{"id":"https://openalex.org/W4210919600","doi":"https://doi.org/10.1371/journal.pcbi.1009720","title":"In silico prediction of HIV-1-host molecular interactions and their directionality","display_name":"In silico prediction of HIV-1-host molecular interactions and their directionality","publication_year":2022,"publication_date":"2022-02-08","ids":{"openalex":"https://openalex.org/W4210919600","doi":"https://doi.org/10.1371/journal.pcbi.1009720","pmid":"https://pubmed.ncbi.nlm.nih.gov/35134057"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009720&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004073409","display_name":"Haiting Chai","orcid":"https://orcid.org/0000-0003-0558-3965"},"institutions":[{"id":"https://openalex.org/I4210146449","display_name":"MRC University of Glasgow Centre for Virus Research","ror":"https://ror.org/03vaer060","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210146449","https://openalex.org/I7882870","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haiting Chai","raw_affiliation_strings":["MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210146449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033093938","display_name":"Quan Gu","orcid":"https://orcid.org/0000-0002-1201-6734"},"institutions":[{"id":"https://openalex.org/I4210146449","display_name":"MRC University of Glasgow Centre for Virus Research","ror":"https://ror.org/03vaer060","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210146449","https://openalex.org/I7882870","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Quan Gu","raw_affiliation_strings":["MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210146449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027557443","display_name":"Joseph Hughes","orcid":"https://orcid.org/0000-0003-2556-2563"},"institutions":[{"id":"https://openalex.org/I4210146449","display_name":"MRC University of Glasgow Centre for Virus Research","ror":"https://ror.org/03vaer060","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210146449","https://openalex.org/I7882870","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Hughes","raw_affiliation_strings":["MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210146449"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082064376","display_name":"David L. Robertson","orcid":"https://orcid.org/0000-0001-6338-0221"},"institutions":[{"id":"https://openalex.org/I4210146449","display_name":"MRC University of Glasgow Centre for Virus Research","ror":"https://ror.org/03vaer060","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210146449","https://openalex.org/I7882870","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David L. Robertson","raw_affiliation_strings":["MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210146449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082064376"],"corresponding_institution_ids":["https://openalex.org/I4210146449"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5156,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65257444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"18","issue":"2","first_page":"e1009720","last_page":"e1009720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.6899512410163879},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6688916683197021},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6508084535598755},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6171514987945557},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5746327638626099},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4880918264389038},{"id":"https://openalex.org/keywords/directionality","display_name":"Directionality","score":0.4721118211746216},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3626144826412201},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32863104343414307},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3058597147464752},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2096056342124939}],"concepts":[{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6899512410163879},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6688916683197021},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6508084535598755},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6171514987945557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5746327638626099},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4880918264389038},{"id":"https://openalex.org/C29648211","wikidata":"https://www.wikidata.org/wiki/Q1995607","display_name":"Directionality","level":2,"score":0.4721118211746216},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3626144826412201},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32863104343414307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3058597147464752},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2096056342124939}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35134057","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35134057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:265616","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1009720","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009720","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9c3c63d712434eb9a6b1a026b6ebd601","is_oa":true,"landing_page_url":"https://doaj.org/article/9c3c63d712434eb9a6b1a026b6ebd601","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009720 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8856524","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8856524","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2206474454","display_name":null,"funder_award_id":"MC_UU_12014","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5126738005","display_name":null,"funder_award_id":"MC_UU_1201412","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5566807808","display_name":null,"funder_award_id":"MC_UU_","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8128754418","display_name":null,"funder_award_id":"1201412","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8339569505","display_name":null,"funder_award_id":"201706620069","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G8589651859","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"}],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210919600.pdf","grobid_xml":"https://content.openalex.org/works/W4210919600.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W1521671672","https://openalex.org/W1546341583","https://openalex.org/W1727897997","https://openalex.org/W1802930479","https://openalex.org/W1823429634","https://openalex.org/W1932434485","https://openalex.org/W1956613997","https://openalex.org/W1966060871","https://openalex.org/W1967572918","https://openalex.org/W1971226986","https://openalex.org/W1977209252","https://openalex.org/W1980923315","https://openalex.org/W1981879850","https://openalex.org/W1986339588","https://openalex.org/W1989277387","https://openalex.org/W1990210083","https://openalex.org/W1991614900","https://openalex.org/W1996062837","https://openalex.org/W1998804829","https://openalex.org/W1999048558","https://openalex.org/W2012771827","https://openalex.org/W2016199502","https://openalex.org/W2019726061","https://openalex.org/W2022978872","https://openalex.org/W2023159617","https://openalex.org/W2023303702","https://openalex.org/W2026082551","https://openalex.org/W2028273907","https://openalex.org/W2029930485","https://openalex.org/W2030030165","https://openalex.org/W2031950455","https://openalex.org/W2035252561","https://openalex.org/W2043570667","https://openalex.org/W2051307379","https://openalex.org/W2056614917","https://openalex.org/W2060797027","https://openalex.org/W2064163367","https://openalex.org/W2065978544","https://openalex.org/W2068065064","https://openalex.org/W2077398039","https://openalex.org/W2095056958","https://openalex.org/W2096603314","https://openalex.org/W2096858144","https://openalex.org/W2101005439","https://openalex.org/W2104167780","https://openalex.org/W2105476170","https://openalex.org/W2107174433","https://openalex.org/W2118077323","https://openalex.org/W2118601386","https://openalex.org/W2119067551","https://openalex.org/W2126267084","https://openalex.org/W2126877059","https://openalex.org/W2127424905","https://openalex.org/W2128586991","https://openalex.org/W2134197776","https://openalex.org/W2137124164","https://openalex.org/W2144893438","https://openalex.org/W2149870286","https://openalex.org/W2152528007","https://openalex.org/W2153635508","https://openalex.org/W2155804510","https://openalex.org/W2156269526","https://openalex.org/W2156465034","https://openalex.org/W2163038531","https://openalex.org/W2165703995","https://openalex.org/W2170747616","https://openalex.org/W2173732482","https://openalex.org/W2174697928","https://openalex.org/W2184875956","https://openalex.org/W2198318089","https://openalex.org/W2206815873","https://openalex.org/W2304458632","https://openalex.org/W2529663014","https://openalex.org/W2534390616","https://openalex.org/W2559588208","https://openalex.org/W2562928006","https://openalex.org/W2581184152","https://openalex.org/W2585038741","https://openalex.org/W2594364047","https://openalex.org/W2611171255","https://openalex.org/W2619280902","https://openalex.org/W2757598598","https://openalex.org/W2759289851","https://openalex.org/W2766459919","https://openalex.org/W2790709905","https://openalex.org/W2792450944","https://openalex.org/W2806512480","https://openalex.org/W2806805867","https://openalex.org/W2806884808","https://openalex.org/W2809190716","https://openalex.org/W2892265819","https://openalex.org/W2915769855","https://openalex.org/W2921113176","https://openalex.org/W2949274170","https://openalex.org/W2950595506","https://openalex.org/W2950653175","https://openalex.org/W2953515605","https://openalex.org/W2990714382","https://openalex.org/W2999309192","https://openalex.org/W3008762879","https://openalex.org/W3028912875","https://openalex.org/W3040312898","https://openalex.org/W3044020843","https://openalex.org/W3081339151","https://openalex.org/W3146840857","https://openalex.org/W4206037526","https://openalex.org/W4206694472","https://openalex.org/W4211183388","https://openalex.org/W4231254854","https://openalex.org/W4237335579","https://openalex.org/W4242422263","https://openalex.org/W4293430819","https://openalex.org/W6806115372","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W2624817431","https://openalex.org/W2950752483","https://openalex.org/W2794987474","https://openalex.org/W33032069","https://openalex.org/W1599251874","https://openalex.org/W4232225082","https://openalex.org/W2029088481","https://openalex.org/W2334790377","https://openalex.org/W2473013794","https://openalex.org/W3129816939"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2,36,48],"type":[3],"1":[4],"(HIV-1)":[5],"continues":[6],"to":[7,26,173],"be":[8],"a":[9,23,44,75,90],"major":[10],"cause":[11],"of":[12,31,47,62,83,95,164,176,188],"disease":[13],"and":[14,37,51,81,108,113,125,193],"premature":[15],"death.":[16],"As":[17,131],"with":[18,69,89,135],"all":[19],"viruses,":[20],"HIV-1":[21,85,137,192],"exploits":[22],"host":[24,39,52,63,196],"cell":[25],"replicate.":[27],"Improving":[28],"our":[29,116],"understanding":[30,46],"the":[32,60,79,84,93,96,123,136,142,162,165,184,189],"molecular":[33,167],"interactions":[34,168,190],"between":[35,122,191],"human":[38,128,195],"proteins":[40,87,129],"is":[41,169,204],"crucial":[42],"for":[43,65,78,201],"mechanistic":[45],"biology,":[49],"infection":[50,138],"antiviral":[53,70,100],"activities.":[54],"This":[55],"knowledge":[56],"will":[57],"potentially":[58],"permit":[59],"identification":[61],"molecules":[64],"targeting":[66],"by":[67,133],"drugs":[68],"properties.":[71,158],"Here,":[72],"we":[73,151,182],"propose":[74],"data-driven":[76],"approach":[77],"analysis":[80],"prediction":[82],"interacting":[86,127],"(VIPs)":[88],"focus":[91],"on":[92],"directionality":[94],"interaction:":[97],"host-dependency":[98],"versus":[99,178],"factors.":[101],"Using":[102],"support":[103],"vector":[104],"machine":[105],"learning":[106],"models":[107,154],"features":[109],"encompassing":[110],"genetic,":[111],"proteomic":[112],"network":[114],"properties,":[115],"results":[117],"reveal":[118],"some":[119],"significant":[120],"differences":[121],"VIPs":[124],"non-HIV-1":[126],"(non-VIPs).":[130],"assessed":[132],"comparison":[134],"pathway":[139],"data":[140],"in":[141],"Reactome":[143],"database":[144],"(sensitivity":[145],">":[146],"90%,":[147],"threshold":[148],"=":[149],"0.5),":[150],"demonstrate":[152],"these":[153],"have":[155],"good":[156],"generalization":[157],"We":[159],"find":[160],"that":[161],"'direction'":[163],"HIV-1-host":[166],"also":[170],"predictable":[171],"due":[172],"different":[174],"characteristics":[175],"'forward'/pro-viral":[177],"'backward'/pro-host":[179],"proteins.":[180,197],"Additionally,":[181],"infer":[183],"previously":[185],"unknown":[186],"direction":[187],"1351":[194],"A":[198],"web":[199],"server":[200],"performing":[202],"predictions":[203],"available":[205],"at":[206],"http://hivpre.cvr.gla.ac.uk/.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}