{"id":"https://openalex.org/W3204382898","doi":"https://doi.org/10.1371/journal.pcbi.1009475","title":"Engineering gene overlaps to sustain genetic constructs in vivo","display_name":"Engineering gene overlaps to sustain genetic constructs in vivo","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W3204382898","doi":"https://doi.org/10.1371/journal.pcbi.1009475","mag":"3204382898","pmid":"https://pubmed.ncbi.nlm.nih.gov/34624014"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009475","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009475&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009475&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021545267","display_name":"Antoine Decrulle","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine L. Decrulle","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074810950","display_name":"Antoine Fr\u00e9noy","orcid":"https://orcid.org/0000-0002-3539-8915"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Antoine Fr\u00e9noy","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, CNRS UMR5525, Grenoble, France","Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","TIMC-BCM - Biologie Computationnelle et Mod\u00e9lisation (Pavillon Taillefer, Rond-point de la Croix de Vie, 38700 La Tronche - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, CNRS UMR5525, Grenoble, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]},{"raw_affiliation_string":"TIMC-BCM - Biologie Computationnelle et Mod\u00e9lisation (Pavillon Taillefer, Rond-point de la Croix de Vie, 38700 La Tronche - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036056507","display_name":"Thomas A. Meiller-Legrand","orcid":"https://orcid.org/0000-0001-6472-2991"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas A. Meiller-Legrand","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036551333","display_name":"Aude Bernheim","orcid":"https://orcid.org/0000-0003-0212-777X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aude Bernheim","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056996051","display_name":"Chantal Lotton","orcid":"https://orcid.org/0000-0003-4453-340X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chantal Lotton","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062215861","display_name":"Arnaud Gutierrez","orcid":"https://orcid.org/0000-0002-9512-0659"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Gutierrez","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047096952","display_name":"Ariel B. Lindner","orcid":"https://orcid.org/0000-0001-5015-6511"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210098463","display_name":"Center for Research and Interdisciplinarity","ror":"https://ror.org/00zbj9525","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210098463"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ariel B. Lindner","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM U1001, Paris, France","Universit\u00e9 de Paris, INSERM U1284, Center for Research and Interdisciplinarity (CRI), Paris, France","UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","CRI - Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (8 bis, rue Charles V\r\n75004 Paris - France)"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1001, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM U1284, Center for Research and Interdisciplinarity (CRI), Paris, France","institution_ids":["https://openalex.org/I4210098463","https://openalex.org/I204730241","https://openalex.org/I154526488"]},{"raw_affiliation_string":"UPCit\u00e9 - Universit\u00e9 Paris Cit\u00e9 (85 boulevard Saint-Germain\r\n75006 Paris - France)","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I204730241"]},{"raw_affiliation_string":"CRI - Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (8 bis, rue Charles V\r\n75004 Paris - France)","institution_ids":["https://openalex.org/I4210098463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047096952","https://openalex.org/A5074810950"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091437","https://openalex.org/I4210098463","https://openalex.org/I4210131199","https://openalex.org/I899635006"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7303,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.69506607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"10","first_page":"e1009475","last_page":"e1009475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7747961282730103},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6525640487670898},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.6368631720542908},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6014243960380554},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5639230608940125},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5018951892852783},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4972522556781769},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.48038750886917114},{"id":"https://openalex.org/keywords/negative-selection","display_name":"Negative selection","score":0.4770228862762451},{"id":"https://openalex.org/keywords/genetic-fitness","display_name":"Genetic Fitness","score":0.4444020688533783},{"id":"https://openalex.org/keywords/gene-selection","display_name":"Gene selection","score":0.4316464066505432},{"id":"https://openalex.org/keywords/natural-selection","display_name":"Natural selection","score":0.4217067360877991},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4172452688217163},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2253238558769226},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.13932955265045166},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12591677904129028},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08090603351593018}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7747961282730103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6525640487670898},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6368631720542908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6014243960380554},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5639230608940125},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5018951892852783},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4972522556781769},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48038750886917114},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.4770228862762451},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.4444020688533783},{"id":"https://openalex.org/C2984324147","wikidata":"https://www.wikidata.org/wiki/Q3080021","display_name":"Gene selection","level":5,"score":0.4316464066505432},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.4217067360877991},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4172452688217163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2253238558769226},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.13932955265045166},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12591677904129028},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08090603351593018},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016364","descriptor_name":"Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016364","descriptor_name":"Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016364","descriptor_name":"Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009475","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009475&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34624014","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34624014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03800488v1","is_oa":false,"landing_page_url":"https://hal.science/hal-03800488","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (10), pp.e1009475. &#x27E8;10.1371/journal.pcbi.1009475&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:f2bd32c24ae24d3ca118ea95cdf465b0","is_oa":true,"landing_page_url":"https://doaj.org/article/f2bd32c24ae24d3ca118ea95cdf465b0","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 10, p e1009475 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8528312","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8528312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009475","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009475&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324477","display_name":"Fondation Bettencourt Schueller","ror":"https://ror.org/02p3abx23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204382898.pdf","grobid_xml":"https://content.openalex.org/works/W3204382898.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W89691187","https://openalex.org/W98776576","https://openalex.org/W1512810258","https://openalex.org/W1550165896","https://openalex.org/W1566245339","https://openalex.org/W1590001370","https://openalex.org/W1606217776","https://openalex.org/W1823198322","https://openalex.org/W1905467344","https://openalex.org/W1948215829","https://openalex.org/W1968752956","https://openalex.org/W1972014674","https://openalex.org/W1972915118","https://openalex.org/W1978119727","https://openalex.org/W1984874903","https://openalex.org/W1988327779","https://openalex.org/W1990585969","https://openalex.org/W1990695168","https://openalex.org/W1993712384","https://openalex.org/W1994028898","https://openalex.org/W2000219748","https://openalex.org/W2000989493","https://openalex.org/W2003593714","https://openalex.org/W2004361023","https://openalex.org/W2008127844","https://openalex.org/W2011343696","https://openalex.org/W2012136538","https://openalex.org/W2017710819","https://openalex.org/W2019385975","https://openalex.org/W2027839322","https://openalex.org/W2029132648","https://openalex.org/W2040525210","https://openalex.org/W2056390565","https://openalex.org/W2060969855","https://openalex.org/W2066200885","https://openalex.org/W2082161669","https://openalex.org/W2091100027","https://openalex.org/W2092247774","https://openalex.org/W2093194605","https://openalex.org/W2096286650","https://openalex.org/W2096978472","https://openalex.org/W2098390695","https://openalex.org/W2112269135","https://openalex.org/W2113422929","https://openalex.org/W2122332608","https://openalex.org/W2122686110","https://openalex.org/W2133790733","https://openalex.org/W2135751988","https://openalex.org/W2139566973","https://openalex.org/W2139970361","https://openalex.org/W2142391696","https://openalex.org/W2147189708","https://openalex.org/W2149174733","https://openalex.org/W2153303237","https://openalex.org/W2159573893","https://openalex.org/W2165479490","https://openalex.org/W2166064969","https://openalex.org/W2166323054","https://openalex.org/W2170343590","https://openalex.org/W2192893656","https://openalex.org/W2279510465","https://openalex.org/W2609066137","https://openalex.org/W2788004430","https://openalex.org/W2790907951","https://openalex.org/W2793677392","https://openalex.org/W2890000868","https://openalex.org/W2900490866","https://openalex.org/W2949337188","https://openalex.org/W2967786918","https://openalex.org/W2991110084","https://openalex.org/W3000068290","https://openalex.org/W4243772627","https://openalex.org/W6680683667"],"related_works":["https://openalex.org/W4211107165","https://openalex.org/W2349120000","https://openalex.org/W2021562946","https://openalex.org/W3167338276","https://openalex.org/W2751446000","https://openalex.org/W2164024974","https://openalex.org/W4241375051","https://openalex.org/W4385442993","https://openalex.org/W1982812732","https://openalex.org/W4384493312"],"abstract_inverted_index":{"Evolution":[0],"is":[1],"often":[2],"an":[3,61,66,70,121],"obstacle":[4],"to":[5,13,40,58,73,110],"the":[6,14,42,108,117,135,151,156,163,167],"engineering":[7],"of":[8,16,44,85,95,105,137,155,166],"stable":[9],"biological":[10],"systems":[11],"due":[12],"selection":[15,132],"mutations":[17,91,106],"inactivating":[18],"costly":[19,45,126],"gene":[20,68,72,109,127],"circuits.":[21],"Gene":[22],"overlaps":[23],"induce":[24],"important":[25],"constraints":[26,36],"on":[27,116],"sequences":[28],"and":[29,54,169],"their":[30],"evolution.":[31],"We":[32,51],"show":[33],"that":[34,101],"these":[35],"can":[37],"be":[38],"harnessed":[39],"increase":[41],"stability":[43,173],"genes":[46,94],"by":[47,130,133],"purging":[48],"loss-of-function":[49],"mutations.":[50],"combine":[52],"computational":[53],"synthetic":[55,149],"biology":[56],"approaches":[57],"rationally":[59],"design":[60],"overlapping":[62,80,97],"reading":[63,81],"frame":[64],"expressing":[65],"essential":[67,118],"within":[69],"existing":[71],"protect.":[74],"Our":[75],"algorithm":[76],"succeeded":[77],"in":[78,83,92],"creating":[79],"frames":[82],"80%":[84],"E.":[86],"coli":[87],"genes.":[88],"Experimentally,":[89],"scoring":[90],"both":[93],"such":[96],"construct,":[98],"we":[99],"found":[100],"a":[102,113,125,141],"significant":[103],"fraction":[104],"impacting":[107],"protect":[111],"have":[112],"deleterious":[114],"effect":[115],"gene.":[119],"Such":[120],"overlap":[122,152],"thus":[123,170],"protects":[124],"from":[128],"removal":[129,139],"natural":[131],"associating":[134],"benefit":[136],"this":[138],"with":[140],"larger":[142],"or":[143],"even":[144],"lethal":[145],"cost.":[146],"In":[147],"our":[148],"constructs,":[150],"converts":[153],"many":[154],"possible":[157],"mutants":[158],"into":[159],"evolutionary":[160,164],"dead-ends,":[161],"reducing":[162],"potential":[165],"system":[168],"increasing":[171],"its":[172],"over":[174],"time.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
