{"id":"https://openalex.org/W4200459601","doi":"https://doi.org/10.1371/journal.pcbi.1009646","title":"In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction","display_name":"In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction","publication_year":2021,"publication_date":"2021-12-06","ids":{"openalex":"https://openalex.org/W4200459601","doi":"https://doi.org/10.1371/journal.pcbi.1009646","pmid":"https://pubmed.ncbi.nlm.nih.gov/34871310"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009646","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009646","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009646&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009646&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071305139","display_name":"Stefano Longobardi","orcid":"https://orcid.org/0000-0002-0111-0047"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stefano Longobardi","raw_affiliation_strings":["Cardiac Electromechanics Research Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-0111-0047","affiliations":[{"raw_affiliation_string":"Cardiac Electromechanics Research Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019600201","display_name":"Anna Sher","orcid":"https://orcid.org/0000-0001-7159-0173"},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Sher","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7159-0173","affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000435552","display_name":"Steven Niederer","orcid":"https://orcid.org/0000-0002-4612-6982"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven A. Niederer","raw_affiliation_strings":["Cardiac Electromechanics Research Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-4612-6982","affiliations":[{"raw_affiliation_string":"Cardiac Electromechanics Research Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071305139"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7296,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.73498688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"12","first_page":"e1009646","last_page":"e1009646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10409","display_name":"Fuel Cells and Related Materials","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcomere","display_name":"Sarcomere","score":0.7529810667037964},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"Ejection fraction","score":0.5563621520996094},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"Heart failure with preserved ejection fraction","score":0.5509669780731201},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.5470864772796631},{"id":"https://openalex.org/keywords/isovolumetric-contraction","display_name":"Isovolumetric contraction","score":0.520086407661438},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.46961385011672974},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4382658004760742},{"id":"https://openalex.org/keywords/ventricular-pressure","display_name":"Ventricular pressure","score":0.4227238595485687},{"id":"https://openalex.org/keywords/cardiac-function-curve","display_name":"Cardiac function curve","score":0.41578859090805054},{"id":"https://openalex.org/keywords/diastole","display_name":"Diastole","score":0.3230104446411133},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28664541244506836},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.28320568799972534},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.2782922387123108},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.25838208198547363}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.7529810667037964},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5563621520996094},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5509669780731201},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5470864772796631},{"id":"https://openalex.org/C39078644","wikidata":"https://www.wikidata.org/wiki/Q17092725","display_name":"Isovolumetric contraction","level":4,"score":0.520086407661438},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46961385011672974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4382658004760742},{"id":"https://openalex.org/C26635844","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular pressure","level":3,"score":0.4227238595485687},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.41578859090805054},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.3230104446411133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28664541244506836},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.28320568799972534},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2782922387123108},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.25838208198547363}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009646","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009646","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009646&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34871310","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34871310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/30a4c70a-947e-417b-9d11-b5b0976b83b5","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/30a4c70a-947e-417b-9d11-b5b0976b83b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Longobardi, S, Sher, A & Niederer, S 2021, 'In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction', PLoS Computational Biology, vol. 17, no. 12, e1009646. https://doi.org/10.1371/JOURNAL.PCBI.1009646","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:8675924","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8675924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b8b15d0b75044eefa8f3abbc12f64f5c","is_oa":true,"landing_page_url":"https://doaj.org/article/b8b15d0b75044eefa8f3abbc12f64f5c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 12, p e1009646 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009646","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009646","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009646&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1190480411","display_name":null,"funder_award_id":"NS/A000049/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1247657515","display_name":null,"funder_award_id":"[WT203148/Z/16/Z]","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1251496372","display_name":null,"funder_award_id":"EP/P01268X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1271318647","display_name":null,"funder_award_id":"WT203148/Z/16/Z","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G1322964166","display_name":"King's College London Medical Engineering Centre of Research Excellence","funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2045667589","display_name":"Personalised Model Based Optimal Lead Guidance in Cardiac Resynchronisation Therapy","funder_award_id":"EP/M012492/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2119833926","display_name":null,"funder_award_id":"WT 203148/Z/16","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2417159676","display_name":null,"funder_award_id":"WT 203148/Z/16/Z)","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2841443304","display_name":"Uncertainty Quantification in Prospective and Predictive Patient Specific Cardiac Models","funder_award_id":"EP/P01268X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3773670102","display_name":null,"funder_award_id":"PG/13/37/30280","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3843692265","display_name":null,"funder_award_id":"A000049","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G427633563","display_name":"The BHF-Turing Cardiovascular Data Science Awards (First call): Quantifying functional co-variation in calcium handling proteins in cardiac myocytes (joint funding with The Alan Turing Institute)","funder_award_id":"SP/18/6/33805","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4327884091","display_name":null,"funder_award_id":"PREDICT-HF 864055","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G5907639349","display_name":"King's College London Medical Engineering Centre of Research Excellence","funder_award_id":"203148","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6562481342","display_name":null,"funder_award_id":"PG/15/91/31812","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7044186993","display_name":"The role of scar morphology and location in arrhythmogenic risk following cardiac resynchronisation therapy in patients with ischaemic heart disease","funder_award_id":"PG/15/91/31812","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7533812842","display_name":"The interdependence of anatomy and function in atrial fibrillation","funder_award_id":"PG/13/37/30280","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7650934720","display_name":null,"funder_award_id":"EP/M012492/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G811271348","display_name":null,"funder_award_id":"NS/A000049/1]","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8303168876","display_name":null,"funder_award_id":"WT 203148/Z/16/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G938335843","display_name":null,"funder_award_id":"203148/ Z/16/Z","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320321058","display_name":"King's Health Partners","ror":"https://ror.org/01xcsye48"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200459601.pdf","grobid_xml":"https://content.openalex.org/works/W4200459601.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1502527850","https://openalex.org/W1968687630","https://openalex.org/W1980953366","https://openalex.org/W1994610789","https://openalex.org/W2023348396","https://openalex.org/W2041043028","https://openalex.org/W2055077989","https://openalex.org/W2076567530","https://openalex.org/W2088765131","https://openalex.org/W2100907438","https://openalex.org/W2101589741","https://openalex.org/W2125107816","https://openalex.org/W2132670047","https://openalex.org/W2277697424","https://openalex.org/W2306006469","https://openalex.org/W2439081208","https://openalex.org/W2569457803","https://openalex.org/W2610625640","https://openalex.org/W2619481688","https://openalex.org/W2741413018","https://openalex.org/W2799881750","https://openalex.org/W2888825293","https://openalex.org/W2893995718","https://openalex.org/W2896310504","https://openalex.org/W2928427555","https://openalex.org/W3002101747","https://openalex.org/W3026223623","https://openalex.org/W3041393275","https://openalex.org/W3176361360"],"related_works":["https://openalex.org/W1987861550","https://openalex.org/W2383615017","https://openalex.org/W2090895581","https://openalex.org/W2440984857","https://openalex.org/W2181684470","https://openalex.org/W4308366794","https://openalex.org/W2429170846","https://openalex.org/W1989106589","https://openalex.org/W2018089186","https://openalex.org/W2079871045"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"with":[2,12],"preserved":[3],"ejection":[4,212],"fraction":[5],"(HFpEF)":[6],"is":[7,53,58],"a":[8,63,109,149,197,266],"complex":[9],"disease":[10],"associated":[11],"multiple":[13],"co-morbidities,":[14],"where":[15],"impaired":[16,82],"cardiac":[17,28,66,83,127,287],"mechanics":[18,29,67],"are":[19],"often":[20],"the":[21,25,39,42,70,155,162,185,200,207,245,249,298,302,311,315],"end":[22],"effect.":[23],"At":[24],"cellular":[26,45,97,101],"level,":[27],"can":[30,92,238,276,289],"be":[31,93,277,290],"pharmacologically":[32],"manipulated":[33],"by":[34,117,143,211,229,296],"altering":[35,96],"calcium":[36,98,123,173,306],"signalling":[37],"and":[38,48,61,85,129,171,175,177,221,233,242,254,272,300,308],"sarcomere.":[40],"However,":[41],"link":[43],"between":[44],"level":[46],"modulations":[47],"whole":[49],"organ":[50,186],"pump":[51,188],"function":[52,84,91,247,288],"incompletely":[54],"understood.":[55],"Our":[56],"goal":[57],"to":[59,75,86,121,153,159,195,279,304],"develop":[60],"use":[62],"multi-scale":[64],"computational":[65],"model":[68,133,198],"of":[69,161,184,199,218,244,260,268],"obese":[71],"ZSF1":[72,201,250,294],"HFpEF":[73],"rat":[74,104,202,251],"identify":[76,280],"important":[77],"biomechanical":[78],"mechanisms":[79],"that":[80,140,228,286],"underpin":[81],"predict":[87],"how":[88,265],"whole-heart":[89],"mechanical":[90],"recovered":[94,206,292],"through":[95],"dynamics":[99,174],"and/or":[100],"contraction.":[102],"The":[103,132],"heart":[105],"was":[106,169],"modelled":[107],"using":[108],"3D":[110],"biventricular":[111],"biomechanics":[112],"model.":[113],"Biomechanics":[114],"were":[115,141],"described":[116,142,210],"16":[118,156],"parameters,":[119],"corresponding":[120],"intracellular":[122,305],"transient,":[124],"sarcomere":[125,312],"dynamics,":[126],"tissue":[128],"hemodynamics":[130],"properties.":[131],"simulated":[134],"left":[135],"ventricular":[136],"(LV)":[137],"pressure-volume":[138],"loops":[139],"14":[144,163],"scalar":[145],"features.":[146],"We":[147,190,226,263,284],"trained":[148],"Gaussian":[150],"process":[151],"emulator":[152],"map":[154],"input":[157],"parameters":[158],"each":[160],"outputs.":[164],"A":[165],"global":[166],"sensitivity":[167],"analysis":[168],"performed,":[170],"identified":[172],"thin":[176,232],"thick":[178,234],"filament":[179,235],"kinetics":[180],"as":[181],"key":[182],"determinants":[183],"scale":[187],"function.":[189],"employed":[191],"Bayesian":[192],"history":[193],"matching":[194],"build":[196],"heart.":[203],"Next,":[204],"we":[205,237,257],"LV":[208,246],"function,":[209],"fraction,":[213],"peak":[214],"pressure,":[215],"maximum":[216],"rate":[217],"pressure":[219],"rise":[220],"isovolumetric":[222],"relaxation":[223],"time":[224],"constant.":[225],"found":[227],"manipulating":[230],"calcium,":[231],"properties":[236],"recover":[239],"34%,":[240],"28%":[241],"24%":[243],"in":[248,293,314],"heart,":[252],"respectively,":[253],"39%":[255],"if":[256],"manipulate":[258],"all":[259],"them":[261],"together.":[262],"demonstrated":[264],"combination":[267],"biophysically":[269],"based":[270],"models":[271],"their":[273],"derived":[274],"emulators":[275],"used":[278],"potential":[281],"pharmacological":[282],"targets.":[283],"predicted":[285],"best":[291],"rats":[295],"desensitising":[297],"myofilament":[299],"reducing":[301],"affinity":[303],"concentration":[307],"overall":[309],"prolonging":[310],"staying":[313],"active":[316],"force":[317],"generating":[318],"state.":[319]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}