{"id":"https://openalex.org/W4283361046","doi":"https://doi.org/10.1371/journal.pcbi.1009743","title":"Modeling cortical synaptic effects of anesthesia and their cholinergic reversal","display_name":"Modeling cortical synaptic effects of anesthesia and their cholinergic reversal","publication_year":2022,"publication_date":"2022-06-23","ids":{"openalex":"https://openalex.org/W4283361046","doi":"https://doi.org/10.1371/journal.pcbi.1009743","pmid":"https://pubmed.ncbi.nlm.nih.gov/35737717"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009743","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009743&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009743&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005362597","display_name":"Bolaji Eniwaye","orcid":"https://orcid.org/0000-0002-2455-6973"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bolaji P. Eniwaye","raw_affiliation_strings":["Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000878033","display_name":"Victoria Booth","orcid":"https://orcid.org/0000-0003-2586-8001"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victoria Booth","raw_affiliation_strings":["Department of Mathematics and Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091398848","display_name":"Anthony G. Hudetz","orcid":"https://orcid.org/0000-0003-2241-1751"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony G. Hudetz","raw_affiliation_strings":["Center for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]},{"raw_affiliation_string":"Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009654819","display_name":"Micha\u0142 \u017bochowski","orcid":"https://orcid.org/0000-0002-1722-986X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michal Zochowski","raw_affiliation_strings":["Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Physics and Biophysics Program, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]},{"raw_affiliation_string":"Department of Physics and Biophysics Program, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000878033","https://openalex.org/A5009654819","https://openalex.org/A5091398848"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.255,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53178123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"18","issue":"6","first_page":"e1009743","last_page":"e1009743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6064485907554626},{"id":"https://openalex.org/keywords/cholinergic","display_name":"Cholinergic","score":0.5133592486381531},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31052982807159424}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6064485907554626},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5133592486381531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31052982807159424}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018681","descriptor_name":"Anesthetics, General","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018681","descriptor_name":"Anesthetics, General","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018681","descriptor_name":"Anesthetics, General","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009743","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009743&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35737717","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35737717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009743","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009743","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e2aba519a87a43cb91ca18b1b7135f22","is_oa":true,"landing_page_url":"https://doaj.org/article/e2aba519a87a43cb91ca18b1b7135f22","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1009743 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9258872","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9258872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009743","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009743&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G198739881","display_name":null,"funder_award_id":"1749430","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3409427960","display_name":null,"funder_award_id":"R01EB018297","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5302026050","display_name":null,"funder_award_id":"R01-GM056398","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5338288056","display_name":null,"funder_award_id":"BCS-1749430","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5680560073","display_name":null,"funder_award_id":"EB018297","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6894402473","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7473533323","display_name":null,"funder_award_id":"R01-GM056398","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8198785557","display_name":null,"funder_award_id":"R01EB018297","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8763350010","display_name":null,"funder_award_id":"Rackham Merit Fellowship","funder_id":"https://openalex.org/F4320332462","funder_display_name":"Horace H. Rackham School of Graduate Studies, University of Michigan"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332462","display_name":"Horace H. Rackham School of Graduate Studies, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283361046.pdf","grobid_xml":"https://content.openalex.org/works/W4283361046.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W5663574","https://openalex.org/W1482008299","https://openalex.org/W1551029289","https://openalex.org/W1593945036","https://openalex.org/W1921182138","https://openalex.org/W1967982683","https://openalex.org/W1969483526","https://openalex.org/W1978348024","https://openalex.org/W1985673618","https://openalex.org/W1985940938","https://openalex.org/W1988881714","https://openalex.org/W1994450638","https://openalex.org/W2001227279","https://openalex.org/W2001631404","https://openalex.org/W2016448315","https://openalex.org/W2024677729","https://openalex.org/W2027045997","https://openalex.org/W2030278876","https://openalex.org/W2030682910","https://openalex.org/W2038141274","https://openalex.org/W2038276856","https://openalex.org/W2038382211","https://openalex.org/W2040841203","https://openalex.org/W2042076346","https://openalex.org/W2043101183","https://openalex.org/W2043533591","https://openalex.org/W2044670283","https://openalex.org/W2045221743","https://openalex.org/W2050248597","https://openalex.org/W2051441950","https://openalex.org/W2052546219","https://openalex.org/W2054845099","https://openalex.org/W2055241837","https://openalex.org/W2060294841","https://openalex.org/W2062090709","https://openalex.org/W2064286037","https://openalex.org/W2066305892","https://openalex.org/W2072366454","https://openalex.org/W2074671627","https://openalex.org/W2079300845","https://openalex.org/W2081213752","https://openalex.org/W2087740844","https://openalex.org/W2088715256","https://openalex.org/W2090414491","https://openalex.org/W2092492330","https://openalex.org/W2101101880","https://openalex.org/W2105927641","https://openalex.org/W2109116383","https://openalex.org/W2111382819","https://openalex.org/W2114629025","https://openalex.org/W2115131237","https://openalex.org/W2119687729","https://openalex.org/W2135390742","https://openalex.org/W2135801855","https://openalex.org/W2139367190","https://openalex.org/W2144457047","https://openalex.org/W2151570166","https://openalex.org/W2154697573","https://openalex.org/W2156194072","https://openalex.org/W2157074639","https://openalex.org/W2162013747","https://openalex.org/W2165826392","https://openalex.org/W2172099311","https://openalex.org/W2297915641","https://openalex.org/W2301156330","https://openalex.org/W2323947669","https://openalex.org/W2394834952","https://openalex.org/W2520471192","https://openalex.org/W2545605790","https://openalex.org/W2607355772","https://openalex.org/W2625859860","https://openalex.org/W2737674920","https://openalex.org/W2782436909","https://openalex.org/W2786504149","https://openalex.org/W2790348769","https://openalex.org/W2792275927","https://openalex.org/W2794797278","https://openalex.org/W2807176893","https://openalex.org/W2899124619","https://openalex.org/W2901217622","https://openalex.org/W2982191444","https://openalex.org/W2991217205","https://openalex.org/W3005675585","https://openalex.org/W3005696893","https://openalex.org/W3008500251","https://openalex.org/W3015834540","https://openalex.org/W3045808667","https://openalex.org/W3097648505","https://openalex.org/W3119643299","https://openalex.org/W3130584179","https://openalex.org/W3158658289","https://openalex.org/W4298038674","https://openalex.org/W6697455108","https://openalex.org/W6843046736"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W1951208502","https://openalex.org/W3094184128"],"abstract_inverted_index":{"General":[0],"anesthetics":[1,27],"work":[2],"through":[3,132],"a":[4,100,104,137,207],"variety":[5],"of":[6,16,20,25,39,79,86,103,106,116,148,161,176,180,187,190,215],"molecular":[7],"mechanisms":[8,85],"while":[9,33],"resulting":[10],"in":[11,30,51,66,68,121,157,167],"the":[12,23,40,47,69,76,80,83,90,113,158,185,212],"common":[13,26],"end":[14],"point":[15],"sedation":[17],"and":[18,57,108,124,126,153,200],"loss":[19],"consciousness.":[21],"Generally,":[22],"administration":[24],"induces":[28],"reduction":[29],"synaptic":[31,35,42,122,182],"excitation":[32],"promoting":[34],"inhibition.":[36],"Exogenous":[37],"modulation":[38],"anesthetics'":[41],"effects":[43,115,175],"can":[44,71],"help":[45],"determine":[46],"neuronal":[48,151,209],"pathways":[49],"involved":[50],"anesthesia.":[52],"For":[53],"example,":[54],"both":[55],"animal":[56],"human":[58],"studies":[59],"have":[60,93],"shown":[61],"that":[62,171],"exogenously":[63],"induced":[64],"increases":[65],"acetylcholine":[67,177],"brain":[70],"elicit":[72],"wakeful-like":[73],"behavior":[74],"despite":[75],"continued":[77],"presence":[78],"anesthetic.":[81],"However,":[82],"underlying":[84],"anesthesia":[87,164,216],"reversal":[88,128,186,214],"at":[89],"cellular":[91],"level":[92],"not":[94],"been":[95],"investigated.":[96],"Here":[97],"we":[98],"apply":[99],"computational":[101],"model":[102,143,205],"network":[105,154],"excitatory":[107],"inhibitory":[109],"neurons":[110],"to":[111,119,141,145],"simulate":[112],"network-wide":[114],"anesthesia,":[117],"due":[118],"changes":[120,183],"inhibition":[123],"excitation,":[125],"their":[127],"by":[129],"cholinergic":[130,213],"activation":[131],"muscarinic":[133,173],"receptors.":[134],"We":[135,169],"use":[136],"differential":[138],"evolution":[139],"algorithm":[140],"fit":[142],"parameters":[144],"match":[146],"measures":[147],"spiking":[149,192],"activity,":[150,193],"connectivity,":[152,195],"dynamics":[155],"recorded":[156],"visual":[159],"cortex":[160],"rodents":[162],"during":[163],"with":[165,218],"desflurane":[166],"vivo.":[168],"find":[170],"facilitating":[172],"receptor":[174],"on":[178],"top":[179],"anesthetic-induced":[181],"predicts":[184,206],"anesthetic":[188],"suppression":[189],"neurons'":[191],"functional":[194],"as":[196,198],"well":[197],"pairwise":[199],"population":[201],"interactions.":[202],"Thus,":[203],"our":[204],"specific":[208],"mechanism":[210],"for":[211],"consistent":[217],"experimental":[219],"behavioral":[220],"observations.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
