{"id":"https://openalex.org/W4206728593","doi":"https://doi.org/10.1371/journal.pcbi.1009782","title":"Ictal wavefront propagation in slices and simulations with conductance-based refractory density model","display_name":"Ictal wavefront propagation in slices and simulations with conductance-based refractory density model","publication_year":2022,"publication_date":"2022-01-18","ids":{"openalex":"https://openalex.org/W4206728593","doi":"https://doi.org/10.1371/journal.pcbi.1009782","pmid":"https://pubmed.ncbi.nlm.nih.gov/35041661"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009782&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077603985","display_name":"Anton V. Chizhov","orcid":"https://orcid.org/0000-0002-7993-6770"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I95568926","display_name":"Ioffe Institute","ror":"https://ror.org/05dkdaa55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I95568926"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Anton V. Chizhov","raw_affiliation_strings":["Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7993-6770","affiliations":[{"raw_affiliation_string":"Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I95568926"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054408516","display_name":"Dmitry V. Amakhin","orcid":"https://orcid.org/0000-0002-7098-4768"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry V. Amakhin","raw_affiliation_strings":["Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7098-4768","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111716073","display_name":"Elena Y. Smirnova","orcid":null},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]},{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]},{"id":"https://openalex.org/I95568926","display_name":"Ioffe Institute","ror":"https://ror.org/05dkdaa55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I95568926"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Yu. Smirnova","raw_affiliation_strings":["Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9518-5022","affiliations":[{"raw_affiliation_string":"Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I95568926"]},{"raw_affiliation_string":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I3018698992","https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054294231","display_name":"Aleksey V. Zaitsev","orcid":"https://orcid.org/0000-0002-4503-0647"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksey V. Zaitsev","raw_affiliation_strings":["Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4503-0647","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077603985"],"corresponding_institution_ids":["https://openalex.org/I163234304","https://openalex.org/I95568926"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5305,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80936324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"e1009782","last_page":"e1009782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamatergic","display_name":"Glutamatergic","score":0.7365349531173706},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5555272698402405},{"id":"https://openalex.org/keywords/potassium","display_name":"Potassium","score":0.527335524559021},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.5241743922233582},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.5208014249801636},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.47834512591362},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.47082191705703735},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4381345510482788},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.4333834946155548},{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.42392703890800476},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.21580326557159424},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19946101307868958},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.16346850991249084},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12486523389816284},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.08011999726295471}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.7365349531173706},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5555272698402405},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.527335524559021},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5241743922233582},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5208014249801636},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.47834512591362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47082191705703735},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4381345510482788},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4333834946155548},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.42392703890800476},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.21580326557159424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19946101307868958},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16346850991249084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12486523389816284},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.08011999726295471},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35041661","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35041661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e39460eea8f0452da74a7a3c1451cb44","is_oa":true,"landing_page_url":"https://doaj.org/article/e39460eea8f0452da74a7a3c1451cb44","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 1, p e1009782 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8797236","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8797236","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5586113583","display_name":null,"funder_award_id":"21-15-00416","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206728593.pdf","grobid_xml":"https://content.openalex.org/works/W4206728593.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1505388130","https://openalex.org/W1575874727","https://openalex.org/W1792676559","https://openalex.org/W1876420458","https://openalex.org/W1886118302","https://openalex.org/W1923614344","https://openalex.org/W1943709675","https://openalex.org/W1968796590","https://openalex.org/W1969736421","https://openalex.org/W1970604942","https://openalex.org/W1973119090","https://openalex.org/W1975934006","https://openalex.org/W1976448470","https://openalex.org/W1979787136","https://openalex.org/W1987876337","https://openalex.org/W1992147695","https://openalex.org/W1994416969","https://openalex.org/W1996405162","https://openalex.org/W1998504251","https://openalex.org/W2005155116","https://openalex.org/W2006745709","https://openalex.org/W2009332732","https://openalex.org/W2011426280","https://openalex.org/W2019137683","https://openalex.org/W2021844472","https://openalex.org/W2028756092","https://openalex.org/W2030798246","https://openalex.org/W2031003452","https://openalex.org/W2034457899","https://openalex.org/W2052163800","https://openalex.org/W2052805224","https://openalex.org/W2056571308","https://openalex.org/W2076462587","https://openalex.org/W2078654278","https://openalex.org/W2083011228","https://openalex.org/W2092533498","https://openalex.org/W2105752803","https://openalex.org/W2106826848","https://openalex.org/W2117632966","https://openalex.org/W2117918745","https://openalex.org/W2125616660","https://openalex.org/W2126012718","https://openalex.org/W2128790805","https://openalex.org/W2131797361","https://openalex.org/W2132572841","https://openalex.org/W2147225543","https://openalex.org/W2152472106","https://openalex.org/W2157338202","https://openalex.org/W2167970717","https://openalex.org/W2170437301","https://openalex.org/W2219448291","https://openalex.org/W2259404637","https://openalex.org/W2319172225","https://openalex.org/W2341346280","https://openalex.org/W2407057039","https://openalex.org/W2517697301","https://openalex.org/W2529957121","https://openalex.org/W2530677564","https://openalex.org/W2597049367","https://openalex.org/W2604172498","https://openalex.org/W2729704653","https://openalex.org/W2744076086","https://openalex.org/W2755082117","https://openalex.org/W2761540508","https://openalex.org/W2761700512","https://openalex.org/W2789008353","https://openalex.org/W2801224133","https://openalex.org/W2807174788","https://openalex.org/W2894870229","https://openalex.org/W2899039169","https://openalex.org/W2902305020","https://openalex.org/W2905491903","https://openalex.org/W2921970464","https://openalex.org/W2922233429","https://openalex.org/W2961644928","https://openalex.org/W2976031621","https://openalex.org/W2979026150","https://openalex.org/W3000676033","https://openalex.org/W3016055321","https://openalex.org/W3043850893","https://openalex.org/W3099188581","https://openalex.org/W3109363472","https://openalex.org/W4231081240","https://openalex.org/W4388117959"],"related_works":["https://openalex.org/W2096412015","https://openalex.org/W3047019626","https://openalex.org/W2130055373","https://openalex.org/W2043630892","https://openalex.org/W4318668938","https://openalex.org/W2026410709","https://openalex.org/W2017632516","https://openalex.org/W2046007129","https://openalex.org/W3049111871","https://openalex.org/W1568287360"],"abstract_inverted_index":{"The":[0,55,87,120,158,171],"mechanisms":[1,20,56],"determining":[2],"ictal":[3],"discharge":[4],"(ID)":[5],"propagation":[6,60,201],"are":[7],"still":[8],"not":[9,154],"clear.":[10],"In":[11,141],"the":[12,74,113,137,147,162,168,186,191,195,204],"present":[13],"study,":[14],"we":[15,41],"aimed":[16],"to":[17,101,179,203],"examine":[18],"these":[19],"in":[21,37,84,146],"animal":[22],"and":[23,31,76,81,105,111,130,152,182,200],"mathematical":[24],"models":[25],"of":[26,49,57,115,173,194,197,206],"epileptiform":[27],"activity.":[28],"Using":[29],"double-patch":[30],"extracellular":[32,116,148],"potassium":[33,117,127,143],"ion":[34,82,103,118,128,134,144],"concentration":[35],"recordings":[36],"rat":[38],"hippocampal-cortical":[39],"slices,":[40],"observed":[42],"that":[43,72],"IDs":[44],"moved":[45],"at":[46],"a":[47,65,106],"speed":[48],"about":[50],"1":[51],"mm/s":[52],"or":[53],"less.":[54],"such":[58],"slow":[59],"have":[61],"been":[62],"studied":[63],"with":[64],"mathematical,":[66],"conductance-based":[67],"refractory":[68],"density":[69],"(CBRD)":[70],"model":[71],"describes":[73],"GABA-":[75],"glutamatergic":[77,183],"neuronal":[78],"populations'":[79],"interactions":[80],"dynamics":[83],"brain":[85],"tissue.":[86],"modeling":[88],"study":[89],"reveals":[90],"two":[91],"main":[92],"factors":[93],"triggerring":[94],"IDs:":[95],"(i)":[96],"increased":[97],"interneuronal":[98],"activity":[99],"leading":[100],"chloride":[102,133],"accumulation":[104,135,172],"consequent":[107],"depolarizing":[108],"GABAergic":[109],"effect":[110],"(ii)":[112],"elevation":[114],"concentration.":[119],"local":[121,126],"synaptic":[122],"transmission":[123],"followed":[124],"by":[125],"extrusion":[129],"GABA":[131],"receptor-mediated":[132],"underlies":[136],"ID":[138,169,198],"wavefront's":[139],"propagation.":[140],"contrast,":[142],"diffusion":[145],"space":[149],"is":[150],"slower":[151],"does":[153],"affect":[155],"ID's":[156],"speed.":[157],"short":[159],"discharges,":[160],"constituting":[161],"ID,":[163],"propagate":[164],"much":[165],"faster":[166],"than":[167],"front.":[170],"sodium":[174],"ions":[175],"inside":[176],"neurons":[177],"due":[178],"their":[180],"hyperactivity":[181],"currents":[184],"boosts":[185],"Na+/K+":[187],"pump,":[188],"which":[189],"terminates":[190],"ID.":[192],"Knowledge":[193],"mechanism":[196],"generation":[199],"contributes":[202],"development":[205],"new":[207],"treatments":[208],"against":[209],"epilepsy.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}