[228],"[Formula:":[229,273],"see":[230,274],"text]":[231,275],"correlates":[232],"with":[233],"index":[235],"dispersion":[237],"De.":[238],"In":[239],"limit":[241],"\u03b3\u21920,":[242],"burst":[245,259,271],"size":[246,272],"reaches":[247],"maximum":[249],"set":[250],"by":[251],"closing":[253],"hc.":[255],"When":[256],"\u03b1\u226a1,":[257],"sizes":[260],"geometrically":[262],"distributed,":[263],"large":[265],"even":[267],"while":[268],"small.":[277],"Last,":[278],"preliminary":[279],"results":[280],"relative":[283],"static":[286,304],"defects":[289,296],"presented":[291],"show":[293],"induce":[298],"equal":[299],"or":[300],"greater":[301],"than":[303],"bottle":[305],"necks.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}