{"id":"https://openalex.org/W3182705924","doi":"https://doi.org/10.1371/journal.pcbi.1009806","title":"Known allosteric proteins have central roles in genetic disease","display_name":"Known allosteric proteins have central roles in genetic disease","publication_year":2022,"publication_date":"2022-02-09","ids":{"openalex":"https://openalex.org/W3182705924","doi":"https://doi.org/10.1371/journal.pcbi.1009806","mag":"3182705924","pmid":"https://pubmed.ncbi.nlm.nih.gov/35139069"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009806","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009806","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009806","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072224909","display_name":"Gy\u00f6rgy Abrus\u00e1n","orcid":"https://orcid.org/0000-0003-4375-1552"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gy\u00f6rgy Abrus\u00e1n","raw_affiliation_strings":["Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, School of Medicine, University of Cambridge, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, School of Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"David B. Ascher","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Australia","Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom","Structural Biology and Bioinformatics, Department of Biochemistry, Bio21 Institute, University of Melbourne, Melbourne, Australia"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Department of Biochemistry, Bio21 Institute, University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056977453","display_name":"Michael Inouye","orcid":"https://orcid.org/0000-0001-9413-6520"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]},{"id":"https://openalex.org/I4210128584","display_name":"The Alan Turing Institute","ror":"https://ror.org/035dkdb55","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210128584"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Michael Inouye","raw_affiliation_strings":["British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia","Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, School of Medicine, University of Cambridge, Cambridge, United Kingdom","Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","The Alan Turing Institute, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I241749"]},{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I241749"]},{"raw_affiliation_string":"Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, School of Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I241749"]},{"raw_affiliation_string":"The Alan Turing Institute, London, United Kingdom","institution_ids":["https://openalex.org/I4210128584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072224909"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.868,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70070184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"e1009806","last_page":"e1009806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.9774839878082275},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5545356869697571},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4972114861011505},{"id":"https://openalex.org/keywords/allosteric-enzyme","display_name":"Allosteric enzyme","score":0.4905020594596863},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.457878053188324},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3111479878425598},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14267051219940186},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09982234239578247}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9774839878082275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5545356869697571},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4972114861011505},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.4905020594596863},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.457878053188324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3111479878425598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14267051219940186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09982234239578247},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009806","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009806","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35139069","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35139069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:2107.04318","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2107.04318","pdf_url":"https://arxiv.org/pdf/2107.04318","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10138267","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10138267","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10138267/pdf/pcbi.1009806.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5e86738f66e145208bb7bc016c0711ae","is_oa":true,"landing_page_url":"https://doaj.org/article/5e86738f66e145208bb7bc016c0711ae","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009806 (2022)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/349315","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/349315","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009806","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009806","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G1187375252","display_name":null,"funder_award_id":"1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1219560291","display_name":null,"funder_award_id":"Economic","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G1465635051","display_name":null,"funder_award_id":"BRC-1215-2001","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G1671907826","display_name":null,"funder_award_id":"RG/13/13/30194","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1895122974","display_name":null,"funder_award_id":"BRC-1215-20014","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2266788633","display_name":null,"funder_award_id":"RG/13/13/30194; RG/18/13/33946","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4798457227","display_name":null,"funder_award_id":"Chair","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5309236915","display_name":null,"funder_award_id":"BRC-1215-20014","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G6454673195","display_name":null,"funder_award_id":"GNT1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6641991021","display_name":null,"funder_award_id":"BRC-1215-20014","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7595091512","display_name":null,"funder_award_id":"RG/13/13/30194","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8004734101","display_name":null,"funder_award_id":"RE/13/6/30180","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320313269","display_name":"Scottish Government","ror":"https://ror.org/04v2xmd71"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320333685","display_name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","ror":"https://ror.org/01613vh25"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320335543","display_name":"Health and Social Care Research and Development Division","ror":null},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":null},{"id":"https://openalex.org/F7757660664","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W35601271","https://openalex.org/W229097380","https://openalex.org/W1771087982","https://openalex.org/W1956577542","https://openalex.org/W1964439982","https://openalex.org/W1969353942","https://openalex.org/W1974093948","https://openalex.org/W1974906797","https://openalex.org/W1983294545","https://openalex.org/W1984695931","https://openalex.org/W1987370132","https://openalex.org/W2014252415","https://openalex.org/W2015807753","https://openalex.org/W2018661561","https://openalex.org/W2036919909","https://openalex.org/W2038464976","https://openalex.org/W2041205020","https://openalex.org/W2041386815","https://openalex.org/W2043764521","https://openalex.org/W2049524895","https://openalex.org/W2049682677","https://openalex.org/W2051978340","https://openalex.org/W2055560422","https://openalex.org/W2083045667","https://openalex.org/W2084168100","https://openalex.org/W2107268689","https://openalex.org/W2119097398","https://openalex.org/W2119114096","https://openalex.org/W2123027763","https://openalex.org/W2124045889","https://openalex.org/W2132629607","https://openalex.org/W2132926880","https://openalex.org/W2137200212","https://openalex.org/W2138122982","https://openalex.org/W2145100181","https://openalex.org/W2146208101","https://openalex.org/W2150318080","https://openalex.org/W2152404535","https://openalex.org/W2223752691","https://openalex.org/W2283716387","https://openalex.org/W2283818235","https://openalex.org/W2319108204","https://openalex.org/W2423210081","https://openalex.org/W2439991713","https://openalex.org/W2493614923","https://openalex.org/W2554687533","https://openalex.org/W2560058357","https://openalex.org/W2604078450","https://openalex.org/W2762272043","https://openalex.org/W2766459919","https://openalex.org/W2767281692","https://openalex.org/W2793189814","https://openalex.org/W2794930605","https://openalex.org/W2810768392","https://openalex.org/W2899563546","https://openalex.org/W2900629010","https://openalex.org/W2901303766","https://openalex.org/W2901527454","https://openalex.org/W2903465260","https://openalex.org/W2904247712","https://openalex.org/W2906494960","https://openalex.org/W2906592661","https://openalex.org/W2937705502","https://openalex.org/W2949386030","https://openalex.org/W2953167359","https://openalex.org/W2957192401","https://openalex.org/W2957571565","https://openalex.org/W2960291854","https://openalex.org/W2971284101","https://openalex.org/W2973356752","https://openalex.org/W2979294349","https://openalex.org/W2982347394","https://openalex.org/W2986586492","https://openalex.org/W2990435446","https://openalex.org/W2991998196","https://openalex.org/W3006316865","https://openalex.org/W3007324177","https://openalex.org/W3024498749","https://openalex.org/W3029661147","https://openalex.org/W3046468150","https://openalex.org/W3093053585","https://openalex.org/W3112376646","https://openalex.org/W4229487902","https://openalex.org/W4234501961","https://openalex.org/W4285724617","https://openalex.org/W6769161958","https://openalex.org/W7073602326"],"related_works":["https://openalex.org/W2049682677","https://openalex.org/W2034301964","https://openalex.org/W2463850709","https://openalex.org/W3164888202","https://openalex.org/W2751232480","https://openalex.org/W1982170406","https://openalex.org/W2333603516","https://openalex.org/W2088091011","https://openalex.org/W4231759675","https://openalex.org/W2087813258"],"abstract_inverted_index":{"Allostery":[0],"is":[1,91,151],"a":[2],"form":[3],"of":[4,22,28,61,119,146],"protein":[5],"regulation,":[6],"where":[7],"ligands":[8],"that":[9,68],"bind":[10],"sites":[11,36],"located":[12],"apart":[13],"from":[14,126],"the":[15,20,23,53,59,120,144],"active":[16,41,54],"site":[17],"can":[18],"modify":[19],"activity":[21],"protein.":[24],"The":[25],"molecular":[26],"mechanisms":[27],"allostery":[29,62],"have":[30],"been":[31],"extensively":[32],"studied,":[33],"because":[34],"allosteric":[35,71,96,134,147],"are":[37,47,73,103,131],"less":[38,165],"conserved":[39],"than":[40,50,86],"sites,":[42],"and":[43,82,89,97,142,164],"drugs":[44,51],"targeting":[45],"them":[46],"more":[48,85],"specific":[49],"binding":[52],"sites.":[55],"Here":[56],"we":[57],"quantify":[58],"importance":[60,138,145],"in":[63,75,99,105,149,160],"genetic":[64,80],"disease.":[65],"We":[66],"show":[67],"1)":[69],"known":[70],"proteins":[72,148],"central":[74,121,158],"disease":[76,81,108,150],"networks,":[77,163],"contribute":[78],"to":[79,139,156,167],"comorbidities":[83],"much":[84],"non-allosteric":[87],"proteins,":[88,135],"there":[90],"an":[92],"association":[93,129],"between":[94],"being":[95],"involvement":[98],"disease;":[100],"2)":[101],"they":[102],"enriched":[104,132],"many":[106],"major":[107],"types":[109],"like":[110],"hematopoietic":[111],"diseases,":[112,114],"cardiovascular":[113],"cancers,":[115],"diabetes,":[116],"or":[117],"diseases":[118],"nervous":[122],"system;":[123],"3)":[124],"variants":[125],"cancer":[127],"genome-wide":[128],"studies":[130],"near":[133],"indicating":[136],"their":[137,157,168],"polygenic":[140],"traits;":[141],"4)":[143],"due,":[152],"at":[153],"least":[154],"partly,":[155],"positions":[159],"protein-protein":[161],"interaction":[162],"due":[166],"dynamical":[169],"properties.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}