{"id":"https://openalex.org/W3161309983","doi":"https://doi.org/10.1371/journal.pcbi.1009746","title":"Interpretable machine learning for high-dimensional trajectories of aging health","display_name":"Interpretable machine learning for high-dimensional trajectories of aging health","publication_year":2022,"publication_date":"2022-01-10","ids":{"openalex":"https://openalex.org/W3161309983","doi":"https://doi.org/10.1371/journal.pcbi.1009746","mag":"3161309983","pmid":"https://pubmed.ncbi.nlm.nih.gov/35007286"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009746","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009746","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009746","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112710513","display_name":"Spencer Farrell","orcid":null},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Spencer Farrell","raw_affiliation_strings":["Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105459433","display_name":"Arnold Mitnitski","orcid":"https://orcid.org/0000-0003-4596-2847"},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arnold Mitnitski","raw_affiliation_strings":["Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006205778","display_name":"Kenneth Rockwood","orcid":"https://orcid.org/0000-0002-6674-995X"},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kenneth Rockwood","raw_affiliation_strings":["Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6674-995X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066857721","display_name":"Andrew D. Rutenberg","orcid":"https://orcid.org/0000-0002-4264-6809"},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Andrew D. Rutenberg","raw_affiliation_strings":["Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4264-6809","affiliations":[{"raw_affiliation_string":"Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066857721","https://openalex.org/A5112710513"],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3761,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.87851504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"e1009746","last_page":"e1009746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12011","display_name":"Insurance, Mortality, Demography, Risk Management","score":0.9745000004768372,"subfield":{"id":"https://openalex.org/subfields/3317","display_name":"Demography"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5466259121894836},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5392035841941833},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.5190149545669556},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5014069080352783},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.47669145464897156},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.41662001609802246}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5466259121894836},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5392035841941833},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.5190149545669556},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5014069080352783},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.47669145464897156},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.41662001609802246},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019456","descriptor_name":"Health Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019456","descriptor_name":"Health Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019456","descriptor_name":"Health Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009746","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009746","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35007286","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35007286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:2105.03410","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2105.03410","pdf_url":"https://arxiv.org/pdf/2105.03410","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1009746","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009746","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8c06fd74e44340e4a3bff9cb2909a549","is_oa":true,"landing_page_url":"https://doaj.org/article/8c06fd74e44340e4a3bff9cb2909a549","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 1, p e1009746 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8782527","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8782527","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009746","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009746","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1136192895","display_name":null,"funder_award_id":"RGPIN 2019","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3444390807","display_name":null,"funder_award_id":"05888","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4900102816","display_name":null,"funder_award_id":"RGPIN 2019-05888","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5428952409","display_name":null,"funder_award_id":"PJT-156114","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320309985","display_name":"Dalhousie Medical Research Foundation","ror":"https://ror.org/01vsjtq46"},{"id":"https://openalex.org/F4320321629","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1502716447","https://openalex.org/W1908200954","https://openalex.org/W1965639860","https://openalex.org/W1974047233","https://openalex.org/W1986546598","https://openalex.org/W1990667054","https://openalex.org/W2000703258","https://openalex.org/W2027831836","https://openalex.org/W2034734284","https://openalex.org/W2039816778","https://openalex.org/W2054059225","https://openalex.org/W2054444429","https://openalex.org/W2060705109","https://openalex.org/W2060733516","https://openalex.org/W2064186732","https://openalex.org/W2101234009","https://openalex.org/W2103747245","https://openalex.org/W2117663940","https://openalex.org/W2122825543","https://openalex.org/W2126525177","https://openalex.org/W2134589175","https://openalex.org/W2139520621","https://openalex.org/W2157331557","https://openalex.org/W2160619958","https://openalex.org/W2164059021","https://openalex.org/W2168228291","https://openalex.org/W2186184898","https://openalex.org/W2187187251","https://openalex.org/W2225156818","https://openalex.org/W2331124579","https://openalex.org/W2465845227","https://openalex.org/W2554024225","https://openalex.org/W2588388246","https://openalex.org/W2590844674","https://openalex.org/W2594519060","https://openalex.org/W2605191235","https://openalex.org/W2734256217","https://openalex.org/W2753381103","https://openalex.org/W2837018467","https://openalex.org/W2902482795","https://openalex.org/W2911294116","https://openalex.org/W2914034186","https://openalex.org/W2939373830","https://openalex.org/W2945976633","https://openalex.org/W2947722222","https://openalex.org/W2951064640","https://openalex.org/W2962906313","https://openalex.org/W2962948639","https://openalex.org/W2963022764","https://openalex.org/W2963090522","https://openalex.org/W2963246719","https://openalex.org/W2963383494","https://openalex.org/W2963760270","https://openalex.org/W2971278153","https://openalex.org/W2974138729","https://openalex.org/W2981958095","https://openalex.org/W2994160326","https://openalex.org/W2995774252","https://openalex.org/W2996897098","https://openalex.org/W2998915709","https://openalex.org/W2999026783","https://openalex.org/W3000114476","https://openalex.org/W3000365770","https://openalex.org/W3000851847","https://openalex.org/W3004883806","https://openalex.org/W3031152617","https://openalex.org/W3038272954","https://openalex.org/W3046438816","https://openalex.org/W3048225388","https://openalex.org/W3099175442","https://openalex.org/W3101380508","https://openalex.org/W3104020727","https://openalex.org/W3114944639","https://openalex.org/W3147894994","https://openalex.org/W4239794595","https://openalex.org/W4287555256","https://openalex.org/W4289366598","https://openalex.org/W4293343253","https://openalex.org/W4297798428","https://openalex.org/W4298826872","https://openalex.org/W6675354045","https://openalex.org/W6733848097","https://openalex.org/W6782313702","https://openalex.org/W6929869393"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W3107602296","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"We":[0,31,114,143],"have":[1],"built":[2],"a":[3,53],"computational":[4],"model":[5,63,126,146,159,165],"for":[6,138],"individual":[7,74],"aging":[8,160,184],"trajectories":[9,77],"of":[10,34,73,89,109,119],"health":[11,44,76,82,94,103,112,139,161,189],"and":[12,18,21,27,78,84,127,141,180],"survival,":[13],"which":[14],"contains":[15],"physical,":[16],"functional,":[17],"biological":[19],"variables,":[20],"is":[22,64,71],"conditioned":[23],"on":[24],"demographic,":[25],"lifestyle,":[26],"medical":[28],"background":[29],"information.":[30],"combine":[32],"techniques":[33],"modern":[35],"machine":[36],"learning":[37],"with":[38,147],"an":[39,86],"interpretable":[40,60,87],"interaction":[41],"network,":[42],"where":[43],"variables":[45,104],"are":[46],"coupled":[47],"by":[48],"explicit":[49],"pair-wise":[50],"interactions":[51,91],"within":[52],"stochastic":[54],"dynamical":[55],"system.":[56],"Our":[57,163],"dynamic":[58],"joint":[59],"network":[61,88,97],"(DJIN)":[62],"scalable":[65],"to":[66,123,152,157,169,176,181],"large":[67],"longitudinal":[68],"data":[69,122],"sets,":[70],"predictive":[72],"high-dimensional":[75],"survival":[79],"from":[80],"baseline":[81],"states,":[83],"infers":[85],"directed":[90],"between":[92,102],"the":[93,154],"variables.":[95,113],"The":[96],"identifies":[98],"plausible":[99],"physiological":[100],"connections":[101],"as":[105,107],"well":[106],"clusters":[108],"strongly":[110],"connected":[111],"use":[115],"English":[116],"Longitudinal":[117],"Study":[118],"Aging":[120],"(ELSA)":[121],"train":[124],"our":[125,145],"show":[128],"that":[129,173],"it":[130],"performs":[131],"better":[132],"than":[133],"multiple":[134],"dedicated":[135],"linear":[136],"models":[137,151],"outcomes":[140,185],"survival.":[142],"compare":[144],"flexible":[148],"lower-dimensional":[149],"latent-space":[150],"explore":[153],"dimensionality":[155],"required":[156],"accurately":[158],"outcomes.":[162],"DJIN":[164],"can":[166],"be":[167],"used":[168],"generate":[170],"synthetic":[171],"individuals":[172],"age":[174],"realistically,":[175],"impute":[177],"missing":[178],"data,":[179],"simulate":[182],"future":[183],"given":[186],"arbitrary":[187],"initial":[188],"states.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
