{"id":"https://openalex.org/W4213417941","doi":"https://doi.org/10.1371/journal.pcbi.1009732","title":"Evolutionary information helps understand distinctive features of the angiotensin II receptors AT1 and AT2 in amniota","display_name":"Evolutionary information helps understand distinctive features of the angiotensin II receptors AT1 and AT2 in amniota","publication_year":2022,"publication_date":"2022-02-24","ids":{"openalex":"https://openalex.org/W4213417941","doi":"https://doi.org/10.1371/journal.pcbi.1009732","pmid":"https://pubmed.ncbi.nlm.nih.gov/35202400"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009732","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009732","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009732&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009732&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040161668","display_name":"Rym Ben Boubaker","orcid":"https://orcid.org/0000-0002-3329-1831"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155524","display_name":"Mitochondrial and Cardiovascular Physiopathology","ror":"https://ror.org/03hqv2x85","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387155524","https://openalex.org/I49451733"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rym Ben Boubaker","raw_affiliation_strings":["CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale"],"raw_orcid":"https://orcid.org/0000-0002-3329-1831","affiliations":[{"raw_affiliation_string":"CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I49451733","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale","institution_ids":["https://openalex.org/I4387155524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011748414","display_name":"Asma Tiss","orcid":"https://orcid.org/0000-0002-2448-2062"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110695","display_name":"Universit\u00e9 Tunis Carthage","ror":"https://ror.org/01xf5pq20","country_code":"TN","type":"education","lineage":["https://openalex.org/I4210110695"]},{"id":"https://openalex.org/I42731748","display_name":"National Institute of Applied Science and Technology","ror":"https://ror.org/00qn2rd91","country_code":"TN","type":"facility","lineage":["https://openalex.org/I42731748"]},{"id":"https://openalex.org/I4387155524","display_name":"Mitochondrial and Cardiovascular Physiopathology","ror":"https://ror.org/03hqv2x85","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387155524","https://openalex.org/I49451733"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR","TN"],"is_corresponding":false,"raw_author_name":"Asma Tiss","raw_affiliation_strings":["CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","INSAT de Tunis, Universit\u00e9 de Carthage, Carthage, Tunisie","MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale","Universit\u00e9 de Carthage (Tunisie)"],"raw_orcid":"https://orcid.org/0000-0002-2448-2062","affiliations":[{"raw_affiliation_string":"CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I49451733","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INSAT de Tunis, Universit\u00e9 de Carthage, Carthage, Tunisie","institution_ids":["https://openalex.org/I4210110695","https://openalex.org/I42731748"]},{"raw_affiliation_string":"MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale","institution_ids":["https://openalex.org/I4387155524"]},{"raw_affiliation_string":"Universit\u00e9 de Carthage (Tunisie)","institution_ids":["https://openalex.org/I4210110695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101911171","display_name":"Daniel Henrion","orcid":"https://orcid.org/0000-0003-1094-0285"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155524","display_name":"Mitochondrial and Cardiovascular Physiopathology","ror":"https://ror.org/03hqv2x85","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387155524","https://openalex.org/I49451733"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Henrion","raw_affiliation_strings":["CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale"],"raw_orcid":"https://orcid.org/0000-0003-1094-0285","affiliations":[{"raw_affiliation_string":"CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I49451733","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale","institution_ids":["https://openalex.org/I4387155524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066398054","display_name":"Hajer Guissouma","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110695","display_name":"Universit\u00e9 Tunis Carthage","ror":"https://ror.org/01xf5pq20","country_code":"TN","type":"education","lineage":["https://openalex.org/I4210110695"]},{"id":"https://openalex.org/I42731748","display_name":"National Institute of Applied Science and Technology","ror":"https://ror.org/00qn2rd91","country_code":"TN","type":"facility","lineage":["https://openalex.org/I42731748"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hajer Guissouma","raw_affiliation_strings":["INSAT de Tunis, Universit\u00e9 de Carthage, Carthage, Tunisie","Universit\u00e9 de Carthage (Tunisie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSAT de Tunis, Universit\u00e9 de Carthage, Carthage, Tunisie","institution_ids":["https://openalex.org/I4210110695","https://openalex.org/I42731748"]},{"raw_affiliation_string":"Universit\u00e9 de Carthage (Tunisie)","institution_ids":["https://openalex.org/I4210110695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023901131","display_name":"Marie Chabbert","orcid":"https://orcid.org/0000-0002-5182-0987"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155524","display_name":"Mitochondrial and Cardiovascular Physiopathology","ror":"https://ror.org/03hqv2x85","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387155524","https://openalex.org/I49451733"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie Chabbert","raw_affiliation_strings":["CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale"],"raw_orcid":"https://orcid.org/0000-0002-5182-0987","affiliations":[{"raw_affiliation_string":"CNRS UMR 6015 - INSERM U1083, Laboratoire MITOVASC, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I49451733","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale","institution_ids":["https://openalex.org/I4387155524"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023901131"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387155524","https://openalex.org/I49451733"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2283,"currency":"EUR","value_usd":2462},"fwci":0.3275,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5757894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"18","issue":"2","first_page":"e1009732","last_page":"e1009732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-receptor-type-1","display_name":"Angiotensin II receptor type 1","score":0.8287220597267151},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"Angiotensin II","score":0.6826547384262085},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6632630825042725},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5378977060317993},{"id":"https://openalex.org/keywords/renin\u2013angiotensin-system","display_name":"Renin\u2013angiotensin system","score":0.49472686648368835},{"id":"https://openalex.org/keywords/angiotensin-receptor","display_name":"Angiotensin receptor","score":0.4655851423740387},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.45983001589775085},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4478783905506134},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.44404157996177673},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.42789626121520996},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38400983810424805},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3285553455352783},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30938631296157837},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.2241506576538086},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09404006600379944}],"concepts":[{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.8287220597267151},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6826547384262085},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6632630825042725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5378977060317993},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.49472686648368835},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.4655851423740387},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.45983001589775085},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4478783905506134},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.44404157996177673},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42789626121520996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38400983810424805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3285553455352783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30938631296157837},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2241506576538086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09404006600379944},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009732","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009732","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009732&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35202400","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35202400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03767265v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03767265","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2022, 18 (2), pp.e1009732. &#x27E8;10.1371/journal.pcbi.1009732&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:c0002b163fee40a19b67a1f0e12be0e9","is_oa":true,"landing_page_url":"https://doaj.org/article/c0002b163fee40a19b67a1f0e12be0e9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c9e8f753b11d4350accc4797b5d49ace","is_oa":true,"landing_page_url":"https://doaj.org/article/c9e8f753b11d4350accc4797b5d49ace","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009732 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8870451","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8870451","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009732","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009732","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009732&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.6800000071525574,"display_name":"Life below water"}],"awards":[{"id":"https://openalex.org/G7115529251","display_name":null,"funder_award_id":"100567","funder_id":"https://openalex.org/F4320326256","funder_display_name":"Grand \u00c9quipement National De Calcul Intensif"}],"funders":[{"id":"https://openalex.org/F4320319409","display_name":"University of Carthage","ror":"https://ror.org/057x6za15"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320325007","display_name":"Universite Angers","ror":"https://ror.org/04yrqp957"},{"id":"https://openalex.org/F4320326256","display_name":"Grand \u00c9quipement National De Calcul Intensif","ror":"https://ror.org/0010d1q40"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213417941.pdf"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W163498145","https://openalex.org/W1512110535","https://openalex.org/W1593501931","https://openalex.org/W1967163969","https://openalex.org/W1967513025","https://openalex.org/W1981403357","https://openalex.org/W1983074420","https://openalex.org/W1984132657","https://openalex.org/W1992899488","https://openalex.org/W1995233943","https://openalex.org/W2000987100","https://openalex.org/W2001051130","https://openalex.org/W2005174659","https://openalex.org/W2007258535","https://openalex.org/W2018882645","https://openalex.org/W2021477328","https://openalex.org/W2021520922","https://openalex.org/W2027790571","https://openalex.org/W2029357834","https://openalex.org/W2029667189","https://openalex.org/W2047372255","https://openalex.org/W2056986890","https://openalex.org/W2058160393","https://openalex.org/W2058653824","https://openalex.org/W2060872117","https://openalex.org/W2062296203","https://openalex.org/W2065283382","https://openalex.org/W2066414494","https://openalex.org/W2067973462","https://openalex.org/W2087276894","https://openalex.org/W2105316610","https://openalex.org/W2108281249","https://openalex.org/W2110177837","https://openalex.org/W2116084547","https://openalex.org/W2119199305","https://openalex.org/W2132632499","https://openalex.org/W2137015675","https://openalex.org/W2138173257","https://openalex.org/W2144049010","https://openalex.org/W2144744785","https://openalex.org/W2150981663","https://openalex.org/W2153525853","https://openalex.org/W2154319440","https://openalex.org/W2156777159","https://openalex.org/W2158266834","https://openalex.org/W2158302928","https://openalex.org/W2161644181","https://openalex.org/W2165634194","https://openalex.org/W2172221536","https://openalex.org/W2183358035","https://openalex.org/W2321948417","https://openalex.org/W2397337586","https://openalex.org/W2406250479","https://openalex.org/W2529251769","https://openalex.org/W2559626295","https://openalex.org/W2588448590","https://openalex.org/W2605291555","https://openalex.org/W2625441704","https://openalex.org/W2726705340","https://openalex.org/W2754957776","https://openalex.org/W2773978638","https://openalex.org/W2791947132","https://openalex.org/W2806295635","https://openalex.org/W2808661197","https://openalex.org/W2810001758","https://openalex.org/W2893189760","https://openalex.org/W2894335751","https://openalex.org/W2910849968","https://openalex.org/W2923681300","https://openalex.org/W2952263612","https://openalex.org/W2969292601","https://openalex.org/W2975385530","https://openalex.org/W2982539434","https://openalex.org/W2998309061","https://openalex.org/W3006950105","https://openalex.org/W3007079711","https://openalex.org/W3014159159","https://openalex.org/W3089246638","https://openalex.org/W3092707751","https://openalex.org/W3136918052","https://openalex.org/W3185406944"],"related_works":["https://openalex.org/W1991157605","https://openalex.org/W2020125834","https://openalex.org/W2321507356","https://openalex.org/W2418445678","https://openalex.org/W2090731568","https://openalex.org/W1977216511","https://openalex.org/W2092435511","https://openalex.org/W2022197230","https://openalex.org/W2009954323","https://openalex.org/W2003262069"],"abstract_inverted_index":{"In":[0,178],"vertebrates,":[1],"the":[2,14,72,98,106,122,128,146,158,179,183,190,196,215,221,230,233],"octopeptide":[3],"angiotensin":[4],"II":[5],"(AngII)":[6],"is":[7,170],"an":[8,102],"important":[9],"in":[10,76,132,151,168,176,186,195,211],"vivo":[11],"regulator":[12],"of":[13,33,47,105,127,181,193,218,232],"cardiovascular":[15],"system.":[16,235],"It":[17,62],"acts":[18],"mainly":[19],"through":[20],"two":[21,55],"G":[22],"protein-coupled":[23],"receptors,":[24,35],"AT1":[25,48,78,93,137,153,169,188],"and":[26,49,79,83,101,121,135,138,142,154,220],"AT2.":[27,80,177],"To":[28],"better":[29],"understand":[30],"distinctive":[31],"features":[32],"these":[34],"we":[36],"carried":[37],"out":[38],"a":[39,44,173],"phylogenetic":[40],"analysis":[41],"that":[42,65,145],"revealed":[43,64],"mirror":[45],"evolution":[46],"AT2,":[50],"each":[51],"one":[52],"split":[53],"into":[54],"clades,":[56],"separating":[57],"fish":[58,161],"from":[59,97,140,160],"terrestrial":[60],"receptors.":[61],"also":[63],"hallmark":[66],"mutations":[67,225],"occurred":[68],"at,":[69],"or":[70],"near,":[71],"sodium":[73,89,129,150],"binding":[74,90,107,130],"site":[75],"both":[77,152],"Electrostatics":[81],"computations":[82],"molecular":[84],"dynamics":[85],"simulations":[86],"support":[87],"maintained":[88],"to":[91,112,115,162,202],"human":[92,119],"with":[94],"slow":[95],"ingress":[96],"extracellular":[99],"side":[100],"electrostatic":[103],"component":[104],"free":[108],"energy":[109],"around":[110,116],"-3kT,":[111],"be":[113],"compared":[114],"-2kT":[117],"for":[118,229],"AT2":[120,139,155,213],"\u03b4":[123],"opioid":[124],"receptor.":[125],"Comparison":[126],"modes":[131],"wild":[133],"type":[134],"mutated":[136],"humans":[141],"eels":[143],"indicates":[144],"allosteric":[147],"control":[148],"by":[149,172],"evolved":[156],"during":[157],"transition":[159],"amniota.":[163],"The":[164,208],"unusual":[165],"S7.46N":[166],"mutation":[167,175],"mirrored":[171],"L3.36M":[174],"presence":[180],"sodium,":[182],"N7.46":[184],"pattern":[185,210],"amniota":[187,212],"stabilizes":[189],"inward":[191],"orientation":[192,217],"N3.35":[194,204,219],"apo":[197],"receptor,":[198],"which":[199],"should":[200],"contribute":[201],"efficient":[203],"driven":[205],"biased":[206],"signaling.":[207],"M3.36":[209],"favours":[214],"outward":[216],"receptor":[222],"promiscuity.":[223],"Both":[224],"have":[226],"physiological":[227],"consequences":[228],"regulation":[231],"renin-angiotensin":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-01-15T23:16:33.117629","created_date":"2025-10-10T00:00:00"}
