{"id":"https://openalex.org/W3212457072","doi":"https://doi.org/10.1371/journal.pcbi.1009576","title":"Programming cell growth into different cluster shapes using diffusible signals","display_name":"Programming cell growth into different cluster shapes using diffusible signals","publication_year":2021,"publication_date":"2021-11-08","ids":{"openalex":"https://openalex.org/W3212457072","doi":"https://doi.org/10.1371/journal.pcbi.1009576","mag":"3212457072","pmid":"https://pubmed.ncbi.nlm.nih.gov/34748539"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009576","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009576","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058784998","display_name":"Yipei Guo","orcid":"https://orcid.org/0000-0002-4583-8865"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yipei Guo","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America","Program in Biophysics, Harvard University, Boston, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4583-8865","affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Biophysics, Harvard University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067199884","display_name":"Mor Nitzan","orcid":"https://orcid.org/0000-0003-0074-9196"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mor Nitzan","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001027226","display_name":"Michael P. Brenner","orcid":"https://orcid.org/0000-0002-5673-7947"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Brenner","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5673-7947","affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058784998"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5402,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61108807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"11","first_page":"e1009576","last_page":"e1009576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.5300868153572083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5283896327018738},{"id":"https://openalex.org/keywords/genetic-programming","display_name":"Genetic programming","score":0.5255704522132874},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4477415978908539},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38907063007354736},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36721330881118774},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3424128293991089}],"concepts":[{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.5300868153572083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5283896327018738},{"id":"https://openalex.org/C110332635","wikidata":"https://www.wikidata.org/wiki/Q629498","display_name":"Genetic programming","level":2,"score":0.5255704522132874},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4477415978908539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38907063007354736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36721330881118774},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3424128293991089},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000067470","descriptor_name":"Cellular Reprogramming Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022081","descriptor_name":"Cell Surface Extensions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022081","descriptor_name":"Cell Surface Extensions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022081","descriptor_name":"Cell Surface Extensions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009576","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34748539","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34748539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:85a2c56e6abf4ee6bfbf13147ce55aa5","is_oa":true,"landing_page_url":"https://doaj.org/article/85a2c56e6abf4ee6bfbf13147ce55aa5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 11, p e1009576 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8601629","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8601629","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009576","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009576","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.4000000059604645}],"awards":[{"id":"https://openalex.org/G2129718055","display_name":null,"funder_award_id":"DMR-1420570","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G2559566616","display_name":null,"funder_award_id":"DMR-1420570","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3051460182","display_name":null,"funder_award_id":"ONR N00014-17-1-3029","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G309880346","display_name":null,"funder_award_id":"DMS-1715477","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3366412161","display_name":null,"funder_award_id":"1420570","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G3953734904","display_name":null,"funder_award_id":"DMR-1420570","funder_id":"https://openalex.org/F4320309622","funder_display_name":"Harvard University"},{"id":"https://openalex.org/G4220372196","display_name":null,"funder_award_id":"1420570","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G4504108201","display_name":null,"funder_award_id":"N00014-17-1","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G691196364","display_name":null,"funder_award_id":"DMS-1715477, MRSEC DMR-1420570, ONR N00014-17-1-3029","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"},{"id":"https://openalex.org/G7320158924","display_name":null,"funder_award_id":"N00014-17-1-3029","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G7943943447","display_name":null,"funder_award_id":"ONR N00014-17-1-3029","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G8291819164","display_name":"Research and Education in Physical Mathematics","funder_award_id":"1715477","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8647306799","display_name":null,"funder_award_id":"DMR-1420570","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G8864360135","display_name":"Materials Research Science and Engineering Center","funder_award_id":"1420570","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4026159580","display_name":"Schmidt Futures","ror":null},{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320323278","display_name":"Council for Higher Education","ror":"https://ror.org/036mqp197"},{"id":"https://openalex.org/F4320333422","display_name":"Materials Research Science and Engineering Center, Harvard University","ror":null},{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320338027","display_name":"FAS Division of Science, Harvard University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1532184470","https://openalex.org/W1989327195","https://openalex.org/W1993199560","https://openalex.org/W2003095799","https://openalex.org/W2006033261","https://openalex.org/W2007737253","https://openalex.org/W2018658742","https://openalex.org/W2024425536","https://openalex.org/W2032930150","https://openalex.org/W2039340752","https://openalex.org/W2039942900","https://openalex.org/W2047377602","https://openalex.org/W2053239308","https://openalex.org/W2057347583","https://openalex.org/W2094729630","https://openalex.org/W2111072594","https://openalex.org/W2118208715","https://openalex.org/W2123011056","https://openalex.org/W2128494980","https://openalex.org/W2133420849","https://openalex.org/W2133906055","https://openalex.org/W2134365732","https://openalex.org/W2137202581","https://openalex.org/W2141334319","https://openalex.org/W2157103346","https://openalex.org/W2157546970","https://openalex.org/W2161337189","https://openalex.org/W2256857837","https://openalex.org/W2559221547","https://openalex.org/W2600587427","https://openalex.org/W2615819784","https://openalex.org/W2751928832","https://openalex.org/W2759790292","https://openalex.org/W2791552377","https://openalex.org/W2796439542","https://openalex.org/W2806766210","https://openalex.org/W2904952367","https://openalex.org/W2916359453","https://openalex.org/W2945141339","https://openalex.org/W2953308056","https://openalex.org/W2963701805","https://openalex.org/W3093183764","https://openalex.org/W3103091954","https://openalex.org/W4235813374"],"related_works":["https://openalex.org/W2968285896","https://openalex.org/W2102997898","https://openalex.org/W1662819506","https://openalex.org/W2381504162","https://openalex.org/W4367596775","https://openalex.org/W4285805598","https://openalex.org/W4318240128","https://openalex.org/W2381116869","https://openalex.org/W1983569565","https://openalex.org/W2950487361"],"abstract_inverted_index":{"Advances":[0],"in":[1],"genetic":[2,11],"engineering":[3],"technologies":[4],"have":[5,14],"allowed":[6],"the":[7,26,37,95,102,109,124,145,162],"construction":[8],"of":[9,21,28,97,104,111,126,141,147,164],"artificial":[10],"circuits,":[12],"which":[13],"been":[15],"used":[16,92,159],"to":[17,40,42,62,93,160],"generate":[18],"spatial":[19],"patterns":[20],"differential":[22],"gene":[23],"expression.":[24],"However,":[25],"question":[27],"how":[29,35,64,87,101,153],"cells":[30,65],"can":[31,66,80,90,143],"be":[32,91,131,158],"programmed,":[33],"and":[34,100,137],"complex":[36],"rules":[38],"need":[39],"be,":[41],"achieve":[43],"a":[44,59,117,169],"desired":[45,170],"tissue":[46],"morphology":[47],"has":[48],"received":[49],"less":[50],"attention.":[51],"Here,":[52],"we":[53],"address":[54],"these":[55],"questions":[56],"by":[57,75],"developing":[58],"mathematical":[60],"model":[61],"study":[63],"collectively":[67],"grow":[68],"into":[69],"clusters":[70],"with":[71,108,133],"different":[72],"structural":[73],"morphologies":[74],"secreting":[76],"diffusible":[77],"signals":[78,142],"that":[79,116,138],"influence":[81],"cellular":[82,98],"growth":[83,88,119,135],"rates.":[84],"We":[85,114],"formulate":[86],"regulators":[89],"control":[94],"formation":[96,125],"protrusions":[99,128],"range":[103],"achievable":[105],"structures":[106],"scales":[107],"number":[110],"distinct":[112],"signals.":[113],"show":[115],"single":[118],"inhibitor":[120],"is":[121],"insufficient":[122],"for":[123,167],"multiple":[127,134],"but":[129],"may":[130],"achieved":[132],"inhibitors,":[136],"other":[139],"types":[140],"regulate":[144],"shape":[146],"protrusion":[148],"tips.":[149],"These":[150],"examples":[151],"illustrate":[152],"our":[154],"approach":[155],"could":[156],"potentially":[157],"guide":[161],"design":[163],"regulatory":[165],"circuits":[166],"achieving":[168],"target":[171],"structure.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-06-23T13:55:30.953635","created_date":"2025-10-10T00:00:00"}