{"id":"https://openalex.org/W4200511755","doi":"https://doi.org/10.1371/journal.pcbi.1009629","title":"Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant","display_name":"Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant","publication_year":2021,"publication_date":"2021-12-16","ids":{"openalex":"https://openalex.org/W4200511755","doi":"https://doi.org/10.1371/journal.pcbi.1009629","pmid":"https://pubmed.ncbi.nlm.nih.gov/34914688"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009629","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009629","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009629","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002867395","display_name":"Joseph Larsen","orcid":"https://orcid.org/0000-0002-4670-683X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Larsen","raw_affiliation_strings":["Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America","Quantitative and Computational Biology, Department of Biological Science, University of Southern California, Los Angeles, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4670-683X","affiliations":[{"raw_affiliation_string":"Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I4210119461","https://openalex.org/I1174212"]},{"raw_affiliation_string":"Quantitative and Computational Biology, Department of Biological Science, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109681375","display_name":"Margaret R. Martin","orcid":"https://orcid.org/0000-0001-6631-9434"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret R. Martin","raw_affiliation_strings":["Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035082371","display_name":"John D. Martin","orcid":"https://orcid.org/0000-0002-9828-8203"},"institutions":[{"id":"https://openalex.org/I4210137177","display_name":"Materia (United States)","ror":"https://ror.org/03tx9ef16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210137177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John D. Martin","raw_affiliation_strings":["Materia Therapeutics, Las Vegas, Nevada, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9828-8203","affiliations":[{"raw_affiliation_string":"Materia Therapeutics, Las Vegas, Nevada, United States of America","institution_ids":["https://openalex.org/I4210137177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025053302","display_name":"James Hicks","orcid":"https://orcid.org/0000-0001-5353-4338"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James B. Hicks","raw_affiliation_strings":["Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5353-4338","affiliations":[{"raw_affiliation_string":"Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I4210119461","https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000472988","display_name":"Peter K\u00fchn","orcid":"https://orcid.org/0000-0003-2629-4505"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Kuhn","raw_affiliation_strings":["Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2629-4505","affiliations":[{"raw_affiliation_string":"Convergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I4210119461","https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000472988","https://openalex.org/A5025053302","https://openalex.org/A5035082371"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210119461","https://openalex.org/I4210137177"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6296,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8671119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"17","issue":"12","first_page":"e1009629","last_page":"e1009629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.8469172716140747},{"id":"https://openalex.org/keywords/nausea","display_name":"Nausea","score":0.7749963998794556},{"id":"https://openalex.org/keywords/vomiting","display_name":"Vomiting","score":0.7617936730384827},{"id":"https://openalex.org/keywords/diarrhea","display_name":"Diarrhea","score":0.6510340571403503},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5920326113700867},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5612077713012695},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5006439685821533},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.4806722104549408},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.468725323677063},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.44864919781684875},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.4135195016860962},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2941383719444275},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.2866666913032532},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.2530388832092285},{"id":"https://openalex.org/keywords/history","display_name":"History","score":0.10165613889694214}],"concepts":[{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.8469172716140747},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.7749963998794556},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.7617936730384827},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.6510340571403503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5920326113700867},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5612077713012695},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5006439685821533},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.4806722104549408},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.468725323677063},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.44864919781684875},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4135195016860962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2941383719444275},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2866666913032532},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2530388832092285},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.10165613889694214},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009629","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009629","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34914688","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34914688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009629","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009629","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a37362253dfc4503af87a4d2e6443a66","is_oa":true,"landing_page_url":"https://doaj.org/article/a37362253dfc4503af87a4d2e6443a66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 12, p e1009629 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8675677","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8675677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009629","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009629","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1976698644","https://openalex.org/W2059684559","https://openalex.org/W2149958386","https://openalex.org/W2582743722","https://openalex.org/W2605343262","https://openalex.org/W3008049045","https://openalex.org/W3008874180","https://openalex.org/W3009155534","https://openalex.org/W3010071846","https://openalex.org/W3010538497","https://openalex.org/W3012587129","https://openalex.org/W3013125498","https://openalex.org/W3013270768","https://openalex.org/W3014486521","https://openalex.org/W3015281372","https://openalex.org/W3016785135","https://openalex.org/W3021329327","https://openalex.org/W3021742658","https://openalex.org/W3022687324","https://openalex.org/W3023098338","https://openalex.org/W3023441241","https://openalex.org/W3023494626","https://openalex.org/W3023519397","https://openalex.org/W3025009722","https://openalex.org/W3027377573","https://openalex.org/W3030234117","https://openalex.org/W3031584350","https://openalex.org/W3034312608","https://openalex.org/W3034857588","https://openalex.org/W3036796082","https://openalex.org/W3037848912","https://openalex.org/W3038085205","https://openalex.org/W3038689217","https://openalex.org/W3039901154","https://openalex.org/W3041319886","https://openalex.org/W3043431476","https://openalex.org/W3043723311","https://openalex.org/W3046581048","https://openalex.org/W3046681865","https://openalex.org/W3047011525","https://openalex.org/W3048657824","https://openalex.org/W3048762468","https://openalex.org/W3049233984","https://openalex.org/W3081130635","https://openalex.org/W3081270060","https://openalex.org/W3084354284","https://openalex.org/W3089272419","https://openalex.org/W3092141723","https://openalex.org/W3101992496","https://openalex.org/W3109022689","https://openalex.org/W3112362785","https://openalex.org/W3129662604","https://openalex.org/W3130749172","https://openalex.org/W3134208712","https://openalex.org/W3137149656","https://openalex.org/W3139074260","https://openalex.org/W3156343712","https://openalex.org/W3184226105","https://openalex.org/W6775912745","https://openalex.org/W6776001934","https://openalex.org/W6787457316"],"related_works":["https://openalex.org/W148728087","https://openalex.org/W2375265431","https://openalex.org/W2030053732","https://openalex.org/W4232799063","https://openalex.org/W2005374976","https://openalex.org/W4237990459","https://openalex.org/W1979418062","https://openalex.org/W2033508602","https://openalex.org/W2765896093","https://openalex.org/W111787504"],"abstract_inverted_index":{"Identifying":[0],"order":[1,34,57,72,92,204,235],"of":[2,5,35,44,58,64,73,93,162,227],"symptom":[3,49,180,203,228,234],"onset":[4],"infectious":[6,66],"diseases":[7,67],"might":[8,178],"aid":[9],"in":[10,15,46,77,102,105,110,126,155,168,190,240,261],"differentiating":[11],"symptomatic":[12],"infections":[13],"earlier":[14],"a":[16,29],"population":[17],"thereby":[18],"enabling":[19],"non-pharmaceutical":[20],"interventions":[21],"and":[22,53,104,120,137,219,243],"reducing":[23],"disease":[24,242],"spread.":[25],"Previously,":[26],"we":[27,86,173,185],"developed":[28],"mathematical":[30],"model":[31],"predicting":[32],"the":[33,41,56,78,91,99,106,127,144,156,159,163,169,194,200,207,245],"symptoms":[36,60,75,94],"based":[37],"on":[38],"data":[39,96],"from":[40,62,97,151,193],"initial":[42,100,170],"outbreak":[43,164],"SARS-CoV-2":[45,146,189],"China":[47,103,111,171],"using":[48,95],"occurrence":[50],"at":[51],"diagnosis":[52],"found":[54,186],"that":[55,63,143,148,175,187,233,247],"COVID-19":[59,74],"differed":[61],"other":[65],"including":[68],"influenza.":[69],"Whether":[70],"this":[71,176,183],"holds":[76],"USA":[79,128,157,208],"under":[80],"changing":[81],"conditions":[82],"is":[83,250],"unclear.":[84],"Here,":[85],"use":[87],"modeling":[88],"to":[89,115,132,153,199,206,259],"predict":[90],"both":[98],"outbreaks":[101],"USA.":[107],"Whereas":[108],"patients":[109,125],"were":[112,129],"more":[113,130,251,257],"likely":[114,131,258],"have":[116,133],"fever":[117,136],"before":[118,123,135,140,263],"cough":[119,134,260],"then":[121,138],"nausea/vomiting":[122],"diarrhea,":[124],"diarrhea":[139],"nausea/vomiting.":[141],"Given":[142],"D614G":[145,201,248],"variant":[147,249],"rapidly":[149],"spread":[150],"Europe":[152],"predominate":[154],"during":[158],"first":[160],"wave":[161],"was":[165],"not":[166,222],"present":[167],"outbreak,":[172],"hypothesized":[174],"mutation":[177,239],"affect":[179,223],"order.":[181,229],"Supporting":[182],"notion,":[184],"as":[188],"Japan":[191],"shifted":[192,205],"original":[195],"Wuhan":[196],"reference":[197],"strain":[198],"variant,":[202],"pattern.":[209],"Google":[210],"Trends":[211],"analyses":[212],"supported":[213],"these":[214],"findings,":[215],"while":[216],"weather,":[217],"age,":[218],"comorbidities":[220],"did":[221],"our":[224],"model's":[225],"predictions":[226],"These":[230],"findings":[231],"indicate":[232],"can":[236],"change":[237],"with":[238,266],"viral":[241],"raise":[244],"possibility":[246],"transmissible":[252],"because":[253],"infected":[254],"people":[255],"are":[256],"public":[262],"being":[264],"incapacitated":[265],"fever.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
