{"id":"https://openalex.org/W4226052652","doi":"https://doi.org/10.1371/journal.pcbi.1009638","title":"The impact of whole genome duplications on the human gene regulatory networks","display_name":"The impact of whole genome duplications on the human gene regulatory networks","publication_year":2021,"publication_date":"2021-12-06","ids":{"openalex":"https://openalex.org/W4226052652","doi":"https://doi.org/10.1371/journal.pcbi.1009638","pmid":"https://pubmed.ncbi.nlm.nih.gov/34871317"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009638","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009638","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023342239","display_name":"Francesco Mottes","orcid":"https://orcid.org/0000-0002-8858-2484"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Mottes","raw_affiliation_strings":["Department of Physics, University of Turin & INFN, Turin, Italy","UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)"],"raw_orcid":"https://orcid.org/0000-0002-8858-2484","affiliations":[{"raw_affiliation_string":"Department of Physics, University of Turin & INFN, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005496584","display_name":"Chiara Villa","orcid":"https://orcid.org/0000-0003-3127-0532"},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210158291","display_name":"Laboratoire Jacques-Louis Lions","ror":"https://ror.org/04xmteb38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210141950","https://openalex.org/I4210158291"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Chiara Villa","raw_affiliation_strings":["School of Mathematics and Statistics, University of St Andrews, Mathematical Institute, North Haugh, St Andrews, United Kingdom","LJLL (UMR_7598) - Laboratoire Jacques-Louis Lions (Sorbonne-Universit\u00e9, Bo\u00eete courrier 187 - 75252 Paris Cedex 05 - France)"],"raw_orcid":"https://orcid.org/0000-0003-3127-0532","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, University of St Andrews, Mathematical Institute, North Haugh, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]},{"raw_affiliation_string":"LJLL (UMR_7598) - Laboratoire Jacques-Louis Lions (Sorbonne-Universit\u00e9, Bo\u00eete courrier 187 - 75252 Paris Cedex 05 - France)","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210158291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032497784","display_name":"Matteo Osella","orcid":"https://orcid.org/0000-0002-4916-5434"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Osella","raw_affiliation_strings":["Department of Physics, University of Turin & INFN, Turin, Italy","UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)"],"raw_orcid":"https://orcid.org/0000-0002-4916-5434","affiliations":[{"raw_affiliation_string":"Department of Physics, University of Turin & INFN, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031508753","display_name":"Michele Caselle","orcid":"https://orcid.org/0000-0001-5488-142X"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Caselle","raw_affiliation_strings":["Department of Physics, University of Turin & INFN, Turin, Italy","UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)"],"raw_orcid":"https://orcid.org/0000-0001-5488-142X","affiliations":[{"raw_affiliation_string":"Department of Physics, University of Turin & INFN, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031508753"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7914,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85881028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"12","first_page":"e1009638","last_page":"e1009638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.780436098575592},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.7203897833824158},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6378665566444397},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5977839827537537},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5626749992370605},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5114544630050659},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.501746416091919},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.47657179832458496},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43532121181488037},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4328952729701996},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.43149811029434204},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18118789792060852}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.780436098575592},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7203897833824158},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6378665566444397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5977839827537537},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5626749992370605},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5114544630050659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.501746416091919},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47657179832458496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43532121181488037},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4328952729701996},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43149811029434204},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18118789792060852}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009638","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34871317","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34871317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04415666v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04415666","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (12), pp.e1009638. ⟨10.1371/journal.pcbi.1009638⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:8541b59330fc445085cd28e667a08ded","is_oa":true,"landing_page_url":"https://doaj.org/article/8541b59330fc445085cd28e667a08ded","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 12, p e1009638 (2021)","raw_type":"article"},{"id":"pmh:oai:iris.unito.it:2318/1841857","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1841857","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8675932","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8675932","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009638","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1673643808","display_name":null,"funder_award_id":"L.232/2016","funder_id":"https://openalex.org/F4320317295","funder_display_name":"Dipartimenti di Eccellenza"},{"id":"https://openalex.org/G3006576871","display_name":null,"funder_award_id":"2018-2022","funder_id":"https://openalex.org/F4320317295","funder_display_name":"Dipartimenti di Eccellenza"},{"id":"https://openalex.org/G4956079712","display_name":null,"funder_award_id":"2018-2022","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G5329322851","display_name":null,"funder_award_id":"232/2016","funder_id":"https://openalex.org/F4320317295","funder_display_name":"Dipartimenti di Eccellenza"},{"id":"https://openalex.org/G5417130124","display_name":null,"funder_award_id":"232/2016","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G7108750294","display_name":null,"funder_award_id":"L.232/2016","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320317295","display_name":"Dipartimenti di Eccellenza","ror":null},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W156481159","https://openalex.org/W873873667","https://openalex.org/W1482831047","https://openalex.org/W1494075612","https://openalex.org/W1641544182","https://openalex.org/W1971231926","https://openalex.org/W1976215839","https://openalex.org/W1976378620","https://openalex.org/W1976445111","https://openalex.org/W1995514688","https://openalex.org/W1995863037","https://openalex.org/W2001554877","https://openalex.org/W2002923824","https://openalex.org/W2009088119","https://openalex.org/W2010407417","https://openalex.org/W2013527764","https://openalex.org/W2018239038","https://openalex.org/W2019591778","https://openalex.org/W2022589976","https://openalex.org/W2038012561","https://openalex.org/W2043199743","https://openalex.org/W2043946672","https://openalex.org/W2047405437","https://openalex.org/W2057652201","https://openalex.org/W2061354140","https://openalex.org/W2064181369","https://openalex.org/W2081933515","https://openalex.org/W2084139224","https://openalex.org/W2087601715","https://openalex.org/W2089499317","https://openalex.org/W2090588073","https://openalex.org/W2095289434","https://openalex.org/W2098522644","https://openalex.org/W2103111028","https://openalex.org/W2110336366","https://openalex.org/W2110699703","https://openalex.org/W2112262143","https://openalex.org/W2112780227","https://openalex.org/W2117298796","https://openalex.org/W2125469896","https://openalex.org/W2128440410","https://openalex.org/W2131706188","https://openalex.org/W2136949053","https://openalex.org/W2141781797","https://openalex.org/W2144893438","https://openalex.org/W2152876917","https://openalex.org/W2153624566","https://openalex.org/W2154533018","https://openalex.org/W2156684099","https://openalex.org/W2156737316","https://openalex.org/W2158292347","https://openalex.org/W2163296115","https://openalex.org/W2166212839","https://openalex.org/W2172266008","https://openalex.org/W2285387404","https://openalex.org/W2398498907","https://openalex.org/W2519117646","https://openalex.org/W2528271650","https://openalex.org/W2612079819","https://openalex.org/W2740048744","https://openalex.org/W2768632638","https://openalex.org/W2768781242","https://openalex.org/W2782454362","https://openalex.org/W2790428952","https://openalex.org/W2802960899","https://openalex.org/W2900569176","https://openalex.org/W2900839584","https://openalex.org/W2964315448","https://openalex.org/W2965320044","https://openalex.org/W2981031252","https://openalex.org/W2990002161","https://openalex.org/W2990559567","https://openalex.org/W3011796864","https://openalex.org/W3037808763","https://openalex.org/W3096568637","https://openalex.org/W3099289621","https://openalex.org/W4205247356","https://openalex.org/W4229487902","https://openalex.org/W4254977540","https://openalex.org/W4297845870"],"related_works":["https://openalex.org/W2010571965","https://openalex.org/W2002709996","https://openalex.org/W3128451840","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2115810854","https://openalex.org/W2380236774","https://openalex.org/W4317476908","https://openalex.org/W4291672717"],"abstract_inverted_index":{"This":[0],"work":[1],"studies":[2],"the":[3,6,15,18,22,25,44,54,58,85,114,137,151,161,165,198,206],"effects":[4],"of":[5,9,17,24,46,57,71,88,116,140,164,205,209],"two":[7,138,152],"rounds":[8],"Whole":[10],"Genome":[11],"Duplication":[12],"(WGD)":[13],"at":[14],"origin":[16],"vertebrate":[19,166],"lineage":[20],"on":[21,33,177],"architecture":[23],"human":[26],"gene":[27],"regulatory":[28,119,127,167],"networks.":[29],"We":[30,62],"integrate":[31],"information":[32],"transcriptional":[34],"regulation,":[35,37],"miRNA":[36],"and":[38,48,74,101,105,123,181,190],"protein-protein":[39],"interactions":[40],"to":[41,95,183],"comparatively":[42],"analyse":[43],"role":[45,112,158],"WGD":[47,79,153,210],"Small":[49],"Scale":[50],"Duplications":[51],"(SSD)":[52],"in":[53,84,113,130,143,159,196,212],"structural":[55],"properties":[56],"resulting":[59],"multilayer":[60],"network.":[61,86],"show":[63],"that":[64,150],"complex":[65],"network":[66,168],"motifs,":[67],"such":[68],"as":[69,201],"combinations":[70],"feed-forward":[72],"loops":[73],"bifan":[75],"arrays,":[76],"deriving":[77],"from":[78],"events":[80,154],"are":[81,129],"specifically":[82],"enriched":[83],"Pairs":[87],"WGD-derived":[89,106],"proteins":[90],"display":[91],"a":[92,110,117,156],"strong":[93,118],"tendency":[94],"interact":[96],"both":[97],"with":[98,102,174],"each":[99],"other":[100],"common":[103],"partners":[104],"transcription":[107],"factors":[108],"play":[109],"prominent":[111],"retention":[115],"redundancy.":[120],"Combinatorial":[121],"regulation":[122],"synergy":[124],"between":[125],"different":[126,144],"layers":[128],"general":[131],"enhanced":[132],"by":[133,169],"duplication":[134],"events,":[135],"but":[136],"types":[139],"duplications":[141,211],"contribute":[142],"ways.":[145],"Overall,":[146],"our":[147],"findings":[148],"suggest":[149],"played":[155],"substantial":[157],"increasing":[160],"multi-layer":[162],"complexity":[163],"enhancing":[170],"its":[171,178],"combinatorial":[172],"organization,":[173],"potential":[175],"consequences":[176],"overall":[179],"robustness":[180],"ability":[182],"perform":[184],"high-level":[185],"functions":[186],"like":[187],"signal":[188],"integration":[189],"noise":[191],"control.":[192],"Lastly,":[193],"we":[194],"discuss":[195],"detail":[197],"RAR/RXR":[199],"pathway":[200],"an":[202],"illustrative":[203],"example":[204],"evolutionary":[207],"impact":[208],"human.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}